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N Engl J Med December 2011 PMID 22085343

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.

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Mentions

58
Peak: 5 in Oct 2025
across 7 sources since Dec 2011

Extended reach

156,437
potential audience

Total likes

4,070

Video views

104,883

Mentions per month

Dec 2011 – Dec 2025

Where it's discussed

  • Reddit17 posts
  • Instagram14 posts
  • News9 articles
  • X / Twitter7 posts
  • Blogs5 articles
  • Facebook4 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions frequently challenge earlier beliefs about cholesterol management, exemplified by comments questioning why niacin didn't reduce cardiovascular events despite improving lipid profiles, and references to negative results in trials like AIM-high. The tone oscillates between skepticism and curiosity, reflecting active engagement with the research's implications but with limited consensus on its clinical significance.

AgreementLow agreement

The discussions generally question the effectiveness of niacin, reflecting some disagreement with previous positive notions, especially pointing out the negative outcomes of clinical trials.

InterestHigh interest

The topics generate high interest, as users are focused on the implications of lipid-raising drugs and the recent study's findings.

EngagementModerate engagement

Participants actively dissect the study's results and previous research, including references to specific trials and biochemical markers, indicating a moderate level of detailed engagement.

ImpactNeutral impact

While the conversations highlight ongoing debates and challenge prior assumptions, the overall influence on clinical practice remains uncertain, leading to a neutral impact score.

Abstract in brief

  • The study investigated whether adding extended-release niacin to statin therapy would further reduce residual cardiovascular risk in patients with established disease, but the trial was stopped early after 3 years due to lack of evidence showing benefit.
  • While niacin improved HDL cholesterol and lowered triglyceride and LDL levels, it did not significantly decrease the incidence of major cardiovascular events compared to placebo.
  • These findings suggest that, despite better lipid profiles, niacin did not provide additional protection against cardiovascular events in patients already on intensive statin therapy.]
Read the full abstract

Top posts

Most liked on X and Bluesky
cardio-met
@cardiomet_CE · X

36) #Nicotinic_acid was long used due to its favorable effects on #HDL_C, #LDL_C, and #TG. ☝️However, two negative #RCTs (https://t.co/TFFCGTVoUw and https://t.co/EpLwUi00LR ) and its poor tolerability

Jul 20, 2022 · 2 likes · 4,212 followers View post →
Anish Koka, MD
@anish_koka · X

Listening to someone extoll virtues of Niacin - (B3) .. but then why was AIM-high RCT negative? .. even though niacin group had lower Triglyerides and higher HDL? Cc @CharlesMBrenner https://t.co/WpPjDBhxao

Feb 21, 2022 · 1 like · 28,287 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

@heavensfreckles Yes of course. https://t.co/2TVL7wuC8J

Mar 27, 2025 · 1 like · 12,959 followers View post →
Tejas Kulkarni
@TejasTekk · X

Across major outcome trials that pharmacologically raised HDL-C (torcetrapib, dalcetrapib, niacin ± laropiprant), cardiovascular events were not reduced https://t.co/Vttl43gSkd https://t.co/yNNfHLCFxi https://t.co/wAT1juHIwF https://t.co/aQdYdFSLb6 https://t.co/cUSC19T2YU

Oct 10, 2025 · 1 like · 4,448 followers View post →
Karageorgos
@Karageorgos15 · X

Doctors were Wrong about Cholesterol and Heart Disease https://t.co/iqLiIa2qBM via @YouTube

Dec 30, 2025 · 610 followers View post →
goufpeera
@goufpeera2 · X

https://t.co/xg5r3n9K1N

Dec 30, 2025 · 408 followers View post →

All mentions

goufpeera
@goufpeera2 · X

https://t.co/xg5r3n9K1N

Dec 30, 2025 · 408 followers View post →
Karageorgos
@Karageorgos15 · X

Doctors were Wrong about Cholesterol and Heart Disease https://t.co/iqLiIa2qBM via @YouTube

Dec 30, 2025 · 610 followers View post →
Willem de MeeDenker
@WMeedenker · X

☝️Doctors were Wrong about Cholesterol and Heart Disease https://t.co/w1DrfS2sHb via @YouTube

Dec 30, 2025 · 140 followers View post →
Tejas Kulkarni
@TejasTekk · X

Across major outcome trials that pharmacologically raised HDL-C (torcetrapib, dalcetrapib, niacin ± laropiprant), cardiovascular events were not reduced https://t.co/Vttl43gSkd https://t.co/yNNfHLCFxi https://t.co/wAT1juHIwF https://t.co/aQdYdFSLb6 https://t.co/cUSC19T2YU

Oct 10, 2025 · 1 like · 4,448 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

@heavensfreckles Yes of course. https://t.co/2TVL7wuC8J

Mar 27, 2025 · 1 like · 12,959 followers View post →
cardio-met
@cardiomet_CE · X

36) #Nicotinic_acid was long used due to its favorable effects on #HDL_C, #LDL_C, and #TG. ☝️However, two negative #RCTs (https://t.co/TFFCGTVoUw and https://t.co/EpLwUi00LR ) and its poor tolerability

Jul 20, 2022 · 2 likes · 4,212 followers View post →
Anish Koka, MD
@anish_koka · X

Listening to someone extoll virtues of Niacin - (B3) .. but then why was AIM-high RCT negative? .. even though niacin group had lower Triglyerides and higher HDL? Cc @CharlesMBrenner https://t.co/WpPjDBhxao

Feb 21, 2022 · 1 like · 28,287 followers View post →
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org/doi/full/10.1056/NEJMoa1107579 https://www.jacc.org/doi/10.1016/j.jacc. 2016.08.038. nejm.org. Niacin in Patients with Low HDL Cholesterol ...

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Attia refererar till AIM-HIGH-studien ett par gånger. https://www.nejm.org/doi/full/10.1056/NEJMoa1107579 · willbot858. • för 2 år sen.

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