JAMA Neurol October 2013 PMID 23978943

Acquired neuromyotonia heralding recurrent thymoma in myasthenia gravis.

Jori Fleisher, Megan Richie, Raymond Price, Steven Scherer, Josep Dalmau, Eric Lancaster

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Abstract in brief

  • The text describes a case where a 53-year-old man with myasthenia gravis and a history of thymectomy developed acquired neuromyotonia, which is an autoimmune condition involving involuntary muscle twitching and antibodies against potassium channel proteins.
  • The recurrence of a malignant thymoma was detected alongside symptomatic neuromyotonia, and antibody tests confirmed the presence of specific proteins (LGI1 and Caspr2) linked to voltage-gated potassium channels.
  • This case emphasizes the importance of checking for thymomas in patients with neuromyotonia or myasthenia gravis, as these conditions often overlap and are part of an autoimmune spectrum.

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Bekir Burak Kılboz, MD
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