Cell Metab February 2014 PMID 24440038

Fasting: molecular mechanisms and clinical applications.

Valter D Longo, Mark P Mattson

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267

Peak: 21 in Sep 2022

across 6 sources since Dec 2017

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The discussions demonstrate high interest and engagement, with comments referencing specific studies like Longo and Mattson’s work, describing fasting's effects on longevity and health, and sharing personal or community experiences with the practice, highlighting both scientific enthusiasm and practical relevance.

AgreementModerate agreement

Most discussions support the scientific findings on fasting’s benefits, with several emphasizing its anti-aging and health-promoting potential.

InterestHigh interest

The posts show high curiosity, referencing molecular mechanisms, clinical applications, and new research, indicating strong interest.

EngagementHigh engagement

Posts include mentions of detailed research, personal experiments, and invitations to conferences, reflecting deep engagement.

ImpactModerate impact

Participants perceive the publication as influential in advancing understanding of fasting’s health benefits, though some skepticism remains.

Abstract in brief

Fasting has been practiced for thousands of years, but recent research shows it plays a key role in cellular responses that reduce damage and inflammation, improve energy use, and strengthen cell protection.
In lower organisms like yeast and worms, long-term fasting can extend lifespan by changing how cells handle stress and metabolism; in rodents, intermittent fasting helps prevent diseases such as diabetes, cancer, and neurodegeneration.
In humans, fasting can aid in reducing obesity, high blood pressure, asthma, and rheumatoid arthritis, showing its potential to slow aging and prevent or treat various health conditions with fewer side effects compared to continuous dieting.

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Intermittent Fasting: Effects on Brain Health and Well-Being

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Effective Muscle Bulking During Fasting Ramadan Tips and Strategies

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Effects of Intermittent Fasting on Weight Loss and Metabolic Health

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Exploring Intermittent Fasting: Health Benefits and Cognitive Effects

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Life Science Stories · Jun 23, 2024 1,859 views

Health Benefits and Methods of Intermittent Fasting Explained

Intermittent fasting is gaining popularity, particularly the 16:8 method where 16 hours are fasted and 8 hours are designated for eating. This episode explores the health benefits of intermittent fasting, its…

Satte Sache · Aug 19, 2021 1,809 views

Intermittent Fasting and Gut Microbiota's Role in Autoimmune Protection

Intermittent fasting reduces MS severity by altering gut bacteria like Lactobacillaceae and Prevotellaceae, and modulating immune responses to decrease inflammation and promote regulation, as shown in mouse models and…

Prof. Pedro Artur · Jul 29, 2018 1,392 views

Fasting Mechanisms and Clinical Benefits Explained

Fasting has been practiced for thousands of years, influencing cellular responses to reduce damage and inflammation, enhance energy metabolism, and promote cell protection. Recent studies highlight its potential in…

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Fasting's Molecular Mechanisms and Health Benefits Explained

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Fasting: Molecular Mechanisms and Clinical Benefits Explored

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Intermittent Fasting Benefits and Risks for Health and Longevity

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Understanding the Metabolic Benefits of Intermittent Fasting in Health Improvement

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Clinical Nutrition 17 · Aug 23, 2020 141 views

Cellular Benefits of Fasting for Disease Prevention and Longevity

Fasting has been practiced for thousands of years and plays a key role in reducing damage and inflammation, improving energy use, and strengthening cell protection. Recent research highlights its potential in disease…

The Bunk · Dec 3, 2017 129 views

Unlocking Autophagy for Weight Loss and Metabolic Health

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Dr. Jess Bilger · Apr 14, 2025 45 views

Optimizing Autophagy Through Intermittent Fasting for Health and Metabolism

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Dr. Jess Bilger · Apr 17, 2025 30 views

Fasting Benefits for Cancer Treatment and Cell Protection Strategies

Fasting has been shown to reduce damage and inflammation, enhance energy utilization, and boost cell protection, potentially improving outcomes in cancer therapy and overall health management.

