N Engl J Med August 2013 PMID 23924004

Glucose levels and risk of dementia.

Paul K Crane, Rod Walker, Rebecca A Hubbard, Ge Li, David M Nathan, Hui Zheng, Sebastien Haneuse, Suzanne Craft, Thomas J Montine, Steven E Kahn, Wayne McCormick, Susan M McCurry, James D Bowen, Eric B Larson

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Mentions

142

Peak: 21 in Jun 2019

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AI synopsis

What people are saying

Discussions emphasize the significance of the research by mentioning phrases like 'brain shrinkage' caused by high blood sugar levels and 'risk factor for dementia', showing concern about neurological health. The tone is serious and analytical, with some users referencing scientific methods, which reflects thoughtful engagement and recognition of the study's potential influence.

AgreementModerate agreement

Most discussions acknowledge the findings linking higher glucose levels to increased dementia risk, showing general support for the article's conclusions.

InterestHigh interest

The discussions demonstrate a strong curiosity about the connection between blood sugar and cognitive decline, highlighting high engagement with the topic.

EngagementModerate engagement

Many contributors reference specific research methods and implications, indicating a thoughtful level of discussion rather than superficial agreement.

ImpactModerate impact

The dialogues suggest that people believe these findings could influence health awareness and preventive approaches, but mostly present a moderate expected impact.

Abstract in brief

Higher glucose levels are associated with an increased risk of developing dementia, even in people who do not have diabetes.
The study found that for non-diabetic older adults, higher average glucose levels over five years raised the risk of dementia, with a notable increase at glucose levels around 115 mg/dL.
Among those with diabetes, higher glucose levels also linked to a greater dementia risk, suggesting that managing blood sugar might help reduce dementia risk across different groups.]

Read the full abstract

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Impact of Blood Glucose Levels on Dementia Risk in Non-Diabetics and Diabetics

Higher glucose levels are associated with an increased risk of developing dementia, even in people who do not have diabetes. Managing blood sugar may help reduce dementia risk across different groups.

張修修的不正常人生 Shosho's Abnormal Life · Jun 17, 2023 122,064 views

Metabolic Factors and Dementia Risk in Aging Populations

Higher glucose levels are associated with an increased risk of developing dementia, even in people who do not have diabetes. The study found that for non-diabetic older adults, higher average glucose levels over five…

Datando a ciência · Dec 10, 2025 9 views

LCHF_Murali | Metabolic Health Consultant

@murali_twin · X

RT @shashiiyengar: Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 25, 2025 · 5 shares · 406 followers View post →

Dr Krishnalal

@_krishnalal · X

RT @shashiiyengar: Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 24, 2025 · 5 shares · 381 followers View post →

Agnes Ayton

@AgnesAyton · X

RT @shashiiyengar: Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 24, 2025 · 5 shares · 7,428 followers View post →

Dr. Sandeep

@KaragadaSandeep · X

RT @shashiiyengar: Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 24, 2025 · 5 shares · 237 followers View post →

Nithin KV | Metabolic Health Consultant

@nitkvdlife · X

RT @shashiiyengar: Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 24, 2025 · 5 shares · 265 followers View post →

Shashi Iyengar | Metabolic Health India®

@shashiiyengar · X

Brain Shrinks on High Blood Sugar High glucose levels → glycation → brain shrinkage. Ref: https://t.co/pTnrPUFbHq

Oct 24, 2025 · 16 likes · 5 shares · 29,652 followers View post →

Ryan Morales❤️

@RelativRyan · X

https://t.co/bcdRZdTH0m

Oct 7, 2025 · 291 followers View post →

ebru koçyiğit

@ebru14ebru · X

RT @BarbaraEbel: Glucose Levels and Risk of Dementia — NEJM http://t.co/qcSyyMNnQ7

Jun 10, 2024 · 1 share View post →

가을 남자

@BuuiCharlie7916 · X

@omgkdr_ 무채혈 혈당측정기 찾고있다면 도움이 되시길.. https://t.co/fmzM4Uec05

Apr 20, 2024 · 2 likes · 1,063 followers View post →

가을 남자

@BuuiCharlie7916 · X

RT @BuuiCharlie7916: 당뇨병은 치매의 위험인자로 우리가 공복 혈당수치 90 ~ 100 식후 2 시간후 혈당수치 150 미만를 유지하고 당화혈색소 ( Hemoglobin A1 C ) 수치를 5.0 ~ 5.5 이하로 유지하는 것은 건강유…

Apr 4, 2024 · 1 share · 1,063 followers View post →

Lucky2020

@Lucky2020589730 · X

RT @Rambat: @haghayeghy @Thekeksociety “Our results suggest that higher glucose levels may be a risk factor for dementia, even among person…

