Not my favorite kind of study, but meta-analysis finds very-low-carbohydrate ketogenic diet to be superior to low-fat diet for long-term weight loss, reduction in BP & triglycerides. The VLCKD diet also increased HDL & LDL more than the LF diet. https://t.co/tsYMX6tFbL https://t.co/1EiOilc1Gw
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.
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Feb 2018 – Nov 2025Where it's discussed
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What people are saying
The discussions reflect a blend of support and skepticism, with some participants emphasizing scientific evidence and possible health benefits, such as improvements in triglycerides and blood pressure, while others criticize the small weight loss differences and potential risks like increased LDL cholesterol. The tone varies from cautious scientific scrutiny to motivational appeals, illustrating both engagement and nuanced evaluation of the article's findings.
Most discussions acknowledge that the meta-analysis shows some benefits of low-carb diets but remain cautious about emphasizing their overall significance due to small weight differences and conflicting evidence.
The discourse demonstrates high curiosity, with many participants referencing specific studies, mechanisms, and health implications, indicating strong engagement with the topic.
Many users reference detailed studies, question methodologies, and compare different diet effects, showing thoughtful and multi-dimensional discussion rather than superficial participation.
While some discussions highlight the potential advantages of ketogenic diets, the overall impact appears moderate, influenced by skepticism, calls for further research, and the recognition of the limited clinical significance of observed benefits.
Abstract in brief
- The meta-analysis compares the long-term effects of very low carbohydrate ketogenic diets (VLCKD) and low-fat diets (LFD) on weight loss and cardiovascular risk factors, analyzing 13 studies with at least 12 months of follow-up.
- It finds that individuals on a VLCKD experience slightly greater weight loss, along with improvements in triglycerides, HDL cholesterol, and blood pressure, suggesting VLCKD could be an effective alternative for long-term obesity management.
- However, some results, such as increases in LDL cholesterol, highlight the need for further research to determine the overall health impacts of VLCKDs compared to traditional low-fat diets.]
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Most liked on X and BlueskyA review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group that followed a low-fat diet. Fat is your friend. Fat helps you with good health. Chose right #nutrition. https://t.co/mTR4R9qFXo
2013 Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials "Individuals assigned to a VLCKD achieve a greater weight loss than those assigned to a LFD in the long term." https://t.co/djUHWqyhzM
@NurMongeZen @pictoline Ya pero ahí concluyen eso solo para personas en tratamiento para Diabetes tipo 2. Hay otros estudios que dicen que elevan el colesterol, y eso para personas que debieran bajar de peso y se les debería controlar el riesgo cardiovascular no es recomendable https://t.co/NWPY6gE4bp
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials https://t.co/daU89xoSxU
@AmandaZZ100 @NutritionCues @BioLayne A meta-analysis of RCTs w/ long-term f/u of VLCKD vs low-fat favored keto diet by -0.91 kg. You know how clinically insignificant that is? You are not fixing the obesity epidemic with 0.91 kg
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Referencias. Bueno, N., De Melo, I., De Oliveira, S., & Da Rocha Ataide, T. (2013). Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.. The British journal of nutrition, 110 7, 1178-87.
