Participants show strong agreement and high interest by discussing the biological mechanisms of vitamin D in serotonin regulation and autism, with some referencing scientific literature and personal experiences, which indicates deep engagement and recognition of the research's potential impact.
AgreementStrong agreement
Most discussions strongly support the findings, with many believing vitamin D deficiency is a key factor in autism, exemplified by phrases like 'Unironically, yes' and 'believe maternal Vitamin D deficiency is the explanation.'
InterestHigh interest
Participants demonstrate high curiosity, discussing detailed mechanisms and implications, such as vitamin D's regulation of serotonin synthesis and its potential role in neurodevelopmental disorders.
EngagementHigh engagement
Posts reference scientific details, past research, and personal experiments, indicating deep analysis and active involvement in understanding the research, e.g., explaining the gene regulation process and sharing previous studies.
ImpactHigh impact
The dialogues suggest the article could significantly influence ongoing research and perceptions about autism and mental health, as many see it as a potentially transformative piece with practical implications like vitamin D supplementation.
Abstract in brief
This article suggests that vitamin D hormone (calcitriol) can influence serotonin production in the brain by activating the gene TPH2, which synthesizes serotonin, and repressing TPH1 in other tissues, potentially explaining some autism-related characteristics.
It links low brain serotonin, high tissue serotonin, low vitamin D levels, and the male prevalence of autism to vitamin D's regulation of serotonin-related genes, also noting the presence of maternal antibodies.
Additionally, hormones like oxytocin and vasopressin, which are involved in social behaviors and also linked to autism, are affected by vitamin D, and supplementing vitamin D and tryptophan could be a cost-effective way to help prevent or improve autism symptoms.]
In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptophan into serotonin in the brain.
Serotonin is critical for impulsive control and it's a really interesting piece to the vitamin D story. https://t.co/LR2DjbDitx
Nov 1, 2021 · 119 likes · 24 shares · 620,811 followersView post →
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rolante
@rolante3 · X
@selentelechia Unironically, yes. I believe maternal Vitamin D deficiency is the explanation for the increase in autism:
https://t.co/rjbBjt0Gj2
May 3, 2025 · 18 likes · 1 share · 198 followersView post →
Feb 4, 2025 · 10 likes · 2 shares · 37,523 followersView post →
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Ed
@egdrennan · X
Mar 3, 2024 · 6 likes · 4 shares · 603 followersView post →
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Rene Sugar
@renesugar · X
https://t.co/T8Ccifd1Gm
"the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3];"
"the high male prevalence of autism;"
"and the presence of maternal antibodies against fetal brain tissue."
Jun 22, 2024 · 3 likes · 3,986 followersView post →
Explore how genetics impact vitamin D absorption, transport, and receptor sensitivity, affecting mental health and deficiency risk despite sun exposure or supplements. Learn practical strategies for personalized vitamin…
This video explores how vitamin D hormone influences serotonin production in the brain, potentially impacting autism-related traits. It discusses vitamin D's regulation of serotonin genes and its connection to autism…
Feb 4, 2025 · 10 likes · 2 shares · 37,523 followersView post →
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Moosa
@questmoosa · X
Low vitamin D and low dopamine drive schizophrenia and is seen in the physiology of many patients with it.
https://t.co/DYnjPK5HTo
https://t.co/Xj1kwpTY64
https://t.co/T8Ccifd1Gm
"the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3];"
"the high male prevalence of autism;"
"and the presence of maternal antibodies against fetal brain tissue."
Jun 22, 2024 · 3 likes · 3,986 followersView post →
RS
Rene Sugar
@renesugar · X
https://t.co/T8Ccifd1Gm
"The proposed mechanism explains 4 major characteristics associated with autism:"
"the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier;"
Jun 22, 2024 · 1 like · 3,986 followersView post →
RS
Rene Sugar
@renesugar · X
https://t.co/T8CcifctQO
"and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE."
