Sci Transl Med January 2014 PMID 24401940

Altered placebo and drug labeling changes the outcome of episodic migraine attacks.

Slavenka Kam-Hansen, Moshe Jakubowski, John M Kelley, Irving Kirsch, David C Hoaglin, Ted J Kaptchuk, Rami Burstein

Mentions

160
Peak: 8 in May 2021
across 6 sources since Nov 2019

Extended reach

36,477
potential audience

Total likes

34

Video views

251

Mentions per month

Nov 2019 – Jul 2025

Where it's discussed

  • News113 articles
  • Blogs18 articles
  • X / Twitter16 posts
  • Facebook9 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions frequently mention how altered labeling can change the efficacy of treatments, citing specific examples like the placebo effects accounting for over 50% of drug responses, which demonstrates both interest and impact. The tone emphasizes the importance of belief and perception in medical efficacy, supported by references to rigorous studies and their implications for clinical practice.

AgreementModerate agreement

Most discussions emphasize the significance of the study, supporting the idea that patient perceptions and labeling influence migraine treatment outcomes.

InterestHigh interest

The posts show high curiosity and engagement, referencing detailed study findings and implications for medical practice.

EngagementHigh engagement

Participants delve into methodological details and real-world implications, indicating deep engagement with the topic.

ImpactHigh impact

The discussions highlight the potential for changing treatment approaches and understanding placebo effects on health outcomes, reflecting high impact.

Abstract in brief

  • The study found that varying the information given to patients about their medication (negative, neutral, positive) significantly influenced the effectiveness of both placebo and actual drug (Maxalt) in treating migraine attacks.
  • Maxalt was more effective than placebo overall, but the perceived efficacy of placebo increased with more positive labeling, showing that patient expectations play a crucial role in treatment outcomes.
  • The findings suggest that the way treatments are presented and the act of taking medication have substantial therapeutic effects, with positive information enhancing treatment benefits even when no active drug is involved.]

Top posts

Most liked on X and Bluesky
Arturo Goicoechea
@argoicoechea · X

El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan. Altered placebo and drug labeling changes the outcome of episodic migraine attacks https://t.co/imEhhn55VV

May 21, 2021 · 28 likes · 7 shares · 10,940 followers View post →
Asset Management & Export Credits Agency
@TheVolkan7 · X

Kam-Hansen et al., Science Translational Medicine (2014) https://t.co/YinStSwVup The Migraine Study: The Power of Beliefs In one of the most elegant placebo-controlled studies ever conducted, researchers tracked 66 individuals across seven migraine attacks. Each person received https://t.co/xQ3eEPWJls

Jul 13, 2025 · 3 likes · 1 share · 2,219 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/UQm2LxRz4r La alteración del etiquetado de placebo y fármacos modifica el resultado de los ataques de migraña episódica

Aug 20, 2023 · 8,029 followers View post →
GoiGroup
@goi_group · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 2,631 followers View post →
Jeff Headache Ctr
@JeffHeadacheCtr · X

@rburstein16 reviewing the science of placebo and relevance to headache medication, starting with the brilliant rizatriptan - placebo study. Placebo/labeling provided 50% of the drug effect! https://t.co/hLxW4vdgtZ

Nov 23, 2019 · 2,506 followers View post →
mark
@markmulvey · X

"The efficacy of open-label placebo was superior to that of no treatment. Relative to no treatment, the placebo, under each information condition, accounted for more than 50% of the drug effect." https://t.co/wbi9Biwrpp

Aug 16, 2024 · 2,213 followers View post →

All mentions

Export Credits Agency & &Asset Management Advisor
@VolkanK69 · X

RT @TheVolkan7: Kam-Hansen et al., Science Translational Medicine (2014) https://t.co/YinStSwVup The Migraine Study: The Power of Beliefs…

Jul 13, 2025 · 1 share · 2,142 followers View post →
Asset Management & Export Credits Agency
@TheVolkan7 · X

Kam-Hansen et al., Science Translational Medicine (2014) https://t.co/YinStSwVup The Migraine Study: The Power of Beliefs In one of the most elegant placebo-controlled studies ever conducted, researchers tracked 66 individuals across seven migraine attacks. Each person received https://t.co/xQ3eEPWJls

Jul 13, 2025 · 3 likes · 1 share · 2,219 followers View post →
John Maki
@John_W_Maki · X

Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks | Science Translational Medicine https://t.co/19RV0Uo5Li

Jun 6, 2025 · 247 followers View post →
mark
@markmulvey · X

"The efficacy of open-label placebo was superior to that of no treatment. Relative to no treatment, the placebo, under each information condition, accounted for more than 50% of the drug effect." https://t.co/wbi9Biwrpp

Aug 16, 2024 · 2,213 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/UQm2LxRz4r La alteración del etiquetado de placebo y fármacos modifica el resultado de los ataques de migraña episódica

Aug 20, 2023 · 8,029 followers View post →
Człowiek z betonu
@polanskey · X

@patrycjusz220 Nie będę tłumaczył dlaczego rytuał brania lekow pomaga w ich działaniu. Na pewno nie ma to nic wspolnego z "wiarą w leki", prawda? https://t.co/dRPIyPNEMp

Nov 4, 2022 · 611 followers View post →
森丘 保典
@moriyasu1123 · X

@marxindo 「コーチング」関連の授業で紹介しながら「この論文から導き出される教訓はなにか?」と聞いたりしています。 https://t.co/5h9IeyeGka

Aug 3, 2022 · 1,150 followers View post →
Maite Ferran
@FerranMaite · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 22, 2021 · 7 shares · 29 followers View post →
M Antonia Pitarch
@mantoniapipe · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 22, 2021 · 7 shares · 21 followers View post →
Dani Fariñas
@DaniFaEn · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 118 followers View post →
Mauricio Bujáse
@MauMoreen · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 298 followers View post →
Fernando Alonso
@Bolaredo · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 2,107 followers View post →
Apa
@AlpalBe · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 850 followers View post →
GoiGroup
@goi_group · X

RT @argoicoechea: El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan…

May 21, 2021 · 7 shares · 2,631 followers View post →
Arturo Goicoechea
@argoicoechea · X

El poder de la información: un triptan informado como placebo tiene el mismo efecto que un placebo informado como triptan. Altered placebo and drug labeling changes the outcome of episodic migraine attacks https://t.co/imEhhn55VV

May 21, 2021 · 28 likes · 7 shares · 10,940 followers View post →
Jeff Headache Ctr
@JeffHeadacheCtr · X

@rburstein16 reviewing the science of placebo and relevance to headache medication, starting with the brilliant rizatriptan - placebo study. Placebo/labeling provided 50% of the drug effect! https://t.co/hLxW4vdgtZ

Nov 23, 2019 · 2,506 followers View post →