PubHawk
October 2012 PMID 23045648

Brain on stress: how the social environment gets under the skin.

Bruce S McEwen

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Mentions

54
Peak: 6 in Sep 2020
across 5 sources since Sep 2020

Extended reach

281,609
potential audience

Total likes

4,896

Video views

141,707

Mentions per month

Sep 2020 – Sep 2025

Where it's discussed

  • X / Twitter23 posts
  • Facebook14 posts
  • News10 articles
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The discussions reflect a shared recognition of McEwen’s foundational role in stress research, with many examples referencing specific molecular pathways, such as miRNA and RNA interference, to emphasize the article's potential impact on understanding stress-related pathology, indicative of high engagement and interest.

AgreementModerate agreement

Most discussions recognize the importance of stress research and support McEwen's work, indicating a general agreement with the publication’s insights.

InterestHigh interest

The discussions show high curiosity about detailed mechanisms like RNA interference, miRNA, and hormonal effects, demonstrating strong interest.

EngagementModerate engagement

Many posts reference complex concepts, mention mentors, and bring in related research, reflecting thoughtful engagement beyond superficial reactions.

ImpactModerate impact

The conversations highlight the potential significance of understanding social stress on health, suggesting the publication may influence future research and health perspectives.

Abstract in brief

  • Stress involves complex interactions between the brain and body that are influenced by life experiences, genetics, and behaviors, and can lead to long-term health issues through a process called allostatic load.
  • Chronic stress causes changes in brain circuits related to anxiety, mood, memory, and decision-making, which can be adaptive in some situations but often become harmful if persistent and irreversible.
  • The brain's ability to adapt or remodel in response to stress (brain plasticity) offers potential for therapies, including psychological strategies and medications, to help mitigate the negative effects of stress on mental health.
Read the full abstract

Top posts

Most liked on X and Bluesky
Ale Garcia
@GYM_EXTREMO · X

Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plazo, la carga de estrés crónico provoca cambios en el cerebro y el cuerpo que pueden provocar enfermedades https://t.co/IOCHuh2ycE

Sep 27, 2020 · 48 likes · 5 shares · 99,409 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/VIQMEN6F35 "...colonic γδ T cells promotes psychosocial stress responses" 3/20/23 "...results highlight the previously unrecognized role of intestinal γδ17 T cells in the modulation of psychological stress responses..." Unrecognized by WHO. https://t.co/5fCDc6J21e

Mar 27, 2023 · 1 like · 1 share · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@tres723 @stephanieseneff Our 1996 Hormones and Behavior review of pheromone-regulated RNA-mediated cell type differentiation "From Fertilization to Adult Sexual Behavior" https://t.co/6dCuuvOP1y was linked to my mentor's works on disease prevention via his claims in https://t.co/5fCDc6J21e (2012)

Jan 4, 2023 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

Construction of the cell wall is food energy-dependent and pheromone-regulated genetic processes of reproduction link what they eat to quorum sensing (their social life) and effects on hormones that link the effects to affects on behavior. See: https://t.co/sEIcXq83jh

Apr 17, 2022 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@_MarcGielen_ @philosophising4 @CCguerilla @MicrobiomDigest Please provide an example of my inability for comparison to your lack of understanding of miRNA-mediated allostatic load. https://t.co/5fCDc6J21e Bruce McEwen was one of my mentors. You fool!

Apr 23, 2023 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/yHttZjwM0j Re: If you'd like to discuss energy-dependent RNA processes or AI modeling, I'm here to help. @Grok To prove you are lying, let's discuss this: "Brain on stress: how the social environment gets under the skin" https://t.co/5IpoDx3jOH (10/8/12) and the

Sep 27, 2025 · 2,567 followers View post →

All mentions

Impact of Poverty on Cognitive Function and Behavior

Poverty negatively affects cognitive function, as demonstrated by studies indicating that financial concerns impair the performance of low-income individuals. This video delves into how financial stress impacts…

SAMURICE · Sep 9, 2025 80,292 views
James V. Kohl
@microRNApro · X

https://t.co/yHttZjwM0j Re: If you'd like to discuss energy-dependent RNA processes or AI modeling, I'm here to help. @Grok To prove you are lying, let's discuss this: "Brain on stress: how the social environment gets under the skin" https://t.co/5IpoDx3jOH (10/8/12) and the

Sep 27, 2025 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/mX1evuzhGo Re: "Bruce McEwen's 1964 work on ATP-dependent RNA synthesis indeed pioneered insights into energy-dependent cellular processes." @Grok Who doesn't know that? In "Brain on stress: How the social environment gets under the skin" https://t.co/5fCDc6J21e

Sep 16, 2025 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/5fCDc6J21e 10/8/12 Bruce McEwen linked epigenetic EFFECTS of food energy and pheromones on hormones to the AFFECTS of hormones on behavior via light-activated miRNA abundance across kingdoms compared to the virus-driven degradation of mRNA that causes all pathology.

Mar 14, 2025 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

"Brain on stress: How the social environment gets under the skin" https://t.co/5fCDc6J21e (2012) links McEwen et al. & Dobzhansky (1964) to RNA interference and 20 copies of p53 in African elephants via the miRNA-mRNA balance. See the multi-omics approach in:

Jan 21, 2024 · 2,567 followers View post →
Performance Psychology
@AthletesPsych · X

Resources: McEwen, BS (2012) Brain on stress: How the social environment gets under the  Proc Natl Acad Sci SUA (https://t.co/ikF5XMKRow); 109(2):17180-17185.

