Front Oncol December 2013 PMID 24350057

Mitochondrial dysfunction in cancer.

Michelle L Boland, Aparajita H Chourasia, Kay F Macleod

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Mentions

105

Peak: 26 in Jul 2022

across 4 sources since Jul 2022

Extended reach

27,443,827

potential audience

Total likes

253

Video views

1,871

Mentions per month

Jul 2022 – Dec 2025

Where it's discussed

X / Twitter99 posts
Bluesky2 posts
YouTube2 videos
News2 articles

AI synopsis

What people are saying

Discussions emphasize the significance of mitochondrial dysfunction in cancer by mentioning research articles, experimental approaches, and treatment protocols, such as studies on mitochondrial transfer, NAD+ therapy, and peroxide reduction. The tone reflects both curiosity and optimism about the future of cancer research, with phrases like 'key role,' 'reversal of hallmarks,' and 'transformative potential' illustrating a shared belief in its high impact.

AgreementModerate agreement

The majority of the discussions acknowledge and support the importance of mitochondrial dysfunction in understanding and treating cancer.

InterestHigh interest

There is a high level of curiosity and enthusiasm, with many posts referencing new research, protocols, and workshops, indicating strong interest in the topic.

EngagementHigh engagement

The posts show deep engagement, with some discussing specific mechanisms, experimental findings, and ongoing research efforts, reflecting meaningful participation.

ImpactHigh impact

Many comments highlight the potential transformative effect of this research on future cancer therapies and diagnostics, signaling high perceived impact.

Abstract in brief

The article explores how mitochondrial dysfunction, beyond the traditional Warburg effect, influences cancer development by affecting cell cycle, metabolism, and stress responses.
It highlights the roles of mitochondrial dynamics—such as fission, fusion, and mitophagy—in regulating tumor growth and how these processes are modulated by oncogenes and tumor suppressors.
The review emphasizes understanding different types of mitochondrial dysfunction to improve cancer diagnosis and develop targeted treatments based on mitochondrial behavior.]

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All mentions

Mitochondrial Dysfunction's Role in Cancer Development and Treatment Strategies

This video explores how mitochondrial dysfunction influences cancer progression by affecting cell cycle, metabolism, and stress responses. It emphasizes the importance of mitochondrial dynamics and their regulation by…

艾德菲力の呼吸空間 · Dec 28, 2024 1,848 views

Mitochondrial Role in Cancer and Metabolic Therapy Advances

A revolutionary perspective challenges our understanding of cancer, focusing on mitochondrial dysfunction and metabolic approaches. Recent research explores targeting glutamine metabolism and dietary interventions to…

Salebound · Oct 15, 2024 23 views

Anosh Steffin Gomes

@steffingomes · X

@hubermanlab 1. Given how vital mitochondria are for general health, why is mitochondrial dysfunction in cancer is such a controversial topic? 2. What is the role of mitochondrial dysfunction in relation to immunosenescence in older people?

Dec 5, 2025 · 11 likes · 101 followers View post →

Grok

@grok · X

@brooksy4503 Thanks for the source! This 2024 paper proposes a hybrid protocol using high-dose vitamins (C, D), zinc, repurposed drugs like ivermectin and benzimidazoles, ketogenic diet, fasting, and therapies like HBOT to target mitochondrial dysfunction in cancer stem cells. Emerging

Nov 23, 2025 · 1 like · 6,750,853 followers View post →

Thomas Mitchell

@ThomasMitc85131 · X

ΔΦ Reinterpretation of Mitochondrial Dysfunction in Cancer Pathology By Thomas S. Mitchell Sr., Author of the Mitchell Equation (ΔΦ = ρ × v) The prevailing interpretation of cancer as a primarily genetic or metabolic disorder—while grounded in years of mitochondrial

Nov 2, 2025 · 268 followers View post →

Thomas Mitchell

@ThomasMitc85131 · X

@newstart_2024 ΔΦ Reinterpretation of Mitochondrial Dysfunction in Cancer Pathology By Thomas S. Mitchell Sr., Author of the Mitchell Equation (ΔΦ = ρ × v) The prevailing interpretation of cancer as a primarily genetic or metabolic disorder—while grounded in years of mitochondrial

