August 2013 PMID 23770676

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis, Gloria Pascual, Kelly J Morris, Sadaf Khan, Hong Jin, Gopuraja Dharmalingam

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Mentions

Peak: 4 in Feb 2021

across 4 sources since Feb 2021

Extended reach

14,065

potential audience

Total likes

278

Video views

5,232

Mentions per month

Feb 2021 – Jul 2023

Where it's discussed

X / Twitter5 posts
YouTube2 videos
News2 articles
Facebook1 posts

AI synopsis

What people are saying

The collective social discussions mainly focus on the intriguing question of whether aging can be 'contagious,' as posed by Eleanor Sheekey, with some posts mentioning that she discusses this in a short video. The tone is curious but not deeply analytical, reflecting a general interest but limited engagement with the detailed scientific findings of the publication.

AgreementNeither agree nor disagree

The discussions do not clearly show disagreement or strong support; they are more observational or inquisitive.

InterestModerate interest

The tweets indicate a moderate curiosity about the topic, especially highlighted by interest in aging and cellular processes.

EngagementNeutral engagement

Posts mainly reference the video content without deep analytical discussion, suggesting a surface-level engagement.

ImpactNeutral impact

The discussions seem to have limited influence or transformative insights, mostly pointing to the video as a source of information.

Abstract in brief

The study explains how a complex secretory program called SASP, regulated by inflammasome and IL1 signaling, influences paracrine senescence, which is when senescent cells induce nearby normal cells to also become senescent.
Key components of the SASP, such as TGF ligands, VEGF, CCL2, and CCL20, mediate this paracrine effect, with TGF ligands notably affecting cell cycle regulators like p15INK4b and p21CIP1.
The findings highlight that the inflammasome-driven IL1 signaling controls SASP expression, which can reinforce tumor suppression by promoting senescence but may also have pro-tumorigenic effects, suggesting a complex role in cancer biology.

Read the full abstract

All mentions

Inflammasome's Role in Paracrine Senescence and Aging

This video explains how a secretory program called SASP, regulated by the inflammasome and IL1 signaling, influences paracrine senescence, where senescent cells induce nearby cells to also become senescent, affecting…

The Sheekey Science Show · Feb 6, 2021 4,878 views

Understanding the Biology of Aging and Its Causes

Join me on a journey into molecular biology as we explore aging research, including theories like programmed death, antagonistic pleiotropy, and disposable bodies. The video examines causes of aging, current research…

Inside Neuro · Jul 11, 2023 354 views

ReLuxe

@Mo_Porkburger · X

@eigenrobot A 10 minute video by Eleanor Sheekey on this topic https://t.co/LJkDIKpv2q

Jan 9, 2023 · 1 like · 387 followers View post →

Dr. Ugis Kletnieks

@Ugis06209578 · X

https://t.co/EDicaQMwJR

May 1, 2021 · 11 followers View post →

TheSciCommCollective

@Sci_Comm_ · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 2,354 followers View post →

Juan Carlos Acosta

@jucaacoco · X

RT @EleanorSheekey: Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #…

Feb 6, 2021 · 4 shares · 1,116 followers View post →

Eleanor Sheekey

@EleanorSheekey · X

Is aging contagious? Well, i discuss in my latest video; https://t.co/jR1eFmMYqg #aging #senescence #cellsignaling #scicomm #AcademicYouTube https://t.co/XQzhElCPAG

Feb 6, 2021 · 19 likes · 4 shares · 4,911 followers View post →

Which of the following signaling is involved in Paracrine signaling ...

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org/10.1038/s41580-022-00472-z Mechanical signalling affects ... com/ncb/journal/vaop/ncurrent/full/ncb2784.html. 0 reactions ·. 1 ...

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A complex secretory program orchestrated by the inflammasome ...

News

Full text links. Publisher website (DOI) 10.1038/ncb2784. Europe PubMed Central 23770676. Pubmed 23770676. Keywords. Type of publication.

Aug 1, 2013 View →

Las células jubiladas contagian su senescencia a las vecinas