@JeremyAnso @NutritionMadeS3 Carb restriciton also seems to reliably increase c-reactive protein and LDL cholesterol. not good. https://t.co/80giXP5GHU https://t.co/QQ355kudFx
@Frances47398864 @CovidNoGood @AlexWallasch https://t.co/mLUXGp6UyN
@thelowcarb_rd @CGTCFA So you're just not aware how to synthesize the preponderance of evidence. So for example, doi: 10.1017/S0007114513000548 finds a keto effect size of 0.3-0.6 for weight loss. Whereas the placebo arm of a weight loss drug trial achieved the same (DOI: 10.1001/jama.2016.7602)
@Sabrusona @EmRatela @Luz_Nieva @bel_bozzolo https://t.co/XnHSAfxUGt
Here's how you can find these studies: Bueno, N.B., et al. (2013) Title: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials Search Terms: "Bueno ketogenic diet meta-analysis 2013" or
The secret to lasting weight loss? Science points to very-low-carb ketogenic diets (VLCKDs). They outperform low-fat diets in: Weight loss Lowering triglycerides Improving cholesterol & blood pressure Are you ready to rethink health? https://pubmed.ncbi.nlm.nih.gov/23651522/ #KetogenicDiet #Health
RT @cybershamansaga: @Tellit007 @ChrisPalmerMD Here's one that shows that a very low carb diet (ketogenic) works better than a high carb di…
@Tellit007 @ChrisPalmerMD Here's one that shows that a very low carb diet (ketogenic) works better than a high carb diet for long-term weight loss while also showing that other biomarkers for disease also improve simultaneously as well. https://t.co/FzHYm3avWJ
Sources: https://t.co/7M9vRqtjWU https://t.co/b4cIMO62SA
@Agusia55377100 @SheBitcoins @Outdoctrination Here's a meta analysis that compared low carb vs low fat diets. They identified 5 that showed statistically significant differences in weight loss. All 5 were low carb. They also lowered blood pressure in addition to the benefits listed earlier. https://t.co/WSpxibWAWn
A continuación, dejamos las fuentes que se han utilizado . ¡Lee por ti mismo
@afalli @g_diets_ 1. https://t.co/F3LtZjpbut 2. https://t.co/nGemIjIPTt 3. https://t.co/YsPsD99jrO 4. https://t.co/7yAG0ex80I
@lean_minded @StJohnsPriest @ChrisSmolinski @MarkBski @823jjd Could you be more specific? Matched to what? What would you regard as an advantage? In healthy, obese, diabetic, etc. people? There are many studies on LC but none on zero carbs. Here’s a meta-analysis that focussed mostly on fat-loss. https://t.co/x1JMbRjyIh
参考: ・https://t.co/drC65U82v6 ・https://t.co/DqyT1BLVsh ・https://t.co/jib4wwkyeW
@renatodumbra I've argued that the difference is unlikely to be clinically significant, but LC consistently leads to slightly more wt loss. Mechanism?: https://t.co/Gn78eHtvUL Other studies: https://t.co/rCZSTdm99u https://t.co/1875t6j7qL https://t.co/qPUyhtzLWo https://t.co/3kpQDkYGwH
@jezykzwierzyk @lavarde__ @alvGurwand Tak wyglądają poważne, recenzowane badania naukowe. Jest tego oczywiście dużo więcej. Poddaj w wątpliwość gdy Abidas podszywa się pod Adidas, a nie łykaj naiwnie pierwsze rekordy z googla ;) 1. https://t.co/Ajw7BF3sw1 2. https://t.co/lOH4V0UxhT 3. https://t.co/jVbOmN3OWI
@veganmim @dr_pachaiyappan @DrAseemMalhotra https://t.co/0tcCDPSXF4 https://t.co/RCeSTMZtvV
Here’s another comparing keto and low-fat, among diets with at least a year of follow-up. Difference? 2 pounds. https://t.co/HGCQNbg4F7 Here, it’s 3 pounds: https://t.co/Vzp4bXcibs
RT @svmurthy: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled tria…
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials #Health #Keto #Weightloss https://t.co/jYs2mgiTok