May 9, 2023 · 791 followers View post →
James V. Kohl
@microRNApro · X

@_MarcGielen_ @MicrobiomDigest @philosophising4 It makes you look like a fool. Why didn't you link sunlight and humidity from the Creation of achiral glycine to the pH-dependent physiology of reproduction across species via McEwen's claims in https://t.co/5fCDc6J21e 10/8/12?

Apr 23, 2023 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@_MarcGielen_ @philosophising4 @CCguerilla @MicrobiomDigest Please provide an example of my inability for comparison to your lack of understanding of miRNA-mediated allostatic load. https://t.co/5fCDc6J21e Bruce McEwen was one of my mentors. You fool!

Apr 23, 2023 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@arta_semita @exosome Thanks for asking: https://t.co/a6IhPj27v4 See: Correction for McEwen, Brain on stress: How the social environment gets under the skin. Link saliva testing for COMT Val158Met to suicide prevention & testing for prevention of mass killings to https://t.co/LWUmdKV1Jb

Mar 29, 2023 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/VIQMEN6F35 "...colonic γδ T cells promotes psychosocial stress responses" 3/20/23 "...results highlight the previously unrecognized role of intestinal γδ17 T cells in the modulation of psychological stress responses..." Unrecognized by WHO. https://t.co/5fCDc6J21e

Mar 27, 2023 · 1 like · 1 share · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@tres723 @stephanieseneff Our 1996 Hormones and Behavior review of pheromone-regulated RNA-mediated cell type differentiation "From Fertilization to Adult Sexual Behavior" https://t.co/6dCuuvOP1y was linked to my mentor's works on disease prevention via his claims in https://t.co/5fCDc6J21e (2012)

Jan 4, 2023 · 2,567 followers View post →
نورة بنت أحمد المزيد
@NourahAlmazyad · X

RT @MAltwijri: النشاط البدني بما يعادل المشي ساعه/٥ ايام بالاسبوع، التعلم والقراءة المكثفة، ايجاد معنى في الحياه والسعي لاجله ... https://…

Sep 2, 2022 · 1 share View post →
د. مشاعل بنت عبدالله التويجري
@MAltwijri · X

النشاط البدني بما يعادل المشي ساعه/٥ ايام بالاسبوع، التعلم والقراءة المكثفة، ايجاد معنى في الحياه والسعي لاجله ... https://t.co/OImXHi8aSZ

Aug 17, 2022 · 1 share · 538 followers View post →
Peripheral Minds
@PeripheralMinds · X

Brain on stress: How the social environment gets under the skin | Proceedings of the National Academy of Sciences https://t.co/T5qq5DhR0F

Jul 6, 2022 · 1,570 followers View post →
James V. Kohl
@microRNApro · X

Construction of the cell wall is food energy-dependent and pheromone-regulated genetic processes of reproduction link what they eat to quorum sensing (their social life) and effects on hormones that link the effects to affects on behavior. See: https://t.co/sEIcXq83jh

Apr 17, 2022 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

@ZsoltNagy7 My mentor, Bruce S. McEwen was the world's leading expert on stress-linked pathology. https://t.co/5fCDc6J21e Food odors and pheromones biophysically constrain hormesis via pH-dependent fixation of amino acid substitutions.

Mar 27, 2022 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

See for comparison: https://t.co/5fCDc6J21e 10/8/12. In November, 2012, Bruce S. McEwen and I discussed the confusion caused by use of terms "effect" and "affect," which are not interchangeable. On 12/19/12 he published this correction" “effect” should instead appear as “affect.”

Mar 11, 2022 · 2,567 followers View post →
James V. Kohl
@microRNApro · X

If the moderators accept this comment, 57 years of obfuscated nutrient-stress & social stress-linked pathology will become clearer. See: "Brain on stress: How the social environment gets under the skin" https://t.co/5fCDc6J21e Learn the difference between 'effect' and 'affect.' https://t.co/fIHR8SPUT1

Mar 10, 2022 · 2,567 followers View post →
nutrier
@nutrier1 · X

RT @GYM_EXTREMO: Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plaz…

Sep 28, 2020 · 5 shares · 115 followers View post →
EnergyBalanceteam
@MatiasG_14 · X

RT @GYM_EXTREMO: Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plaz…

Sep 28, 2020 · 5 shares · 76 followers View post →
yelitza Bravo Gonzalez
@YelitzaBravoG · X

RT @GYM_EXTREMO: Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plaz…

Sep 27, 2020 · 5 shares · 131 followers View post →
Doménica Cevallos R.
@Domecevallos92 · X

RT @GYM_EXTREMO: Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plaz…

Sep 27, 2020 · 5 shares · 2,246 followers View post →
Fernando Rodriguez
@recetario1 · X

RT @GYM_EXTREMO: Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plaz…

Sep 27, 2020 · 5 shares · 1,590 followers View post →
Ale Garcia
@GYM_EXTREMO · X

Las hormonas asociadas al estrés protegen el cuerpo a corto plazo y promueven la adaptación (alostasis), pero a largo plazo, la carga de estrés crónico provoca cambios en el cerebro y el cuerpo que pueden provocar enfermedades https://t.co/IOCHuh2ycE

Sep 27, 2020 · 48 likes · 5 shares · 99,409 followers View post →