Nature April 2011 PMID 21475195

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.

Zeneng Wang, Elizabeth Klipfell, Brian J Bennett, Robert Koeth, Bruce S Levison, Brandon Dugar, Ariel E Feldstein, Earl B Britt, Xiaoming Fu, Yoon-Mi Chung, Yuping Wu, Phil Schauer, Jonathan D Smith, Hooman Allayee, W H Wilson Tang

Mentions

83
Peak: 2 in Sep 2024
across 6 sources since Jun 2016

Extended reach

2,464
potential audience

Total likes

36

Video views

1,943

Mentions per month

Jun 2016 – May 2025

Where it's discussed

  • News34 articles
  • Blogs22 articles
  • Facebook17 posts
  • YouTube4 videos
  • Reddit4 posts
  • X / Twitter2 posts

AI synopsis

What people are saying

The discussions reflect cautious interest, with posters mentioning the identification of metabolites like TMAO and their links to CVD, but they also highlight the current limitations, such as the study being in mice. The tone suggests curiosity about the biological mechanisms while remaining aware of the need for further research.

AgreementModerate agreement

Most posters acknowledge the research findings and their potential significance, with some questioning the current application to humans since the primary evidence is from mice.

InterestModerate interest

Discussions show moderate curiosity, especially about the metabolites and their implications, but limited enthusiasm or deep engagement is evident.

EngagementNeutral engagement

Comments are brief and mainly confirm understanding or seek clarification, without extensive analysis or debate.

ImpactNeutral impact

The overall view is that the findings are noteworthy but not yet transformative or conclusive regarding human health.

Abstract in brief

  • Metabolomics research shows potential in identifying pathways associated with cardiovascular disease (CVD), the leading global cause of death.
  • By analyzing plasma metabolites, three specific compounds—choline, trimethylamine N-oxide (TMAO), and betaine—were found to predict CVD risk in a large clinical study.
  • The study highlights the connection between dietary phosphatidylcholine, gut bacteria, and atherosclerosis, opening doors for new diagnostic and treatment strategies for heart disease.

Top posts

Most liked on X and Bluesky
Tyrone Penning ✝️
@TyronePenning · X

@q21407434 @djwilso @StickmanBleedin Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an independent large clinical cohort. https://t.co/Gxi3R3Ov0O

Oct 19, 2022 · 1 like · 417 followers View post →
Guillaume Mertens
@Mertens__GM · X

@fmfclips Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, https://t.co/DRI7xBKoiQ I know it's in mice, but have you read any negative effects?

Jul 30, 2024 · 1 like · 106 followers View post →

All mentions

Guillaume Mertens
@Mertens__GM · X

@fmfclips Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, https://t.co/DRI7xBKoiQ I know it's in mice, but have you read any negative effects?

Jul 30, 2024 · 1 like · 106 followers View post →
Tyrone Penning ✝️
@TyronePenning · X

@q21407434 @djwilso @StickmanBleedin Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an independent large clinical cohort. https://t.co/Gxi3R3Ov0O

Oct 19, 2022 · 1 like · 417 followers View post →