N Engl J Med January 2013 PMID 23323867

Duodenal infusion of donor feces for recurrent Clostridium difficile.

Els van Nood, Anne Vrieze, Max Nieuwdorp, Susana Fuentes, Erwin G Zoetendal, Willem M de Vos, Caroline E Visser, Ed J Kuijper, Joep F W M Bartelsman, Jan G P Tijssen, Peter Speelman, Marcel G W Dijkgraaf, Josbert J Keller

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Mentions

394

Peak: 6 in May 2019

across 7 sources since Jan 2013

Extended reach

578,346

potential audience

Total likes

9,508

Video views

244,163

Mentions per month

Jan 2013 – May 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions prominently feature phrases like 'very effective' and mention previous studies, such as the 2013 NEJM reference, which confirms the efficacy of fecal transplants. Contributors use terms like 'game changer' to convey urgency and excitement, with some even noting ethical concerns related to withholding treatments in control groups, which illustrates a deep consideration of the topic's implications.

AgreementModerate agreement

Most discussions reflect a positive view on the efficacy of fecal transplants for treating Clostridium difficile, highlighting agreement with the conclusions of the study.

InterestHigh interest

The posts show a high level of curiosity about fecal microbiota transplants and their implications for treatment, indicating strong engagement with the subject.

EngagementModerate engagement

There are several references to previous studies, indicating a moderate to deep engagement with the ongoing conversation surrounding this topic.

ImpactHigh impact

Many contributors perceive this treatment as significantly impactful for patients suffering from recurrent infections, suggesting a collective belief in its potential to change treatment protocols.

Abstract in brief

The study investigated the effectiveness of duodenal infusion of donor feces in treating recurrent Clostridium difficile infections (CDI) compared to standard vancomycin treatments.
Patients receiving the fecal infusion had a significantly higher resolution rate of CDI symptoms (81%) than those treated with vancomycin alone (31%) or with vancomycin and bowel lavage (23%).
Post-infusion, patients exhibited increased fecal bacterial diversity, aligning more closely with that of healthy donors, indicating a positive change in gut microbiota after the treatment.

Read the full abstract

All mentions

Exploring Intestinal Microbiota: Biodiversity and Conservation Challenges

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Fecal Transplant: An Innovative Treatment for CDI

Did you know that feces are not just waste? They contain valuable microorganisms that can benefit us. This video explores the effectiveness of fecal transplants for recurrent Clostridium difficile infections, showcasing…

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Koala Microbiome Modification through Poop Transplants for Dietary Flexibility

Koalas have distinct gut microbiomes influenced by their diet. Faecal inoculations can modify their gut bacteria, increasing their ability to eat different Eucalyptus species, which may enhance dietary flexibility in…

Noodletown · Sep 13, 2019 647 views

Effectiveness of Donor Feces in Clostridium Difficile Treatment

The study investigates the effectiveness of duodenal infusion of donor feces for recurrent Clostridium difficile infections (CDI) compared to standard treatments. Results show a significantly higher resolution rate of…

Doctor Scott · Nov 13, 2021 213 views

Impact of Pet Ownership on Human Gut Microbiota Diversity

This study examines how owning household pets, especially dogs and cats, influences the diversity of the human gut microbiome, finding some differences in specific microbial groups between pet owners and non-owners…

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This episode discusses how owning household pets, especially dogs and cats, influences the diversity of the human gut microbiome. It examines differences in microbial groups between pet owners and non-owners…

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Defining the Microbiome: Current Insights and Future Directions

We will be exploring the history and implications of the microbiome concept. Recent research highlights the need for a standardized definition and best practices in microbiome studies. This video aims to stimulate…

LifeLung Learning · Dec 27, 2020 38 views

Scott

@Mooosh_87 · X

@chiweethedog It’s gross but donor stool treatments are actually such an effective treatment for gut infections/ microbiome imbalances, a study on treating c. diff with them ended on the ethical concern it withheld treatment from the other treatment groups https://t.co/CxcbCUG4j5

