June 2012 PMID 22682224

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Carles Cantó, Riekelt H Houtkooper, Eija Pirinen, Dou Y Youn, Maaike H Oosterveer, Yana Cen, Pablo J Fernandez-Marcos, Hiroyasu Yamamoto, Pénélope A Andreux, Philippe Cettour-Rose, Karl Gademann, Chris Rinsch, Kristina Schoonjans, Anthony A Sauve, Johan Auwerx

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Mentions

Peak: 12 in Jan 2023

across 6 sources since Oct 2019

Extended reach

298,746

potential audience

Total likes

161

Video views

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Mentions per month

Oct 2019 – Sep 2025

Where it's discussed

X / Twitter17 posts
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YouTube3 videos
Reddit2 posts

AI synopsis

What people are saying

Comments highlight the promising effects of nicotinamide riboside in combating obesity, with examples like the experiment showing mice resisting weight gain on a high-fat diet, and mentions of enzymes like SIRT1 and SIRT3. The tone combines scientific curiosity with optimism, demonstrating active engagement and interest in the metabolic implications of the research.

AgreementModerate agreement

Most discussions express support or interest in the research findings, emphasizing the potential benefits of NR in reducing obesity and promising metabolic improvements.

InterestHigh interest

Posts show high curiosity about the implications and mechanisms, with mentions of specific enzymes and experimental results indicating active engagement.

EngagementModerate engagement

Some posts reference key studies and biochemical processes, suggesting a moderate level of detailed discussion and analysis.

ImpactModerate impact

The tone and content reflect awareness of potential health and therapeutic impacts, but the discussions mainly focus on preliminary findings rather than broad societal change.

Abstract in brief

Nicotinamide riboside (NR), a natural precursor to NAD, boosts NAD levels in cells and tissues, leading to increased activity of sirtuin enzymes like SIRT1 and SIRT3, which are important for regulating oxidative metabolism.
By increasing NAD availability through NR supplementation, the study found that it enhances mitochondrial function, helps activate protective metabolic pathways, and shields against obesity caused by high-fat diets.
Overall, NR has potential as a nutritional supplement to improve mitochondrial health and combat metabolic and age-related diseases linked to mitochondrial dysfunction.

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All mentions

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