Jun 22, 2024 · 2 likes · 3,986 followersView post →
RS
Rene Sugar
@renesugar · X
https://t.co/T8Ccifd1Gm
"Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE)"
Jun 22, 2024 · 2 likes · 3,986 followersView post →
RS
Rene Sugar
@renesugar · X
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
https://t.co/T8Ccifd1Gm
Jun 22, 2024 · 2 likes · 3,986 followersView post →
Mar 3, 2024 · 4 shares · 25,639 followersView post →
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Ed
@egdrennan · X
Mar 3, 2024 · 6 likes · 4 shares · 603 followersView post →
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Nicholas Shaw
@Lambdoid · X
@jackso92509 @rwillowfish @awaisaftab Brain serotonin is made in the brain by a specific type of tryptophan hydroxylase. The gene that encodes it has a promoter which is activated by vitamin D. Gut tryptophan hydroxylase is suppressed by vitamin D.
https://t.co/RYu0IAfkON.
@AllyTransforms @IainCampbellPhD @hubermanlab @ChrisPalmerMD Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
https://t.co/NDVLUubvkn
Vitamin D and the omega-3 fatty acids control serotonin synthesis […] ADHD, bipolar disorder, schizophrenia, and impulsive behavior
https://t.co/1LW4F7QSFp
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 433 followersView post →
MC
michael cluer
@mikecluer · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 788 followersView post →
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Ser Kevin //
@Dark_Realist · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 1,454 followersView post →
RB
Rich Bartlebaugh
@richbartlebaugh · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 576 followersView post →
CK
Chris Kong
@ChrisHKong · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 705 followersView post →
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EM727
@EM7275 · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 2,461 followersView post →
DL
Drea4Liberty
@drea4liberty · X
RT @foundmyfitness: In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptopha…
Nov 1, 2021 · 24 shares · 4,478 followersView post →
DP
Dr. Rhonda Patrick
@foundmyfitness · X
In 2014 I published a paper showing in silico evidence that vitamin D regulates the gene (TPH2) that converts tryptophan into serotonin in the brain.
Serotonin is critical for impulsive control and it's a really interesting piece to the vitamin D story. https://t.co/LR2DjbDitx
Nov 1, 2021 · 119 likes · 24 shares · 620,811 followersView post →
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contacool
@LuisMir12804822 · X
RT @YoVivoD: Referencias: Patrick RP, et al. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014 J…
@ILiebold Ian, your point about the overall strength of the effect in this particular is sound. As for overall plausibility, see my own published work which provides a hypothetical mechanism by which vitamin D may have specific neurodevelopmental effects. https://t.co/LR2DjbDitx
Nov 9, 2020 · 2 likes · 620,811 followersView post →
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Annie Shum
@insightspedia · X
@foundmyfitness and Dr Bruce Ames 2014 paper: "Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism. FASEB J. 2014;28:2398–2413. doi: 10.1096/fj.13-246546.
Vitamins and Hormones, Volume 100 | PDF | Vitamin D | Biology
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http://dx.doi.org/10.1096/fj.10-177816. Matkovits, T., & Christakos, S ... 13-246546. Patrick, R. P., & Ames, B. N. (2015). Vitamin D and the omega-3 ...
With Nature in Mind The Ecotherapy Manual For Mental Health ...
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... 10.1096/fj.13-246546 fj.13-246546. Pendse, B., Westrin, A. and Engström, G. (1999) 'Temperament traits in seasonal affective disorder, suicide attempters ...
Aluminum and Glyphosate Can Synergistically Induce Pineal Gland ...
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(ePub Ahead of Print) http://dx.doi.org/10.1096/fj.13-246546 [140] Kuberan, B., Lech, M., Borjigin, J. and Rosenberg, R.D. (2004) Light-Induced 3-O ...
Faseb j, 28(6), 2398-2413. doi:10.1096/fj.13-246546. Pennesi, C. M. ve Klein, L. C. (2012). Effectiveness of the gluten-free, casein-free diet for children ...
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