Chem Biol March 2014 PMID 24529992

Vitamin D metabolism, mechanism of action, and clinical applications.

Daniel D Bikle

Mentions

44
Peak: 1 in Apr 2020
across 5 sources since Apr 2020

Extended reach

10,679
potential audience

Total likes

21

Video views

533

Mentions per month

Apr 2020 – Aug 2025

Where it's discussed

  • News30 articles
  • Facebook6 posts
  • X / Twitter4 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone reflects curiosity and appreciation for the detailed mechanisms, such as comments about UVB exposure variability affecting vitamin D synthesis, and references to the importance of understanding dosage requirements, exemplifying attentive engagement with the research's practical and scientific relevance.

AgreementModerate agreement

Most discussions agree that vitamin D metabolism is complex and relevant, as evidenced by supportive comments referencing the detailed mechanisms and clinical importance.

InterestHigh interest

Posts show high interest, with mentions of questions about necessary vitamin D levels and factors influencing production, indicating engagement with the topic's practical implications.

EngagementModerate engagement

Some posts delve into specifics, discussing UVB variability and potential health impacts, reflecting a moderate depth of engagement.

ImpactModerate impact

The discussions suggest recognition of the scientific and clinical significance of vitamin D research, though not explicitly emphasizing revolutionary impacts.

Abstract in brief

  • Vitamin D3 is produced in the skin when exposed to UV light, while D2 comes from plants, specifically from ergosterol.
  • Vitamin D is metabolized first in the liver to 25-hydroxyvitamin D (25OHD), then in the kidney to its active form, 1,25-dihydroxyvitamin D (125OH2D), which binds to the vitamin D receptor (VDR) to regulate gene activity.
  • The activity of vitamin D involves many genes and is cell-specific, with ongoing development of analogs to treat specific diseases with fewer side effects.]

Top posts

Most liked on X and Bluesky
Trevor Sutcliffe
@TrevorSutcliffe · X

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications The intensity of UVB from sunlight varies according to season & latitude, so the further one lives from the equator, the less time of the year one can rely on solar exposure to produce D3 https://t.co/DfvziUmd25

Apr 20, 2020 · 4 likes · 6,290 followers View post →
Angelus caelorum
@CaelorumAngelus · X

How Much Vitamin D Is Necessary?

Mar 3, 2023 · 1 like · 3,309 followers View post →
sunflwr
@sunflwr971 · X

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications https://t.co/71YyNaYd4D

Aug 30, 2022 · 461 followers View post →
monsieur le king-size
@_saladzone · X

@Da_Woodge @myceliummage Bozo. See Bikle, Daniel D. (2014). Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. Chemistry & Biology, 21(3), 319–329

Jun 4, 2024 · 87 followers View post →

All mentions

monsieur le king-size
@_saladzone · X

@Da_Woodge @myceliummage Bozo. See Bikle, Daniel D. (2014). Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. Chemistry & Biology, 21(3), 319–329

Jun 4, 2024 · 87 followers View post →
Angelus caelorum
@CaelorumAngelus · X

How Much Vitamin D Is Necessary?

Mar 3, 2023 · 1 like · 3,309 followers View post →
sunflwr
@sunflwr971 · X

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications https://t.co/71YyNaYd4D

Aug 30, 2022 · 461 followers View post →
Trevor Sutcliffe
@TrevorSutcliffe · X

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications The intensity of UVB from sunlight varies according to season & latitude, so the further one lives from the equator, the less time of the year one can rely on solar exposure to produce D3 https://t.co/DfvziUmd25

Apr 20, 2020 · 4 likes · 6,290 followers View post →