J Androl October 2014 PMID 22879528

Aging and declining testosterone: past, present, and hopes for the future.

Barry R Zirkin, Joyce Lisa Tenover

Mentions

11
Peak: 1 in Mar 2020
across 3 sources since Mar 2020

Extended reach

4,726,193
potential audience

Total likes

78,954

Video views

4,721,702

Mentions per month

Mar 2020 – Aug 2025

Where it's discussed

  • YouTube5 videos
  • News4 articles
  • X / Twitter2 posts

AI synopsis

What people are saying

The discussion reflects mild interest with acknowledgment of the review's content, such as noting the controversy surrounding testosterone therapy and its effects on mood, with phrases like 'little controversy' and focus on whether depletion causes changes or treatment helps mood; tone remains somewhat neutral and factual.

AgreementNeither agree nor disagree

The discussion shows some acknowledgment that the article summarizes past research, but there's minimal consensus or strong agreement expressed.

InterestModerate interest

Participants express a mild interest, mainly recognizing the review's focus on controversial issues and implications for mood and aging.

EngagementModerate engagement

Comments reflect some engagement, with references to controversy and specific aspects like hormone treatment, but lack deep analysis or critique.

ImpactNeutral impact

The overall tone suggests a neutral or moderate impact, as participants recognize the review's relevance but do not emphasize significant influence or major shifts in perspectives.

Abstract in brief

  • As men age, their serum testosterone (T) levels tend to decline, while luteinizing hormone (LH) levels stay the same or increase slightly, affecting aspects like body composition, energy, muscle strength, sexual and cognitive functions, and mood.
  • The main reason for the drop in testosterone is that aging testes become less able to produce T, partly because aged Leydig cells (the cells responsible for T production) don't respond as well to LH stimulation, as seen in both humans and rat models.
  • The review discusses the molecular reasons behind declining T synthesis with Leydig cell aging, reviews current T replacement therapies, addresses ongoing controversies, and explores future clinical directions for treating older men.]

Top posts

Most liked on X and Bluesky
jamnic77 https://bsky.app/profile/jamnic
@jamnic77 · X

@MadamEarth This is a review done in 2013. There does seem to be a little controversy about it, but this seems to focus on whether testosterone treatment can improve mood in aging men, not whether depletion causes the changes. https://t.co/A8eB2fzxqV

Jan 12, 2021 · 2,831 followers View post →
Dr. L C Sunda
@drsunda · X

Aging and Declining Testosterone: Past, Present, and Hopes for the Future https://t.co/UtnPFw6dXf

Mar 1, 2020 · 1,661 followers View post →

All mentions

jamnic77 https://bsky.app/profile/jamnic
@jamnic77 · X

@MadamEarth This is a review done in 2013. There does seem to be a little controversy about it, but this seems to focus on whether testosterone treatment can improve mood in aging men, not whether depletion causes the changes. https://t.co/A8eB2fzxqV

Jan 12, 2021 · 2,831 followers View post →
Dr. L C Sunda
@drsunda · X

Aging and Declining Testosterone: Past, Present, and Hopes for the Future https://t.co/UtnPFw6dXf

Mar 1, 2020 · 1,661 followers View post →