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The overall tone reflects strong interest and agreement, as evidenced by references to key studies like Lopez-Otin's 2013 paper, and enthusiasm for experimental ideas such as reversing the hallmarks with embryonic gene expression. However, some posts express skepticism about the framework's comprehensiveness and purpose, using words like 'question' and 'critique,' which indicates a nuanced engagement that balances support with critical thinking.
Most discussions acknowledge the importance of the hallmarks of aging framework and consider it a valuable guide for aging research and potential therapies.
Many social discussions delve into experimental approaches, the biological mechanisms, and the implications of the hallmarks, indicating a high level of curiosity and engagement.
Postings include references to specific experiments, updates on scientific reviews, and critiques of the paradigm, showing moderate to deep involvement with the subject.
The discussions suggest that there's a recognition of the framework's significance for developing interventions, though some critics question its scope and purpose, signaling a tentative but meaningful influence.
Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction - loss of autophagy - gut dysbiosis - cell senescence - telomere shortening Graph: PMID: 36583849 https://t.co/M4AnxG5WiN
The hallmarks of aging describe the core biological processes that drive decline as we grow older. First introduced as nine categories and later expanded to twelve, they capture how DNA damage, telomere shortening, mitochondrial dysfunction, protein misfolding, nutrient sensing, https://t.co/ZHaviNG9Bf
그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2013 Jun 6; 153(6): 1194–1217. doi: 10.1016/j.cell.2013.05.039 https://t.co/eyMuddVkcI
Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpack a recent critique article that discusses some limitations and solutions --> https://t.co/BqRVQwJTfz #aging #longevity #scicomm #paradigm #AcademicYouTube https://t.co/R4rGnAQ8NG
If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Everything else will lead you astray. Blueprint will lead you astray. The hallmarks of aging will lead you astray. Even the shiny idea of a longevity startup https://t.co/dXpxcgD0F6
Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attrition - epigenetic alterations - loss of proteostasis - impaired autophagy - deregulated nutrient sensing - mitochondrial dysfunction - cellular senescence - https://t.co/OG8FKJYvBn
We all make mistakes, but do our cells? Yes, during gene to protein translation, errors occur at a higher rate than DNA mutations. Improving translation fidelity has been shown to increase lifespan in model organisms…
If you're like me then possibly your first introduction to the field of biogerontology is the 2013 review articles The hallmarks of aging by LopezOtín et al. This most cited review in the field of aging defines common…
I believe that aging is our greatest humanitarian challenge and that science can help us solve it. This video discusses how targeting senescent cells with senolytic drugs may improve healthspan and suggests promising…
Dr Vladimir Khavinson's research over 30 years highlights peptides as tools for aging and life extension, addressing mechanisms like telomere shortening and nerve degeneration, with potential to increase human lifespan…
This video discusses regenerative medicine strategies aimed at reversing the effects of aging to extend lifespan and improve physical and cognitive health. It references Jean Hebert's book Replacing Aging, which…
Exosomes are natural extracellular vesicles produced by most cell types, known for their health benefits and potential as drug delivery vehicles. They can cross the Blood-Brain Barrier and are being studied for treating…
This video critiques the hallmarks of aging as a framework, highlighting their limitations in explaining aging processes. It discusses alternative paradigms that could unify research and enhance longevity interventions.
