Publications by authors named "Jonathan D Smith"

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Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation.
Jessica C Lal, Chengsheng Mao, Yadi Zhou, Shamone R Gore-Panter, Julie H Rennison, Beth S Lovano, Laurie Castel, Jiyoung Shin, A Marc Gillinov, Jonathan D Smith

Cell Rep Med· October 2022

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Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
Robert A Koeth, Zeneng Wang, Bruce S Levison, Jennifer A Buffa, Elin Org, Brendan T Sheehy, Earl B Britt, Xiaoming Fu, Yuping Wu, Lin Li

May 2013

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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Zeneng Wang, Elizabeth Klipfell, Brian J Bennett, Robert Koeth, Bruce S Levison, Brandon Dugar, Ariel E Feldstein, Earl B Britt, Xiaoming Fu, Yoon-Mi Chung

Nature· April 2011

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Zbp1 promotes atherosclerosis and lesion necrosis in mice.
Juying Han, Emmanuel Opoku, Gregory Brubaker, Jonathan D Smith

Atherosclerosis· November 2025

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Spatial transcriptomics in the human left atrial appendage and pulmonary vein sleeve.
Han Sun, Juying Han, Christine S Moravec, Toshihiro Okamoto, Kenneth R McCurry, Jonathan D Smith

Cardiovasc Pathol· November 2025

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Macrophage-Kruppel-Like Transcription Factor 6 Signaling Promotes Experimental Atherogenesis.
Hang Pong Ng, Atif Zafar, Rachel Diamond-Zaluski, Gun-Dong Kim, Kartik Bhat, Jonathan D Smith

Am J Pathol· September 2025

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ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D.
Nilam Bhandari, Ashutosh Prince, Mariam R Khan, C Alicia Traughber, Kalash Neupane, Jonathan D Smith

Proc Natl Acad Sci U S A· June 2025

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Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
Seung Hoan Choi, Sean J Jurgens, Ling Xiao, Matthew C Hill, Christopher M Haggerty, Jonathan D Smith, Nicholas L Smith, J Gustav Smith

Nat Genet· March 2025

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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells.
Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Jonathan D Smith

Biomedicines· January 2025

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Common Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits.
Nana Liu, Jeffrey Hsu, Gautam Mahajan, Han Sun, Kenneth R Laurita, Jonathan D Smith

Circ Genom Precis Med· October 2024

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Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the and Genes.
Sojin Y Wass, Han Sun, Gregory Tchou, Nana Liu, David R Van Wagoner, Jonathan D Smith

Int J Mol Sci· September 2024

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Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice.
C Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari, Kalash Neupane, Jonathan D Smith

J Am Heart Assoc· April 2024

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Membrane-bound -acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Jonathan D Smith

Elife· April 2024

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Artificial Sweeteners: A New Dietary Environmental Risk Factor for Atrial Fibrillation?
Robert A Koeth, Jonathan D Smith, Mina K Chung

Circ Arrhythm Electrophysiol· March 2024

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Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury.
Venkateshwari Varadharajan, Lyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Jonathan D Smith

bioRxiv· January 2024

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Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation.
Jie Jia, Abul Arif, Belinda Willard, Jonathan D Smith, Dennis J Stuehr

Mol Cell· November 2023

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Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice.
C Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari, Kalash Neupane, Jonathan D Smith

bioRxiv· October 2023

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Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling.
Gregory Tchou, Daniela Ponce-Balbuena, Nana Liu, Shamone Gore-Panter, Jeffrey Hsu, Jonathan D Smith

JACC Basic Transl Sci· October 2023

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Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.
Sojin Youn Wass, Erik J Offerman, Han Sun, Jeffrey Hsu, Julie H Rennison, Jonathan D Smith

Heart Rhythm· September 2023

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Connecting the Dots From GWAS to Function in Atrial Fibrillation for .
Sojin Y Wass, Jonathan D Smith, Mina K Chung

Circ Res· August 2023

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Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Saurabh Mishra, Nicole Welch, Manikandan Karthikeyan, Annette Bellar, Ryan Musich, Jonathan D Smith

Aging Cell· July 2023

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CSL112 Infusion Rapidly Increases APOA1 Exchange Rate via Specific Serum Amyloid-Poor HDL Subpopulations When Administered to Patients Post-Myocardial Infarction.
Svetlana A Didichenko, Elena Velkoska, Alexei V Navdaev, Brandon H Greene, Shuhui Wang Lorkowski, Jonathan D Smith

Arterioscler Thromb Vasc Biol· June 2023

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Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease.
Amy H Attaway, Annette Bellar, Nicole Welch, Jinendiran Sekar, Avinash Kumar, Jonathan D Smith

J Cachexia Sarcopenia Muscle· April 2023

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Impavido attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.
C Alicia Traughber, Amanda J Iacano, Kalash Neupane, Mariam R Khan, Emmanuel Opoku, Jonathan D Smith

iScience· April 2023

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Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
C Alicia Traughber, Gauravi M Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R Khan, Jonathan D Smith

iScience· February 2023

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The Molecular Medicine PhD program alumni perceptions of career preparedness.
Valerie Chepp, Claire Baker, Sarah Kostiha, Jonathan D Smith

PLoS One· November 2022

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Stent-based delivery of AAV2 vectors encoding oxidation-resistant apoA1.
Bahman Hooshdaran, Benjamin B Pressly, Ivan S Alferiev, Jonathan D Smith, Philip W Zoltick

Sci Rep· March 2022

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