Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.

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Crémieux

@cremieuxrecueil · X

Source: https://t.co/d3eWKyWJ4O https://t.co/GFRkDuVIv0 https://t.co/5jLWnu5lBU

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Michael Albert, MD

@MichaelAlbertMD · X

9/ While you may be unimpressed by the ARD, several elegant studies demonstrate the value of LDL-c lowering on risk reduction as related to the absolute decrease over time (LDL-yrs), giving birth to the concept: "lower for longer." ↪️SO THERE'S NUANCE!

MD

Mike Hart, M.D

@drmikehart · X

3. I'm limiting my saturated fat to 7-10% of my calories because saturated fat causes high LDL, which is an independent risk factor for heart disease. https://t.co/4817z3P4Eb

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Dinos Stamoulis

@DinosStamoulis · X

@DrBrandonPettke Let’s be clear though…there is a direct link between the increased levels of LDL and your risk for heart disease. Prolonged exposure is not a good thing. https://t.co/OLlez5YW1R

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Joel "Heart Prevention" Kahn MD, FACC

@drjkahn · X

I have participated in many research projects but I am really proud of this one. Widely quoted. #kahnchronicle https://t.co/R1Gs1JIdC1

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Mike Hart, M.D

@drmikehart · X

Mendelian randomization study

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Mike Hart, M.D

@drmikehart · X

Mendelian randomization study

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Ozer Tayiz

@ozertayizx · X

@bakrantz @Mark_Sisson Mendellian randomization showing cholesterol causes cardiovascular disease: "The causal relationship between low-density lipoprotein cholesterol (LDL-C) and coronary atherosclerosis is well established." https://t.co/MqsgmgBweV

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Breno Santos

@Brepoiughfhjkl · X

@TylerDurne62894 @fiscaldofim Se você não tem nenhuma crítica válida contra o artigo, é só dizer. Aliás, ele é corroborado por Randomizações Mendelianas. Portadores homozigóticos de mutações de perda de função no gene PCSK9 têm níveis tão baixos quanto 30 mg/dL sem problemas de saúde. https://t.co/MNXNBV7Ymz

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Breno Santos

@Brepoiughfhjkl · X

@FinleySawyer1 @WongEXE___ Sure, you can just look at any Mendelian Randomization study. https://t.co/MNXNBV7Ymz

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Leftist Trail Runner

@vegantrailrun · X

@Abdulthe_G_ @DelusionPosting https://t.co/ioS1IkFpnb

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Hsainoh

@Jog_DMC · X

@EdLatimore If interested these are two better quality studies that better control for confounders and actually tracked LDL levels over time 2/2:- https://t.co/WGXUiDVTHd https://t.co/YOkFihTUCd

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Cal

@caldenbasi · X

@RustySashwaite @Marion436842126 I believe it's this one: Here is the link to "Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomization Analysis": https://t.co/ZlX2gmFOkj

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Colleen Griffith

@Griffith17431 · X

RT @cremieuxrecueil: Source: https://t.co/d3eWKyWJ4O https://t.co/GFRkDuVIv0 https://t.co/5jLWnu5lBU

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Crémieux

@cremieuxrecueil · X

Source: https://t.co/d3eWKyWJ4O https://t.co/GFRkDuVIv0 https://t.co/5jLWnu5lBU

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Tim

@TimothyAdriaens · X

@MasalaFry69 @ashlaurlune @m_jan72 @GeneralMCNews You’re not rejecting “non-science.” You’re rejecting: https://t.co/Ht5o00k1vh https://t.co/7EvVzu6Kwc https://t.co/iFdanNqXig https://t.co/4BlD0ixfN6 That’s not science skepticism. That’s wholesale denial.