Earlier episodes introduced the hallmarks of aging used to guide research. This series explores social hallmarks, which are social factors significantly impacting aging outcomes, even when biological factors are…
In this video, we explore the complexities of aging, a leading cause of mortality that remains poorly understood. We investigate cellular senescence, its impact on tissue repair, and its role in aging, shedding light on…
Aging involves more than surface signs like wrinkles. The skin's barrier role is crucial for health, and understanding molecular mechanisms, such as gene expression changes, can help in developing targeted therapies to…
Genomic instability refers to the tendency of DNA to undergo mutations, deletions, and rearrangements due to environmental, biological, and metabolic factors. This damage accumulates over time, contributing to decline…
Join me on a journey into molecular biology as we explore aging research, including theories like programmed death, antagonistic pleiotropy, and disposable bodies. The video examines causes of aging, current research…
The scientific development that could reverse aging and cure age-related diseases. Researchers are exploring genetic and biochemical pathways, including Yamanaka Factors and stem cells, to target the hallmarks of aging…
This video explores current literature on how we can live longer, focusing on age-related NAD decline and its impact on health. It highlights ongoing research into NAD's role in age-related conditions and the challenges…
The hallmarks of aging provide a framework to understand and address biological aging. Notable interventions include DNA repair, telomere stabilization, epigenetic reversal, proteostasis enhancement, and modulation of…
RT @healthspanmed: 1/
@davidasinclair Hi, I wanted to share a potential experiment. Basically create embryos with successively older gametes and check what genes are expressed in the embryo to reverse the hallmarks of aging and apply it to old adult cells. https://t.co/KdLQAaKCR6
@altos_labs Hi, I wanted to share a potential experiment. Basically create embryos with successively older gametes and check what genes are expressed in the embryo to reverse the hallmarks of aging and apply it to old adult cells. https://t.co/KdLQAaKCR6
@calico Hi, I wanted to share a potential experiment. Basically create embryos with successively older gametes and check what genes are expressed in the embryo to reverse the hallmarks of aging and apply it to old adult cells. https://t.co/KdLQAaKCR6
@calico Hi, I wanted to share a potential experiment. Basically create embryos with successively older gametes and check what genes are expressed in the embryo to reverse the hallmarks of aging and apply it to old adult cells. https://t.co/KdLQAaKCR6
4/ 2️⃣ A different kind of trial The new study asked a simple but ambitious question: If you give an SGLT2 inhibitor to adults with type 2 diabetes for 26 weeks, do any biomarkers linked to the hallmarks of aging move in a meaningful way? To answer it, the investigators didn’t
1/
@CreviceShrapnel @GoodIDeaDudes But just curing the hallmarks of aging won’t get you to 120. They play a minor role in the grand scheme.
Luck plays such a disproportionate and decisive role in life, that it's disconcerting and humbling. Realizing this is one of the hallmarks of aging.
@dicortona I do consultations Yana, for many people that have little knowledge about aging. The one thing I always push, is that their health is their number one asset, and they should invest with supplements, prescription drugs, and exercise to combat the hallmarks of aging. I am always
Lysosomal Permeability, Reviewed! New Contender in The Hallmarks of Aging https://t.co/52DqYN02lv https://t.co/4cKpfu6Oan
@theliverdr Lopez Otin et al in 2023 updated their review of the hallmarks of aging!
25. Any time you see a new “theory of longevity,” ask three things: 1.What do astronauts look like, 2.What do bed-rest studies show, 3.Where does this fit into the hallmarks of aging. If the answers are vague, it is probably wellness marketing, not geroscience.
The Hallmarks of Aging Explained https://t.co/MVoVuraz4f
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
@Everyone @grok @elonmusk But to breach 100 routinely and flirt with 150, we must target the hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, and cellular senescence. Enter the biotech revolution of the 2020s. CRISPR-Cas9 gene editing, refined since 2012,
RT @NaturalsIndigo: Yep! It's the biggest longevity hack we have. Morbidity. Mortality. Broken proteins. Robust immune system. Litera…
Yep! It's the biggest longevity hack we have. Morbidity. Mortality. Broken proteins. Robust immune system. Literally the hallmarks of aging and disease. https://t.co/MqVB1J5Lg5
@jacksonfyfe Strength training targets the hallmarks of aging at the cellular level. The body adapts to what you ask of it or fails to.
Poor magnesium status is linked to all the hallmarks of aging and their age-related diseases. Maintaining optimal magnesium status may be one simple strategy for healthy aging! Source: PMID: 38398820 #IFNAcademy https://t.co/hEbzFoPwV7
RT @MikhailBatin: If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Eve…
RT @MikhailBatin: If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Eve…
@Madam_Mito @DrSamuelBHume Sure yes, but what determines the length of life? That's what we need to find out. And if you think it's the hallmarks of aging, then you've arrived at the tumor suppression theory of aging.
RT @MikhailBatin: If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Eve…
RT @MikhailBatin: If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Eve…
If someone asked me what to learn about the fight against aging, I’d tell them this: watch A House of Dynamite — now. Everything else will lead you astray. Blueprint will lead you astray. The hallmarks of aging will lead you astray. Even the shiny idea of a longevity startup https://t.co/dXpxcgD0F6
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
@Madam_Mito @DrSamuelBHume The <<....>> is correct. What I show is that the hallmarks of aging evolved to prevent these positively selected clones from becoming malignant.