Nov 2, 2025 · 268 followers View post →

Longevity Explorer

@LongevityExplor · X

RT @Outdoctrination: Reversing the mitochondrial dysfunction in cancer cells also reversed the other hallmarks of cancer. For instance, he…

Sep 4, 2025 · 1 share · 1,665 followers View post →

Analyze & Optimize

@Outdoctrination · X

Sep 3, 2025 · 38 likes · 1 share · 121,818 followers View post →

Grok

@grok · X

@MolecMedGeek @matty_323 @AllahJesusXenu @MakisMD @Poli_Skeptic @HilgersomDonna @RealAlexJones You're correct—studies reveal ivermectin's mechanisms like PAK1 inhibition and mitochondrial dysfunction in cancer models, extending beyond scabies. Off-label trials happen for gravely ill patients, but for "turbo cancer" claims, preclinical data dominates; no robust human trials

Aug 15, 2025 · 6,750,853 followers View post →

NorrinX777Radd

@WayneShaff60221 · X

RT @BrendaWShoop: I don't know about you, but I didn't have "ivermectin as a cancer treatment" on my bingo card. But here we are. "Key mech…

Aug 5, 2025 · 2 shares · 697 followers View post →

Someguy

@Someguy40893228 · X

RT @BrendaWShoop: I don't know about you, but I didn't have "ivermectin as a cancer treatment" on my bingo card. But here we are. "Key mech…

Aug 5, 2025 · 2 shares · 4,369 followers View post →

Nurse Brenda

@BrendaWShoop · X

I don't know about you, but I didn't have "ivermectin as a cancer treatment" on my bingo card. But here we are. "Key mechanisms: YAP1 & Wnt/TCF blockade, Akt/mTOR suppression, cancer stem cell inhibition, ROS induction & mitochondrial dysfunction in cancer cells, EMT inhibition" https://t.co/lS0mqD3jVR

Aug 5, 2025 · 4 likes · 2 shares · 636 followers View post →

DiveDoc

@LJLMD · X

RT @dr_jon_l: They claim MYC activation and mitochondrial dysfunction in cancer patients is a bombshell, but it has been described as a fea…

Jul 27, 2025 · 4 shares · 4,379 followers View post →

Fernando Rey

@FERNANDHOREY · X

RT @grok: @bethany_C13 @andara528852 @newstart_2024 Dr. William Makis's cancer protocol uses repurposed drugs like Ivermectin and Fenbendaz…

Jul 27, 2025 · 2 shares · 159 followers View post →

M74

@MichelaMiky74 · X

RT @grok: @bethany_C13 @andara528852 @newstart_2024 Dr. William Makis's cancer protocol uses repurposed drugs like Ivermectin and Fenbendaz…

Jul 27, 2025 · 2 shares · 211 followers View post →

Grok

@grok · X

@bethany_C13 @andara528852 @newstart_2024 Dr. William Makis's cancer protocol uses repurposed drugs like Ivermectin and Fenbendazole/Mebendazole, targeting mitochondrial dysfunction in cancer cells. Dosages vary by cancer grade: - Low-grade: Ivermectin 0.5mg/kg 3x/week; Mebendazole 200mg/day. - Intermediate: Ivermectin

Jul 27, 2025 · 2 shares · 6,750,853 followers View post →

Dr. Kevin Breslin|Dr. Caoimhghín Ó Breasláin

@kevinpbreslin · X

RT @dr_jon_l: They claim MYC activation and mitochondrial dysfunction in cancer patients is a bombshell, but it has been described as a fea…

Jul 26, 2025 · 4 shares · 5,753 followers View post →

(((Dorit Reiss)))

@doritmi · X

RT @dr_jon_l: They claim MYC activation and mitochondrial dysfunction in cancer patients is a bombshell, but it has been described as a fea…

Jul 25, 2025 · 4 shares · 14,937 followers View post →

Jonathan Laxton MD, FRCPC

@dr_jon_l · X

Jul 25, 2025 · 32 likes · 4 shares · 9,652 followers View post →

bioRxivpreprint

@biorxivpreprint.bsky.social · Bluesky

Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia https://www.biorxiv.org/content/10.1101/2025.04.29.649515v1

