February 2012 PMID 22265598

Three-dimensional folding and functional organization principles of the Drosophila genome.

Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, Giacomo Cavalli

Mentions

27
Peak: 6 in Feb 2022
across 4 sources since Apr 2021

Extended reach

133,616
potential audience

Total likes

2,150

Video views

118,424

Mentions per month

Apr 2021 – Jun 2025

Where it's discussed

  • X / Twitter18 posts
  • Blogs4 articles
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate high interest through words like 'impressive' and 'amazing', emphasizing visualizations and advancing understanding of genome structure, which encourage deep engagement. The overall tone, combining enthusiasm with technical appreciation, highlights recognition of the research’s significance and potential influence on fields like personalized medicine.

AgreementModerate agreement

Most discussions express positive recognition of the significance and clarity of the research, with few expressing skepticism.

InterestHigh interest

The technical complexity and innovative visuals generate high interest among participants, reflected in enthusiastic comments.

EngagementHigh engagement

Many discussions delve into detailed explanations of genome organization and mention specific concepts like chromatin domains, indicating deep engagement.

ImpactModerate impact

While there is excitement about the advancements, most posts highlight the potential for future applications rather than immediate societal impact.

Abstract in brief

  • The study reveals that the Drosophila genome is organized into distinct physical domains that correspond to areas of active or repressive gene activity, and these domains are arranged hierarchically within the chromosome.
  • Inactive regions tend to be more condensed and confined within their own territories, while active regions extend outward to make contacts within and between chromosomes, facilitating gene regulation.
  • The research also identifies specific long-range contacts between repressed domains managed by Polycomb proteins, providing a basis for predicting chromosome structure and understanding its functional organization.]

Top posts

Most liked on X and Bluesky
BioDecoded
@BioDecoded · X

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome | Cell https://t.co/3eok6FC20H #genomics https://t.co/uSWN2s3nNO

Apr 9, 2021 · 7 likes · 1 share · 8,872 followers View post →
Oxford BioDynamics
@OxBioDynamics · X

Superb animation by the Cavalli lab showing the 3D organization of the genome! Amazing to be part of this growing field as we continue to advance personalized healthcare through development of new 3D genomic tools. @giacomo_cavalli @IGH_MTP https://t.co/wiWJYCg61I

Dec 13, 2021 · 5 likes · 440 followers View post →
Fred BERNARD
@FredBernard_78 · X

L'organisation tridimensionnelle de notre génome https://t.co/ZspqTWyT9V via @YouTube

Mar 2, 2022 · 4 likes · 424 followers View post →
adsell
@adnsellam1 · X

The 3D Organization of Our Genome https://t.co/r6JJmP0Udb via @YouTube

Feb 9, 2022 · 3 likes · 1 share · 431 followers View post →
小樋井蓮人
@CoherentTheWave · X

染色体の3次元構造の階層性についてのわかりやすい動画 https://t.co/ghutF032df

Jun 29, 2025 · 3 likes · 1 share · 208 followers View post →
Francisco J. Esteban
@fjesteban · X

La Organización 3D de Nuestro Genoma https://t.co/1XEyTfZ8uj vía @YouTube

Feb 9, 2022 · 1 like · 1 share · 899 followers View post →

All mentions

メランコリーちゃん(論文)
@ArticleKls · X

RT @CoherentTheWave: 染色体の3次元構造の階層性についてのわかりやすい動画 https://t.co/ghutF032df

Jun 29, 2025 · 1 share · 166 followers View post →
小樋井蓮人
@CoherentTheWave · X

染色体の3次元構造の階層性についてのわかりやすい動画 https://t.co/ghutF032df

Jun 29, 2025 · 3 likes · 1 share · 208 followers View post →
BioScience_geek#
@Ashley_GGY6 · X

https://t.co/QNZjUbdFtt

Dec 5, 2024 · 30 followers View post →
吳冠廷tinger wu
@tingerwu · X

我們基因組的三維組織 https://t.co/AbaaEAgxOG 來自 @YouTube

Sep 23, 2024 · 497 followers View post →
Virgile Adam (
@Dr_Fluo · X

Impressive! https://t.co/bZmdp8XQ7y

Sep 6, 2024 · 1 like · 328 followers View post →
Vlad Cojocaru
@cojocarulab · X

Its DNA day ... https://t.co/MAhW7RS0fU

Apr 25, 2024 · 1 like · 303 followers View post →
Lisa
@LisaED38 · X

ADN des mammifères -mécanisme d’extrusion de boucles de chromatine, impliquant la Cohésine et la protéine CTCF- sélection d'articles + une vidéo pour illustrer une hypothèse qui fait encore débat et diffère probablement de cette belle animation pédagogique https://t.co/i852QO2ssz

Apr 12, 2022 · 1 like · 2 followers View post →
CrocodileChuck
@CrocodileChuck · X

Annals Of DNA Compaction Cavalli Labs' Animation of DNA Packing Across 4 Orders of Magnitude in the Nucleus; from Nucleosomes -> Clutches -> Chromatin Nanodomains -> TADS -> Chromosomes: https://t.co/Ij3KFeqgB0… https://t.co/EdLKSsUKk5

Mar 16, 2022 · 577 followers View post →
Fred BERNARD
@FredBernard_78 · X

L'organisation tridimensionnelle de notre génome https://t.co/ZspqTWyT9V via @YouTube

Mar 2, 2022 · 4 likes · 424 followers View post →
Labex Who Am I?
@labexWhoamI · X

Feb 11, 2022 · 1 like · 564 followers View post →
adsell
@adnsellam1 · X

The 3D Organization of Our Genome https://t.co/r6JJmP0Udb via @YouTube

Feb 9, 2022 · 3 likes · 1 share · 431 followers View post →
Piluka Esteban. www.pasostorcidos.com
@PilukaEsteban · X

RT @fjesteban: La Organización 3D de Nuestro Genoma https://t.co/1XEyTfZ8uj vía @YouTube

Feb 9, 2022 · 1 share · 270 followers View post →
Francisco J. Esteban
@fjesteban · X

La Organización 3D de Nuestro Genoma https://t.co/1XEyTfZ8uj vía @YouTube

Feb 9, 2022 · 1 like · 1 share · 899 followers View post →
Antoine Villette
@BestOfMoocs · X

L'organisation tridimensionnelle de notre génome https://t.co/Gyhp2wZXJ8 via @YouTube

Feb 9, 2022 · 46 followers View post →
CrocodileChuck
@CrocodileChuck · X

Annals Of Cellular Compartmentalisation From Nucleosomes -> Chromosomes, Across Six Orders of Magnitude: https://t.co/0BWkjxiSbO https://t.co/YlACdiZ7jN

Dec 31, 2021 · 577 followers View post →
Oxford BioDynamics
@OxBioDynamics · X

Superb animation by the Cavalli lab showing the 3D organization of the genome! Amazing to be part of this growing field as we continue to advance personalized healthcare through development of new 3D genomic tools. @giacomo_cavalli @IGH_MTP https://t.co/wiWJYCg61I

Dec 13, 2021 · 5 likes · 440 followers View post →
Kumar Saurabh Singh
@Kumar_S_Singh · X

RT @BioDecoded: Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome | Cell https://t.co/3eok6FC20H #…

Apr 9, 2021 · 1 share · 545 followers View post →
BioDecoded
@BioDecoded · X

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome | Cell https://t.co/3eok6FC20H #genomics https://t.co/uSWN2s3nNO

Apr 9, 2021 · 7 likes · 1 share · 8,872 followers View post →