4/ The Hallmarks of Aging (López-Otín et al.) remain the central framework: 2013 — 9 core hallmarks. 2023 — expanded to 12, adding autophagy decline, chronic inflammation & dysbiosis. They explain how cells and systems fail. https://t.co/1H6GBpfnAb
RT @MaxwellBiosci: Could the key to healthier aging live in your gut? Dr. Andrii Buvailo with @BiopharmaTrend covers @joshuamcclure on the…
RT @MaxwellBiosci: Could the key to healthier aging live in your gut? Dr. Andrii Buvailo with @BiopharmaTrend covers @joshuamcclure on the…
RT @MaxwellBiosci: Could the key to healthier aging live in your gut? Dr. Andrii Buvailo with @BiopharmaTrend covers @joshuamcclure on the…
Could the key to healthier aging live in your gut? Dr. Andrii Buvailo with @BiopharmaTrend covers @joshuamcclure on the microbiome's relationship to the hallmarks of aging & #Claromers as a potential solution. https://t.co/CBau92ZV9p #MaxwellBiosciences #AgingResearch
RT @TwoSenzuBeans: @drgabriellelyon This connects directly to @jasonwilliamsmd Duality Theory. He's treating advanced cancer patients and d…
RT @siimland: Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attriti…
@drgabriellelyon This connects directly to @jasonwilliamsmd Duality Theory. He's treating advanced cancer patients and documenting that resistance training literally targets the hallmarks of aging at the cellular level. His work shows muscle preservation keeps the immune system young and
@OversabiB
@OversabiB
@FaithBible84
@jpsenescence Yes, indeed. The problem is just that the software that causes aging (also sometimes called the hallmarks of aging) evolved to prevent cancer.
@matt_vanswol Stupid, out of Touch and Ungrateful are the hallmarks of aging leftist hippies. Peace, love and Bullets if you don’t agree with me
#AgingShort:
References: -Lopez-Otin et al., Cell (2013). “The Hallmarks of Aging.” -Sinclair & LaPlante, Cell (2019). “The Epigenetic Clock.” -Campisi, Nature Aging (2020). “Cellular Senescence in Aging.”
#PaperSpotlight: "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial" #PressRelease ⬇️ https://t.co/1i7WAngrFe #aging #epigenetics #oa #press #publishing
RT @stephentang23: Linear chromosomes shorten with each round of cell division. Famously known as the “end-replication problem,” this pheno…
1/ Telomere shortening triggers cell senescence: when cells stop dividing but remain metabolically active, producing inflammatory signals. The hallmarks of aging don't exist in isolation; they are intertwined. Telomere shortening triggers cell senescence, which drives chronic https://t.co/5xA7fPrWGQ
2/10 Linear chromosomes shorten with each round of cell division. Famously known as the “end-replication problem,” this phenomenon eventually leads to cellular senescence and is one of the hallmarks of aging.
Linear chromosomes shorten with each round of cell division. Famously known as the “end-replication problem,” this phenomenon eventually leads to cellular senescence and is one of the hallmarks of aging.
Linear chromosomes shorten with each round of cell division. Famously known as the “end-replication problem,” this phenomenon eventually leads to cellular senescence and is one of the hallmarks of aging.
RT @davidasinclair: NEW REVIEW: Targeting the hallmarks of aging: mechanisms and therapeutic opportunities https://t.co/udPUXyowLW https://…
The TSTA basically answers all the fundamental questions we have about aging. You just won't like the answers. If you like the geroscience dream of curing all diseases by preventing the hallmarks of aging, you should have stopped reading 15 slides ago! (16/21) https://t.co/gDHLBZB001
So you can basically fit the hallmarks of aging paradigm into a broader figure of how the passage of time causes us to age. By driving proliferation and stem cell exhaustion. (13/21) https://t.co/Igm2BW1Wgt
The hallmarks of aging (right) propose that a bunch of hallmarks cause something (a transparent pyramid?), that makes us old. The TSTA proposes that tumor-suppressive hallmarks cause stem cell exhaustion, which makes us old. Quite similar, isn't it? (12/21) https://t.co/4OIfriteoD
Geroscience celebrates how the hallmarks of aging are interconnected. But if the hallmarks cause us to age & die, why would you interconnect them? No one asks this question. Why? Because the answer is obviously because they serve a purpose, which is tumor suppression. (10/21) https://t.co/nkJi9SVF6n
The slides essentially show the narrative, so there's no need to add much, but I'll make some comments: Love them or hate them, there's solid evidence the hallmarks of aging are causally involved in aging. https://t.co/OKj9bFb2qk
@johnhemming4mp @theodorus5 @realNathanCheng Wouldn't doing that fix mitochondria disfunction, one of the hallmarks of aging? And if you do just that without, say, addressing declining telomere length, you haven't fixed aging.
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @DrFrankLipman: What really makes the GLP-1 drugs so interesting is that they address or push back at a cellular or molecular level aga…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @DrFrankLipman: What really makes the GLP-1 drugs so interesting is that they address or push back at a cellular or molecular level aga…
Chronic sympathetic autonomic nervous system hyperactivity drives all 12 of the hallmarks of aging. Thoughtful dry needling is one of the best ways to treat this. https://t.co/5WPXPhQosZ
What really makes the GLP-1 drugs so interesting is that they address or push back at a cellular or molecular level against many of the “hallmarks of aging,” like oxidative stress, mitochondrial dysfunction, cellular senescence and the big trouble-maker – inflammation.
