Mitochondrion May 2014 PMID 23981537

Metabolic features of the cell danger response.

Robert K Naviaux

Mentions

66
Peak: 5 in Sep 2023
across 7 sources since Aug 2016

Extended reach

241,278
potential audience

Total likes

64

Video views

729

Mentions per month

Aug 2016 – Oct 2025

Where it's discussed

  • X / Twitter36 posts
  • News14 articles
  • Facebook8 posts
  • Blogs3 articles
  • YouTube2 videos
  • Reddit2 posts
  • TikTok1 posts

AI synopsis

What people are saying

Many discussions underline the significance of the CDR in health, with phrases like 'must read' and 'landmark paper' illustrating strong agreement and interest. Participants explore its implications by sharing examples of metabolic changes, molecular mechanisms, and potential links to chronic diseases, demonstrating deep engagement and recognition of its broad impact.

AgreementStrong agreement

Most posts strongly support the importance and relevance of the cell danger response (CDR), often emphasizing its significance in health and disease.

InterestHigh interest

The discussions demonstrate high enthusiasm and curiosity, with many posts calling the paper a 'must read' and highlighting its groundbreaking implications.

EngagementHigh engagement

Participants delve into detailed explanations, referencing related research and sharing opinions about mechanisms and consequences, indicating deep engagement.

ImpactHigh impact

The discussions suggest that the article could reshape understanding of chronic conditions and influence future research and treatment approaches, reflecting high perceived impact.

Abstract in brief

  • The cell danger response (CDR) is an evolutionary metabolic process that protects cells and the whole body from various threats by triggering a series of metabolic changes, such as shifts in energy use, redox state, and protein dynamics.
  • When threats are neutralized, the body activates anti-inflammatory and regenerative pathways to restore balance; however, prolonged CDR can disrupt overall metabolism, gut health, and organ function, leading to chronic disease.
  • The brain, especially the brainstem, plays a central role in controlling the CDR, coordinating whole-body responses to threats, and influencing development and behavior, emphasizing the importance of metabolic regulation in health and disease.]

Top posts

Most liked on X and Bluesky
GeoCK
@GeoEduOne · X

@Emma40025133 It could be due to the cell danger response, which is controlled by the autonomic nervous system. Basically, when under threat the body has a coordinated response, which includes alerted metabolism https://t.co/Nhr4qY6gA4(CDR,the%20cellular%20capacity%20for%20homeostasis.

Jan 5, 2024 · 13 likes · 1 share · 6,131 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

@NataliaHodgins @remissionbiome @chydorina Here's a great Naviaux paper about cell danger: https://t.co/RR2bKCPp8W In his hypothesis, the mitochondria are purposely going into a lower energy state. from that paper, "When the CDR persists abnormally, whole body metabolism and the gut microbiome are disturbed, the

Apr 2, 2023 · 8 likes · 9,637 followers View post →
chydorina
@chydorina · X

Metabolic features of the cell danger response https://t.co/b8ytVxmvZo

Jul 14, 2023 · 7 likes · 1 share · 16,424 followers View post →
James Foulger
@jifoulger · X

@Cov19longtail @MECFSNews Cell Danger Response is on hypothesis https://t.co/ikKbuMUHYR

Nov 5, 2020 · 6 likes · 2,146 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Metabolic features of the cell danger response https://t.co/eppKdvO2lz

May 22, 2021 · 4 likes · 133,562 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

"[CDR] is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic mismatch between available resources and functional capacity produces a cascade of changes." https://t.co/tGEQqMSgFo

Sep 22, 2022 · 4 likes · 9,637 followers View post →

All mentions

Sibylle Reith
@Komplexmedizin · X

@heniek_htw Robert K. Naviaux Metabolic features of the cell danger response https://t.co/nd2wPjvgfN

Sep 28, 2024 · 3 likes · 158 followers View post →
ℂ
@WhenCatsRuleUs · X

@growthfactororg Metabolic features of the cell danger response, by Robert K. Naviaux https://t.co/zF9XZu3Auo

Aug 26, 2024 · 5,418 followers View post →
Jan L Wade Esquire
@JanLWadeEsquire · X

