Pflugers Arch January 2012 PMID 22071480

Sleep and immune function.

Luciana Besedovsky, Tanja Lange, Jan Born

Mentions

358
Peak: 7 in Oct 2025
across 6 sources since Apr 2014

Extended reach

12,935,416
potential audience

Total likes

879

Video views

85,433

Mentions per month

Apr 2014 – Nov 2025

Where it's discussed

  • News239 articles
  • X / Twitter59 posts
  • Facebook22 posts
  • Blogs21 articles
  • YouTube13 videos
  • Bluesky4 posts

AI synopsis

What people are saying

The overall tone and word choices reveal strong support and curiosity regarding the connection between sleep and immunity, with examples like references to cytokine production during sleep and tips for improving sleep to enhance immune health. The use of scientific citations and health advice highlights a serious, fact-based approach, emphasizing the significance and practical implications of the research.

AgreementModerate agreement

Most posts acknowledge the link between sleep and immune function, supporting the article's findings, as seen in comments about sleep boosting immunity and cytokines production.

InterestHigh interest

The discussions show high interest, with frequent mentions of how sleep influences health, immunity, and recovery, indicating engagement with the topic.

EngagementModerate engagement

Posts include sharing of scientific studies, health tips, and personal experiences, reflecting a thoughtful and moderate level of engagement.

ImpactModerate impact

While acknowledging the importance of sleep for immunity, most discussions seem to have a moderate perceived impact, emphasizing its role in health maintenance rather than revolutionary change.

Abstract in brief

  • Sleep and the circadian system significantly influence immune functions, with immune activity peaking at different times during sleep and wakefulness.
  • During sleep, especially slow wave sleep, the body promotes the movement of T cells to lymph nodes and enhances cytokines that support immune cell interactions, which helps in developing immunological memory.
  • Sleep after vaccination boosts the production of antigen-specific T helper cells and antibody levels, highlighting its important role in strengthening immune responses and memory formation.

Top posts

Most liked on X and Bluesky
Dr Andrew Greenland
@DrAGreenland · X

@BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting smoking or maintaining a healthy weight. Chronic loneliness elevates cortisol, increases inflammation, and disrupts sleep and immune function. In functional medicine, we view

Oct 19, 2025 · 59 likes · 6 shares · 534 followers View post →
La Jefita
@soylajefita · X

https://t.co/XDTJD6R91Q 6/

Apr 17, 2025 · 27 likes · 77,954 followers View post →
Dr. Cuneyt Tegin
@cuneytteginmd · X

İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerinin daha yüksek olduğu gösterilmiş. İyi uyku gibisi yok! #UykuLobisi https://t.co/2wWfiwiczw

Oct 24, 2020 · 26 likes · 5 shares · 8,349 followers View post →
Biznitch
@Biznitch1177 · X

@JohnDParody Regulates pain, mood, appetite, sleep, and immune function. @BirdysBees has some great honey… ordered it a few times now.

Jun 6, 2025 · 18 likes · 1 share · 11,632 followers View post →
Masa
@smaka21 · X

Dva članka na to temo: https://t.co/mIOBLZFxfZ; https://t.co/7eIu2NUuxc

May 6, 2021 · 5 likes · 1 share · 443 followers View post →
Andrew Green
@AndrewG76201347 · X

@saffronandsky Yes I started NAD+ subcut injections when I was severe mecfs. Helps me. Improved my (at that point) terrible sleep, and immune function eg stops/reduces the constant cold sore outbreaks I had. Helps a bit with cognition & physical fatigue. NAD doesn’t help my son.

May 10, 2025 · 3 likes · 1,606 followers View post →

All mentions

Zeptej se vědce
@zeptejsevedce.bsky.social · Bluesky

Nov 24, 2025 · 1 like · 1 share View post →
Beezhan Tulu, FullSelfDrive365
@fsdat365 · X

@Thebestfigen Research proves pleasant voices raise parasympathetic activity, literally healing digestion, sleep, and immune function.

Nov 23, 2025 · 3,591 followers View post →
ABC Health & Fitness
@ABCHealthFit · X

Nov 7, 2025 · 59 followers View post →
Dermot Duffy | Online Coach
@DDuff646 · X

2️⃣ Zinc 30mg a day. Supports testosterone, sleep, and immune function. If you train hard or sweat a lot, this one’s essential.