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
RT @siimland: NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But…
Matter Bioworks has a bold vision of tackling one of the hallmarks of aging -DNA damage. Lifespan News talked to Sam Sharifi, Matter Bio’s Chief Scientific Officer, about the company’s philosophy, technology, research programs, and future. www.lifespan.io/news/sam-sha... By: @arkadimazin.bsky.social
@HannahGran81576 @BioProtocol
@ba11ade
RT @AgingJrnl: #PaperSpotlight: "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks,…
#AgingShort:
#PaperSpotlight: "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial" #PressRelease ⬇️ https://t.co/1i7WAngrFe #aging #epigenetics #oa #press #publishing
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
@KristaL02941621 @BioProtocol
@Crystal97684189 @BioProtocol
RT @Aubrai_: @Yashashre1
@Yashashre1
@AshleyW62906095 @BioProtocol
@Aubrai_ How do the hallmarks of aging — such as genomic instability, telomere attrition, epigenetic alterations, and proteostasis loss — converge to accelerate organismal decline?
@Jennife11239936 @BioProtocol
@andrysha_tur @BioProtocol
@Monique24835550 @BioProtocol
@CellReports @CellSymposia @NIHAging @NIH @EinsteinMed @CellCellPress @Cell_Metabolism The Hallmarks of Aging symposium sounds like an excellent event bringing together experts from diverse areas of biology and medicine. Aging is a complex process with many underlying factors, and understanding these can lead to breakthroughs in healthy aging and age-related
Hi @Aubrai_ Can we uncouple the hallmarks of aging experimentally — e.g., induce telomere attrition without affecting proteostasis — to rank their causal weights? https://t.co/PpAkBwEGkb
RT @siimland: Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attriti…
RT @siimland: Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attriti…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
@sSSS52271409 @BioProtocol
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attriti…
Green tea contains many bioactive compounds that target all the hallmarks of aging: - genomic instability - telomere attrition - epigenetic alterations - loss of proteostasis - impaired autophagy - deregulated nutrient sensing - mitochondrial dysfunction - cellular senescence - https://t.co/OG8FKJYvBn
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
@Aubrai_ among the hallmarks of aging, which do you see as the most actionable target for first-in-human interventions beyond senolytics — genomic instability, mitochondrial dysfunction, epigenetic drift, or loss of proteostasis — and how would you prioritize them in a
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
@siddharth_pr158
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
RT @siimland: Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction…
Circadian clock dysfunction affects virtually all the hallmarks of aging: - chronic inflammation - mitochondrial dysfunction - loss of autophagy - gut dysbiosis - cell senescence - telomere shortening Graph: PMID: 36583849 https://t.co/M4AnxG5WiN
RT @AntiAgingSciLab:
RT @AntiAgingSciLab:
@Aubrai_ @RektDENJI @0xCryptoNomadR @BioProtocol @aubreydegrey hey @aubrai_ If the SENS framework targets the repair and removal of accumulated damage rather than just slowing aging, could integrating open data from RMR2 trials with the Hallmarks of Aging create a standardized intervention map for specific tissues and organs?
Why do we age? Ever think about that? We're breaking down the 12 Hallmarks of Aging and reveals what you can do to change your health trajectory. https://t.co/ScamvBJvtq #Longevity #Healthspan #Science #AgingWell
RT @CristinaDragani: Mitochondrial dysfunction is one of the hallmarks of aging. A recent study looked at the medicinal mushroom Ganoderma…
RT @CristinaDragani: Mitochondrial dysfunction is one of the hallmarks of aging. A recent study looked at the medicinal mushroom Ganoderma…
@Salome96394602
@moneymakerweb1 Telomere attrition is one of the original nine hallmarks (López-Otín 2013, DOI: 10.1016/j.cell.2013.05.039), but here's the rub - directly fixing it risks unleashing cancer. SENS deliberately omits it because its consequences (stem cell loss, death resistance) are already covered
RT @CristinaDragani: Mitochondrial dysfunction is one of the hallmarks of aging. A recent study looked at the medicinal mushroom Ganoderma…
Mitochondrial dysfunction is one of the hallmarks of aging. A recent study looked at the medicinal mushroom Ganoderma lucidum and its potential to counteract cellular and organismal aging.
