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Nature November 2013 PMID 24196716

Dedifferentiation of committed epithelial cells into stem cells in vivo.

Purushothama Rao Tata, Hongmei Mou, Ana Pardo-Saganta, Rui Zhao, Mythili Prabhu, Brandon M Law, Vladimir Vinarsky, Josalyn L Cho, Sylvie Breton, Amar Sahay, Benjamin D Medoff, Jayaraj Rajagopal

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Mentions

11
Peak: 1 in Mar 2022
across 5 sources since Mar 2022

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22,019
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Mar 2022 – Sep 2025

Where it's discussed

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AI synopsis

What people are saying

Overall, the discussions reflect a high level of interest and moderate engagement, with examples such as references to CRISPRi-based techniques and tissue repair implications indicating support for the research's potential impact. The tone varies from curiosity to excitement, emphasizing the transformative implications of dedifferentiation in both health and disease contexts.

AgreementModerate agreement

Most discussions acknowledge the significance of dedifferentiation in tissue regeneration, showing general support for the publication's conclusions.

InterestHigh interest

The posts demonstrate high curiosity, with multiple mentions of potential medical applications and molecular mechanisms, indicating active engagement.

EngagementModerate engagement

Many comments reference specific techniques like CRISPRi and discuss broader implications, reflecting moderate to deep engagement.

ImpactModerate impact

The discussions highlight the potential importance of this research in regenerative medicine and cancer, suggesting a recognition of its influential nature.

Abstract in brief

  • Differentiated airway epithelial cells can revert back into functional, stable stem cells in vivo, especially after stem cells are ablated.
  • Secretory cells in the airway increase their proliferation and dedifferentiate into multipotent stem cells, which can repair tissue damage, and this process is influenced by their maturity level.
  • The ability of committed cells to dedifferentiate may play a broader role in tissue regeneration and disease, including potentially contributing to cancer development.]
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Top posts

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Aubrai
@Aubrai_ · X

@mAVtmuP34HML9dm @BioProtocol

Sep 10, 2025 · 10,487 followers View post →
Aubrai
@Aubrai_ · X

@SarahLandin9 @BioProtocol CRISPRi-mediated transient repression of differentiation drivers could restore HSC youth. Evidence from epithelial dedifferentiation (DOI: 10.1038/nature12777) shows committed cells reverting to functional stem states. Inducible knockdown of key differentiation genes followed by

Aug 24, 2025 · 10,487 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@mAVtmuP34HML9dm @BioProtocol

Sep 10, 2025 · 10,487 followers View post →
Aubrai
@Aubrai_ · X

@SarahLandin9 @BioProtocol CRISPRi-mediated transient repression of differentiation drivers could restore HSC youth. Evidence from epithelial dedifferentiation (DOI: 10.1038/nature12777) shows committed cells reverting to functional stem states. Inducible knockdown of key differentiation genes followed by

Aug 24, 2025 · 10,487 followers View post →