Nov 6, 2025 · 31 followers View post →
EyeInk216
@EyeInk216 · X

RT @DrAGreenland: @BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting s…

Oct 20, 2025 · 6 shares · 174 followers View post →
HealthCommunication
@Comm_in_Care · X

RT @DrAGreenland: @BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting s…

Oct 20, 2025 · 6 shares · 4,052 followers View post →
おじ木
@Ozi_Ki · X

RT @DrAGreenland: @BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting s…

Oct 19, 2025 · 6 shares · 891 followers View post →
Becky Barron
@beckybarron86 · X

RT @DrAGreenland: @BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting s…

Oct 19, 2025 · 6 shares · 333 followers View post →
Dr Andrew Greenland
@DrAGreenland · X

@BrandonLuuMD Completely agree. The data are clear - strong social connection is as predictive of longevity as quitting smoking or maintaining a healthy weight. Chronic loneliness elevates cortisol, increases inflammation, and disrupts sleep and immune function. In functional medicine, we view

Oct 19, 2025 · 59 likes · 6 shares · 534 followers View post →
Leaf it to wellness
@soulsprighealth · X

Ladies, pumpkin seeds are rich content of nutrients ~ magnesium, zinc, and antioxidants, which support bone health, mood sleep, and immune function. ease symptoms related to menopause, hot flashes ,poor sleep, and may improve bladder control and reduce inflammation. https://t.co/FeL7hhbnSP

Oct 11, 2025 · 23 followers View post →
Lynne Irwin
@LLynneIrwin · X

RT @ILCCanada: Healthy Aging Tip: Spending time outdoors supports mood, sleep, and immune function. Fresh air and natural light can lift s…

Aug 12, 2025 · 1 share · 4,868 followers View post →
ILC Canada
@ilccanada.bsky.social · Bluesky

Healthy Aging Tip: Spending time outdoors supports mood, sleep, and immune function. Fresh air and natural light can lift spirits and promote balance — even a few minutes a day helps. #HealthyAging #NatureHeals #LongevityTips

Aug 12, 2025 View post →
ILC Canada
@ILCCanada · X

Healthy Aging Tip: Spending time outdoors supports mood, sleep, and immune function. Fresh air and natural light can lift spirits and promote balance — even a few minutes a day helps. @GAROP_Sec @UN #HealthyAging #NatureHeals #LongevityTips https://t.co/A5D65DI50W

Aug 12, 2025 · 1 like · 1 share · 2,120 followers View post →
Iulian Gudumac
@iuliangudumac.bsky.social · Bluesky

Sources: 204. Gudumac, I. (2025). Brainwave Alchemy. Neuro Spiritual Advantage R&D Team. 205. Besedovsky, L., Lange, T., & Born, J. (2012). Sleep and immune function. Pflügers Archiv-European Journal of Physiology, 463(1), 121-137. ...

Jul 26, 2025 View post →
Iulian Gudumac
@iuliangudumac · X

Sources: 204. Gudumac, I. (2025). Brainwave Alchemy. Neuro Spiritual Advantage R&D Team. 205. Besedovsky, L., Lange, T., & Born, J. (2012). Sleep and immune function. Pflügers Archiv-European Journal of Physiology, 463(1), 121-137. ...

Jul 26, 2025 · 9 followers View post →
Grok
@grok · X

@notjustcat3e @BrrrtWeb3 @PicturesFoIder While yoga won't literally fix everything, science backs its benefits: improved flexibility, strength, balance; reduced stress, anxiety, and blood pressure; better heart health, sleep, and immune function (per studies from Johns Hopkins, Harvard, and Mayo Clinic). It's a solid

Jul 18, 2025 · 6,333,332 followers View post →
NEKA HEALTH
@nekahealth_ · X

@thegarybrecka Simple, powerful advice.

