Physiol Rev July 2013 PMID 23899560

Exercise, GLUT4, and skeletal muscle glucose uptake.

Erik A Richter, Mark Hargreaves

Mentions

92
Peak: 27 in Jan 2023
across 4 sources since Apr 2019

Extended reach

1,603,851
potential audience

Total likes

21,016

Video views

851,763

Mentions per month

Apr 2019 – Nov 2025

Where it's discussed

  • X / Twitter68 posts
  • News10 articles
  • YouTube8 videos
  • Facebook6 posts

AI synopsis

What people are saying

The collective responses show strong agreement with the importance of exercise in GLUT4 regulation, exemplified by mentions of its effects on muscle glucose uptake and references to signaling pathways. The tone is informative and motivated, with participants sharing additional resources and practical advice, reflecting high interest and engagement that could influence health practices.

AgreementModerate agreement

Most discussions acknowledge and support the importance of exercise in increasing GLUT4 and improving glucose uptake, indicating general agreement with the research findings.

InterestHigh interest

The posts demonstrate high interest by citing detailed mechanisms, sharing related content like podcasts, and discussing practical implications for blood sugar management.

EngagementModerate engagement

Several posts engage deeply by referencing signaling pathways, sharing examples of how exercise impacts GLUT4, and connecting it to broader health goals.

ImpactHigh impact

The discussions likely influence readers' understanding of exercise's role in glucose regulation and may motivate health-related behaviors, suggesting significant impact.

Abstract in brief

  • Glucose is a key energy source for muscle during exercise, and its uptake is regulated by the GLUT4 transporter which moves to the muscle cell surface during contraction, facilitating glucose entry.
  • The process of GLUT4 translocation involves complex signaling pathways triggered by muscle contraction, involving molecules like AMPK, Ca2+, NOS, Rab GTPases, SNARE proteins, and the cytoskeleton.
  • Regular exercise increases GLUT4 expression in muscle cells through signaling pathways that involve kinases like AMPK and CaMKII, which enhance GLUT4 gene transcription, leading to better glucose uptake and improved insulin sensitivity in health and disease.

Top posts

Most liked on X and Bluesky
Pablo Zumaquero Jarana
@pzjarana · X

Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemia. Antes de bajar como locos los hidratos de la dieta y tener ansiedad por no tomarlos... ENTRENA! https://t.co/guydli9n8m https://t.co/UdZ2mnwxtJ

Jan 24, 2023 · 91 likes · 28 shares · 21,797 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose intolerant person follows exercise with more carbs, it's like using a bucket to bail out a boat while there's a hole in the hull. https://t.co/u4y9qSEw1S

Nov 8, 2022 · 52 likes · 7 shares · 291,054 followers View post →
NYBO@NEXS journal club
@NYBO_NEXS_KU_DK · X

new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake" (see link in comments) - enjoy input from a true expert in the area and the paper for comprehensive review/details https://t.co/VECvbM7Obg

Aug 17, 2023 · 26 likes · 5 shares · 281 followers View post →
aqua
@quaticaPh · X

1. Exercise increases GLUT-4 glucose receptor expression/translocation in muscle 2. GLUT-4 receptors increase glucose uptake by muscle, instead of the liver/fat tissue 3. We want muscle to get as much glucose as possible, and adipose tissue to get little https://t.co/DSOEvVZVgA https://t.co/yCJlFGVB2B

Mar 20, 2024 · 7 likes · 2 shares · 3,114 followers View post →
Alejandro A.D.
@realalejandroAD · X

SOURCES: lmao forgot to add em yesterday momento alli Mag & Exercise performance overview https://t.co/l3lGXTm7va GLUT4, Muscle & Exercise: https://t.co/vK8h3RlCMm All GLUT https://t.co/W29W9XiRyU Mag & Glucose & Lactate https://t.co/nLj47Rg2ou

Mar 10, 2021 · 6 likes · 2 shares · 15,453 followers View post →
أسيد | OSAID
@OSAID_FIT · X