De Dioses · Feb 28, 2023 23 views

Hypertonic Autophagy During Ramadan Fasting Explained

This video explains hypertonic autophagy during Ramadan, highlighting its role in cellular responses that reduce damage, inflammation, and improve energy use, with implications for health and aging.

chibani salim · Apr 24, 2022 21 views

Understanding Chronotherapy and Social Jet Lag Effects on Health

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Fasting Triggers Rapid Cellular Repair and Detoxification

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Effective Intermittent Fasting Method for Rapid Weight Loss and Health Improvement

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Intermittent Fasting Induces Fat Browning and Combats Obesity

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Effects of Intermittent Fasting on Metabolism and Hormonal Health

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Dr. Joel P. Rutkowski- President

@RutkowskiDr · X

6. PMC - PubMed Central. "Fasting: Molecular Mechanisms and Clinical Applications." https://t.co/mwuDUNjQsU 7. American Heart Association Newsroom. "8-hour time-restricted eating linked to a 91 percent higher risk of cardiovascular death." https://t.co/VRCwHNNcRH

Jul 1, 2025 · 466 followers View post →

bo☆♡

@Bos_Edtwt · X

Oct 20, 2024 · 3 likes · 292 followers View post →

Deadly Zen

@deadlyZen_ · X

@chiragbarjatyaa Research Papers: 1- Autophagy in Human Health and Disease" by Mizushima, N., & Komatsu, M. - New England Journal of Medicine 2- Fasting: Molecular Mechanisms and Clinical Applications" by Longo, V. D., & Mattson, M. P. - Cell Metabolism Contd..

Sep 13, 2024 · 88 followers View post →

Sidetracked

@SDAFS56788141 · X

@mgoldenboyz @deadcatbottom @adamscrabble Maybe you just don't know much about it and instead of being incredulous, be curious. Longo, V. D., & Mattson, M. P. (2014). Fasting: Molecular mechanisms and clinical applications.Cell Metabolism, 19(2), 181-192. This review discusses the molecular and physiological

Sep 2, 2024 · 1 like · 501 followers View post →

Scott Fuller

@ScottLsu · X

@GI_Pearls @CMichaelGibson Suggest review from VD Longo and MP Mattson in Cell. Fasting is not CR to a different degree; it's different in kind. https://t.co/fUDIO1a0ix

May 31, 2024 · 17 followers View post →

Nathalia Le Hen

@NathaliaLeHen · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 6, 2023 · 8 shares · 2,710 followers View post →

Javed Alam

@jalam1001 · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 5, 2023 · 8 shares · 1,010 followers View post →

John T Weatherly

@jtwheat27 · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 4, 2023 · 8 shares · 5,005 followers View post →

AKSHAY

@Danaveni_Akshay · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 4, 2023 · 8 shares · 114 followers View post →

Alex Ojeda-Aravena

@AOjeda_Aravena · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 4, 2023 · 8 shares · 95 followers View post →

daniel varela PhD

@dr_dvarela_P4T · X

RT @Jozo_Grgic: Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 4, 2023 · 8 shares · 927 followers View post →

Jozo Grgic

@Jozo_Grgic · X

Fasting: Molecular Mechanisms and Clinical Applications https://t.co/biKX25pPfR https://t.co/4a45jc8f5c

Aug 4, 2023 · 32 likes · 8 shares · 5,462 followers View post →

Eating Savvy

@EatingSavvy · X

Intermittent fasting may have anti-aging effects and promote longevity. Source: Longo VD, Mattson MP. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-192. #AntiAging #healthylifestyle #Intermittentfasting

May 28, 2023 · 44 followers View post →

mobina.selki

@mobina_selki · X

@usiriss شما واقعا پزشکی؟ میشه یه کم مطالعه داشته باشید حداقل آبروی صنف نره https://t.co/OstHayRRXD https://t.co/vvqpHeW4Mm https://t.co/X590EotUtW https://t.co/vzNLWTjo72 https://t.co/XZj3K2j4DS

Apr 4, 2023 · 903 followers View post →

Chandrasekaran

@dramcsekar · X

RT @agingdoc1: Fasting: Molecular Mechanisms and Clinical Applications (2014) Valter Longo1 and Mark P. Mattson https://t.co/wiw2V9KTMD h…

