Three-dimensional folding and functional organization principles of the Drosophila genome.

Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, Giacomo Cavalli

February 2012

Synopsis of Social media discussions

The discussions demonstrate high interest through words like 'impressive' and 'amazing', emphasizing visualizations and advancing understanding of genome structure, which encourage deep engagement. The overall tone, combining enthusiasm with technical appreciation, highlights recognition of the research’s significance and potential influence on fields like personalized medicine.

A
Agreement
 Moderate agreement

Most discussions express positive recognition of the significance and clarity of the research, with few expressing skepticism.

I
Interest
 High level of interest

The technical complexity and innovative visuals generate high interest among participants, reflected in enthusiastic comments.

E
Engagement
 High engagement

Many discussions delve into detailed explanations of genome organization and mention specific concepts like chromatin domains, indicating deep engagement.

I
Impact
 Moderate level of impact

While there is excitement about the advancements, most posts highlight the potential for future applications rather than immediate societal impact.

Social Mentions

YouTube

2 Videos

Twitter

18 Posts

Blogs

4 Articles

News

3 Articles

Metrics

Video Views

118,424

Total Likes

2,150

Extended Reach

133,616

Social Features

27

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Three-Dimensional Genome Organization and Functionality

Three-Dimensional Genome Organization and Functionality

This video reviews current understanding of genome organization in the 3D space of the cell nucleus, from nucleosomes to chromosome territories, highlighting hierarchical folding, TADs, and compartments, as well as ongoing debates in the field.

Cavalli lab videos

November 8, 2021

117,330 views

3D Genome Organization and Function in the Cell Nucleus

3D Genome Organization and Function in the Cell Nucleus

This video reviews our understanding of genome organization in three dimensions within the cell nucleus, from nucleosomes to whole chromosomes, highlighting hierarchical chromatin folding, TADs, and compartments, and their roles in gene regulation.

Cavalli lab videos

February 15, 2022

1,094 views

  • メランコリーちゃん(論文)
    @ArticleKls (Twitter)

    RT @CoherentTheWave: 染色体の3次元構造の階層性についてのわかりやすい動画 https://t.co/ghutF032df
    view full post

    June 29, 2025

    1

  • 小樋井蓮人
    @CoherentTheWave (Twitter)

    染色体の3次元構造の階層性についてのわかりやすい動画 https://t.co/ghutF032df
    view full post

    June 29, 2025

    3

    1

  • BioScience_geek#
    @Ashley_GGY6 (Twitter)

    https://t.co/QNZjUbdFtt
    view full post

    December 5, 2024

  • 吳冠廷tinger wu
    @tingerwu (Twitter)

    我們基因組的三維組織 https://t.co/AbaaEAgxOG 來自 @YouTube
    view full post

    September 23, 2024

  • Virgile Adam (
    @Dr_Fluo (Twitter)

    Impressive! https://t.co/bZmdp8XQ7y
    view full post

    September 6, 2024

    1

  • Vlad Cojocaru
    @cojocarulab (Twitter)

    Its DNA day ... https://t.co/MAhW7RS0fU
    view full post

    April 25, 2024

    1

  • Lisa
    @LisaED38 (Twitter)

    ADN des mammifères -mécanisme d’extrusion de boucles de chromatine, impliquant la Cohésine et la protéine CTCF- sélection d'articles + une vidéo pour illustrer une hypothèse qui fait encore débat et diffère probablement de cette belle animation pédagogique https://t.co/i852QO2ssz
    view full post

    April 12, 2022

    1

  • CrocodileChuck
    @CrocodileChuck (Twitter)

    Annals Of DNA Compaction Cavalli Labs' Animation of DNA Packing Across 4 Orders of Magnitude in the Nucleus; from Nucleosomes -> Clutches -> Chromatin Nanodomains -> TADS -> Chromosomes: https://t.co/Ij3KFeqgB0… https://t.co/EdLKSsUKk5
    view full post

    March 16, 2022

  • Fred BERNARD
    @FredBernard_78 (Twitter)

    L'organisation tridimensionnelle de notre génome https://t.co/ZspqTWyT9V via @YouTube
    view full post

    March 2, 2022

    4

  • Labex Who Am I?
    @labexWhoamI (Twitter)


    view full post

    February 11, 2022

    1

  • adsell
    @adnsellam1 (Twitter)

    The 3D Organization of Our Genome https://t.co/r6JJmP0Udb via @YouTube
    view full post

    February 9, 2022

    3

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  • Piluka Esteban. www.pasostorcidos.com
    @PilukaEsteban (Twitter)

    RT @fjesteban: La Organización 3D de Nuestro Genoma https://t.co/1XEyTfZ8uj vía @YouTube
    view full post

    February 9, 2022

    1

  • Francisco J. Esteban
    @fjesteban (Twitter)

    La Organización 3D de Nuestro Genoma https://t.co/1XEyTfZ8uj vía @YouTube
    view full post

    February 9, 2022

    1

    1

  • Antoine Villette
    @BestOfMoocs (Twitter)

    L'organisation tridimensionnelle de notre génome https://t.co/Gyhp2wZXJ8 via @YouTube
    view full post

    February 9, 2022

  • CrocodileChuck
    @CrocodileChuck (Twitter)

    Annals Of Cellular Compartmentalisation From Nucleosomes -> Chromosomes, Across Six Orders of Magnitude: https://t.co/0BWkjxiSbO https://t.co/YlACdiZ7jN
    view full post

    December 31, 2021

  • Oxford BioDynamics
    @OxBioDynamics (Twitter)

    Superb animation by the Cavalli lab showing the 3D organization of the genome! Amazing to be part of this growing field as we continue to advance personalized healthcare through development of new 3D genomic tools. @giacomo_cavalli @IGH_MTP https://t.co/wiWJYCg61I
    view full post

    December 13, 2021

    5

  • Kumar Saurabh Singh
    @Kumar_S_Singh (Twitter)

    RT @BioDecoded: Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome | Cell https://t.co/3eok6FC20H #…
    view full post

    April 9, 2021

    1

  • BioDecoded
    @BioDecoded (Twitter)

    Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome | Cell https://t.co/3eok6FC20H #genomics https://t.co/uSWN2s3nNO
    view full post

    April 9, 2021

    7

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Abstract Synopsis

  • The study reveals that the Drosophila genome is organized into distinct physical domains that correspond to areas of active or repressive gene activity, and these domains are arranged hierarchically within the chromosome.
  • Inactive regions tend to be more condensed and confined within their own territories, while active regions extend outward to make contacts within and between chromosomes, facilitating gene regulation.
  • The research also identifies specific long-range contacts between repressed domains managed by Polycomb proteins, providing a basis for predicting chromosome structure and understanding its functional organization.]