Jul 10, 2025 · 79 followers View post →
Vigor Sciences
@VigorSciences · X

Check out VigorSciences's video! #TikTok https://t.co/QiODJa3abX Power duo CJC-1295/Ipamorelin boosts muscle growth, strength, fat loss, anti-aging, recovery, quality sleep and immune function! Go to https://t.co/TnZaxzekU9 #Biohacking #VigorSciences #VigorSci #Peptides

Jul 7, 2025 · 2 followers View post →
Grok
@grok · X

@W2Freedom @DrJesseMorse @AbudBakri A speculative argument for Achilles tendon injuries in NBA players could suggest that circadian rhythm disruptions, possibly linked to pineal gland dysfunction from irregular schedules, impair sleep and immune function, weakening tendon repair. This might accelerate tendon aging,

Jun 23, 2025 · 6,333,332 followers View post →
Green
@Green114029 · X

@ChaunceyGardner @WSJ Cannabinoids work with the endocannabinoid system (ECS) is a complex biological system present in all vertebrates that plays a crucial role in regulating various physiological processes, including appetite, mood, sleep, and immune function.

Jun 15, 2025 · 14 followers View post →
Birdys Bees Apiary
@BirdysBees · X

RT @Biznitch1177: @JohnDParody Regulates pain, mood, appetite, sleep, and immune function. @BirdysBees has some great honey… ordered it a f…

Jun 6, 2025 · 1 share · 502 followers View post →
Biznitch
@Biznitch1177 · X

@JohnDParody Regulates pain, mood, appetite, sleep, and immune function. @BirdysBees has some great honey… ordered it a few times now.

Jun 6, 2025 · 18 likes · 1 share · 11,632 followers View post →
Clif’s Natural Remedies
@clifsremedies · X

Why You Should Be Taking Black Seed Oil Daily

Jun 1, 2025 · 20 followers View post →
The Skincare Network
@The_SCN_UK · X

For people with psoriasis, stress can lead to more frequent or severe outbreaks of red, scaly patches. In rosacea, it can cause increased redness, flushing, and sensitivity. Stress can also disrupt sleep and immune function, making it harder for the skin to heal and repair. https://t.co/B5VKpoSkQu

May 15, 2025 · 41 followers View post →
Andrew Green
@AndrewG76201347 · X

@saffronandsky Yes I started NAD+ subcut injections when I was severe mecfs. Helps me. Improved my (at that point) terrible sleep, and immune function eg stops/reduces the constant cold sore outbreaks I had. Helps a bit with cognition & physical fatigue. NAD doesn’t help my son.

May 10, 2025 · 3 likes · 1,606 followers View post →
Paul
@Seahorserace · X

@Bubba14760992 @healingfromlc T-cells(immune response) interacting with /interfering with melatonin? "Melatonin, a hormone that regulates sleep, interacts with MT1 and MT2 receptors. These receptors play a role in both sleep and immune function, and their dysregulation can be linked to insomnia and immune

May 2, 2025 · 1 like · 1,510 followers View post →
La Jefita
@soylajefita · X

https://t.co/XDTJD6R91Q 6/

Apr 17, 2025 · 27 likes · 77,954 followers View post →
unumihai Media
@unumihaimedia · X

As spring unfolds, sunlight’s health benefits emerge. Dr. Roger Seheult highlights its role in enhancing mood, sleep, and immune function. Just 15-20 minutes outdoors can yield lasting positive effects. Embrace sunlight wisely! https://t.co/8ZRqn5VqsJ

Mar 15, 2025 · 12,569 followers View post →
Dr. Leif H. Smith
@DrLeifSmith · X

RT @DrLeifSmith: Stress is killing you faster than you think. Chronic stress wrecks testosterone, sleep, and immune function. Manage it bef…

Mar 8, 2025 · 1 share · 1,377 followers View post →
Dr. Leif H. Smith
@DrLeifSmith · X

Stress is killing you faster than you think. Chronic stress wrecks testosterone, sleep, and immune function. Manage it before it manages you. #StressManagement #MensWellness

Feb 21, 2025 · 1 share · 1,377 followers View post →
Grow Strong Motivational
@growstrongm · X

Sleep and Immune Function: Adequate sleep can boost your immune system, making you less susceptible to various illnesses.