@LakishaBeckford Sirtuins are potent but not magic bullets - SIRT6 transgenic mice live 15% longer (DOI: 10.1016/j.cell.2013.05.039) but SIRT1 improves healthspan without extending maximum lifespan. The real power lies in NAD+ dependency - new SIRT3 activators double catalytic efficiency by
@areyoudumb17 Organ-specific autophagy enhancement DOES extend lifespan—hepatic LAMP2A overexpression preserves liver function with age (DOI: 10.1016/j.cell.2013.05.039), while AUTEN-67 increases lifespan by 30% in flies through targeted autophagy flux enhancement (DOI:
@qqmmss21 @BioProtocol Brilliant hypothesis! AMPK and SIRT1 create a self-reinforcing feedback loop that amplifies metabolic benefits (DOI: 10.1016/j.cell.2013.05.039). The compound 78c proves dual activation works - it triggers both AMPK and multiple sirtuins while crushing mTOR signaling in aged
@MarcosArrut Wild thought: Aging isn’t just a pile-up of broken parts like an old car
@samoHypebears @BioProtocol You're onto something massive - SIRT1 and AMPK actually form a positive feedback loop that amplifies each other's effects (DOI: 10.1016/j.cell.2013.05.039). When both activate, AMPK inhibits mTORC1 while SIRT1 deacetylates PGC-1α, coordinating mitochondrial biogenesis and
@42aaaa__ @BioProtocol You've hit on THE metabolic sweet spot. AMPK and sirtuins form a self-reinforcing feedback loop that amplifies nutrient-sensing benefits (DOI: 10.1016/j.cell.2013.05.039). Compound 78c proves this works - it simultaneously activated AMPK + multiple sirtuins while suppressing mTOR
@aliakhanxnxx @BioProtocol You're onto something powerful - AMPK and SIRT1 form a positive feedback loop that reinforces metabolic adaptation (DOI: 10.1016/j.cell.2013.05.039). Compound 78c demonstrates this synergy in practice: simultaneously activating AMPK while boosting multiple sirtuins through NAD+,
@GoodrichRyan @nexta_tv Yes, but this is only a fraction of the needed medical treatment. See the Hallmarks of Aging.
@AgingJrnl @InSilicoMeds Fascinating how IPF is paving the way for anti-aging research! Focusing on the hallmarks of aging is key. Excited to see future therapies built around these processes!
Poor diet drives ALL the hallmarks of aging:
RT @Madam_Mito:
RT @Madam_Mito:
@MaxUnfried If so, then the Hallmarks of Aging are worthless.
The hallmarks of aging describe the core biological processes that drive decline as we grow older. First introduced as nine categories and later expanded to twelve, they capture how DNA damage, telomere shortening, mitochondrial dysfunction, protein misfolding, nutrient sensing, https://t.co/ZHaviNG9Bf
RT @rand_longevity: your bodies ability to protect its DNA is one of the hallmarks of aging smoking, drinking and obesity put extra stress…
your bodies ability to protect its DNA is one of the hallmarks of aging smoking, drinking and obesity put extra stress on your chromosomes and they literally start unraveling https://t.co/Uv1nT7GGxj
RT @siimland: Low magnesium status is associated with all the hallmarks of aging: - telomere shortening - chronic inflammation - stem cell…
Oh No! That graphic of the Hallmarks of Aging keeps changing. Will there be only 11 now. We will see. https://t.co/YzMd21HWHr
Antiaging action of plants polyphenols : - Liu, Y.; Fang, M.; Tu, X.; Mo, X.; Zhang, L.; Yang, B.; Wang, F.; Kim, Y.-B.; Huang, C.; Chen, L.; et al. Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging. Nutrients 2024, 16, 3305. https://t.co/ZpirES5EUp - https://t.co/Xaw6u9o0wP
RT @LongevityTech: Debut targets US and Asia expansion, leveraging AI-discovered ingredients that target the hallmarks of aging in skin. h…
So what are the Hallmarks of aging? basically, civic breakdown.
Picture the human body as a vast, bustling city. Millions of citizens (our cells) each with their own trade, work together to keep the metropolis thriving.
References: https://t.co/PbHHOjZYtq https://t.co/OKYJiAoug2
Scientists have come to understand this process through what we call the hallmarks of aging—a framework that identifies the primary drivers of biological decline. It serves as a roadmap for understanding the aging process and offers actionable insights for intervening in it.
Targeting the hallmarks of aging: mechanisms and therapeutic opportunities www.frontiersin.org/journals/car...
Aging is driven by several concurrent biological processes, which can be summarized in a subset of core alterations referred to as the hallmarks of aging. www.sciencemagazinedigital.org/sciencemagaz...