@MarbleBenjamin Metabolic features of the cell danger response, Robert K. Naviaux https://t.co/2HthRkHj6z

Jun 30, 2024 · 1 like · 1,893 followers View post →
Lidiando con la Encefalomielitis Miálgica
@Tobalilla · X

@JulioRazona Respuesta al daño celular + relación con rejones y

Mar 18, 2024 · 1,085 followers View post →
MP
@MauP012 · X

RT @GeoEduOne: @Emma40025133 It could be due to the cell danger response, which is controlled by the autonomic nervous system. Basically, w…

Jan 5, 2024 · 1 share · 160 followers View post →
GeoCK
@GeoEduOne · X

@Emma40025133 It could be due to the cell danger response, which is controlled by the autonomic nervous system. Basically, when under threat the body has a coordinated response, which includes alerted metabolism https://t.co/Nhr4qY6gA4(CDR,the%20cellular%20capacity%20for%20homeostasis.

Jan 5, 2024 · 13 likes · 1 share · 6,131 followers View post →
5thAveConciergeMed
@PrivatHealth · X

Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed – NCBI https://t.co/84PZJIwnS9 #functionalsymptoms #healthybrainaging #asthma #Tourettes #Inflammation

Dec 22, 2023 · 298 followers View post →
ihatechrisbalualua
@chrisbalualua · X

Metabolic features of the cell danger response - PubMed https://t.co/gBbvTurC5U

Oct 30, 2023 · 233 followers View post →
SunlightSleepObesitySpecialist
@kolaadetu · X

@drkohilathas The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. https://t.co/g7YLDsiK8K

Sep 20, 2023 · 1 like · 1,973 followers View post →
Joel Dupuis
@JoelDupuis19 · X

@MchP66592467 @ChrisPalmerMD Read the work on Cell Danger response by Dr. Robert Naviaux https://t.co/rS7ELcJ1qM

Sep 19, 2023 · 116 followers View post →
SunlightSleepObesitySpecialist
@kolaadetu · X

The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. https://t.co/g7YLDsiK8K

Sep 19, 2023 · 1,973 followers View post →
K.Balasandar
@BalasandarK · X

RT @jasmeet481: cell danger response leads to glucose resistance. https://t.co/8OS4KI8G8o

Sep 14, 2023 · 1 share · 178 followers View post →
Dr. Jasmeet Kaur (PhD)
@jasmeet481 · X

cell danger response leads to glucose resistance. https://t.co/8OS4KI8G8o

Sep 13, 2023 · 2 likes · 1 share · 4,182 followers View post →
Coco
@AproposCoco · X

RT @chydorina: Metabolic features of the cell danger response https://t.co/b8ytVxmvZo

Jul 14, 2023 · 1 share · 594 followers View post →
chydorina
@chydorina · X

Metabolic features of the cell danger response https://t.co/b8ytVxmvZo

Jul 14, 2023 · 7 likes · 1 share · 16,424 followers View post →
Dr Ed Caddye
@DrEdCaddye · X

@ahandvanish The metabolic features of the cell danger response by Robert Naveaux.

Jun 7, 2023 · 1 like · 561 followers View post →
eutaxy
@eutaxy10 · X

@chydorina @hortonrachel_ https://t.co/pTin9GxtCy

Jun 6, 2023 · 3 likes · 35 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

@NataliaHodgins @remissionbiome @chydorina Here's a great Naviaux paper about cell danger: https://t.co/RR2bKCPp8W In his hypothesis, the mitochondria are purposely going into a lower energy state. from that paper, "When the CDR persists abnormally, whole body metabolism and the gut microbiome are disturbed, the

Apr 2, 2023 · 8 likes · 9,637 followers View post →
Dr. Carissa Doherty ND
@CarissaND · X

RT @ExceptionalNDs: This landmark paper by Dr. Naviaux is a must read! “An understanding of the CDR permits us to reframe old concepts of…

Mar 2, 2023 · 1 share · 594 followers View post →
ExceptionalND
@Exceptional_ND · X

This landmark paper by Dr. Naviaux is a must read! “An understanding of the CDR permits us to reframe old concepts of pathogenesis for a broad array of chronic, developmental, autoimmune, and degenerative disorders.” https://t.co/RtcWmJpo3A