Mar 9, 2024 · 1 share · 23 followers View post →

Karen

@Rambat · X

@haghayeghy @Thekeksociety “Our results suggest that higher glucose levels may be a risk factor for dementia, even among persons without diabetes.” https://t.co/wjdyQsP08c

Mar 9, 2024 · 1 share · 6,980 followers View post →

가을 남자

@BuuiCharlie7916 · X

당뇨병은 치매의 위험인자로 우리가 공복 혈당수치 90 ~ 100 식후 2 시간후 혈당수치 150 미만를 유지하고 당화혈색소 ( Hemoglobin A1 C ) 수치를 5.0 ~ 5.5 이하로 유지하는 것은 건강유지에 큰 도움이 됩니다. https://t.co/fmzM4UdEax https://t.co/sUFFmMGXm0

Feb 26, 2024 · 2 likes · 1 share · 1,063 followers View post →

Carol Taguc

@carolpuigcerda · X

RT @papayaykware: https://t.co/bTkENDAC1v Niveles de glucosa y riesgo de demencia

Oct 4, 2023 · 2 shares · 147 followers View post →

Manu_K_talà ✌️

@Manu_K_tala · X

RT @papayaykware: https://t.co/bTkENDAC1v Niveles de glucosa y riesgo de demencia

Oct 4, 2023 · 2 shares · 5,353 followers View post →

Javi Ciborro

@papayaykware · X

https://t.co/bTkENDAC1v Niveles de glucosa y riesgo de demencia

Oct 4, 2023 · 2 shares · 8,020 followers View post →

The Original Justin Templer

@JustinTemplerSr · X

@Alexzia777 @SteakAndIron "every cell in the human body runs on glucose".. until they can't, and then you become diabetic and develop alzheimer's. Too many carbs = cell death https://t.co/zvGuYuJx6A

Sep 18, 2023 · 1,361 followers View post →

Javi Ciborro

@papayaykware · X

https://t.co/bTkENDAC1v Nuestros resultados sugieren que unos niveles de glucosa más elevados pueden ser un factor de riesgo de demencia, incluso entre personas sin diabetes

Aug 18, 2023 · 8,020 followers View post →

Avus

@poppacarne · X

It’s surprising that this information isn’t being pushed heavily to the public considering it was in NEJM 10 years ago. @KenDBerryMD https://t.co/uBwpehAgCL https://t.co/r8QgdXCgos

Jan 10, 2023 · 423 followers View post →

Sandra.in.NYC

@PaniciSan · X

RT @chefserenapoon: a great study connecting glucose levels & the risk of dementia ⤵️ https://t.co/wWmQh8PcW2

Sep 1, 2022 · 3 shares · 102 followers View post →

P-B3g3

@PB3g3r · X

RT @chefserenapoon: a great study connecting glucose levels & the risk of dementia ⤵️ https://t.co/wWmQh8PcW2

Sep 1, 2022 · 3 shares · 386 followers View post →

Ana

@luxherbalist · X

RT @chefserenapoon: a great study connecting glucose levels & the risk of dementia ⤵️ https://t.co/wWmQh8PcW2

Sep 1, 2022 · 3 shares · 16 followers View post →

Chef Serena Poon

@chefserenapoon · X

a great study connecting glucose levels & the risk of dementia ⤵️ https://t.co/wWmQh8PcW2

Sep 1, 2022 · 3 likes · 3 shares · 19,632 followers View post →

Johns Hopkins Memory & Aging

@JH_Memory_Aging · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jul 13, 2022 · 9 shares · 2,923 followers View post →

Abu Shoyeb, MD

@abushoyeb · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 28, 2022 · 9 shares · 706 followers View post →

a2 Collective | a2PilotAwards.ai

@a2_collective · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 9 shares · 316 followers View post →

Ranjan Nanda

@RanjanN2022 · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 9 shares · 394 followers View post →

Evangeline Mantzioris PhD APD AccSD

@EMantzioris · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 9 shares · 1,170 followers View post →

Dr. Fawaz Alzaid

@DrFAlzaid · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 9 shares · 1,704 followers View post →

Alexander Dakhovnik

@ADakhovnik · X

RT @agingdoc1: Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 9 shares · 79 followers View post →

Agingdoc

@agingdoc1 · X

Glucose Levels and Risk of Dementia https://t.co/aGQvY111Cs https://t.co/9lZiyrMYVh

Jun 27, 2022 · 22 likes · 9 shares · 44,287 followers View post →

DancingDax

@DancingDax · X

RT @keisuke4713: 血糖値と認知症risk https://t.co/QGzNPD4y9S 血糖値のわずかな上昇でさえ、認知症のリスクの上昇と関連過去5年間の平均血糖値と認知症発症との関連：図 A 糖尿病なし：認知症riskは血糖値上昇とともに↑ B 糖尿病:…

