June 2013 PMID 22804774

The endocannabinoid system and the brain.

Raphael Mechoulam, Linda A Parker

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Mentions

Peak: 4 in Jun 2022

across 6 sources since Nov 2020

Extended reach

17,221

potential audience

Total likes

Video views

275

Mentions per month

Nov 2020 – Aug 2025

Where it's discussed

X / Twitter11 posts
Facebook11 posts
News6 articles
YouTube2 videos
Reddit2 posts
Bluesky1 posts

AI synopsis

What people are saying

Analysis shows that many discussions celebrate the foundational discoveries of the endocannabinoid system, such as the work of Professor Mechoulam, and explore its broader implications, using words like 'pioneered,' 'wonder,' and 'related,' which reflect both respect and curiosity about future research directions.

AgreementModerate agreement

Most posts acknowledge the importance of the research, highlighting discoveries and historical significance, indicating general agreement with its value.

InterestHigh interest

Posts display high curiosity, referencing historical context, scientific details, and potential related systems, showing a strong interest.

EngagementModerate engagement

Conversations include references to specific research, scientists like Mechoulam, and potential implications, indicating a moderate level of detailed engagement.

ImpactModerate impact

Discussions suggest that the research influences understanding of cannabis and brain functions, though mostly in exploratory or speculative terms, implying moderate impact.

Abstract in brief

The endocannabinoid system, involving receptors like CB1 and CB2, along with endogenous cannabinoids such as anandamide, influences both brain functions and peripheral processes, with key discoveries occurring decades after THC's identification.
Research shows that this system plays a role in various brain activities including anxiety, depression, neurogenesis, reward, cognition, learning, and memory, often exhibiting biphasic effects where different doses can have opposite outcomes.
Recent findings have identified many endocannabinoid-like compounds in the brain, but only a few have been studied for their impact on the central nervous system, suggesting future research could reveal more about their influence on brain health and functions.]

Read the full abstract

All mentions

Understanding Runner's High and Its Neurochemical Basis

Running can seem challenging, but some people experience the runner's high or euphoria. This video explores how this state is achieved and the neurochemical pathways involved, focusing on cannabinoid receptors and…

Carrera Larga · Jul 18, 2022 251 views

How THC Affects the Brain and Its Widespread Impacts

How THC affects the brain and why its effects are so diverse. The endocannabinoid system, involving CB1 and CB2 receptors, influences brain functions such as anxiety, depression, neurogenesis, reward, cognition…

Logbuch 42 – Wissenschaft 2go · Apr 7, 2025 24 views

Snowden St.

@snowden.st · Bluesky

I would happily put some chips down on a prediction that the endocannabinoid system and the brain-gut system that semaglutide is working with are somewhat related.

Aug 29, 2025 · 1 like View post →

ElectraTect

@ElectraTect · X

Although the structure of #tetrahydrocannabinol (THC) was isolated in the 1960s, it wasn’t long before CB1 and CB2 #receptors were discovered. We continue to discover endocannabinoid-like compounds. Read more about the endocannabinoid system: https://t.co/UYVROioKHn #CannabisFact https://t.co/J50yEhiSt9

Apr 13, 2023 · 149 followers View post →

Kaliko Castille

@WizKaliko · X

Mar 11, 2023 · 4,030 followers View post →

Murray

@murrayelliot · X

RT @CBDbrothers: Ever wondered about the Endocannabinoid System and the Brain? Here's a great article - https://t.co/1FQNlKoQdh https://t.…

Jun 11, 2022 · 3 shares · 1,390 followers View post →

CBD Brothers BSE

@BseToa · X

RT @CBDbrothers: Ever wondered about the Endocannabinoid System and the Brain? Here's a great article - https://t.co/1FQNlKoQdh https://t.…

Jun 8, 2022 · 3 shares · 113 followers View post →

diet.strings

@dietstrings · X

RT @CBDbrothers: Ever wondered about the Endocannabinoid System and the Brain? Here's a great article - https://t.co/1FQNlKoQdh https://t.…

Jun 8, 2022 · 3 shares · 204 followers View post →

CBD Brothers

@CBDbrothers · X

Ever wondered about the Endocannabinoid System and the Brain? Here's a great article - https://t.co/1FQNlKoQdh https://t.co/kBXi65Uhpg

Jun 8, 2022 · 3 likes · 3 shares · 2,707 followers View post →

Cynthia

@cynthiabydesign · X

RT @meccanismo: Happy 91st birthday professor Raphael Mechoulam! #Cannabis https://t.co/aE0iRDrgdP

Nov 8, 2021 · 1 share · 2,897 followers View post →

Giuliano Gavazzi

@meccanismo · X

Happy 91st birthday professor Raphael Mechoulam! #Cannabis https://t.co/aE0iRDrgdP

Nov 5, 2021 · 1 like · 1 share · 667 followers View post →

Giuliano Gavazzi

@meccanismo · X

Nov 1, 2021 · 1 like · 667 followers View post →

Don Caldwell

@dcaldwell1984 · X

@DanBartkowiak @GovernorTomWolf EVEN more SCIENCE!!! https://t.co/90HtU5CamY

Feb 8, 2021 · 185 followers View post →

Jim the Meadowman

@ragabonz · X

@weemisstim @stephen84105724 @alidupont 1. Mechoulam R, Parker LA. The endocannabinoid system and the brain. Annu Rev Psychol 2013;64:21-47.

Nov 27, 2020 · 3,910 followers View post →

The endocannabinoid system and the brain.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Understanding Runner's High and Its Neurochemical Basis

How THC Affects the Brain and Its Widespread Impacts