October 2012 PMID 22983386

Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies.

Samuele Cortese, Clare Kelly, Camille Chabernaud, Erika Proal, Adriana Di Martino, Michael P Milham, F Xavier Castellanos

Mentions

60
Peak: 5 in Jul 2025
across 4 sources since Jan 2019

Extended reach

25,120
potential audience

Total likes

142

Video views

3,087

Mentions per month

Jan 2019 – Jul 2025

Where it's discussed

  • News44 articles
  • X / Twitter8 posts
  • YouTube6 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions demonstrate a generally positive view of the research, with participants referencing earlier meta-analyses and neuroanatomical differences, such as prefrontal cortex and basal ganglia involvement. The tone varies from supportive to critical, with some posts emphasizing the importance of biomarkers and others questioning interpretations, which collectively foster a meaningful exchange about the article's implications.

AgreementModerate agreement

Most discussions recognize the validity and significance of the research, with some referencing previous studies or meta-analyses to support claims.

InterestModerate interest

Participants show moderate curiosity, engaging with nuanced points about brain differences and potential biomarkers, indicating some genuine interest.

EngagementModerate engagement

Comments reflect active exchanges, including critiques, citations of supporting studies, and detailed descriptions of brain regions involved.

ImpactModerate impact

The conversations seem to influence current understanding by highlighting specific neurological findings and debates about ADHD, suggesting a moderate level of impact.

Abstract in brief

  • The study conducted a meta-analysis of functional MRI studies to examine brain activation differences between individuals with ADHD and control subjects, focusing on various neuronal systems and age groups.
  • Results indicated that children with ADHD showed hypoactivation in executive function and attention-related networks, while adults exhibited hypoactivation in the frontoparietal system and hyperactivation in visual and dorsal attention networks.
  • Findings highlighted that ADHD-related brain dysfunction affects both cognitive and sensorimotor processes, suggesting a complex interaction of factors including task features, independent of comorbidities or prior stimulant treatment.

Top posts

Most liked on X and Bluesky
shivan bhavnani
@ss_bhav · X

@DrMcFillin the truth is people are on a spectrum. there are real differences between people regarding attention / brains etc. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies https://t.co/lywFQt49nD

Jun 3, 2025 · 2 likes · 1 share · 1,597 followers View post →
Michael Merrifield
@AstroMikeMerri · X

@ClarkeMicah As usual, your confident unsupported assertion is incorrect. But, also as usual, I am sure you will just ignore this documented fact, because to do otherwise would be to recognise your own total ignorance. (https://t.co/yKpWI7ry6j) https://t.co/iRQBTqW40n

Jul 11, 2021 · 1 like · 10,963 followers View post →
James Booth
@DrJamesBooth · X

@KarenJamesSP Interestingly, the studies in #ADHD seem to converge on differences in prefrontal cortex and the basal ganglia, in terms of gray matter, https://t.co/mF1Xnk4avz, white matter, https://t.co/owcmX2AY49, and function, https://t.co/9BvRaMiBdQ https://t.co/JRHe8Jad1e

Jan 16, 2020 · 1 like · 6,385 followers View post →
Kathryn LifeLearner
@ApingSpring · X

RT @ss_bhav: @DrMcFillin the truth is people are on a spectrum. there are real differences between people regarding attention / brains etc.…

Jun 3, 2025 · 1 share · 2,661 followers View post →
Cock Jockey
@Shuttlecock7 · X

@BroadHearse2 @Boneclacker @ClarkeMicah @Will_Sutcliffe8 @wself https://t.co/qd0LDWBVk3

Jan 12, 2019 · 227 followers View post →
Tone
@Swampmaws · X

@stomababe @MailOnline This is incorrect. See: Cortese et al. 2013 meta analysis for starters: https://t.co/9zte5Zx01M

Mar 13, 2025 · 103 followers View post →

All mentions

Kathryn LifeLearner
@ApingSpring · X

RT @ss_bhav: @DrMcFillin the truth is people are on a spectrum. there are real differences between people regarding attention / brains etc.…

Jun 3, 2025 · 1 share · 2,661 followers View post →
shivan bhavnani
@ss_bhav · X

@DrMcFillin the truth is people are on a spectrum. there are real differences between people regarding attention / brains etc. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies https://t.co/lywFQt49nD

Jun 3, 2025 · 2 likes · 1 share · 1,597 followers View post →
Tone
@Swampmaws · X

@stomababe @MailOnline This is incorrect. See: Cortese et al. 2013 meta analysis for starters: https://t.co/9zte5Zx01M

Mar 13, 2025 · 103 followers View post →
Egmont
@egm0nt · X

@derekcopley @cwracal_ Like you’re gonna have to explain this if you want to keep clinging onto your delusion https://t.co/hGpeEcLcLZ https://t.co/bFSHklzduO

Sep 6, 2022 · 40 followers View post →
Natalia
@nataliataurreko · X

@CapitalistFraud -Meta-analysis showcasing morphological brain differences in ADHD https://t.co/DLzz4s8pTN -Bio marker for detecting ADHD https://t.co/qkthMYflKW -Differences in ToM in ADHD https://t.co/F7OWXXknjs 2/2

Apr 29, 2022 · 54 followers View post →
Michael Merrifield
@AstroMikeMerri · X

@ClarkeMicah As usual, your confident unsupported assertion is incorrect. But, also as usual, I am sure you will just ignore this documented fact, because to do otherwise would be to recognise your own total ignorance. (https://t.co/yKpWI7ry6j) https://t.co/iRQBTqW40n

Jul 11, 2021 · 1 like · 10,963 followers View post →
James Booth
@DrJamesBooth · X

@KarenJamesSP Interestingly, the studies in #ADHD seem to converge on differences in prefrontal cortex and the basal ganglia, in terms of gray matter, https://t.co/mF1Xnk4avz, white matter, https://t.co/owcmX2AY49, and function, https://t.co/9BvRaMiBdQ https://t.co/JRHe8Jad1e

Jan 16, 2020 · 1 like · 6,385 followers View post →
Cock Jockey
@Shuttlecock7 · X

@BroadHearse2 @Boneclacker @ClarkeMicah @Will_Sutcliffe8 @wself https://t.co/qd0LDWBVk3

Jan 12, 2019 · 227 followers View post →