Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.

Romain A Studer, Benoit H Dessailly, Christine A Orengo

February 2013 Biochem J

Synopsis of Social media discussions

The discussions demonstrate strong interest through queries about what mutations are and their relevance to variants like Omicron, with posts emphasizing the significance of understanding protein changes. The tone combines educational curiosity with recognition of the importance of mutation research in managing viral threats, reflecting thoughtful engagement and acknowledgment of the article's broader significance.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of understanding mutations, especially in the context of variants like Omicron.

I
Interest
 High level of interest

Posts show a high level of curiosity about mutations and their implications, especially relating to viral evolution.

E
Engagement
 Moderate level of engagement

Participants reference specific concepts such as protein structure and mutations, indicating active thought and discussion.

I
Impact
 Moderate level of impact

The discussions highlight the relevance of the research for public health and understanding viral behavior, suggesting a moderate to high perceived impact.

Social Mentions

YouTube

3 Videos

Twitter

6 Posts

Blogs

3 Articles

News

2 Articles

Metrics

Video Views

4,020

Total Likes

105

Extended Reach

9,408

Social Features

14

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Understanding Mutations and Their Impact on Protein Function

Understanding Mutations and Their Impact on Protein Function

This video explains how amino acid mutations influence protein structure and function, highlighting their role in evolution and disease. It emphasizes recent advances in tools integrating biophysics, structure, and evolutionary studies to better understand beneficial and harmful mutations.

bioZone

December 13, 2021

3,174 views

Understanding Omicron Variants and Their Impact on Protein Function

Understanding Omicron Variants and Their Impact on Protein Function

This review discusses how amino acid mutations affect protein structure and function. It highlights the role of natural selection in protein evolution and recent advances in tools to analyze mutation impacts, especially in viruses like Omicron.

bioZone

December 13, 2021

429 views

Understanding Omicron Mutations and Their Impact on Protein Function

Understanding Omicron Mutations and Their Impact on Protein Function

This video explores how amino acid mutations affect protein structure and function, highlighting their role in viral evolution and disease. It discusses factors influencing mutation impact and recent advances in research tools.

bioZone

December 13, 2021

417 views

  • TheSciCommCollective
    @Sci_Comm_ (Twitter)

    RT @thebiozone: lets talk omicron and mutations: first- what are mutations? (1/4) click below to support us by watching on YouTube
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    December 17, 2021

    2

  • Academic YouTubers
    @YTacademics (Twitter)

    RT @thebiozone: lets talk omicron and mutations: first- what are mutations? (1/4) click below to support us by watching on YouTube
    view full post

    December 15, 2021

    2

  • bioZone
    @thebiozone (Twitter)

    and finally- what does this mean for the new #Omicron variant? (3/4) https://t.co/qa1kf1cH4w https://t.co/NEAIpvFOR4
    view full post

    December 14, 2021

    1

  • bioZone
    @thebiozone (Twitter)

    what do mutations do? #Omicron (2/4) https://t.co/dwTKKbcIUI https://t.co/d11RxZfKu7
    view full post

    December 14, 2021

    1

  • Michael Carmody
    @m_carmody (Twitter)

    Residue Mutations and Their Impact on Protein Structure and Function: Detecting Beneficial and Pathogenic Changes - PubMed https://t.co/jc3ALz0iEE
    view full post

    March 30, 2020

  • K.I.
    @genolib_19 (Twitter)

    Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes https://t.co/vLJniYjQGp
    view full post

    May 4, 2019

Abstract Synopsis

  • This review discusses how amino acid mutations in proteins can influence their structure and function, highlighting how proteins evolve through periods of conservation and rapid change driven by natural selection.
  • It explains that the impact of mutations depends on various factors, such as the mutation's location within the protein's 3D structure and whether residues coevolve to maintain stability, with structural changes sometimes dramatically affecting protein function.
  • The review also emphasizes recent advances in tools and methods that combine protein biophysics, structure, and evolutionary studies to better understand how mutations, including beneficial and harmful ones, shape protein evolution, especially in contexts like viruses and animal genetics.]