Mar 2, 2023 · 4 shares · 381 followers View post →

Christophe Wyns

@christophewyns · X

@InvestigationRF Je ne sais pas si ça couvre l'endométriose, mais le jeûne a bien des vertus scientifiquement prouvées https://t.co/2h9SVYt8KF https://t.co/VPOdCU00CU https://t.co/c5mpjPq6h5 https://t.co/CxB4jbdEXp https://t.co/gnOjQWJspM https://t.co/I1jVPwY6Cg

Nov 16, 2022 · 371 followers View post →

Christophe Wyns

@christophewyns · X

@ordre_medecins @franceinter @InvestigationRF @radiofrance Oui oui je sais, ça vous fait chier qu'un truc gratuit comme le jeûne aie des vertus médicales évidentes qui ne vous rapporteront pas d'argent, qui peuvent vous faire perdre des clients... https://t.co/gnOjQWJspM

Nov 16, 2022 · 2 likes · 371 followers View post →

Camarada Vero

@galenavero · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 24, 2022 · 20 shares · 596 followers View post →

Susan Gutierrez

@Gutierrez_Susy · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 24, 2022 · 20 shares · 28 followers View post →

Doña Raggedy ANN

@AnicilloPaz · X

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Sep 24, 2022 · 20 shares · 559 followers View post →

Kary Barba

@NutKary · X

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Sep 24, 2022 · 20 shares · 326 followers View post →

Nutrióloga Clínica Magaly Lizaola

@MaggyLizaola · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 24, 2022 · 20 shares · 1,797 followers View post →

Iván

@yakidama_ivan · X

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Carlos

@de_montecristo · X

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Sep 24, 2022 · 20 shares · 2,749 followers View post →

D r a k o

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claimshero.eth

@claimshero__eth · X

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Sep 24, 2022 · 20 shares · 129 followers View post →

Dr. Andres Bailon

@ecuaholanda · X

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Sep 23, 2022 · 20 shares · 112 followers View post →

Sputnik my love ...

@SputnikMyLove_ · X

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Jorge Ahumada Tello

@KoKe_Tello · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 23, 2022 · 20 shares · 105 followers View post →

Pablo Maure Inmunoterapia

@PInmunoterapia · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 23, 2022 · 20 shares · 1,513 followers View post →

Raul Ortiz

@DoctorRaulOrtiz · X

RT @IberianCitizen: Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 23, 2022 · 20 shares · 278 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Fasting: Molecular Mechanisms and Clinical Applications (2014) Valter Longo1 and Mark P. Mattson https://t.co/wiw2V9KTMD h…

Sep 23, 2022 · 4 shares · 133 followers View post →

Farfalla

@Farfall18256348 · X

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Sep 23, 2022 · 20 shares · 84 followers View post →

anita chula

@pipitachula · X

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Sep 23, 2022 · 20 shares · 313 followers View post →

IberianCitizen

@IberianCitizen · X

Ayuno: mecanismos moleculares y aplicaciones clínicas

Sep 23, 2022 · 44 likes · 20 shares · 12,928 followers View post →

ComunidadLongevidad

@Com_longevidad · X

RT @agingdoc1: Fasting: Molecular Mechanisms and Clinical Applications (2014) Valter Longo1 and Mark P. Mattson https://t.co/wiw2V9KTMD h…

Sep 23, 2022 · 4 shares · 16 followers View post →

BillOckham

@BillOccham0 · X

RT @agingdoc1: Fasting: Molecular Mechanisms and Clinical Applications (2014) Valter Longo1 and Mark P. Mattson https://t.co/wiw2V9KTMD h…

Sep 23, 2022 · 4 shares · 593 followers View post →

Agingdoc

@agingdoc1 · X

Fasting: Molecular Mechanisms and Clinical Applications (2014) Valter Longo1 and Mark P. Mattson https://t.co/wiw2V9KTMD https://t.co/ULB2cMZdvw

