Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing.

Kit-Man Lau, Kwok-Kin Lai, Cheuk-Lun Liu, Jacqueline Chor-Wing Tam, Ming-Ho To, Hin-Fai Kwok, Ching-Po Lau, Chun-Hay Ko, Ping-Chung Leung, Kwok-Pui Fung, Simon Kar-Sing Poon, Clara Bik-San Lau

May 2012

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3 Videos

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12 Posts

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3 Posts

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Video Views

82,044

Total Likes

1,298

Extended Reach

90,638

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18

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Abstract Synopsis

  • The study explores the synergistic effects of Astragali Radix (AR) and Rehmanniae Radix (RR) in a herbal formula called NF3, showing that combined use significantly enhances diabetic wound healing in rats, primarily through tissue regeneration, blood vessel formation, and reducing inflammation.
  • While individually AR and RR did not promote wound healing at certain doses, their combination in NF3 demonstrated a notable reduction in wound size, indicating a synergistic interaction that enhances healing processes.
  • Mechanistic tests revealed that AR was more effective in reducing inflammation and promoting fibroblast growth, whereas NF3 uniquely supported angiogenesis, with overall findings suggesting that the herbal interactions amplify each other's therapeutic effects in diabetic wound repair.