@MoreiraViictor @souzaxmay Em tempo, seguem vários estudos que mostram que eu ao menos não tô sozinho nessa (de perder peso em low carb rs e cetose) https://t.co/In9mwALKBI https://t.co/orhH90L700 https://t.co/iJEcBqzCJA
@NurMongeZen @pictoline Ya pero ahí concluyen eso solo para personas en tratamiento para Diabetes tipo 2. Hay otros estudios que dicen que elevan el colesterol, y eso para personas que debieran bajar de peso y se les debería controlar el riesgo cardiovascular no es recomendable https://t.co/NWPY6gE4bp
@PenelopeFigtree @Lpa_Doc https://t.co/F9RMSjzZ0Q https://t.co/bUkYDJNoIS Also, a meta analysis of four RCTs showed ketogenic diets had a better effect on CRP than low fat diets: https://t.co/ehSPxOqvXo https://t.co/u8y6NDXK4v... 2/2
@JimJohnsonSci Keto vs LF: -6% vs -5%. Hardly moving the needle either way from a population health standpoint. Do you have any RCT data to share? https://t.co/1875t6j7qL
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
RT @DrSubhasree: A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group th…
A review of 13 studies found people who followed the keto diet lost an average of 2 pounds (0.9 kg) more than the group that followed a low-fat diet. Fat is your friend. Fat helps you with good health. Chose right #nutrition. https://t.co/mTR4R9qFXo
RT @UMSRCNFNDR: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled tr…
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials | British Journal of Nutrition | Cambridge Core https://t.co/Q8q5v3aL57
@MNEJ3241 @DannaTyler1 @mmejoanna @Trader_Joker @davidasinclair And the metanalysis of rct's vs low low fat did show greater weight loss. https://t.co/eYJinRNt3S
@MNEJ3241 @DannaTyler1 @mmejoanna @Trader_Joker @davidasinclair And a metanalysis of rct's showed it improved basically all parameters as well or better then a low fat diet. Seems awful! https://t.co/eYJinRNt3S
@jelliejeni @travissmithJP @Oraclezzzz When it comes to nutrition, the science is usually pretty all over the place, it's a difficult and murky field of study. What I will say is that ketogenic diets *CAN* in controlled studies and properly adhered to, generate favorable results. E.G. https://t.co/TsVrtohY3b
In fact, "Large randomised clinical trials with long-term dietary interventions aiming weight loss showed that individuals under intensive lifestyle interventions lose about 4·8 kg" https://t.co/VghBGs5LED Looks like "pop-pill medical culture" ain't too shabby!
@BioLayne OK, let's start with a bit of actual science. https://t.co/b353V3EdTl
RT @Oalfahdi: 25. (أبحاث لمزيد قراءة: ) 1. كامبريدج: https://t.co/bdMIDnr9NZ 2. https://t.co/lXNS6EiBfC 3. https://t.co/bf4kJETShk 4. h…
4/ C2 continued: And many risk factors for CV dz can and will improve with LC, VLKCD, or any weight loss intervention for that matter https://t.co/1875t61w2b
@GidMK @DrNadolsky @JeffryGerberMD @virtahealth You raise important concerns worth investigating. If the meta-analysis is wrong, it should be corrected (or withdrawn). However, knowing most of the original lit, I think effect sizes are probably in the right ballpark, and broadly consistent with other MA https://t.co/DVDmOiMrDA
RT @derecktafuma: "The role of very-low-carbohydrate ketogenic diets (VLCKD) in the long-term management of obesity is not well…" https://t…
"The role of very-low-carbohydrate ketogenic diets (VLCKD) in the long-term management of obesity is not well…" https://t.co/sA9RBUcIJs.