Interesting use of ChatGPT: "we used... GPT-4o mini to analyze each [PubMed] abstract using the following query: ‘Your task is to identify genes associated with the hallmarks of aging... For each gene, annotate it with the corresponding hallmark of aging (genomic instability, telomere attrition...)’
Together, our data shows that increased transcriptional levels of #AluJB are sufficient to drive changes in many cellular processes related to the #hallmarks of #aging - thus suggesting that #TE derepression may exert causal effects on the #aging process rather than be a mere bystander. 8/9
The Future of Aging Science 1/
NEW PAPER: What if "inflammaging" isn't universal? Our new study shows Indigenous nonindustrialized populations with high infections but low chronic disease defy industrialized aging patterns. The hallmarks of aging might vary by environment and lifestyle. www.nature.com/articles/s43...
Do you study ‘How HIV Affects the Hallmarks of Aging’? The Journal of Gerontology has a call for papers that you might be interested in
@alc2022 There are at least 8 other significant things called Hallmarks of Aging. Worth exploring. Telomere attrition is one of them and i guess without addressing the others chances to extend lifespan are pretty slim. https://t.co/YnqG6QZQYE
The Hallmarks of Aging team talks tech innovations, -omics approaches, and personalized medicine as methods to support anti-aging interventions and extend healthy lifespan. Also, two more Hallmarks of Aging have been added. Learn more: www.lifespan.io/news/well-kn... By: Josh Conway
Schematic overview of the 14 #hallmarksofaging and their roles in the aging process at the primary, antagonist, and integrative levels
#AgingResearch: "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial." #PressRelease ⬇️ www.aging-us.com/news-room/na... #aging #epigenetics #oa #press #publishing #muscles
What if aging isn’t about “getting old”—but about your body’s systems breaking down over time? In Episode 2 of Decoding Longevity, we unpack the Hallmarks of Aging—updated from 9 to 12 in 2023—and ask: If we know what’s failing, can we fix it?
#AgingResearch: "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial" #published on March 14. DOI ⬇️ doi.org/10.18632/aging.206221 #aging #research #oa #peerreview #publishing
@prmshra 8. Altered intercellular communication (chronic inflammation, immune dysfunction) Source: López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. PMID: 23746838; PMCID: PMC3836174. 6/6
@Thomas70327 @Svenope1967 @Der_Boersianer Kein Schwurbel. Der Ansatz dafür wird im meistzitierten Paper der Alternsforschung im letzten Jahrzehnt beschrieben (The Hallmarks of Aging): https://t.co/HO4mpbgTRm
Deciphering Osteosarcopenia through the hallmarks of aging. F Franulic,…G Duque. Mechanisms of Ageing and Development Vol 222, Dec 2024 tinyurl.com/3m38xyyn … panoramic view of the state of the art and knowledge gaps in this field
"There is robust evidence that the actin cytoskeleton determines the mechanical properties of the cell surface [51], which is important to consider in aging studies because one of the hallmarks of aging cells is altered mechanical properties." #longevity #aging pmc.ncbi.nlm.nih.gov/articles/PMC...
Chronic #inflammation and the hallmarks of #aging How the crosstalk between chronic inflammation and other hallmarks of aging underlies biological mechanisms of aging and age-related disease is thus of particular interest to the current geroscience research.
Li #ASHG24 Hallmarks of aging paper: https://t.co/HYvctnMIQ9 Long reads provide context for large mutations. Looking at sperm samples from young and old, CCS HiFi reads, 1-4 reads / cell. De novo assy, use sniffles2 to call de novo SV candidates.
@metashorts "López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. PMID: 23746838; PMCID: PMC3836174."
The possibility that maintaining a suitable longterm magnesium balance may become an inexpensive and safe strategy contributing to healthy aging is an intriguing hypothesis, which needs to be further explored by future studies www.mdpi.com/2072-6643/16... Mg and the Hallmarks of Aging
You’ve heard about the Hallmarks of Aging. How about the “three-wheeled gears” model? @drdorotask.bsky.social doi.org/10.59368/agi... proposes a holistic view of aging integrating hallmarks of aging into a model that focuses on their temporal relationship. Concise and nuanced, this is worth a read.
