December 2011 PMID 22190370

Resolving postoperative neuroinflammation and cognitive decline.

Niccolò Terrando, Lars I Eriksson, Jae Kyu Ryu, Ting Yang, Claudia Monaco, Marc Feldmann, Malin Jonsson Fagerlund, Israel F Charo, Katerina Akassoglou, Mervyn Maze

Mentions

6
Peak: 3 in Aug 2023
across 2 sources since Aug 2023

Extended reach

11,156
potential audience

Total likes

5

Video views

12

Mentions per month

Aug 2023 – Oct 2025

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight notable findings linking BBB breakdown and neuroinflammation with postoperative cognitive issues, with phrases like 'more evidence' and references to past research emphasizing ongoing scientific interest. The tone reflects curiosity and recognition of the study's importance, although specific detailed analysis is limited.

AgreementModerate agreement

The posts validate the findings by referencing existing evidence of blood-brain barrier (BBB) dysfunction in patients with postoperative delirium, indicating support for the publication's conclusions.

InterestHigh interest

The discussions demonstrate high interest by connecting recent research with past studies and mentioning implications for understanding neuroinflammation.

EngagementModerate engagement

Postings contain references to specific researchers and studies, showing moderate engagement with the research details.

ImpactModerate impact

The focus on BBB dysfunction and neuroinflammation suggests the research could influence future clinical approaches, though the discussions are primarily exploratory.

Abstract in brief

  • Surgery triggers an immune response that can compromise the blood-brain barrier (BBB) and lead to macrophage infiltration in the hippocampus, causing neuroinflammation and cognitive decline.
  • Deleting specific genes involved in inflammation signaling (like IKK) in mice prevents BBB disruption and reduces brain inflammation after surgery, highlighting potential targets for intervention.
  • Activation of the cholinergic pathway, specifically through nicotinic acetylcholine receptors, can help resolve inflammation, protect the BBB, and prevent cognitive decline post-surgery.]

Top posts

Most liked on X and Bluesky
Niccolò Terrando
@NiccoloTerrando · X

Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders. Just > a decade when in the @AkassoglouLab we found fibrinogen in the brain of mice after orthopedic surgery. Also @ANA_journals https://t.co/5C1aw0LVYT

Aug 27, 2023 · 5 likes · 2 shares · 701 followers View post →
POPLINE
@POPLINE_org · X

Resolving postoperative neuroinflammation and cognitive decline https://t.co/ZaiYUb7l47 https://t.co/g8r2W68LT5

Mar 8, 2024 · 5,184 followers View post →
Katerina Akassoglou
@AkassoglouLab · X

RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…

Aug 27, 2023 · 2 shares · 4,864 followers View post →
Dave Lambert
@DaveGLambert · X

RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…

Aug 28, 2023 · 2 shares · 383 followers View post →

All mentions

POPLINE
@POPLINE_org · X

Resolving postoperative neuroinflammation and cognitive decline https://t.co/ZaiYUb7l47 https://t.co/g8r2W68LT5

Mar 8, 2024 · 5,184 followers View post →
Dave Lambert
@DaveGLambert · X

RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…

Aug 28, 2023 · 2 shares · 383 followers View post →
Katerina Akassoglou
@AkassoglouLab · X

RT @NiccoloTerrando: Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders.…

Aug 27, 2023 · 2 shares · 4,864 followers View post →
Niccolò Terrando
@NiccoloTerrando · X

Great to see more evidence of BBB dysfunction in patients with delirium from this and recent works by @ProfRobSanders. Just > a decade when in the @AkassoglouLab we found fibrinogen in the brain of mice after orthopedic surgery. Also @ANA_journals https://t.co/5C1aw0LVYT

Aug 27, 2023 · 5 likes · 2 shares · 701 followers View post →