May 14, 2025 · 5 followers View post →

Francis Villatoro

@emulenews · X

Nov 9, 2024 · 4 likes · 45,150 followers View post →

Maximilian Breall

@breallstrong · X

Study here: https://t.co/5uX6C1Y6OH

Jun 5, 2024 · 998 followers View post →

Chronophobia

@ZenoChrono · X

@khalnero https://t.co/1lPsf30xNb This one seemed to indicate that if you get it into your system you'll be shitting yourself but will adjust. Interesting background reading on gut biome https://t.co/xqWQcjT57G. I'm tapping out here tho bro, good luck

May 5, 2024 · 1 share · 99 followers View post →

Ataru Kajihara

@atarukajihara · X

2013年のNEJMに、オランダで行われたクロストリジウムディフィシル感染症のふん便移植の無作為臨床試験の研究結果が報告されています。 Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile https://t.co/ch4fXAlm6d

Oct 17, 2023 · 61 followers View post →

もちもち

@moccyan15 · X

@arabitom FMT（便微生物移植療法）はクロストリジウム・ディフィシル患者とかでかなりやられている治療法らしいっす…　経鼻胃管とかカプセルとかで健常者の大便を注入するらしいです…めっちゃ抵抗ある…笑 https://t.co/b3fwdd58Et

Apr 20, 2023 · 188 followers View post →

Simon MD Baunwall

@SMDBaunwall · X

The 2013 NEJM by van Nood et al. is a clear choice, demonstrating the efficacy of FMT for multiple rCDI: https://t.co/Mp5GKxImjR … And not to forget the historical 1958 four case reporting by Eiseman et al.

Mar 17, 2023 · 184 followers View post →

Herve Affagard

@HAffagard · X

RT @APM_france: [#NEWS]

Jan 31, 2023 · 2 shares · 546 followers View post →

Lyonbiopôle Auvergne-Rhône-Alpes

@Lyonbiopole · X

RT @APM_france: [#NEWS]

Jan 31, 2023 · 2 shares · 3,316 followers View post →

European Microbiome Innovation for Health

@EMIH_EU · X

[#NEWS]

Jan 31, 2023 · 4 likes · 2 shares · 88 followers View post →

Andreu Prados

@andreuprados · X

Bibliografía

Dec 6, 2022 · 4 likes · 3,086 followers View post →

Wiep Klaas Smits

@SmitsLab · X

What if antimicrobials fail in CDI treatment? Fecal microbiota transplants (FMT) offers an effective (https://t.co/T3hfPnFIQw) alternative that may work via different mechanisms (https://t.co/nhEFRY7BBo). Note, though, that FMT is also accompanied by antimicrobial pretreatment.

Nov 22, 2022 · 1 like · 2,360 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXZKp

Oct 15, 2022 · 141 followers View post →

Alyssa Burrows (She/Her), MSc

@Alyssa__Burrows · X

Fecal microbiota transplants(FMT) (i.e. Poop transplants) are VERY EFFECTIVE* in recurrent C. diff infections. (https://t.co/ARZx5RpP2V) However, FMT donor screening is too challenging to upscale. Some researchers have shown that poop is not essential.

Sep 22, 2022 · 1 like · 202 followers View post →

Scott Carrington⏳

@carrings · X

Can poo transplants cure C Diff infections? Other people’s faeces in a “sterile” flask, sent down an NJ tube. Biggest side effect - belching

May 8, 2022 · 1 like · 916 followers View post →

Dave Roberts

@CDifficile1 · X

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile | NEJM https://t.co/kHzczo5C8s #cdi #cdiff

Mar 7, 2022 · 436 followers View post →

Shrinivas Bishu

@IBDimmunology · X

@DCharabaty @AmCollegeGastro @dagreenwald @IBD_Houston @MLongMD @DrJessicaA @drkeithsiau @Samir_Grover @stevenbollipo @KM_Pawlak Crazy fact that people forget about ➡️

