September 2013 PMID 24009397

Gut microbiota from twins discordant for obesity modulate metabolism in mice.

Vanessa K Ridaura, Jeremiah J Faith, Federico E Rey, Jiye Cheng, Alexis E Duncan, Andrew L Kau, Nicholas W Griffin, Vincent Lombard, Bernard Henrissat, James R Bain, Michael J Muehlbauer, Olga Ilkayeva, Clay F Semenkovich, Katsuhiko Funai, David K Hayashi

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Mentions

317
Peak: 7 in May 2021
across 6 sources since Jun 2019

Extended reach

286,845
potential audience

Total likes

637

Video views

19,256

Mentions per month

Jun 2019 – Oct 2025

Where it's discussed

  • News165 articles
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  • Blogs47 articles
  • X / Twitter25 posts
  • YouTube6 videos
  • Reddit6 posts

AI synopsis

What people are saying

This collection of social discussions indicates a generally positive and intrigued response, with examples like references to transplanting microbiota making mice gain or lose weight, and questions about genetic versus microbial influences. The tone includes curiosity and cautious optimism, with some posts emphasizing the potential therapeutic implications, demonstrating moderate but meaningful engagement with the research's impact.

AgreementModerate agreement

Most discussions recognize the validity of the study, especially in relation to how gut microbiota influence obesity, as seen in posts confirming the effects of microbiota transfer on weight.

InterestHigh interest

There's a high level of curiosity about the research, evidenced by comments highlighting the fascinating link between microbiota and metabolism and questions about genetic vs. microbial factors.

EngagementModerate engagement

Posts reflect moderate engagement with some referencing specific aspects, like differences in microbiomes between twins or the potential for microbiome modification, indicating thoughtful consideration.

ImpactModerate impact

Readers seem to appreciate the significance of the findings, noting they could influence future obesity treatments or understanding, though some remain cautious about overgeneralization.

Abstract in brief

  • The study shows that gut microbiota from twins discordant for obesity can influence body weight and metabolism in germ-free mice, and these effects can be transmitted through fecal transplants.
  • When mice with an obese twin's microbiota were cohoused with mice with a lean twin's microbiota, the lean microbiota prevented obesity development, illustrating the potential for microbiota to modify metabolic health.
  • The protective effects depended on specific bacterial groups, particularly Bacteroidetes, and were influenced by diet, highlighting how diet-microbiota interactions can rapidly impact obesity-related traits.]

Top posts

Most liked on X and Bluesky
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the #microbiome from the obese twin (but not the lean twin) into mice will make the mice obese. That's so cool! https://t.co/AQ3DPxgSAy https://t.co/HVcoOntU3p

May 22, 2021 · 32 likes · 6 shares · 108,832 followers View post →
Elisa Haas, MD
@ElisaAHaas · X

@DavidMacklinMD @jen_logue @AbdTahrani And when identical twins are discordant in weight? Still, very unlikely to be an issue of “self-control”, rather, perturbations on the gut microbiota may play a vital role: Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice https://t.co/REisUgPqbj

Feb 14, 2021 · 6 likes · 3 shares · 445 followers View post →
Nate
@BarstoolSyria · X

Transplanting gut bacteria from obese humans into germ-free mice made the mice gain more fat, even on the same diet. https://t.co/G3SoLjJ9ct https://t.co/Z2HGNE4ex7

Aug 14, 2025 · 3 likes · 2,290 followers View post →
Matt Quinn
@Mqsley · X

https://t.co/NO9Sg4wIEh

Jul 1, 2024 · 2 likes · 5,308 followers View post →
Federico
@Fedocles · X

@josephmjauregui Hay un paper muy interesante de gemelos discordantes en obesidad. Las bacterias de los flacos protegen a ratones sometidos a dietas ricas en grasas. Las bacterias se regulan por interacciones con el sistema inmune y ahí si somos todos distintos https://t.co/TXtg0w2xIE

Jan 26, 2022 · 1 like · 388 followers View post →
Ethan
@EthanCastr · X

@Outdoctrination I'm sure you've seen it, but just a reminder. Putting an obese human gut-microbiome makes mice obese. Putting lean human gut microbiome makes mice lean. https://t.co/f7aRWtPAiS

Aug 28, 2023 · 1 like · 356 followers View post →

All mentions

Nate
@BarstoolSyria · X

Transplanting gut bacteria from obese humans into germ-free mice made the mice gain more fat, even on the same diet. https://t.co/G3SoLjJ9ct https://t.co/Z2HGNE4ex7

Aug 14, 2025 · 3 likes · 2,290 followers View post →
aoifesimone
@aoifesimone · X

@radartabs @RichardJMurphy Not exactly. My mum is overweight, I'm not and yet my diet is way worse than hers. There are genetic and gastroenterological factors at play. Gut biome can influence weight. Studies on faecal transplants show this https://t.co/4mZqNp07B4

Oct 15, 2024 · 1 like · 294 followers View post →
Matt Quinn
@Mqsley · X

https://t.co/NO9Sg4wIEh

Jul 1, 2024 · 2 likes · 5,308 followers View post →
Chris
@ChrisThSlumpGod · X

@ayakawife @ouiouiapey https://t.co/Dq4AWFSj2C it could be because of the type of bacteria that lives in her gut