Jun 18, 2022 · 2 shares · 563 followers View post →

CaDe

@CarDen1974 · X

@AJacqisborn @Dragica77 Onzin, van suiker krijg je geen hoge bloedsuiker ALS je gezond bent. En hoog bloedsuiker is gewoon een onafhankelijke risico factor voor dementia https://t.co/OAIJN4oyJq

Jun 9, 2022 · 225 followers View post →

Michael Brandt

@MichaelDBrandt · X

Apr 8, 2022 · 8 likes · 5,295 followers View post →

Pedro Lopez-Ayala

@LopezAyalaP · X

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_24_com

@_24_com · X

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tune

@keisuke4713 · X

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Psicólogo Rodrigo Giannangelo

@PsicoRodrigoG · X

Oct 19, 2021 · 22 followers View post →

Dr. Emmanuel E. Nwusulor

@NwusulorDr · X

Glucose Levels and Risk of Dementia | NEJM https://t.co/5nLrntXAGK

May 19, 2021 · 858 followers View post →

MMA and Boxing Fight Analyst

@kostasfant · X

"Our results suggest that higher glucose levels may be a risk factor for dementia, even among persons without diabetes." https://t.co/esMFEZJ9Xl

Sep 21, 2019 · 5,796 followers View post →

Cañas Rojas Hernando

@suramericano10 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 771 followers View post →

Un Héroe de la FAC

@F1509 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 1,804 followers View post →

Luis Eduardo

@LuisEdu620829 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 8,718 followers View post →

Myriam Durán

@myrdur · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 5,042 followers View post →

Jose A.

@Josealexsanche · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 994 followers View post →

Scratchin'Pro

@ScratchinPro · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 3,380 followers View post →

Llanerita

@LSaccharina · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 1,304 followers View post →

Colombia humana

@olg12020 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 2,140 followers View post →

Mauricio Martinez U

@stuart_MU · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 2,437 followers View post →

abraham montenegro

@abrahammontene5 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 4,287 followers View post →

henry rubio

@HenrubioRubio · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 754 followers View post →

Jose

@jose55dsl · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 1,128 followers View post →

gloriad53m--dq

@gloriadm_553 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 13,524 followers View post →

RodrigoPerlazaPrado

@ortopediatrico · X

@merv59 Buen día Martica... https://t.co/LkOd6UecZ2

Jun 12, 2019 · 901 followers View post →

ToroYo

@ToroYo1 · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 693 followers View post →

Chicuco-price

@ChicucoP · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 46 followers View post →

Barreja

@TheSaubisNFT · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 15,367 followers View post →

Alexander Vargas

@Alexandermuiska · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 1,829 followers View post →

LeilaCaroChujfi

@LeilaCaroChujfi · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 28,765 followers View post →

Dr Mandrake

@drmandrake_ · X

RT @alemar_dul: 4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 20 shares · 838 followers View post →

DraSwetty

@Telomerasa0406 · X

4. Niveles de glucosa asociados a demencia. La prestigiosa NEJM https://t.co/gRk5ZpMVTm

Jun 12, 2019 · 36 likes · 20 shares · 28,253 followers View post →

OxfordNeuroCrit

@OxfordNeuroCrit · X

RT @PriscoLara: Mythbusting in Neurocritical care with @GMeyfroidt Glucose levels and risk of dementia https://t.co/4lnSKAfYGn

May 9, 2019 · 2 shares · 1,991 followers View post →

MARCO MELONI

@marcomeloni80 · X

RT @PriscoLara: Mythbusting in Neurocritical care with @GMeyfroidt Glucose levels and risk of dementia https://t.co/4lnSKAfYGn

May 9, 2019 · 2 shares · 21 followers View post →

ᒪᗩᖇᗩ ᑭᖇIᔕᑕO

@PriscoLara · X

Mythbusting in Neurocritical care with @GMeyfroidt Glucose levels and risk of dementia https://t.co/4lnSKAfYGn

May 9, 2019 · 3 likes · 2 shares · 1,102 followers View post →

Mars Sy

@SyArchmsy · X

https://t.co/r3tPLrCEu0

Mar 19, 2019 · 340 followers View post →

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Less time in individualized HbA1C target range is associated with ...

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https://www.nejm.org/doi/full/10.1056/NEJMoa1215740. I would cut carbs and supplement with MCT and /or exogenous ketones before considering ...

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Your brain controls everything! Fuel it with exercise, a healthy diet ...

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Walking with a smile boosts your mood and reduces stress! ‍♂️ A li ...

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Does diabetes cause dementia?

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... levels leads to higher risks of Dementia. http://www.nejm. org/doi/full/10.1056/NEJMoa1215740#t=articleDiscu ssion · Patela Lo ·

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learn the benefits of walking with me! #mindfuldiabetes ...