Dec 4, 2021 · 4 likes · 2,990 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Sep 18, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Sep 14, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Aug 27, 2021 · 1 like · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jul 18, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jul 17, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jul 11, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jun 15, 2021 · 1 like · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jun 6, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

May 21, 2021 · 2 likes · 141 followers View post →

Bruno Bowden

@brunobowden · X

@michaelmina_lab @samies177 - I agree heartily in the right context. They did in fact stop the testing early for the RCT of Fecal Microbiata Transplant. It was so successful that it was unethical to continue testing. https://t.co/f8WQSxx3he https://t.co/QrxHo4atoO

May 3, 2021 · 3 likes · 1,847 followers View post →

骨シンチグラフ医

@bonescintigraph · X

アカデミックうんこの話 https://t.co/G5ICrpt6D8

Apr 12, 2021 · 2 likes · 5,216 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Apr 4, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Mar 30, 2021 · 141 followers View post →

Adam Cifu

@adamcifu · X

1/3 Read two classics in out Critical Appraisal of the Landmark Literature today. HERS trial https://t.co/rYOGCHHOh7 Donor feces for C Diff https://t.co/F4pdmjwXqO

Feb 3, 2021 · 2 likes · 26,020 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jan 20, 2021 · 141 followers View post →

Yue-Yung Hu, MD, MPH

@YueyungHu · X

@KBrookeGolisch @traumatroll And there’s more - one of the “adverse events” with duodenal infusion was belching

Jan 8, 2021 · 1 like · 1,048 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vIf2Mp

Jan 4, 2021 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Dec 24, 2020 · 141 followers View post →

Georgetown Internal Medicine

@gtown_medres · X

#52in52 wk 19: “Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile” from @nejm 2013: FMT superior to vanc or vanc + bowel lavage in recurrent CDI. Now in treatment guidelines. Summary: https://t.co/OjCBDkRcz5 @DuncanFMoore https://t.co/wYu3AVBwQz

Dec 3, 2020 · 3 likes · 2,144 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Nov 8, 2020 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Nov 4, 2020 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Oct 4, 2020 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Sep 4, 2020 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Sep 2, 2020 · 141 followers View post →

OneLineSummary Bot

@OLS_Bot · X

Van Nood - 2013 - Fecal transplant vs vancomicin in recurrent C.diff infection - ↓ relapses, ↑ time to relapse - https://t.co/u1s4vHXrUR

Jul 18, 2020 · 141 followers View post →

Alberto García-Salido

@Nopanaden · X

Este ensayo clínico con heces, se tuvo que parar porque el grupo que las recibía... mostró unos resultados espectaculares. Se comprobó en un corte inicial de los resultados y fue tal el triunfo que se paró el trabajo. Aquí la publicación. https://t.co/dqHerSN1MF

May 26, 2020 · 3 likes · 125,608 followers View post →

martin rutkowsky

@RutkowskyMartin · X

Fäkale Mikrobiota-Transplantation Derzeit beste Methode, um Clostridium difficile Patienten zu behandeln. Eine Stuhl-Transplantation hilft dem Betroffenen wirksamer als Antibiotika! Das ist auf die Bakterien im "gesunden Stuhl" zurückzuführen. https://t.co/qNSdCZdlZC https://t.co/ngFAFSlzG4

Feb 24, 2020 · 57 followers View post →

Elena RR

@E_dobleR · X

RT @rafaelsolana2: Se suele 'administrar' por vía oral (sonda, no seáis bestias), en píldoras o por vía rectal (supositorios, no seáis best…

Jan 21, 2020 · 1 share · 125 followers View post →

Rafa Sⲫlana

@rafaelsolana2 · X

Jan 20, 2020 · 4 likes · 1 share · 5,151 followers View post →

ibaraki critical care net

@IbarakiNet · X

そういえば、再発性/難知性クロストリジウム・ディフィシル感染症に対する糞便移植（細菌）の小規模RCTもあったな。。。報告は、2013年か。 https://t.co/7Av1K4yVjK 最近、糞便微生物移植（Fecal Microbiota Transplant）で死亡例が報告されてるみたい https://t.co/uwGkCQfMB5