@ptibra1 أكيد يجميل ، تفضل

Mar 3, 2022 · 3 likes · 25,762 followers View post →

All mentions

Anand Nagu
@anandnagu · X

RT @thestrongdoc: @anandnagu Ton of evidence. https://t.co/ilhDUaFUlp https://t.co/aC00rs4Och https://t.co/PD9UQAC7db https://t.co/MJNesYZ…

Apr 2, 2024 · 1 share · 4,118 followers View post →
Dr Neha Chawla || FreeGym
@thestrongdoc · X

@anandnagu Ton of evidence. https://t.co/ilhDUaFUlp https://t.co/aC00rs4Och https://t.co/PD9UQAC7db https://t.co/MJNesYZ7Nk

Apr 2, 2024 · 1 like · 1 share · 10,008 followers View post →
oecolamp
@oecolamp · X

RT @quaticaPh: 1. Exercise increases GLUT-4 glucose receptor expression/translocation in muscle 2. GLUT-4 receptors increase glucose uptak…

Mar 20, 2024 · 2 shares · 812 followers View post →
Seeker
@_forest_seeker_ · X

RT @quaticaPh: 1. Exercise increases GLUT-4 glucose receptor expression/translocation in muscle 2. GLUT-4 receptors increase glucose uptak…

Mar 20, 2024 · 2 shares · 15,050 followers View post →
aqua
@quaticaPh · X

1. Exercise increases GLUT-4 glucose receptor expression/translocation in muscle 2. GLUT-4 receptors increase glucose uptake by muscle, instead of the liver/fat tissue 3. We want muscle to get as much glucose as possible, and adipose tissue to get little https://t.co/DSOEvVZVgA https://t.co/yCJlFGVB2B

Mar 20, 2024 · 7 likes · 2 shares · 3,114 followers View post →
ruth salas
@ruthsal74210457 · X

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake | Physiological Reviews https://t.co/cu8OhumQVI

Feb 21, 2024 View post →
まいち
@maiti_86 · X

@SgVnYDTilrYxxpm @muscle_penguin_ インスリン作用不足では痩せます。 そんな話をしているのではなくて、グリコーゲンの枯渇に対してはインスリン非依存でGLUT4がトランスロケーションされるという話でエビデンスも出したんですよ。 とにかくこちらの論文を読んでください。 糖尿病とか関係ありません。 https://t.co/cnGACxJxL3

Dec 8, 2023 · 10,627 followers View post →
まいち
@maiti_86 · X

@SgVnYDTilrYxxpm @muscle_penguin_ 「インスリンを出す健常者のエビデンスは?」 別に糖尿病患者に限った話ではないんですが。。。 インスリン非依存だから出ても出なくても同じですよ。 https://t.co/cnGACxJxL3

Dec 8, 2023 · 1 like · 10,627 followers View post →
Eve Beavers
@espacetimeCO · X

RT @NYBO_NEXS_KU_DK: new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake"…

Sep 24, 2023 · 5 shares · 904 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @NYBO_NEXS_KU_DK: new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake"…

Aug 21, 2023 · 5 shares · 404 followers View post →
Erik A. Richter
@proferikrichter · X

RT @NYBO_NEXS_KU_DK: new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake"…

Aug 21, 2023 · 5 shares · 2,280 followers View post →
NYBO@NEXS journal club
@NYBO_NEXS_KU_DK · X

RT @NYBO_NEXS_KU_DK: new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake"…

Aug 18, 2023 · 5 shares · 281 followers View post →
Lars Nybo
@Nyborger_Nybo · X

RT @NYBO_NEXS_KU_DK: new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake"…

Aug 17, 2023 · 5 shares · 1,478 followers View post →
NYBO@NEXS journal club
@NYBO_NEXS_KU_DK · X

new podcast with @proferikrichter available - the paper in focus "Exercise, GLUT4, and skeletal muscle glucose uptake" (see link in comments) - enjoy input from a true expert in the area and the paper for comprehensive review/details https://t.co/VECvbM7Obg

