May 2013 PMID 23563705

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Robert A Koeth, Zeneng Wang, Bruce S Levison, Jennifer A Buffa, Elin Org, Brendan T Sheehy, Earl B Britt, Xiaoming Fu, Yuping Wu, Lin Li, Jonathan D Smith, Joseph A DiDonato, Jun Chen, Hongzhe Li, Gary D Wu

Mentions

247
Peak: 6 in Nov 2022
across 6 sources since Jun 2016

Extended reach

285,573
potential audience

Total likes

28

Video views

167

Mentions per month

Jun 2016 – Mar 2025

Where it's discussed

  • Facebook110 posts
  • News74 articles
  • Blogs36 articles
  • X / Twitter18 posts
  • Reddit6 posts
  • YouTube3 videos

AI synopsis

What people are saying

The collection of posts reveals a shared concern about the role of gut microbes in metabolizing nutrients from red meat that may promote heart disease, using words like 'promotes' and 'sensible' to express agreement and significance. Some posts cite related studies, compare vegan and meat-based diets, and debate the science behind TMAO, showing active engagement and understanding of the research's impact on health choices.

AgreementModerate agreement

Most discussions support the idea that red meat's nutrient L-carnitine, processed by gut microbes, contributes to atherosclerosis, indicating general agreement with the publication's findings.

InterestHigh interest

Posts show high curiosity about the health implications, particularly about reducing TMAO levels and the role of gut bacteria, reflecting strong interest.

EngagementModerate engagement

Discussions include references to mechanisms, related research, and opinions on broader health effects, demonstrating a moderate level of deep engagement.

ImpactModerate impact

Many recognize the potential health risks linked to red meat consumption, suggesting the article could influence dietary choices and scientific understanding.

Abstract in brief

  • The study shows that the gut bacteria metabolize L-carnitine, a nutrient found in red meat, producing trimethylamine N-oxide (TMAO), which accelerates atherosclerosis in mice.
  • In humans, those who eat more red meat and have certain gut bacteria produce higher TMAO levels, which are associated with increased risk of cardiovascular disease and adverse cardiac events.
  • Experimentally, increasing dietary L-carnitine in mice boosts TMA and TMAO production, promoting atherosclerosis, but these effects can be prevented by suppressing gut bacteria, highlighting the microbiota's role in CVD risk linked to red meat consumption.

Top posts

Most liked on X and Bluesky
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 niacin摂取でカルニチンの生合成を助ける https://t.co/MWiHk7Kac5

Nov 21, 2022 · 18 likes · 4 shares · 124,793 followers View post →
Some Person
@psstpassiton · X

@CarnivoreSapien Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Robert A. Koeth, Zeneng Wang, [...], and Stanley L. Hazen

Feb 6, 2023 · 1 like · 1,988 followers View post →
Dr. Bitcarrot
@expertlivet · X

@nic__carter Being a bitcoiner we should care about long term health https://t.co/ubZ7d40waC

Jul 30, 2021 · 1 like · 874 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 21, 2022 · 4 shares · 124,793 followers View post →
Tabatha
@araran100 · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 27, 2022 · 4 shares · 17,458 followers View post →
Conor Kerley PhD, RD
@ConorKerley · X

@AaronBosterMD Although not too my RCTs of carnitine and atherosclerosis Plausible mechanism first published by Stan Hanzen and colleagues from Cleveland Clinic in Nature Medicine: Intestinal microbiota metabolism of L-carnitine promotes atherosclerosis https://t.co/QrJaAR7icq

Oct 17, 2022 · 4,963 followers View post →

All mentions

FixCare!
@FixCareHealth · X

@SBakerMD Gut microbes, meat digestion lead to CAD. https://t.co/2Uuj33oweZ

Jan 2, 2025 · 223 followers View post →
Tom Hennessy
@ironjustice · X

@KenDBerryMD "Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis" "The presence of specific bacterial taxa in human feces was associated with both plasma TMAO concentration and dietary status" https://t.co/bHKixXUwpw