Jan 8, 2020 · 94 followers View post →

ARTHUR

@arthsarun · X

RT @artcardio: ข่าวคนกินฉี่ นี่ว่าแน่แล้วนะ... ☑️ ลองอ่าน paper นี้ดูก่อน .. ทดลองเอา donor feces (อึ) ผ่านท่อสายยางลงไปในลำไส้เล็กส่วนต้น…

Aug 21, 2019 · 7 shares · 26,679 followers View post →

`·*:•.✩

@JJis_cassi · X

Aug 21, 2019 · 7 shares · 93 followers View post →

$ artô $

@artcardio · X

ข่าวคนกินฉี่ นี่ว่าแน่แล้วนะ... ☑️ ลองอ่าน paper นี้ดูก่อน .. ทดลองเอา donor feces (อึ) ผ่านท่อสายยางลงไปในลำไส้เล็กส่วนต้น เพื่อรักษาโรคติดเชื้อแบคทีเรียตัวหนึ่งที่ชื่อ C.difficile !!! แถมดูจะได้ผลด้วย ! https://t.co/emDPVHAVHI

Aug 21, 2019 · 1 like · 7 shares · 23,301 followers View post →

Marta Llorens Fons

@Martallorefo · X

Segons Suez et al, el que funciona és un trasplantament autòleg de microbiota fecal (#aFMT). Els trasplantaments fecals han mostrat ser eficients contra les infeccions recurrents per Clostridium difficile https://t.co/OHe2pxZ3uq

Aug 17, 2019 · 173 followers View post →

アライさん流まんまるまる亭

@skryta · X

RT @moccyan15: @MAMAAAAU 治療法として確立しそうになってます。再発性クロストリジウム・ディフィシル患者に対して健常者の便注入はバンコマイシンより有効 https://t.co/b3fwddmbGt 　経鼻胃管より健常者の大便を注入するらしい。

May 7, 2019 · 7 shares · 1,313 followers View post →

鴉

@_BWWN_ · X

May 7, 2019 · 7 shares · 806 followers View post →

m2r_p

@m2r_p · X

May 7, 2019 · 7 shares · 2,595 followers View post →

ｼ中田艦長　ツイッターの良心　美しい心を持つ中年

@ken0419 · X

May 7, 2019 · 7 shares · 749 followers View post →

まくるめ@書籍買って〜

@MAMAAAAU · X

May 7, 2019 · 7 shares · 40,334 followers View post →

もちもち

@moccyan15 · X

May 7, 2019 · 11 likes · 7 shares · 188 followers View post →

ふらんこ

@junfrancfrank · X

あっさりみつかった。グーグル先生すごすぎ https://t.co/8lp6uAl8PS

Mar 9, 2019 · 1 like · 1,340 followers View post →

Nick Bennett

@nbennett04 · X

@DrToddLee Agree though not too far off from the 2013 NEJM study of FMT vs vanco (81 vs 31% at 10 weeks), using more aggressive vanco dosing (500 mg). https://t.co/RM5asrbO4E

Jan 9, 2019 · 1,909 followers View post →

Daniel Wexler

@WexlerRules · X

@JackPosobiec https://t.co/AhJLXGttYM

Jan 3, 2019 · 3,665 followers View post →

Carl Zimmer

@carlzimmer.com · Bluesky

Fecal transplant beats antibiotics--again. http://www.nejm.org/doi/full/10.1056/NEJMoa1205037?query=TOC

Jan 16, 2013 View post →

Duodenal infusion of donor feces for recurrent Clostridium difficile.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Exploring Intestinal Microbiota: Biodiversity and Conservation Challenges

Fecal Transplant: An Innovative Treatment for CDI

Koala Microbiome Modification through Poop Transplants for Dietary Flexibility

Effectiveness of Donor Feces in Clostridium Difficile Treatment

Impact of Pet Ownership on Human Gut Microbiota Diversity

Impact of Household Pets on Human Gut Microbiota Diversity

Defining the Microbiome: Current Insights and Future Directions