Mar 1, 2023 · 1 like · 1 share · 98 followers View post →
@JosefEmhofer
@JFME03081954 · X

@LebenWunder @GrandeBettina 1/2 Ich wäre ein bißchen vorsichtig. Bis jetzt ist nichts Handfestes dabei herausgekommen, meines Wissens nach. Dabei stammt die erste Arbeit darüber bereits von 2013. Review Mitochondrion doi: 10.1016/j.mito.2013.08.006. Epub 2013 Aug 24. Metabolic features of the cell danger

Jan 9, 2023 · 997 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

"[CDR] is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic mismatch between available resources and functional capacity produces a cascade of changes." https://t.co/tGEQqMSgFo

Sep 22, 2022 · 4 likes · 9,637 followers View post →
chydorina
@chydorina · X

@ales_frost The 'memory' is called 'mitocellular hormesis' - Metabolic Features of the Cell Danger Response "Next, a metabolic memory of the exposure that led to the CDR is stored in a way similar to the way the brain stores memories, in the form of durable changes in 1/2

Sep 21, 2022 · 1 like · 16,424 followers View post →
ResilientDad | Optimal Health By Nature
@ResilientDad · X

@Grimhood Is this related to Cell Danger Response? https://t.co/Ls9F7bqieN

Dec 24, 2021 · 3 likes · 13,332 followers View post →
Robert Olney
@boretrol · X

Robert K. Naviaux - Metabolic features of the cell danger response https://t.co/5NIMvxc4SD

Jun 25, 2021 · 1 like · 1,699 followers View post →
Robert Olney
@boretrol · X

Metabolic features of the cell danger response https://t.co/ph6HJ6Dj2f

Jun 25, 2021 · 1,699 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Metabolic features of the cell danger response https://t.co/eppKdvO2lz

May 22, 2021 · 4 likes · 133,562 followers View post →
Robert Olney
@boretrol · X

Metabolic features of the cell danger response https://t.co/gQ8MoOFqWw

Apr 4, 2021 · 2 likes · 1,699 followers View post →
James Foulger
@jifoulger · X

@Cov19longtail @MECFSNews Cell Danger Response is on hypothesis https://t.co/ikKbuMUHYR

Nov 5, 2020 · 6 likes · 2,146 followers View post →
SuraminNow
@SuraminNow · X

RT @Dan_Wyke: Dr Robert Naviaux's 2014 paper 'Metabolic features of the cell danger response' #pwME #MEcfs #MyalgicEncephalomyelitis #myal…

Sep 12, 2020 · 1 share · 400 followers View post →
Jason VanSickle
@holleritsjason · X

"I think every single person on this planet should read this." Dr. Margaret Christensen during the #toxicmoldsummit talk with David Haase. Metabolic features of the cell danger response https://t.co/530B4iIsnu

Aug 21, 2020 · 266 followers View post →
5thAveConciergeMed
@PrivatHealth · X

RT @DrMauricePreter: Worth reposting/rereading! Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed https://t.co…

Jul 27, 2020 · 1 share · 298 followers View post →
Maurice Preter MD
@DrMauricePreter · X

Worth reposting/rereading! Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed https://t.co/mR9uHmiTZF #dietary

Jul 27, 2020 · 1 like · 1 share · 986 followers View post →
Robert Tinti
@R_tinti · X

@GemzME @DrEReinhold @MastCellChat @TravisABenson 2/3 “could be the same thing that coordinates the mitochondrial and metabolic features of the cell danger response (CDR) and inflammation5, changes impedance in the nanoneedle10, inhibits recovery from illness by blocking the healing cycle9, induces a dauer-like state11, and”

Dec 22, 2019 · 2 likes · 391 followers View post →
Rene Sugar
@renesugar · X

Metabolic features of the cell danger response https://t.co/ivo06CSDUU

May 15, 2019 · 3,985 followers View post →
Maurice Preter MD
@DrMauricePreter · X

Worth reposting/rereading! Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed #dietary https://t.co/mR9uHmiTZF

Jan 2, 2019 · 986 followers View post →
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