Aug 24, 2023 · 46 followers View post →
Chris Canton
@ChrisCanton99 · X

@erogul1 I’ve heard warnings about Carnitine intake. https://t.co/zCnaMEwODA

Feb 8, 2023 · 15 followers View post →
Some Person
@psstpassiton · X

@CarnivoreSapien Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Robert A. Koeth, Zeneng Wang, [...], and Stanley L. Hazen

Feb 6, 2023 · 1 like · 1,988 followers View post →
Tabatha
@araran100 · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 27, 2022 · 4 shares · 17,458 followers View post →
CCSは誘発地震を起こす可能性ある
@MD_PhD_ivermect · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 27, 2022 · 4 shares · 4,605 followers View post →
まっすー
@mnegishi777 · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 21, 2022 · 4 shares · 271 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

RT @ShigekiKanamori: カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 nia…

Nov 21, 2022 · 4 shares · 124,793 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

カルニチンを摂ってくれと言ってる訳じゃないよ トリメチルアミン-N-オキシド TMAOのアテローム性動脈効果のリスクもあるからね カルニチンが欠乏してる場合の寒さ対策ならという話だから過剰摂取は別の問題がおきる VC B6 niacin摂取でカルニチンの生合成を助ける https://t.co/MWiHk7Kac5

Nov 21, 2022 · 18 likes · 4 shares · 124,793 followers View post →
Kadir Demircan
@kdemircan1 · X

Sporcular neden erken yaşlanır? KIRMIZI ET--- KARNİTİN VE DAMAR SERTLİĞİ Kırmızı ette bulunan bir besin olan karnitinin bağırsak mikrobiyota metabolizması aterosklerozu teşvik eder #spor #et #karnitin #Damar https://t.co/uTmw3iJqy9

Nov 9, 2022 · 1,796 followers View post →
Conor Kerley PhD, RD
@ConorKerley · X

@AaronBosterMD Although not too my RCTs of carnitine and atherosclerosis Plausible mechanism first published by Stan Hanzen and colleagues from Cleveland Clinic in Nature Medicine: Intestinal microbiota metabolism of L-carnitine promotes atherosclerosis https://t.co/QrJaAR7icq

Oct 17, 2022 · 4,963 followers View post →
The Protein-Deficient Vegan
@Pro_Def_Veg · X

@byrnetree @theproof Dr. Stanley Hazen at the Cleveland Clinic has identified TMAO as a contributing factor in the development of diseases. That said, TMAO science is not settled science and the jury is out as to if TMAO is a causitive agent of or a marker for inflammation. https://t.co/84uzoKlt24 https://t.co/Onj89oV1Rv

May 22, 2022 · 127 followers View post →
REBEGE
@REBEGE · X

@dniavi @Cristian_Es21 https://t.co/OOKD8A7vQZ https://t.co/7zVrkMNGri https://t.co/3ZVwQSEjbh

Dec 2, 2021 · 845 followers View post →
BedrosGesaratsian ֍Ⓥ
@gesaratsian · X

@ScepticalDoctor @NanciGuestRDPhD Any evidence in a mammal is enough evidence for me. But as always, it's just my humble opinion. Also, #carnitine: "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis" https://t.co/vHvhoCnmi7

Oct 11, 2021 · 542 followers View post →
Dr. Bitcarrot
@expertlivet · X

@nic__carter Being a bitcoiner we should care about long term health https://t.co/ubZ7d40waC

Jul 30, 2021 · 1 like · 874 followers View post →
Alan Watson
@Alan_Watson_ · X

@JoannaBlythman It seems very sensible to reduce TMAO levels as far as possible as the original research paper indicates. Funny, isn't it, how: 1) vegans have the lowest levels of TMAO overall (& << levels of cardiovascular disease too!) Doi:10.1038/nm.3145 2) you never report this research! https://t.co/tSonhy3jsm

Oct 28, 2020 · 1,524 followers View post →
AwokenTheLBC
@AwokenLbc · X

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis https://t.co/RFmz38rXlF

Oct 21, 2019 · 492 followers View post →
NVMd Medical Home
@FoxdaleMedical · X

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis https://t.co/qJr1nV5xVN

Mar 3, 2019 · 12 followers View post →