Sep 23, 2022 · 6 likes · 4 shares · 41,194 followers View post →

Glory Dey

@GloryDey1 · X

#life #health #fitness: Intermittent Fasting Impact On Circadian Rhythm, Chronic Pain, & Depression Relief! by Doc Snipes #YouTube #Video Impact Details On Brain Metabolism, Neuroplasticity, Moods, Obesity, Curing Diseases, Injury Healing, Body Functions! https://t.co/WksM0y6je2

Jul 29, 2022 · 1,534 followers View post →

AllCEUs Counselor Education with Dawn-Elise Snipes

@AllCEUs · X

Live premier with Doc Snipes at 4pm EST today! Mental (and Physical) Health Benefits of Intermittent Fasting. https://t.co/b9juXeK6KS https://t.co/sNGv3Fqixm

Jul 18, 2022 · 1,682 followers View post →

Carlo Brescia Seminario

@cbrescia · X

Fasting: Molecular Mechanisms and Clinical Applications https://t.co/DhG9VmDiSd

Jan 31, 2022 · 743 followers View post →

23C JAPAN×COACER 清水麗子

@gracecrea_reiko · X

若返り・不老長寿チャンネルシリーズ最終話 YouTube公開しました

Oct 22, 2021 · 2 likes · 1 share · 826 followers View post →

Orlando_uy

@Orlando_uy · X

Review Fasting: Molecular Mechanisms and Clinical Applications. https://t.co/ROr2Zc8rGS

Oct 7, 2021 · 689 followers View post →

TN-BNYS Association

@TnBnys · X

RT @DrpraveenJacob1: Dear Friends, First International online conference on August 16th 2020 (10AM- 5PM). Fasting; Molecular Mechanisms…

Aug 2, 2020 · 1 share · 258 followers View post →

Dr.Praveen Jacob

@DrpraveenJacob1 · X

Aug 2, 2020 · 7 likes · 1 share · 95 followers View post →

@JohnJRambo

@JohnJRambo91 · X

@enbuyukcimbom21 @abs5534 @95keremdmr @lordsinov İki gram aklın olsaydi internetten bir araştırma yapardın. Modern tıp orucun faydaları ile ilgili yüzlerce makale yayınlamış. Bu yobazlığı bıraka ekteki Amerikan bilim adamlarının yayını bir araştır. https://t.co/X6GnEcjh60

Apr 14, 2020 · 1 like · 9 followers View post →

Lewis Woods, MD

@olentheus · X

Fasting: Molecular Mechanisms and Clinical Applications https://t.co/oGidVPu9Xj

Dec 27, 2019 · 80 followers View post →

The Fasting Blog

@thefastingblog · X

In healthy subjects, five-day #FMD cycles are well-tolerated; preliminary feasibility studies in self-selected #cancer patients suggest they do not induce any significant side effects and may improve quality of life. #FastingMimickingDiet #Chemotherapy https://t.co/E3hTVK1N1p

Jul 29, 2019 · 1 like · 1 share · 1,202 followers View post →

Jamaal Williams

@DiseaseFreeBody · X

CrossFit | Fasting and Cancer: Molecular Mechanisms and Clinical Applications https://t.co/Dbxt6Z2Rix

Jun 25, 2019 · 57 followers View post →

DespachoLegal

@despacholegal1 · X

#Dieta #Nutricion #cancer https://t.co/DReNJTuuOY

May 28, 2019 · 505 followers View post →

Julio Gutierrez

@JulioInStudio · X

https://t.co/Vc4wlaWIUo

May 28, 2019 · 1,663 followers View post →

Darma Made

@darmamade · X

Fasting: Molecular Mechanisms and Clinical Applications https://t.co/jiZzNHKTsC

Apr 15, 2019 · 732 followers View post →

Alex Flores

@Dr_alexflores · X

@RosNavas Y se está descubriendo que seguir las prácticas bíblicas mejora la calidad de vida y la supervivencia. Mattson, MP (4 de febrero de 2014). «Fasting: molecular mechanisms and clinical applications». Cell Metabolism 19 (1932-7420): 181-92. PMID 24440038. doi:10.1016/j.cmet.

Apr 6, 2019 · 1 like · 138 followers View post →

Fasting: molecular mechanisms and clinical applications.

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