Acta Physiol (Oxf) March 2014 PMID 24387247

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle.

M V Franchi, P J Atherton, N D Reeves, M Flück, J Williams, W K Mitchell, A Selby, R M Beltran Valls, M V Narici

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Peak: 6 in Oct 2019

across 4 sources since Oct 2019

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What people are saying

Discussions reflect strong interest and moderate engagement with mentions of molecular pathways such as p38 MAPK activation, and references to specific experimental approaches like MRI and 3D ultrasound, illustrating the importance and potential influence of the research in understanding muscle adaptation.

AgreementModerate agreement

Most discussions acknowledge and support the research findings, indicating a consensus on its relevance.

InterestHigh interest

Posts express high curiosity and enthusiasm about the detailed analysis of muscle responses and molecular mechanisms.

EngagementModerate engagement

Comments include references to methodologies, molecular pathways, and ongoing research, showing active engagement.

ImpactModerate impact

The discussions suggest that the research could influence future studies and practical applications in sports science and medicine.

Abstract in brief

The study compared how human skeletal muscle responds to 10 weeks of concentric (CON) and eccentric (ECC) resistance training, finding similar increases in muscle size and strength, but different muscle architectural changes.
ECC training led to greater increases in fascicle length, especially in distal regions of the vastus lateralis, while CON training resulted in larger increases in pennation angle.
Molecular responses showed that ECC-specific p38 MAPK activation occurred without differences in other growth or inflammatory pathways, indicating distinct molecular mechanisms underlying muscle growth from each training mode.]

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All mentions

Are Cheat Reps a Smart Training Strategy for Muscle Growth?

My polite and dramafree defense of cheat reps. The study compares concentric and eccentric training effects on muscle size, strength, and molecular responses, highlighting the importance of understanding different…

Geoffrey Verity Schofield · Jan 13, 2022 126,948 views

Comparing Muscle Growth from Concentric and Eccentric Resistance Training

This video discusses the hypertrophic effects of concentric versus eccentric muscle actions, analyzing their impact on muscle size and strength based on recent research.

筋トレの科学【理学療法士リョウ】 · Sep 16, 2023 35,085 views

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@iamojsn · X

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle - PubMed https://t.co/8ZhKxobk7r

Oct 29, 2025 · 1 like · 15,008 followers View post →

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@iamojsn · X

RT @iamojsn: あとはこんなのとか。 Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle - P…

Mar 26, 2025 · 2 shares · 15,008 followers View post →