August 2013 PMID 23770676

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis, Gloria Pascual, Kelly J Morris, Sadaf Khan, Hong Jin, Gopuraja Dharmalingam

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Mentions

13
Peak: 4 in Feb 2021
across 4 sources since Feb 2021

Extended reach

18,599
potential audience

Total likes

287

Video views

5,363

Mentions per month

Feb 2021 – Oct 2026

Where it's discussed

  • X / Twitter7 posts
  • YouTube3 videos
  • News2 articles
  • Facebook1 posts

AI synopsis

What people are saying

The collection reads like a lightweight, promotional round-up of digital discussions surrounding the article. Posts primarily share or point to external videos and content about aging and senescence, with sparse or no critical analysis of the study's mechanisms (SASP, inflammasome, IL1 signaling) or its nuanced cancer implications. Word choices such as “Is aging contagious?” and “latest video” signal curiosity and educational intent, but the tone remains surface-level and non-committal, reflecting limited impact on scientific discourse within this set.

AgreementNeither agree nor disagree

Overall neutral to mildly curious stance; none of the posts explicitly agrees or disagrees with the article’s conclusions.

InterestModerate interest

Posts show moderate interest by referencing aging, senescence, and discussing related videos; however, depth is limited to mentions and links.

EngagementModerate engagement

Engagement is shallow, mostly sharing or pointing to content rather than debating or analyzing; minimal commentary.

ImpactNeutral impact

Minimal perceived impact in the posts themselves; they mostly promote or reference external content without integrating the article’s findings.

Abstract in brief

  • The study explains how a complex secretory program called SASP, regulated by inflammasome and IL1 signaling, influences paracrine senescence, which is when senescent cells induce nearby normal cells to also become senescent.
  • Key components of the SASP, such as TGF ligands, VEGF, CCL2, and CCL20, mediate this paracrine effect, with TGF ligands notably affecting cell cycle regulators like p15INK4b and p21CIP1.
  • The findings highlight that the inflammasome-driven IL1 signaling controls SASP expression, which can reinforce tumor suppression by promoting senescence but may also have pro-tumorigenic effects, suggesting a complex role in cancer biology.

Top posts

Most liked on X and Bluesky
Eleanor Sheekey
@EleanorSheekey · X

Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #scicomm #AcademicYouTube https://t.co/XQzhElCPAG

Feb 6, 2021 · 19 likes · 4 shares · 4,911 followers View post →
Andrew Caravello, DO
@andrewcaravello · X

https://t.co/Ie1L13mlff

Mar 31, 2026 · 6 likes · 3 shares · 2,185 followers View post →
alphavestcapital.com
@alphavestcap · X

$nwbo @alphavestcap @andrewcaravello Reference Supplement for DCVax RebootedReinstalling Immune Instruction for Aging and DiseaseLink to X Article:https://t.co/PTtrIS17ET. Zhou Y, Li M, Zhou K, et al. STAT3 degradation by PROTAC reprograms dendritic cells for cancer

Mar 31, 2026 · 4 likes · 2,213 followers View post →
ReLuxe
@Mo_Porkburger · X

@eigenrobot A 10 minute video by Eleanor Sheekey on this topic https://t.co/LJkDIKpv2q

Jan 9, 2023 · 1 like · 387 followers View post →
TheSciCommCollective
@Sci_Comm_ · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 2,354 followers View post →
Juan Carlos Acosta
@jucaacoco · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 1,116 followers View post →

All mentions

Understanding the Biology of Aging and Its Causes

Join me on a journey into molecular biology as we explore aging research, including theories like programmed death, antagonistic pleiotropy, and disposable bodies. The video examines causes of aging, current research…

Inside Neuro · Jul 11, 2023 374 views
alphavestcapital.com
@alphavestcap · X

$nwbo @alphavestcap @andrewcaravello Reference Supplement for DCVax RebootedReinstalling Immune Instruction for Aging and DiseaseLink to X Article:https://t.co/PTtrIS17ET. Zhou Y, Li M, Zhou K, et al. STAT3 degradation by PROTAC reprograms dendritic cells for cancer

Mar 31, 2026 · 4 likes · 2,213 followers View post →
Andrew Caravello, DO
@andrewcaravello · X

https://t.co/Ie1L13mlff

Mar 31, 2026 · 6 likes · 3 shares · 2,185 followers View post →
ReLuxe
@Mo_Porkburger · X

@eigenrobot A 10 minute video by Eleanor Sheekey on this topic https://t.co/LJkDIKpv2q

Jan 9, 2023 · 1 like · 387 followers View post →
Dr. Ugis Kletnieks
@Ugis06209578 · X

https://t.co/EDicaQMwJR

May 1, 2021 · 11 followers View post →
TheSciCommCollective
@Sci_Comm_ · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 2,354 followers View post →
Juan Carlos Acosta
@jucaacoco · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 1,116 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #scicomm #AcademicYouTube https://t.co/XQzhElCPAG

Feb 6, 2021 · 19 likes · 4 shares · 4,911 followers View post →
Which of the following signaling is involved in Paracrine signaling ...
Facebook

org/10.1038/s41580-022-00472-z Mechanical signalling affects ... com/ncb/journal/vaop/ncurrent/full/ncb2784.html. 0 reactions ·. 1 ...

Nov 1, 2021 View →
A complex secretory program orchestrated by the inflammasome ...
News

Full text links. Publisher website (DOI) 10.1038/ncb2784. Europe PubMed Central 23770676. Pubmed 23770676. Keywords. Type of publication.

Aug 1, 2013 View →
Las células jubiladas contagian su senescencia a las vecinas
News

DOI: 10.1038/ncb2784. Fuente: CRG. Derechos: Creative Commons. Artículos relacionados. tratamientos genéticos de enfermedades de la sangre.

Jun 19, 2013 View →