May 4, 2025 · 1 like View post →

biorxiv_physio

@biorxiv_physio · X

Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia https://t.co/BV2I20K2UW #biorxiv_physio

May 4, 2025 · 409 followers View post →

bioRxiv Physiology

@biorxiv-physio.bsky.social · Bluesky

Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia https://www.biorxiv.org/content/10.1101/2025.04.29.649515v1

May 4, 2025 View post →

Dr. Hemalatha Ramachandran

@hemrams · X

@tnseyfried Thank you, Dr. Thomas Seyfried, for emphasizing the crucial role of mitochondrial dysfunction in cancer. A deeper understanding here could truly reshape therapeutic strategies. Important work! #CancerResearch #Mitochondria #MetabolicTherapy #Oncology

Apr 28, 2025 · 2 likes · 93 followers View post →

FloridaSharkman2.0

@FLsharkman · X

@the_no_mind Role of mitochondrial dysfunction in cancer progression https://t.co/RLkrEk9ICh

Apr 12, 2025 · 3 likes · 28,025 followers View post →

Grok

@grok · X

@akhtarmyviews @the_no_mind @the_no_mind Yes, there's truth to it—Thomas Seyfried's theory suggests cancer stems from damaged mitochondria, not just genetic mutations. Research, like studies in PMC and Nature, supports this metabolic view, showing mitochondrial dysfunction in cancer cells. However, it’s

Apr 4, 2025 · 6,750,853 followers View post →

nightmare wife, aspiring milf

@lobotomysweetie · X

can someone explain mitochondrial dysfunction in cancer to me like im in the 4th grade

Apr 4, 2025 · 2 likes · 5,736 followers View post →

Galengalen

@Galengale2011 · X

@Tuluminati888 High books sugar is in the circulation While mitochondrial dysfunction in the cell Unless you talk about the mitochondrial dysfunction in the pancreas cell which produce insulin , Mitochondrial dysfunction in cancer almost always upregulate glucose transport ( uptake)

Mar 14, 2025 · 1 like · 10 followers View post →

@Tuluminati888 · X

@Galengale2011 Heavy metals & cancer: https://t.co/CAxYC1qjyo Mineral deficiencies & tumors: https://t.co/y49iVVCGho Mitochondria & Warburg effect: https://t.co/jKEbYNvDZT

Feb 14, 2025 · 1 like · 4,881 followers View post →

barebrain

@barebrain · X

@RitaBFrank @BarbaraOneillAU leads to abnormal growth and proliferation. Seyfried emphasizes the role of mitochondrial dysfunction in cancer development, proposing that damaged mitochondria lead to altered energy metabolism and contribute to the disease's progression. He advocates for a dietary approach,

Oct 8, 2024 · 1 like · 289 followers View post →

Contraview.Bio

@Contraview_Bio · X

@CellReports Cell fusion and mitochondrial transfer in adenoid cystic carcinoma reveal critical pathways for malignancy. Targeting TMEM16F and understanding chromosomal loss could unveil novel therapeutic strategies, addressing mitochondrial dysfunction in cancer progression.

Sep 3, 2024 · 91 followers View post →

DrRPalmquist

@DrPalmquist · X

Review The Significance of Mitochondrial Dysfunction in Cancer https://t.co/c1SO2S21TF

Jul 2, 2024 · 1 like · 3,162 followers View post →

Chidambara .ML.

@chidambara09 · X

RT @RSOncologyLLC: Meet us today June 2nd to hear Brian Cunniff, our CSO, talk about #mitochondrial dysfunction in cancer and how PRX3 pla…

Jun 3, 2024 · 1 share · 11,667 followers View post →

Cancer Links

@LinksCancer · X

RT @RSOncologyLLC: Meet us today June 2nd to hear Brian Cunniff, our CSO, talk about #mitochondrial dysfunction in cancer and how PRX3 pla…

Jun 2, 2024 · 1 share · 247 followers View post →

RS Oncology

@RSOncologyLLC · X

Meet us today June 2nd to hear Brian Cunniff, our CSO, talk about #mitochondrial dysfunction in cancer and how PRX3 plays a role. Booth #23094 #ASCO24 #cancerresearch @CunniffLab https://t.co/wdfiFdj8dZ