Aug 17, 2023 · 26 likes · 5 shares · 281 followers View post →
HoraDeportiva
@horadeportivaes · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 25, 2023 · 28 shares · 14 followers View post →
lizmachado_nutri
@Lizbethmachado7 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 442 followers View post →
Swarth_96
@96Swarth · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 88 followers View post →
Gabriel Pérez
@gperez441 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 282 followers View post →
Luis Alberto Marco-Contreras - OLY
@LAlbertoMarco · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 8,982 followers View post →
edinssondp
@edinssondp · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 113 followers View post →
Dani Reyes Olavarría
@Daniitota · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 463 followers View post →
Robert Rodríguez
@rrchinchilla · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 930 followers View post →
Estoico
@EstoicoBlack88 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 747 followers View post →
Aquiles
@Sapiensbici · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 164 followers View post →
DraStrange
@biankaa09 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 64 followers View post →
Imanol Santoyo · Nutricionista
@nutrirritable · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 38 followers View post →
Javierpa95
@javi95lol · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 102 followers View post →
Mariana
@MarianaRSo · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 724 followers View post →
Gustavo Perez
@Sir_Conan93 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 99 followers View post →
Cami Zuloaga
@Cami_Zeta13 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 1,012 followers View post →
Dr. Proteinuria / Dr. RenalGon
@glomeruloso · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 63,312 followers View post →
Noemi
@noeesris · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 451 followers View post →
Ignacio Hernando Valle
@nachoafysalud · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 5,838 followers View post →
Diana Alonso TSD
@DianaAlonsoTSD · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 280 followers View post →
#i
@IgnaBroomr · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 9,581 followers View post →
María José López
@mj_nutricion · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 807 followers View post →
Daniel
@DeshiFisio · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 1,700 followers View post →
Carlos
@MarvinHarris76 · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 4,502 followers View post →
María Asensio
@MariaAsensioDN · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 55 followers View post →
Underyelow Ru
@UnderyelowRu · X

RT @pzjarana: Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemi…

Jan 24, 2023 · 28 shares · 79 followers View post →
Pablo Zumaquero Jarana
@pzjarana · X

Aunque haya resistencia a la insulina, la propia contracción muscular va a sacar GLUT4 a la membrana y se reducirá la glucemia. Antes de bajar como locos los hidratos de la dieta y tener ansiedad por no tomarlos... ENTRENA! https://t.co/guydli9n8m https://t.co/UdZ2mnwxtJ

Jan 24, 2023 · 91 likes · 28 shares · 21,797 followers View post →
LOUIS
@PorcinetteLouis · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 9, 2022 · 7 shares · 3,572 followers View post →
Citizen of EU
@wavetossed · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 9, 2022 · 7 shares · 9,491 followers View post →
Maurício Lima
@dj_surfista · X

O exercício é o estímulo mais potente do aumento dos receptores #GLUT4 musculares que aumentam a captação de glicose. https://t.co/lxjg7hg2tE

Nov 8, 2022 · 1 like · 739 followers View post →
George Dorunda
@Dorunda · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 8, 2022 · 7 shares · 2,166 followers View post →
J P Fanton
@HealthyFellow · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 8, 2022 · 7 shares · 26,021 followers View post →
козел кефир
@cacaoXtawco · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 8, 2022 · 7 shares · 391 followers View post →
Florida_man70
@FloridaMan70 · X

RT @Mangan150: Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose in…

Nov 8, 2022 · 7 shares · 168 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Exercise is the most potent stimulus of increased muscle GLUT4 receptors which increase glucose uptake. But if a glucose intolerant person follows exercise with more carbs, it's like using a bucket to bail out a boat while there's a hole in the hull. https://t.co/u4y9qSEw1S

Nov 8, 2022 · 52 likes · 7 shares · 291,054 followers View post →
David Gómez
@Davidgomct · X

La captación muscular de glucosa está regulada por el suministro de glucosa al músculo

Sep 18, 2022 · 3 likes · 5,153 followers View post →
Kevin Davy
@davykevinp · X

@hjluks @kevinnbass @B_Holmer https://t.co/JL1DS0hGoh

Sep 12, 2022 · 2 likes · 1,312 followers View post →
Patrick Steven Redelfs
@Redelfs8008 · X

