PubHawk
Curr Biol June 2012 PMID 22677291

Bistability, bifurcations, and Waddington's epigenetic landscape.

James E Ferrell

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Mentions

13
Peak: 2 in Jan 2019
across 4 sources since Jan 2019

Extended reach

22,464
potential audience

Total likes

8

Video views

51

Mentions per month

Jan 2019 – Aug 2024

Where it's discussed

  • X / Twitter6 posts
  • News4 articles
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

Discussion examples include a mention of the shift from the classical bifurcation model to the double saddle node with hysteresis, indicating an engagement with complex modeling concepts, and posts sharing videos and insights about pluripotent stem cells, showing an active interest and curiosity about the research implications and applications.

AgreementModerate agreement

Several posts acknowledge new insights or confirm aspects of Waddington's landscape, such as the statement that the landscape's shape is not as originally diagrammed, reflecting moderate agreement with the study's findings.

InterestHigh interest

The discussions show a high level of curiosity, especially around the mathematical modeling and implications for cell development, indicating strong interest.

EngagementModerate engagement

Posts include sharing personal reactions and related content, like videos and explanations, demonstrating active engagement.

ImpactModerate impact

The conversations suggest that the research could influence understanding of developmental biology and modeling, although the impact remains somewhat speculative and preliminary.

Abstract in brief

  • Waddington's epigenetic landscape is a metaphor for cell development where cells are like balls rolling down a landscape with valleys representing different cell fates; valleys form and stay stable due to ridges, illustrating how cells commit to certain destinies.
  • The study finds that in cell fate induction, the landscape changes by the disappearance of valleys (possible fates) through saddle-node bifurcations, which are irreversible, differing from Waddington's picture; in lateral inhibition, a process where cells influence each other, the landscape resembles Waddington's more closely, with valleys splitting reversibly via pitchfork bifurcations.
  • The author suggests a new type of landscape featuring many valleys and ridges from the beginning, where cell fate changes involve both the irreversible loss of some paths (fates) and the creation of new ones through interactions like cell-cell competition, offering a more detailed model of developmental processes.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Alfonso Martinez Arias
@AMartinezArias · X

@WiringTheBrain There is much on this but some helpful expositions. It’s all to do with potentials https://t.co/39COeq2ajV https://t.co/jTnJxrooSC https://t.co/NDRHS2h4Ah https://t.co/fDuZB6xEKX

Jul 8, 2023 · 5 likes · 1 share · 9,289 followers View post →
Benoit Bruneau
@benoitbruneau · X

@TriggerLoop the mathematical modeling by @jsauce7's lab showed that it is not a pitchfork bifurcation as diagrammed in Waddington's landscape, but instead a double saddle node with hysteresis, which is what James Ferrell has proposed for years https://t.co/m55VkpBfo7

Jul 25, 2024 · 3 likes · 9,067 followers View post →
hr_wksh
@hr_wksh · X

RT @n0rr: Bistability, Bifurcations, and Waddington's Epigenetic Landscape https://t.co/fKykvasu23

Jan 22, 2019 · 2 shares · 2,510 followers View post →
たかとー
@takatoh1 · X

RT @n0rr: Bistability, Bifurcations, and Waddington's Epigenetic Landscape https://t.co/fKykvasu23

Jan 22, 2019 · 2 shares · 592 followers View post →
The ReNeural Project
@ReNeural · X

Please like and retweet! This my video on #inducedpluripotentstemcells, or #iPSC--how they work, how they were developed, and what they can be used for. #Disability #DisabilityTwitter #biotech #Biotechnology #Yamanaka #stemcells #Regenerativemedicine https://t.co/A5eUHDBkYq

Sep 5, 2023 · 451 followers View post →
Emmy
@subanima_ · X

@IcarusUnleashed @stravoguine Mais oui, en vrai, le paysage n’est pas prédéfini est c’est un problème bien connu avec le paysage. https://t.co/n643bCl84j

Jan 21, 2023 · 444 followers View post →

All mentions

Benoit Bruneau
@benoitbruneau · X

@TriggerLoop the mathematical modeling by @jsauce7's lab showed that it is not a pitchfork bifurcation as diagrammed in Waddington's landscape, but instead a double saddle node with hysteresis, which is what James Ferrell has proposed for years https://t.co/m55VkpBfo7

Jul 25, 2024 · 3 likes · 9,067 followers View post →
The ReNeural Project
@ReNeural · X

Please like and retweet! This my video on #inducedpluripotentstemcells, or #iPSC--how they work, how they were developed, and what they can be used for. #Disability #DisabilityTwitter #biotech #Biotechnology #Yamanaka #stemcells #Regenerativemedicine https://t.co/A5eUHDBkYq

Sep 5, 2023 · 451 followers View post →
Alfonso Martinez Arias
@AMartinezArias · X

@WiringTheBrain There is much on this but some helpful expositions. It’s all to do with potentials https://t.co/39COeq2ajV https://t.co/jTnJxrooSC https://t.co/NDRHS2h4Ah https://t.co/fDuZB6xEKX

Jul 8, 2023 · 5 likes · 1 share · 9,289 followers View post →
Emmy
@subanima_ · X

@IcarusUnleashed @stravoguine Mais oui, en vrai, le paysage n’est pas prédéfini est c’est un problème bien connu avec le paysage. https://t.co/n643bCl84j

Jan 21, 2023 · 444 followers View post →
hr_wksh
@hr_wksh · X

RT @n0rr: Bistability, Bifurcations, and Waddington's Epigenetic Landscape https://t.co/fKykvasu23

Jan 22, 2019 · 2 shares · 2,510 followers View post →
たかとー
@takatoh1 · X

RT @n0rr: Bistability, Bifurcations, and Waddington's Epigenetic Landscape https://t.co/fKykvasu23

Jan 22, 2019 · 2 shares · 592 followers View post →
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