Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders. Just > a decade when in the @AkassoglouLab we found fibrinogen in the brain of mice after orthopedic surgery. Also @ANA_journals https://t.co/5C1aw0LVYT
Resolving postoperative neuroinflammation and cognitive decline.
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Aug 2023 – Oct 2025Where it's discussed
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X / Twitter4 posts
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YouTube2 videos
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What people are saying
The discussions highlight notable findings linking BBB breakdown and neuroinflammation with postoperative cognitive issues, with phrases like 'more evidence' and references to past research emphasizing ongoing scientific interest. The tone reflects curiosity and recognition of the study's importance, although specific detailed analysis is limited.
The posts validate the findings by referencing existing evidence of blood-brain barrier (BBB) dysfunction in patients with postoperative delirium, indicating support for the publication's conclusions.
The discussions demonstrate high interest by connecting recent research with past studies and mentioning implications for understanding neuroinflammation.
Postings contain references to specific researchers and studies, showing moderate engagement with the research details.
The focus on BBB dysfunction and neuroinflammation suggests the research could influence future clinical approaches, though the discussions are primarily exploratory.
Abstract in brief
- Surgery triggers an immune response that can compromise the blood-brain barrier (BBB) and lead to macrophage infiltration in the hippocampus, causing neuroinflammation and cognitive decline.
- Deleting specific genes involved in inflammation signaling (like IKK) in mice prevents BBB disruption and reduces brain inflammation after surgery, highlighting potential targets for intervention.
- Activation of the cholinergic pathway, specifically through nicotinic acetylcholine receptors, can help resolve inflammation, protect the BBB, and prevent cognitive decline post-surgery.]
Top posts
Most liked on X and BlueskyResolving postoperative neuroinflammation and cognitive decline https://t.co/ZaiYUb7l47 https://t.co/g8r2W68LT5
RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…
RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…
All mentions
Risk Factors for Postoperative Delirium in Hip Fracture Repair Patients
Prolonged surgery time and general anesthesia increase the risk of postoperative delirium in older adults undergoing hip fracture repair, with each additional 30 minutes raising the risk by about 6%. Shorter procedures…
Understanding Risk Factors for Postoperative Neurocognitive Disorders
This video series delves into postoperative neurocognitive disorders, specifically postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). It features key studies that explore cognitive impairment's…
Resolving postoperative neuroinflammation and cognitive decline https://t.co/ZaiYUb7l47 https://t.co/g8r2W68LT5
RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…
RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…
Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders. Just > a decade when in the @AkassoglouLab we found fibrinogen in the brain of mice after orthopedic surgery. Also @ANA_journals https://t.co/5C1aw0LVYT
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