RT @lkhg444: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trial…
RT @lkhg444: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trial…
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials https://t.co/daU89xoSxU
@FoodFirst_Ty Better weight loss. https://t.co/dU1T6gH1hU
@marveloussalvi It depends on how low you going with carb intake. If the goal is simply weight loss it'll work better than fat restriction. https://t.co/cYAjTnzwAC
HDLコレステロールを上げる食事法は… 今回参考にした論文がこちら↓ https://t.co/ERF4AAadDf https://t.co/6gNuu0zYkx / #食事 #科学 #高脂肪 #ケトジェニック #健康 HDLコレステロールを上げる食事法 https://t.co/t3AP0gV9Qh
@AmandaZZ100 @NutritionCues @BioLayne A meta-analysis of RCTs w/ long-term f/u of VLCKD vs low-fat favored keto diet by -0.91 kg. You know how clinically insignificant that is? You are not fixing the obesity epidemic with 0.91 kg
RT @HealthyFellow: Free, Full Text: https://t.co/AXk4kd50IN
Free, Full Text: https://t.co/AXk4kd50IN https://t.co/i2bewpIddN
Not my favorite kind of study, but meta-analysis finds very-low-carbohydrate ketogenic diet to be superior to low-fat diet for long-term weight loss, reduction in BP & triglycerides. The VLCKD diet also increased HDL & LDL more than the LF diet. https://t.co/tsYMX6tFbL https://t.co/1EiOilc1Gw
@HonEB @Chandle74418127 @DeanReyniers @KenDBerryMD Unfortunately, all these supposed mechanisms don't pan out in long term outcomes https://t.co/VghBGs5LED It's also erroneous to assume that a ketogenic diet is always going to be more satiating than a low fat diet https://t.co/PfiIOwjXuu
3. Ketogenic diets do not outperform low fat diets to a meaningful degree (unless you count 2lbs over 12 months as meaningful) https://t.co/VghBGs5LED 4. In a recent trial, a plant based low fat diet resulted in fat loss whereas a keto diet did not https://t.co/PfiIOwjXuu
@sandy_brighton @Eric_OGrey @ChristianTams https://t.co/5JNrbTy2KK Is this one low enough for you ?(<50g carbs a day) No meaningful difference (1.5kg extra weight loss over 12 months)
@bulkbiker @AmandaZZ100 @MacroFour @ChristianTams https://t.co/5JNrbTy2KK Even with very low carbohydrate diets, there is almost no difference in weight loss over 12 months, unless you consider 1.5kg to be a meaningful difference. I'm not saying low carb diets can't be effective, they can. So can low fat
RT @gfj1979: 2013 Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled…
RT @gfj1979: 2013 Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled…
2013 Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials "Individuals assigned to a VLCKD achieve a greater weight loss than those assigned to a LFD in the long term." https://t.co/djUHWqyhzM
RT @Oalfahdi: 25. (أبحاث لمزيد قراءة: ) 1. كامبريدج: https://t.co/bdMIDnr9NZ 2. https://t.co/lXNS6EiBfC 3. https://t.co/bf4kJETShk 4. h…
@ladyinmedicine @BewilderedCopt @LDNBil https://t.co/j4fjx4QVDT source #2
@andreulb @Midietacojea @topapate Dejo por aquí un par de artículos interesantes: Ventajas de una dieta muy baja en carbohidratos: https://t.co/RGmUYFBiLN Beneficios en dietas hipocalóricas bajas en carbs: https://t.co/ZJNkAlK0FV Estudio sobre la reducción de medicación en pac. diab T2: https://t.co/5r7urMBAJI
@Pirulla25 https://t.co/4Ff4B78Qo6
@TheHebrewMan90 https://t.co/gqqPFL4u9K
RT @Mshfawaz: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled tria…
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials https://t.co/H7VQYeT5NM
RT @diegmunoz: Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled tri…
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials https://t.co/QgIiaQyPfA
@Carlitaseguel Estudios hay para todo. Acá Cambridge https://t.co/qsTT4Rf3uq y Harvard https://t.co/SyMuLpq2iz
@bessygprado @clepanto Te hago la pega si te da lata: 1) Recomendación de la ADA y EASD que avalan Low Carb https://t.co/j6HgJ69EXj 2) Sarah Hallberg (MD) https://t.co/mFuTZLEFpl 3) P. Vega, cirujana chilena https://t.co/hWzgkgrC4F 4) Estudio Cambridge https://t.co/qsTT4Rf3uq
@guarencilla Considerando las tasas de obesidad actuales podríamos decir que eso abarca bastante o no? https://t.co/qsTT4Rf3uq
@guarencilla Me interesa especialmente eso de que produce “arritmias” o “trastornos cardiacos” porque acá tienes estudios que demuestran lo contrario https://t.co/qsTT4Rf3uq
@HerrGlucksfall @aburtolab @guarencilla Actualiza tus estudios https://t.co/bHmmGfSZwo / https://t.co/eWNrvqr1wZ / https://t.co/tNLk3mGZLL / https://t.co/qsTT4Rf3uq
RT @Keto__Morphosis:
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