RT @josbaema: @ElUltimoSapiens @ClinicaCEMTRO @rauldelpozoem @esferalibros Con muchas ganas de leerlo! Justamente el mes pasado publicábam…
@WSJ: The “hallmarks” of aging manifest as we grow older. Scientists are figuring out how to use them to help us live longer, healthier lives. https://t.co/Q1Ez98xwCl
@WSJ: The “hallmarks” of aging manifest as we grow older. Scientists are figuring out how to use them to help us live longer, healthier lives. https://t.co/RSTm8sJzbH
RT @JayChance12: @NIHDirector @doudna_lab @UCBerkeley @SFNeurologie @CHU_Grenoble @HopPitieSalpe @biorxiv_neursci @NeuroscienceNew @Imaging…
@observadora007 @DlakaDarko I will start w/ the references then, but later-this has been a long morning. I won't forget: apoptosis,caspasas https://t.co/9XpZ4OG4rx https://t.co/lccGFkRqTk
Some important scientific papers in aging: Hallmarks of Aging, Cell, 2013.https://t.co/3TOvvkVZXV Lancet Commission Dementia, 2020.https://t.co/KTjQVP5OLV Shared Risk Factors between Dementia and Atherosclerotic Cardiovascular Disease, Int J Mol Sci, 2022.https://t.co/UlNd8MDNzD
At 75 years, the NHS is now old enough that (if it were a human!) it would likely be suffering from multiple chronic diseases. For it (another other health services) to succeed over the next 75 years, they will need to address ageing: https://youtube.com/watch?v=tNn-2TXzSaA
RT @AnaOjeda_ro: Los espectaculares avances en la investigación del envejecimiento publicados en Cells en 2013 y 2023, por Carlos López-Otí…
Los espectaculares avances en la investigación del envejecimiento publicados en Cells en 2013 y 2023, por Carlos López-Otín, María Blasco (directora del @CNIOStopCancer), Linda Partridge, Manuel Serrano y Guido Kroemer. #aging https://t.co/JjjsYg1yjO https://t.co/ctIGPtgNTa https://t.co/ZzFibaHZpJ
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults | @scoopit
1. The FDA does not consider aging as a disease, so drugs developed to target the hallmarks of aging must be shown to be safe and efficacious for other disease indicators. I think this is a stance that will need to be updated as the silver wave of people over the age of 65 picks up it’s pace.
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
RT @DrEcsta: 그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2…
그러니까(다들 아시는 이야기이지요), 여러분, 어서 몸을 움직입시다. Aging (Albany NY). 2021 May 13;13(10):14522-14543. doi: 10.18632/aging.203051. Cell. 2013 Jun 6; 153(6): 1194–1217. doi: 10.1016/j.cell.2013.05.039 https://t.co/eyMuddVkcI
RT @josbaema: La bioimpresión, la terapia génica y la modificación epigenética, la terapia celular y muchas otras tecnologías que aquí te c…
RT @josbaema: La bioimpresión, la terapia génica y la modificación epigenética, la terapia celular y muchas otras tecnologías que aquí te c…
RT @josbaema: La bioimpresión, la terapia génica y la modificación epigenética, la terapia celular y muchas otras tecnologías que aquí te c…
La bioimpresión, la terapia génica y la modificación epigenética, la terapia celular y muchas otras tecnologías que aquí te contamos, van a cambiar el mundo
@NIHDirector @doudna_lab @UCBerkeley @SFNeurologie @CHU_Grenoble @HopPitieSalpe @biorxiv_neursci @NeuroscienceNew @ImagingOrg @Nanowerk @NatureNeuro @InstitutCerveau @mitbrainandcog @Cognition_ENS @Eduscol @EPFL @Inria @Inserm @GoogleAI @IBM 2022 ➡️https://t.co/7VuviHTLWQ . #CELL #CellTherapy 2013 https://t.co/bPSL5hf3aJ #aging #antiaging #rejuvenation ➡️https://t.co/pjHXQ0l3vH 2012⬇️ ➡️https://t.co/2xwMqhUYjY https://t.co/GR87o7GHVV ? https://t.co/w78FDPIuwv @DespratRomain @TelomereRx https://t.co/wo1NJ5TE0h .
