@paulpharoah @GMFranceschini Well, take RPs for prostate cancer (https://t.co/pY2BEAfbTH): 10 year follow-up: HR=0.88, p=0.22 for overall survival; HR=0.6, p=0.09 for disease specific. 20 year fu, HR=0.84, p=0.06 for OS; HR=0.63, p=0.06 for DSS 22 year fu, HR=0.84, p=0.04 for OS.
Radical prostatectomy versus observation for localized prostate cancer.
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Sep 2022 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
Discussions revolve around detailed statistical outcomes of the study, such as HR values over 10 and 22 years, and opinions on patient management strategies like PSA testing and biopsies, reflecting moderate interest and engagement. The tone is analytical, referencing survival statistics and clinical practices, which indicates recognition of the study's nuanced implications without dramatic reactions.
The discussions reflect a cautious interpretation of the study's findings, with some emphasis on the nuances of long-term survival data, but there's no strong opposition or full endorsement.
Participants show moderate curiosity about the long-term outcomes and implications, particularly regarding follow-up periods and survival benefits.
Comments cite specific statistics and suggest thoughtfulness, indicating active engagement but not deeply detailed analysis.
The conversations highlight relevant considerations in prostate cancer treatment decisions, suggesting the study influences clinical perspectives without causing widespread change or controversy.
Abstract in brief
- Radical prostatectomy did not significantly reduce all-cause or prostate cancer-specific death rates compared to observation over about 12 years of follow-up in men with localized prostate cancer.
- The study found small percentage differences in mortality between the surgery and observation groups, with radical prostatectomy slightly reducing the risk, especially in men with higher PSA levels or intermediate/high-risk tumors.
- While surgery had some benefits, it also carried risks like adverse events shortly after the procedure, including one death, highlighting the need to carefully weigh the benefits and risks of treatment.
Top posts
Most liked on X and BlueskyRT @lugifel: En asintomáticos no pedir PSA. Y si la han hecho y es <10, no hacer biopsia próstata. Dejar de hacer para poder hacer http://…
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@paulpharoah @GMFranceschini Well, take RPs for prostate cancer (https://t.co/pY2BEAfbTH): 10 year follow-up: HR=0.88, p=0.22 for overall survival; HR=0.6, p=0.09 for disease specific. 20 year fu, HR=0.84, p=0.06 for OS; HR=0.63, p=0.06 for DSS 22 year fu, HR=0.84, p=0.04 for OS.
RT @lugifel: En asintomáticos no pedir PSA. Y si la han hecho y es <10, no hacer biopsia próstata. Dejar de hacer para poder hacer http://…