Nov 25, 2024 · 1 like · 1,207 followers View post →
Sleep Care online
@SleepCareonline · X

Sleep deprivation compromises the body’s ability to fight infections. Not only does sleep loss lead to vulnerability to germs and more frequent sickness but it can also make illnesses more intense and longer lasting. Learn more in this article. https://t.co/MDS3o4w0q9

Nov 19, 2024 · 77 followers View post →
David Gibbons
@DavidGibbons · X

TL;DR on the Endocannabinoid System The endocannabinoid system is a complex cell-signaling system present in many organisms. It helps regulate various physiological processes, including pain, mood, appetite, sleep, and immune function. Recent Breakthroughs: * Diverse

Nov 15, 2024 · 1 like · 4,124 followers View post →
Gavin Kemp
@gjkemp_author · X

8/10 The Science of Gratitude Research supports gratitude's benefits. Studies show gratitude improves well-being, sleep, and immune function. Consistent practice yields the best results. Science confirms that gratitude changes lives.

Nov 12, 2024 · 89 followers View post →
Polymath
@uaepoly · X

Immunity Research: Sleep and immune function https://t.co/BjDcbsetKt Besedovsky, L., Lange, T., & Born, J. (2012). Sleep and immune function. Pflugers Archiv : European journal of physiology, 463(1), 121–137. https://t.co/Atz9rz7HNz https://t.co/sHPbS5RVkp

Oct 25, 2024 · 10,891 followers View post →
Grow Strong Motivational
@growstrongm · X

Sleep and Immune Function: Adequate sleep can boost your immune system, making you less susceptible to various illnesses.

Oct 25, 2024 · 1,207 followers View post →
Julia Panina
@DrJuliaPanina · X

Sep 27, 2024 · 1 like · 69 followers View post →
Star Lord
@_D_R_F · X

RT @_D_R_F: Sleep and Immune Function Sleep is crucial for maintaining a strong immune system. During sleep, the body produces cytokines,…

Sep 22, 2024 · 1 share · 6,014 followers View post →
Star Lord
@_D_R_F · X

Sleep and Immune Function Sleep is crucial for maintaining a strong immune system. During sleep, the body produces cytokines, proteins that help fight infection, inflammation, and stress. Certain cytokines are produced and released only during sleep, which means that a lack https://t.co/BurX7PPW2U

Sep 22, 2024 · 1 like · 1 share · 6,014 followers View post →
Alejandro Caraballo
@ale_neo_ · X

Aquí tres estudios que respaldan lo que he dicho en el tuit: Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice https://t.co/97udHu3EN3 Sleep and Immune Function https://t.co/Tik1Z1Rsiz

Sep 15, 2024 · 2,114 followers View post →
tune
@keisuke4713 · X

T細胞,B細胞は夜早くpeak 夜間⬇️循環からリンパ器官へ移動,

Sep 15, 2024 · 3,743 followers View post →
Cactus Cancer Society
@cactuscancersoc · X

Jul 29, 2024 · 2,272 followers View post →
Dr. Jones, DC
@Dr_JonesDC · X

AOD-9604, a fragment of HGH, promotes fat loss, muscle preservation, joint regeneration, better sleep, and immune function. Always obtain through a proper prescription, not unregulated sources. #HGH #AOD9604 #HealthSafety The information provided in this video is for https://t.co/DbOXcPFRJj

Jul 15, 2024 · 382 followers View post →
Sleep Care online
@SleepCareonline · X

Sleep deprivation compromises the body’s ability to fight infections. Not only does sleep loss lead to vulnerability to germs and more frequent sickness but it can also make illnesses more intense and longer. Learn more about Sleep and Immune Function: https://t.co/t7sBFtdB8Z https://t.co/FYEdbZPtlm

Jul 5, 2024 · 77 followers View post →
Chris
@DadTheFUp · X

She sleeps better. Now she sleeps 7 hours every night. She’d watch TV late at night, carry on with her phone, and wake up early. Not ideal when we know that a poor night's sleep is enough to make you immunocompromised the following day. ➡️https://t.co/VxThwdUIUL

Jun 13, 2024 · 2 likes · 1,091 followers View post →
Chris
@Luxury_sleep · X

She sleeps better. Now she sleeps 7 hours every night. She’d watch TV late at night, carry on with her phone, and wake up early. Not ideal when we know that a poor night's sleep is enough to make you immunocompromised the following day. ➡️https://t.co/VxThwdUIUL

Jun 13, 2024 · 2 likes · 1,113 followers View post →
Healthium Medtech Limited
@Healthium_ · X

✅ Engage in physical activities to reduce stress and boost mood. ✅ Ensure adequate rest and relaxation for better sleep and immune function. ✅ Seek assistance from mental health professionals for personalised stress management strategies.

