@q21407434 @djwilso @StickmanBleedin Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an independent large clinical cohort. https://t.co/Gxi3R3Ov0O
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
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Jun 2016 – May 2025Where it's discussed
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What people are saying
The discussions reflect cautious interest, with posters mentioning the identification of metabolites like TMAO and their links to CVD, but they also highlight the current limitations, such as the study being in mice. The tone suggests curiosity about the biological mechanisms while remaining aware of the need for further research.
Most posters acknowledge the research findings and their potential significance, with some questioning the current application to humans since the primary evidence is from mice.
Discussions show moderate curiosity, especially about the metabolites and their implications, but limited enthusiasm or deep engagement is evident.
Comments are brief and mainly confirm understanding or seek clarification, without extensive analysis or debate.
The overall view is that the findings are noteworthy but not yet transformative or conclusive regarding human health.
Abstract in brief
- Metabolomics research shows potential in identifying pathways associated with cardiovascular disease (CVD), the leading global cause of death.
- By analyzing plasma metabolites, three specific compounds—choline, trimethylamine N-oxide (TMAO), and betaine—were found to predict CVD risk in a large clinical study.
- The study highlights the connection between dietary phosphatidylcholine, gut bacteria, and atherosclerosis, opening doors for new diagnostic and treatment strategies for heart disease.
Top posts
Most liked on X and Bluesky@fmfclips Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, https://t.co/DRI7xBKoiQ I know it's in mice, but have you read any negative effects?
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@fmfclips Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, https://t.co/DRI7xBKoiQ I know it's in mice, but have you read any negative effects?
@q21407434 @djwilso @StickmanBleedin Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an independent large clinical cohort. https://t.co/Gxi3R3Ov0O