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https://doi.org/10.1056/NEJMoa1215740 2. Gómez-Pinilla, F. (2008). Brain foods: The effects of nutrients on brain function. Nature Reviews ...

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Amanda Decker FNP-c, MHP, CKNS

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org/doi/full/10.1056/NEJMoa1215740 https://www.neurology.org/doi/10.1212/WNL. 0000000000214033 Want to work with a provider and team that ...

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Do carbs cause dementia or prevent it? This is a popular topic, and ...

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The brain you save may be your own. Older study says, "It's the sugar. OK?" https://www.nejm. org/doi/full/10.1056/NEJMoa1215740.

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https://doi.org/10.1056/NEJMoa1215740 2. Gómez-Pinilla, F. (2008). Brain foods: The effects of nutrients on brain function. Nature Reviews ...

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High blood sugar linked to cognitive decline and dementia

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Does anyone feel their cognitive ability decline when their blood ...

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Individuals with type 2 diabetes mellitus (T2DM) who experience ...

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U need to know and learning before too late. https://www.cdc.gov ...

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"Blood sugar levels and dementia? Studies are now showing that ...

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New research reveals link between chronic hyperglycemia and ...

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Literally food for thought

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Does the body need sugar? Role in the body and how much to ...

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Glucose levels and risk of dementia. https://www.nejm.org/doi/full/10.1056/NEJMoa1215740; Hantzidiamantis, P. J., et al. (2020). Physiology ...

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# Differences in Longitudinal Fasting Blood Glucose and Mortality ...

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Higher sugar consumption linked to lower cognitive scores

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高GI饮食如何影响机体代谢？对健康有啥影响？_食物

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org/10.1056/NEJMoa1215740(2013).。 16.Seetharaman, S. (2016). The Influences of Dietary Sugar and Related MetabolicDisorders on Cognitive ...

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Is point-of-care glucose testing necessary for non-diabetics?

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High blood sugar linked to cognitive decline

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Thanks to Yvette Gledhill-Powell for posting this. I have always said ...

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HYPOGLYCEMIA; a condition referred to as low blood sugar...not to ...

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... levels leads to higher risks of Dementia. http://www.nejm. org/doi/full/10.1056/NEJMoa1215740#t=articleDiscu ssion. Patela Lo ·

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Does Diabetes Impact Long-Term Cognition? Study Links HbA1c to ...

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“Glucose Levels and Risk of Dementia.” New England Journal of Medicine. 2013. https://www.nejm.org/doi/full/10.1056/NEJMoa1215740. Accessed on ...

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Why singer Selena Gomez may have an increased risk of dementia.

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Yale researchers find brain glucose levels linked to obesity

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健康管理丨久坐或会影响大脑健康！

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NEJM DOI：10.1056/NEJMoa1215740. 【4】Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 ...

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#8 and #9

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SUGAR is the one of the cause of Alzhemiers and Dementia

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ALZHEIMER'S CAUSES: COULD REFINED SUGAR LEAD TO ...

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Heartburn drugs, dementia, Alzheimer's risk for all? T2D, is it the ...

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... 10.1056/NEJMoa1215740#t=abstract. Graph of T2D dementia and cognitive decline. Source: Dementia and cognitive decline in type 2 diabetes and ...

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Alzheimer's disease: type 3 diabetes? - Mapping Ignorance

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doi: 10.1056/NEJMoa1215740 ↩; Musiek, E. S., & Holtzman, D. M. (2015). Three dimensions of the amyloid hypothesis: time, space and 'wingmen ...

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People with diabetes may experience memory problems

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Högt blodsocker kopplas till ökad risk för demens - Dagens Medicin

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Det är tidigare känt att patienter med diabetes oftare får demens. En ny studie i New England Journal of Medicine pekar på att även personer ...

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org/doi/full/10.1056/NEJMoa1215740". - Diabetes hovedårsak til amputasjoner. DAGBLADET.NO. - Diabetes hovedårsak til amputasjoner. Sykdommen ...

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Dementia risk tied to blood sugar level, even with no diabetes ...

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New England Journal of Medicine, 2013; 369 (6): 540 DOI: 10.1056/NEJMoa1215740. Cite This Page: MLA; APA; Chicago. Group Health Research ...

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High blood glucose levels linked to dementia

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... 10.1056/NEJMoa1215740. Alzheimer's info: https://www.alzheimers.gov. Alzheimer's Association: https://www.alz.org. Warning signs: https://www ...

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Glucose levels and risk of dementia.

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Impact of Blood Glucose Levels on Dementia Risk in Non-Diabetics and Diabetics

Metabolic Factors and Dementia Risk in Aging Populations