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Joel "Heart Prevention" Kahn MD, FACC

@drjkahn · X

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Choleste... https://t.co/IgiJvkDcge

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GGnnHAK

@KnnHnngg · X

@Mangan150 but this: https://t.co/yH6ZSkA8u1

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Michael Albert, MD

@MichaelAlbertMD · X

9/ While you may be unimpressed by the ARD, several elegant studies demonstrate the value of LDL-c lowering on risk reduction as related to the absolute decrease over time (LDL-yrs), giving birth to the concept: "lower for longer." ↪️SO THERE'S NUANCE!

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gordo

@amfetamigo · X

@s_batzoglou @siimland @SBakerMD if a six year prospective study is all you need to draw conclusions, how do you feel about mendelian randomization studies that look at decades of high vs low cholesterol exposure and its outcomes? https://t.co/UOjnnBmeET

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Potatus-In-Chief

@PotatusInChief · X

@SmllFries01 @JamesOnekaka @Lauren_Southern @jordanbpeterson This study proved LDL *causes* CVD in a dose-dependent manner irrespective of other risk factors or confounders and that high LDL early in life increases risk later in life since the disease is cumulative and takes decades to develop. https://t.co/0G0vg9njbG

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Kevin Harris

@kevtharris · X

@KellyGoodmanPhD @CaryKelly11 https://t.co/k9zFt1Yeli We know from genetic studies that lower lifetime LDL-c leads to reduced risk of CHD

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Tom Babington

@Tom_Babington1 · X

@OliverCramon @ThelastStyleb16 @drpablocorral It's from here https://t.co/EPKT5mDggg

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Brian Schnettgoecke

@bschnett · X

This study demonstrates similar lifetime LDL exposure risk, though with a different approach: https://t.co/krYwdJ1i9M #MedPeds #Tweetiatrician #MedTwitter #Cardiotwitter

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Kevin Harris

@kevtharris · X

@thalesnemo @shelly_187 @LDLSkeptic https://t.co/k9zFt1XGvK Genetic studies showing longer term exposure to lower ldl levels

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ZKForTre

@ZKForTre · X

@DoctorTro Sure thing. https://t.co/YGT8YFSHSO. https://t.co/CM8XlvnZJj https://t.co/46fDF6yeZO https://t.co/hmwRVqROIJ https://t.co/F1mk00HVZC https://t.co/hylnO1ntaZ https://t.co/oygiA2yjJ3 https://t.co/1eJWOtTVIk

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Dinos Stamoulis

@DinosStamoulis · X

@DrBrandonPettke Let’s be clear though…there is a direct link between the increased levels of LDL and your risk for heart disease. Prolonged exposure is not a good thing. https://t.co/OLlez5YW1R

KH

Kevin Harris

@kevtharris · X

@REV_Insulin_Res @TheBhupiThakur https://t.co/k9zFt1XGvK https://t.co/vfbXkwZIKN we have studies in which folk are randomised genetically to lower levels of LDL & therefore lower risk of CVD

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Kevin Harris

@kevtharris · X

@thalesnemo @shelly_187 https://t.co/k9zFt1XGvK then we have genetic randomisation

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Renato Dumbra

@renatodumbra · X

@primary3down Low LDL is better https://t.co/tz5MVGt1pE

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Kevin Harris

@kevtharris · X

@holmanm @SentientBlobBob @IsgittJohn https://t.co/k9zFt1XGvK

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Kevin Harris

@kevtharris · X

@j_t_2390 @JohnnyScott234 @FusionProgGuy @ElieJarrougeMD @Dr__Guess @NutritionMadeS3 https://t.co/k9zFt1XGvK start with this one from Ference & colleagues

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Brian Schnettgoecke

@bschnett · X

@MikeRoseMDMPH Agreed, for chronic conditions now increasingly affecting kids and young adults it’s about AUC. This is the only study I’ve seen that attempts to quantify risk reduction with early LDL lowering, using genetic LDL-lowering polymorphisms. https://t.co/krYwdJ1PZk