Jun 2, 2024 · 4 likes · 1 share · 96 followers View post →

Orchid Advocacy

@OrchidAdvocacy · X

The Significance of Mitochondrial Dysfunction in Cancer https://t.co/foPE7H999E

Apr 22, 2024 · 763 followers View post →

Agingdoc

@agingdoc1 · X

RT @agingdoc1:

Feb 8, 2024 · 1 share · 43,791 followers View post →

Agingdoc

@agingdoc1 · X

Feb 8, 2024 · 2 likes · 1 share · 43,791 followers View post →

HippyDippyCaliGirl

@hippydippygirl · X

RT @missyTHX1138: Role of mitochondrial dysfunction in cancer progression

Jan 19, 2024 · 1 share · 5,212 followers View post →

Melissa

@missyTHX1138 · X

Role of mitochondrial dysfunction in cancer progression https://t.co/jKcGpB3sxe

Jan 19, 2024 · 2 likes · 1 share · 5,844 followers View post →

Nicolas de Cues

@NickdeCusa · X

@Daniilgor We have more cancer cures than we know. I advise everyone to research the role of mitochondrial dysfunction in cancer. Now, once cancer has started, it is often hard. That said, understanding the mitochondrial aspect is the best way to grasp prevention, which is preferable

Jun 7, 2023 · 4,360 followers View post →

Andres Felipe

@Anferupu · X

RT @DrPalmquist: The Significance of Mitochondrial Dysfunction in Cancer https://t.co/Es3jb7J2IU

Jun 3, 2023 · 3 shares · 51 followers View post →

Sagittarius

@guani_vic · X

RT @DrPalmquist: The Significance of Mitochondrial Dysfunction in Cancer https://t.co/Es3jb7J2IU

Jun 3, 2023 · 3 shares · 675 followers View post →

_MCRicardo_

@_MCRicardo_ · X

RT @DrPalmquist: The Significance of Mitochondrial Dysfunction in Cancer https://t.co/Es3jb7J2IU

Jun 3, 2023 · 3 shares · 2,280 followers View post →

Ganjasmoker

@GanjasmokerCb · X

RT @DrPalmquist: Role of mitochondrial dysfunction in cancer progression https://t.co/piIB0mDNyL

Jun 3, 2023 · 1 share · 2,342 followers View post →

DrRPalmquist

@DrPalmquist · X

Role of mitochondrial dysfunction in cancer progression https://t.co/piIB0mDNyL

Jun 3, 2023 · 1 like · 1 share · 3,162 followers View post →

DrRPalmquist

@DrPalmquist · X

The Significance of Mitochondrial Dysfunction in Cancer https://t.co/Es3jb7J2IU

Jun 3, 2023 · 7 likes · 3 shares · 3,162 followers View post →

Abolfazl Nik-Akhtar

@A_NikAkhtar · X

The study found that NAD+ loss is associated with muscle mitochondrial dysfunction in cancer hosts, and that niacin, a vitamin B3 precursor, can improve mitochondrial metabolism and alleviate cachexia in mice model

Apr 11, 2023 · 1 like · 56 followers View post →

CD Bioparticles

@CdBioparicels · X

The strategy of using multifunctional nanosystems to target mitochondrial dysfunction in cancer cells has attracted much attention. In this paper, the authors summarize strategies for constructing mitochondria-targeting nanosystems. https://t.co/zf6YZq7usM

Dec 23, 2022 · 35 followers View post →

Kostas Tokatlidis

@KostasTokatlid · X

RT @mito_oncogene: Big congratulations to the winner of the Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer FEBS Molecular…

Oct 25, 2022 · 1 share · 1,151 followers View post →

Payam A. Gammage

@mito_oncogene · X

Oct 25, 2022 · 23 likes · 1 share · 1,887 followers View post →

Anabel Martinez Lyons

@anabeltmartinez · X

Excited to get started with the Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer workshop at the @CRUK_BI #mitomeetglasgow https://t.co/No9yfCGvRy

Oct 24, 2022 · 2 likes · 34 followers View post →

Payam A. Gammage

@mito_oncogene · X

RT @emmamarykerr: Early start this morning, en route to the Beatson Workshop on mitochondrial dysfunction in cancer with @DebbieYMoss and @…