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake | Physiological Reviews https://t.co/LM5U4KL4L5

Sep 6, 2022 · 242 followers View post →
living dead girl ( ゾンビ )
@JaneZom · X

This REDUCES BLOOD SUGAR Faster than Anything Else (short and long term) https://t.co/K7wq5U7HLd via @YouTube

Jul 12, 2022 · 466 followers View post →
Beef Ent.
@BeefEnt · X

https://t.co/TrrEzGMBsx

Jun 29, 2022 · 135,745 followers View post →
Sharam Fouladgar-Mercer
@sharamfm · X

RT @SignosHealth: The Fastest Way to Reduce Blood Sugar by @ThomasDeLauer https://t.co/eyoheMCfoz

Jun 15, 2022 · 1 share · 16,836 followers View post →
Signos
@SignosHealth · X

The Fastest Way to Reduce Blood Sugar by @ThomasDeLauer https://t.co/eyoheMCfoz

Jun 15, 2022 · 1 like · 1 share · 785 followers View post →
Henry Brown
@henryviribus · X

This REDUCES BLOOD SUGAR Faster than Anything Else https://t.co/0YONVetSZK #plantbased #vegan #health #accupressure #reflexology #holistichealth #herbs #healing #alkaline #chiropractor #selfhelp #therapy #Fasting #naturalmedicine #remedies #nutrition #minerals #ayurvedic #diy

Jun 15, 2022 · 1,333 followers View post →
Ken Dodge
@Kennytoto · X

https://t.co/cGPeEOvzP4

Jun 14, 2022 · 430 followers View post →
Katherine Gaskins
@KatherineGaskin · X

Important info if you're pre-diabetic or diabetic. https://t.co/GK4nM2ggv4

Jun 14, 2022 · 121 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer The Fastest Way to REDUCE BLOOD SUGAR (short and long term) https://t.co/4hULUzBu63 #keto

Jun 14, 2022 · 347 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/kq4W8Y6xeO https://t.co/X6oRFJ8oaw Discover What Foods To Eat To Lose Weight To discover what foods to eat to lose weight you've got to eat more of the foods that are good for you and less

Apr 18, 2022 · 3 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is BEST TIME to Eat Carbs without STORING Them! https://t.co/nBOEkBhwi1 #keto

Apr 18, 2022 · 347 followers View post →
أسيد | OSAID
@OSAID_FIT · X

@ptibra1 أكيد يجميل ، تفضل

Mar 3, 2022 · 3 likes · 25,762 followers View post →
kike
@FUENTESMANZULLI · X

RT @realalejandroAD: SOURCES: lmao forgot to add em yesterday momento alli Mag & Exercise performance overview https://t.co/l3lGXTm7va GL…

Aug 10, 2021 · 2 shares · 248 followers View post →
\ (•◡•) /
@Karmickonnecti1 · X

@amritabhinder @DrRupani https://t.co/MWBy40tQYm.

Jun 14, 2021 · 624 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @AlliNutrition: SOURCES: lmao forgot to add em yesterday momento alli Mag & Exercise performance overview https://t.co/l3lGXTm7va GLUT…

Mar 10, 2021 · 2 shares · 28,518 followers View post →
Alejandro A.D.
@realalejandroAD · X

SOURCES: lmao forgot to add em yesterday momento alli Mag & Exercise performance overview https://t.co/l3lGXTm7va GLUT4, Muscle & Exercise: https://t.co/vK8h3RlCMm All GLUT https://t.co/W29W9XiRyU Mag & Glucose & Lactate https://t.co/nLj47Rg2ou

Mar 10, 2021 · 6 likes · 2 shares · 15,453 followers View post →
Jason Lauritzen
@JasonLauritzen · X

@ColinSkinner19 Carbs should not be needed for sleep. Even the folks pushing back-loading of carbs realize they have to cheat circadian biology and rely on heavy resistance training to max out GLUT4 translocation to make it "work": https://t.co/MAX0hmWh7H.

Apr 28, 2019 · 412 followers View post →