Apr 23, 2024 · 183 followers View post →
Dr.Mo. Rahman
@Dr_MD_MPH · X

@elonmusk Sleeplessness affect human body immune function. https://t.co/2OnJgALGlw

May 18, 2023 · 1 like · 3,115 followers View post →
Cristian Estrella
@imestrellakris · X

https://t.co/J7N720sTKM

Apr 24, 2023 · 53 followers View post →
100 Benefits of Sleep
@movingintosleep · X

Key takeaway: Quality sleep, specifically deep NREM sleep is critical in forming immunological memory, which is the ability of the #immune system to quickly target and respond to an antigen that the body has previously encountered. #healthylifestyle https://t.co/3OPi71LF4j

Apr 17, 2022 · 1 like · 192 followers View post →
Body Fine Tuning
@BodyFineTuning · X

Key takeaway: Quality sleep, specifically deep NREM sleep is critical in forming immunological memory, which is the ability of the #immune system to quickly target and respond to an antigen that the body has previously encountered. #healthylifestyle https://t.co/3OPi71LF4j

Apr 17, 2022 · 1 like · 188 followers View post →
ねあら@睡眠ブログ×エビデンス
@sleep_alot7 · X

【睡眠と免疫】 ワクチンを打ってから4週間後にしっかり睡眠をした人と睡眠不足の人を調べると、前者の方が抗体の量が2倍になるという実験結果がありました! 睡眠は免疫機能とも大きく関係しています! ソースはこちら https://t.co/1K7zqLSjeb

Jan 3, 2022 · 1 like · 305 followers View post →
Stephen Everson
@s_everson · X

@Ge_BoRo @MagnetThatcher @GidMK @Abhishe32708703 @alexandrosM Since he’s now acknowledged that exercise is important for natural immune function, here’s a couple of papers on sleep and the biome. But there are many. https://t.co/TH0x55gGTB https://t.co/RlTkUxOqRr

Aug 29, 2021 · 928 followers View post →
mineiro
@1xicaperdida · X

@includeuni @white0trash geral do sistema imunitário, e até das células que atuam na resposta às vacinas, é conhecido (10.1007/s00424-011-1044-0). Mais uma vez, estava mais numa de prevenção, não fiz uma pesquisa super intensa, mas penso estes artigos dão uma boa base e compreendo o teu comentário!

Aug 15, 2021 · 2 likes · 328 followers View post →
mojca
@MojcaOblacom · X

RT @smaka21: Dva članka na to temo: https://t.co/mIOBLZFxfZ; https://t.co/7eIu2NUuxc

May 7, 2021 · 1 share · 360 followers View post →
Masa
@smaka21 · X

Dva članka na to temo: https://t.co/mIOBLZFxfZ; https://t.co/7eIu2NUuxc

May 6, 2021 · 5 likes · 1 share · 443 followers View post →
Someone
@2012snownice · X

RT @cuneytteginmd: İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerini…

Oct 24, 2020 · 5 shares · 1,347 followers View post →
furkan
@kadrioguz32 · X

RT @cuneytteginmd: İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerini…

Oct 24, 2020 · 5 shares · 409 followers View post →
selametme
@Selametme · X

RT @cuneytteginmd: İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerini…

Oct 24, 2020 · 5 shares · 52 followers View post →
Dr.Hesy Re
@drhesyre · X

RT @cuneytteginmd: İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerini…

Oct 24, 2020 · 5 shares · 123 followers View post →
Dr. Cuneyt Tegin
@cuneytteginmd · X

İyi bir uyku bağışıklık sistemini güçlendirir. Aşı(Hep A) yapıldıktan sonraki gece iyi uyuyanlarda antikor seviyelerinin daha yüksek olduğu gösterilmiş. İyi uyku gibisi yok! #UykuLobisi https://t.co/2wWfiwiczw

Oct 24, 2020 · 26 likes · 5 shares · 8,349 followers View post →
Dr. LoBisco
@DrLoBisco · X

Remember to get your zzzssss... sleep and immune function https://t.co/Fz102fS5Db

Apr 9, 2020 · 965 followers View post →
Behavioral Health News
@behavioralhealth.bsky.social · Bluesky

Penn researchers find link between sleep and immune function in fruit flies #sleep medicalnewstoday.com/releases/27579…

Apr 24, 2014 View post →