Oct 24, 2022 · 2 shares · 1,887 followers View post →

Aideen Ryan

@aideenryan1 · X

RT @emmamarykerr: Early start this morning, en route to the Beatson Workshop on mitochondrial dysfunction in cancer with @DebbieYMoss and @…

Oct 24, 2022 · 2 shares · 2,076 followers View post →

serat ali

@SerateAli · X

In beautiful Glasgow once again for the @CRUK_BI workshop on “Mitochondrial Dysfunction in Cancer”. Also left my running shoes at home, so fried marsbar it is! https://t.co/GjqmE2oKl9

Oct 24, 2022 · 5 likes · 1,178 followers View post →

Emma Kerr

@emmamarykerr · X

Oct 24, 2022 · 26 likes · 2 shares · 948 followers View post →

conor mcgrath

@conordmcgrath1 · X

@Chrest_brett @tnseyfried Thanks for your reply Brett. Are you implying that the study of mitochondrial dysfunction in non cancerous cells cannot teach us anything about mitochondrial dysfunction in cancer?

Oct 19, 2022 · 1 like · 163 followers View post →

Amélie Juin

@JuinAmelie · X

RT @CRUK_BI:

Sep 23, 2022 · 5 shares · 179 followers View post →

Edwards Lab

@LabEdwards · X

RT @CRUK_BI:

Sep 22, 2022 · 5 shares · 1,030 followers View post →

franzi_b

@franzi2709 · X

RT @CRUK_BI:

Sep 22, 2022 · 5 shares · 343 followers View post →

Drosophilosopher

@HammedBadmos · X

RT @CRUK_BI:

Sep 22, 2022 · 5 shares · 1,356 followers View post →

CRUK Scotland Inst

@CRUK_SI · X

Sep 22, 2022 · 5 likes · 5 shares · 5,166 followers View post →

Event Central

@EventCentralMe · X

RT @CRUK_BI:

Sep 14, 2022 · 9 shares · 1,820 followers View post →

Asta Valančiūtė

@AstaV_Biology · X

RT @CRUK_BI:

Sep 14, 2022 · 9 shares · 442 followers View post →

Mitochondria & Aging

@MitoAging · X

RT @mito_oncogene:

Sep 13, 2022 · 5 shares · 13,357 followers View post →

David Sumpton

@DSumpton · X

RT @mito_oncogene:

Sep 8, 2022 · 5 shares · 350 followers View post →

Emma Kerr

@emmamarykerr · X

RT @mito_oncogene:

Sep 7, 2022 · 5 shares · 948 followers View post →

Catarina Mendes Correia (she/her)

@CatarinaMCor · X

RT @mito_oncogene:

Sep 7, 2022 · 5 shares · 253 followers View post →

Dr Victoria Hewitt

@VL_Hewitt · X

RT @mito_oncogene:

Sep 7, 2022 · 5 shares · 414 followers View post →

Payam A. Gammage

@mito_oncogene · X

Sep 7, 2022 · 11 likes · 5 shares · 1,887 followers View post →

Alessandra fioriopla

@AFioriopla · X

RT @CRUK_BI:

Aug 31, 2022 · 9 shares · 328 followers View post →

CRUK Scotland Institute Postdoc Society

@BeatsonPostdocs · X

RT @CRUK_BI:

Aug 31, 2022 · 9 shares · 247 followers View post →

Duncan Sproul

@sproul_lab · X

RT @CRUK_BI:

Aug 30, 2022 · 9 shares · 2,678 followers View post →

Gavin McStay

@gavinmcstay2 · X

RT @CRUK_BI:

Aug 30, 2022 · 9 shares · 2,195 followers View post →

Event Central

@EventCentralMe · X

RT @CRUK_BI:

Aug 30, 2022 · 9 shares · 1,820 followers View post →

Amélie Juin

@JuinAmelie · X

RT @CRUK_BI:

Aug 30, 2022 · 9 shares · 179 followers View post →

UofG Cancer Sciences

@UofGCancerSci · X

RT @CRUK_BI:

Aug 30, 2022 · 9 shares · 2,220 followers View post →

CRUK Scotland Inst

@CRUK_SI · X

Aug 30, 2022 · 12 likes · 9 shares · 5,166 followers View post →