@MadamEarth This is a review done in 2013. There does seem to be a little controversy about it, but this seems to focus on whether testosterone treatment can improve mood in aging men, not whether depletion causes the changes. https://t.co/A8eB2fzxqV
Aging and declining testosterone: past, present, and hopes for the future.
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Mar 2020 – Aug 2025Where it's discussed
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The discussion reflects mild interest with acknowledgment of the review's content, such as noting the controversy surrounding testosterone therapy and its effects on mood, with phrases like 'little controversy' and focus on whether depletion causes changes or treatment helps mood; tone remains somewhat neutral and factual.
The discussion shows some acknowledgment that the article summarizes past research, but there's minimal consensus or strong agreement expressed.
Participants express a mild interest, mainly recognizing the review's focus on controversial issues and implications for mood and aging.
Comments reflect some engagement, with references to controversy and specific aspects like hormone treatment, but lack deep analysis or critique.
The overall tone suggests a neutral or moderate impact, as participants recognize the review's relevance but do not emphasize significant influence or major shifts in perspectives.
Abstract in brief
- As men age, their serum testosterone (T) levels tend to decline, while luteinizing hormone (LH) levels stay the same or increase slightly, affecting aspects like body composition, energy, muscle strength, sexual and cognitive functions, and mood.
- The main reason for the drop in testosterone is that aging testes become less able to produce T, partly because aged Leydig cells (the cells responsible for T production) don't respond as well to LH stimulation, as seen in both humans and rat models.
- The review discusses the molecular reasons behind declining T synthesis with Leydig cell aging, reviews current T replacement therapies, addresses ongoing controversies, and explores future clinical directions for treating older men.]
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Most liked on X and BlueskyAging and Declining Testosterone: Past, Present, and Hopes for the Future https://t.co/UtnPFw6dXf
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@MadamEarth This is a review done in 2013. There does seem to be a little controversy about it, but this seems to focus on whether testosterone treatment can improve mood in aging men, not whether depletion causes the changes. https://t.co/A8eB2fzxqV
Aging and Declining Testosterone: Past, Present, and Hopes for the Future https://t.co/UtnPFw6dXf
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