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Mike Hart, M.D

@drmikehart · X

3. I'm limiting my saturated fat to 7-10% of my calories because saturated fat causes high LDL, which is an independent risk factor for heart disease. https://t.co/4817z3P4Eb

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Kevin Harris

@kevtharris · X

@pellegrino55555 @dr_jon_l @TekTonic4 @DrAseemMalhotra @bigfatsurprise https://t.co/k9zFt1XGvK the kicker for you LDL-c denialists were the beautiful genetic studies by Brian Ference & colleagues. Goodnight

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Kevin Harris

@kevtharris · X

@YesImaFed @Mangan150 @TyRBeal Looks take a look a some studies that accurately reflect the research shall we? Not ones that measure LDL after a cardiac event https://t.co/k9zFt1XGvK

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Tom Babington

@Tom_Babington1 · X

@John_G_Willis @ScepticalDoctor @bulkbiker @coalhoof @Alecsplaining @MattMadore576 @kevinnbass I'll just post these to brush up your understanding and clear up some misconceptions. https://t.co/UEmtA0zoq3 https://t.co/zCJ1DIKZU0 https://t.co/bgHpwrsfG8 https://t.co/EPKT5mDggg https://t.co/7bo22LtT1D https://t.co/mM0dMK1X1z Now I can go back to ignoring you

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INDI Cardiology Interest Group

@INDI_Cardiology · X

RT @MyNutriWeb: Study link looking into the effect of long-term exposure to lower plasma low-density LDL-C on the risk of coronary heart di…

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MyNutriWeb

@MyNutriWeb · X

Study link looking into the effect of long-term exposure to lower plasma low-density LDL-C on the risk of coronary heart disease https://t.co/C3RVEsl2UW https://t.co/vzDUjPfsRk

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Bhopender Thakur

@TheBhupiThakur · X

RT @MyNutritionSci: @chelseakwt @Tom_Babington1 @fitomnivore @Maclagan_was_OK @DrSeanOMara @ScepticalDoctor @elonmusk @DrEsselstyn @johnmcd…

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Bhopender Thakur

@TheBhupiThakur · X

RT @dylanarmbruste3: https://t.co/POSs7Z3QKY https://t.co/3NkexQ5xLx

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Dylan Armbruster

@dylanarmbruste3 · X

https://t.co/POSs7Z3QKY https://t.co/3NkexQ5xLx

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Bhopender Thakur

@TheBhupiThakur · X

RT @PLooserMD: @chefmo916 @ifixhearts @kevinnbass @CarnivoreMD https://t.co/UvbvMjHXPL https://t.co/chF52iw22E Recent enough for you?

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Shaun Ward

@MyNutritionSci · X

@chelseakwt @Tom_Babington1 @fitomnivore @Maclagan_was_OK @DrSeanOMara @ScepticalDoctor @elonmusk @DrEsselstyn @johnmcdonnellMP @nutrition_facts @DrNealBarnard Mendelian randomisation studies. Those with genetically higher LDL have an increased risk of CVD. Explain why... https://t.co/Fr7JlXymzW

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Jordan Feigenbaum, M.D.

@Jordan_theCoach · X

@BioLayne Looks like Ference 2012 Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease - we cite this in our seminars and our paper on LDL’s effect on ASCVD risk.

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Erick Raffai

@Erick_Raffai · X

RT @drjkahn: I have participated in many research projects but I am really proud of this one. Widely quoted. #kahnchronicle https://t.co/…

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Joel "Heart Prevention" Kahn MD, FACC

@drjkahn · X

I have participated in many research projects but I am really proud of this one. Widely quoted. #kahnchronicle https://t.co/R1Gs1JIdC1

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Emil

@animusblue · X

@AviBittMD @drmatthewnagra @BioLayne In this study they studied polymorphisms that affect LDL levels. They did a randomized controlled trial and what they found was 54,5% decrease in CVD per 1mmol/l. https://t.co/0Ds13EfxNV