May 6, 2024 · 55 followers View post →
たろー|医師•研究者
@Ryotaro_Asano_ · X

https://t.co/LVNYzv7Rmp

Feb 28, 2024 · 235 followers View post →
上楠 木ノ子(あがりくす きのこ)
@kinoko_enfys · X

これは菜食VS動物食ではないんだけど、片方が肥満で片方がそうじゃない双子の腸内細菌を無菌(ノトバイオート)マウスに移植して、入れた細菌によってマウスの代謝が変わるかを調べた話 ついでに出てきたので貼っとく https://t.co/JmxbFHY6sg

Dec 24, 2023 · 621 followers View post →
Ethan
@EthanCastr · X

@Outdoctrination I'm sure you've seen it, but just a reminder. Putting an obese human gut-microbiome makes mice obese. Putting lean human gut microbiome makes mice lean. https://t.co/f7aRWtPAiS

Aug 28, 2023 · 1 like · 356 followers View post →
Calling It All Out
@WulfWords · X

https://t.co/Cw3clLlDZY

Jan 25, 2023 · 34 followers View post →
睡眠良くしたければケトジェニック!(低糖質&高脂質)|小林充典|睡眠歯科医療3000人・減量指導
@tolucky39 · X

参考文献 Gut microbiota from twins discordant for obesity modulate metabolism in mice https://t.co/qF7AIqVWFx デブ菌とヤセ菌の話

Dec 7, 2022 · 1,082 followers View post →
Federico
@Fedocles · X

@josephmjauregui Hay un paper muy interesante de gemelos discordantes en obesidad. Las bacterias de los flacos protegen a ratones sometidos a dietas ricas en grasas. Las bacterias se regulan por interacciones con el sistema inmune y ahí si somos todos distintos https://t.co/TXtg0w2xIE

Jan 26, 2022 · 1 like · 388 followers View post →
Dr Andrew Morrice - JoinedUpHealth
@JoinedUpDoc · X

@ellenfallows @BritSocLM it's an interesting paper - the bits of it I could understand at least! the practical point that emerges is that enriching the diet is only going to work if the right bugs are available to you in this regard it is very reminiscent of https://t.co/pAmeNEWTjr

Jul 13, 2021 · 223 followers View post →
Isatou Sarr
@IsatouSarr4 · X

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice https://t.co/yuBqbLSVMD

Jun 18, 2021 · 1 like · 35 followers View post →
HeartfulEarthCuisine
@HeartfulCuisine · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 23, 2021 · 6 shares · 1,426 followers View post →
Clare Noelle
@ClareNoelle · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 23, 2021 · 6 shares · 49 followers View post →
PC ⛓
@PC65049955 · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 22, 2021 · 6 shares · 1,466 followers View post →
LIYAN
@LIYAN93109461 · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 22, 2021 · 6 shares · 100 followers View post →
(D) (R) (I) Distancing
@StephaniePalosP · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 22, 2021 · 6 shares · 3,196 followers View post →
Alvaro Díaz
@LomoLais · X

RT @nicknorwitz: Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the…

May 22, 2021 · 6 shares · 425 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of Day 433: If a pair of human twins are discordant for obesity, i.e. one is obese and one is not, transplanting the #microbiome from the obese twin (but not the lean twin) into mice will make the mice obese. That's so cool! https://t.co/AQ3DPxgSAy https://t.co/HVcoOntU3p

May 22, 2021 · 32 likes · 6 shares · 108,832 followers View post →
Neil Floch MD
@NeilFlochMD · X

RT @ElisaAHaas: @DavidMacklinMD @jen_logue @AbdTahrani And when identical twins are discordant in weight? Still, very unlikely to be an iss…

Feb 14, 2021 · 3 shares · 130,107 followers View post →
Abd Tahrani
@AbdTahrani · X

RT @ElisaAHaas: @DavidMacklinMD @jen_logue @AbdTahrani And when identical twins are discordant in weight? Still, very unlikely to be an iss…

Feb 14, 2021 · 3 shares · 7,584 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @ElisaAHaas: @DavidMacklinMD @jen_logue @AbdTahrani And when identical twins are discordant in weight? Still, very unlikely to be an iss…

Feb 14, 2021 · 3 shares · 1,369 followers View post →
Elisa Haas, MD
@ElisaAHaas · X

@DavidMacklinMD @jen_logue @AbdTahrani And when identical twins are discordant in weight? Still, very unlikely to be an issue of “self-control”, rather, perturbations on the gut microbiota may play a vital role: Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice https://t.co/REisUgPqbj

Feb 14, 2021 · 6 likes · 3 shares · 445 followers View post →
上楠 木ノ子(あがりくす きのこ)
@kinoko_enfys · X

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice https://t.co/BVfIVkalIG こんな論文も読んだことがある

Oct 28, 2019 · 621 followers View post →
Dr. Eileen Choffnes
@EileenChoffnes · X

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice https://t.co/YMT3s7hg84

Jun 3, 2019 · 941 followers View post →