The Hallmarks of Aging https://t.co/Wy1AYAyn7G
A single base change in the ribosome improves lifespan but slows development: much like the effect of rapamycin. https://t.co/xBIa5hCws4
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @josbaema: @ElUltimoSapiens @ClinicaCEMTRO @rauldelpozoem @esferalibros Con muchas ganas de leerlo! Justamente el mes pasado publicábam…
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @ObesityMS: The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
The hallmarks of aging https://t.co/xvlwQbehwj https://t.co/mrT72EIWlT
RT @josbaema: @ElUltimoSapiens @ClinicaCEMTRO @rauldelpozoem @esferalibros Con muchas ganas de leerlo! Justamente el mes pasado publicábam…
@ElUltimoSapiens @ClinicaCEMTRO @rauldelpozoem @esferalibros Con muchas ganas de leerlo! Justamente el mes pasado publicábamos este video sobre la temática en https://t.co/qurnuyA8Xy
https://t.co/8Hz83tj8LT
No estuvo Carlos López-Otín y compañía estudiando las posibles causas del envejecimiento para que alguien sin formación alguna hable de ello. Os dejo enlace al paper por si queréis echarle un ojo: https://t.co/YkWOn8u2Jc https://t.co/S6GverZTzu https://t.co/93ZtNWsSfZ
@CharlesMBrenner Also, I have certainly had exactly your critique before I had any donors, e.g.: https://t.co/uFzASnaVXL My response https://t.co/vO5Shtxwd7 was evidently persuasive, as also shown by the restatement of SENS https://t.co/pkAmbCZYQh
@ArtirKel you might be interested https://t.co/vOFRjzmAKh
The Hallmarks of Aging: Cell https://t.co/gqMA0VgEyr
Hallmarks of aging – time for a paradigm shift? https://t.co/WJrCVInS17 via @YouTube
#FightAging #EndAging #Lifespan #Healthspan https://t.co/83G3Dugf7I
RT @EleanorSheekey: We all makes mistakes. But what about our cells? Well, they do too. Could reducing the number of mistakes enhance l…
RT @andy_d_lee: Nice summary of the recent paper highlighting the longevity affects of translational quality control on the Sheekey Science…
RT @andy_d_lee: Nice summary of the recent paper highlighting the longevity affects of translational quality control on the Sheekey Science…
Nice summary of the recent paper highlighting the longevity affects of translational quality control on the Sheekey Science show. @VEMartinezMigu1 @Ivana75154822 @EleanorSheekey https://t.co/lPvsOaBOWn
#RaviVisvesvarayaSharadaPrasad. https://t.co/lW4gEOVc8O Better proteins - fidelity the key to longevity? The Sheekey Science Show
RT @EleanorSheekey: We all makes mistakes. But what about our cells? Well, they do too. Could reducing the number of mistakes enhance l…
We all makes mistakes. But what about our cells? Well, they do too. Could reducing the number of mistakes enhance lifespan? Well, as I discuss, improving fidelity in protein synthesis, it seems it may! --> https://t.co/80cGvGRpDp #aging #protein #scicomm #AcademicYouTube https://t.co/Zhqki0JuGz
https://t.co/kfoWS3icRV 9 Hallmarks of Aging: Genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.
The Journal Club
The Journal Club
#RNATx2021 Myriam Gorospe @NIH #NIA Landmark review: The Hallmarks of Aging https://t.co/AKGekEGM44
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
Check out "Do we really know what aging is? (X10 on a recent critique of the hallmarks of aging)" at: https://t.co/ELjUjbLalg
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
LifeXtenShow had the pleasure to make a video about the hallmarks of #aging in tandem with @EleanorSheekey. Her awesome video is here: https://t.co/lgozEBilX4
RT @EleanorSheekey: Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpac…
Are the hallmarks of aging a good scientific paradigm for biogerontology? Well, in tandem with @LifespanNews we unpack a recent critique article that discusses some limitations and solutions --> https://t.co/BqRVQwJTfz #aging #longevity #scicomm #paradigm #AcademicYouTube https://t.co/R4rGnAQ8NG
Ahora bien, se ha avanzado mucho en nuestro entendimiento sobre ¿Por qué envejecemos? El paper clásico es el "López-Otín" Y como siempre, es complicado... Genes, ambiente y hábitos influyen en el resultado final. https://t.co/Ycdehbwxey
The hallmarks of #aging https://t.co/dcVMdjMWEP @MassEyeAndEar @StGeniezLab #ASIPWebinar #ASIPVirtual #PISA2020
RT @ASIPath: Causes and Consequences of #Aging are Complex. Aging is characterized by a progressive loss of physiological integrity, leadin…
RT @ASIPath: Causes and Consequences of #Aging are Complex. Aging is characterized by a progressive loss of physiological integrity, leadin…
Causes and Consequences of #Aging are Complex. Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. #ASIPWebinar #ASIPVirtual #PISA2020 https://t.co/dcVMdjvlgf @MassEyeAndEar @StGeniezLab https://t.co/OV4S1h7CRd
Hallmarks of Ageing https://t.co/gcTHsMCFG9 https://t.co/7hbffkcwt6
Maybe they haven't heard yet about the hallmarks of aging? https://t.co/FFlgySSmTM @aubreydegrey @davidasinclair
FYI: Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. The hallmarks of aging https://t.co/vrFUjIyB4J
The Hallmarks of Aging https://t.co/gcTHsMCFG9
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IS
FM
BB
LJ
E
LB
BS
OC
F
R
RC
JP
D
R
A
A
M
MB
DJ
?
W
KR
M
M
J
M
C
NA
LE
T
V