PubHawk
Am J Physiol Endocrinol Metab April 2014 PMID 24595305

Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit.

José L Areta, Louise M Burke, Donny M Camera, Daniel W D West, Siobhan Crawshay, Daniel R Moore, Trent Stellingwerff, Stuart M Phillips, John A Hawley, Vernon G Coffey

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Mentions

54
Peak: 10 in Oct 2020
across 5 sources since Aug 2019

Extended reach

425,827
potential audience

Total likes

4,985

Video views

121,658

Mentions per month

Aug 2019 – May 2025

Where it's discussed

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  • Facebook16 posts
  • News6 articles
  • YouTube4 videos
  • Reddit3 posts

AI synopsis

What people are saying

The discussions demonstrate robust interest and consensus on the importance of resistance exercise and protein intake for preserving muscle during energy deficits, with posts highlighting detailed mechanisms and practical approaches. Words like 'must do,' 'rescued,' and 'signaling' convey a sense of importance and scientific relevance, reflecting deep engagement and acknowledgment of the study’s impact.

AgreementStrong agreement

Most discussions support the article's findings, emphasizing resistance exercise and protein intake as effective in rescuing muscle synthesis during energy deficits.

InterestHigh interest

Posts show high engagement with the topic, discussing mechanisms and practical applications of the research, indicating strong interest.

EngagementModerate engagement

Several comments reference specific mechanisms like MPS and signaling pathways, demonstrating a moderate depth of engagement with the concepts.

ImpactHigh impact

The discussions highlight the significance of the findings for health, fitness, and nutritional strategies, suggesting notable impact on current practices.

Abstract in brief

  • Short-term energy deficit (ED) lowers resting skeletal muscle protein synthesis (MPS) by 27%, but resistance exercise (REX) can restore MPS to normal levels seen in energy balance (EB).
  • Consuming whey protein after resistance exercise in ED further boosts MPS by 16-34%, with higher protein doses (30 g) leading to greater increases, indicating a dose-dependent effect.
  • The combined effect of exercise and protein intake in ED increases muscle protein signaling (like p70 S6K phosphorylation), suggesting this strategy can help preserve muscle mass during short-term energy shortages.
Read the full abstract

Top posts

Most liked on X and Bluesky
Cody Haun, Ph.D.
@drcodyhaun · X

5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance exercise + 30g protein post-ex ⬆️ MPS by ~35% vs. resting MPS when subjects consumed maintenance cals for 5 days.

Oct 10, 2020 · 58 likes · 9 shares · 3,421 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/8cXuGJnkqC https://t.co/GWEVB986VX

Mar 11, 2023 · 18 likes · 52,115 followers View post →
Dr. Myohead
@DrMyohead · X

@NanciGuestRDPhD @ExphysPhD @mackinprof @mackinprof & others have touched on this W/ better indicators of anabolism than hormones alone. See: https://t.co/61wo8gnI5f https://t.co/CcWXGjlDvs https://t.co/mg0IaRC6fm

Apr 4, 2020 · 16 likes · 1 share · 2,649 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/8cXuGJmMB4 https://t.co/GWEVB97z6p

Dec 22, 2023 · 7 likes · 52,115 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@ExphysPhD @NanciGuestRDPhD Acute mechanism https://t.co/BgDW9YTQS7 Short-term trial https://t.co/J22Q17CQtm 'anabolic resistance' isn't what was measured in that paper IMO, look at the hormones in the Longland trial

Apr 4, 2020 · 3 likes · 56,047 followers View post →
Tsukiyuki/スポーツ栄養
@Tsukiyuki6 · X

A29: こちらの研究報告https://t.co/CtyKVy4tuw のFig. 3.を見ると、エネルギーが十分な場合の安静時に比べてエネルギー不足の安静時は筋肉合成率が下ってしまいますが、トレーニングによる刺激でエネルギーが十分な安静時程度まで回復し、さらにたんぱく質の摂取でより高くなっています。続

Jun 11, 2022 · 3 likes · 845 followers View post →

All mentions

DaRocDok.com®
@DaRocDok · X

3 Things you MUST do to Lose Fat without Losing Muscle [3 Studies] https://t.co/Qwea6LANgB via @YouTube

May 23, 2025 · 1,515 followers View post →
Krupali
@Immyownreflecti · X

https://t.co/p0HMn1dchq

May 7, 2025 · 267 followers View post →
Farmer Ash (from the Strong Sistas)
@strong_sistas · X

[3] https://t.co/l4veZDVJfZ

Oct 19, 2024 · 1 like · 6,976 followers View post →
Gary T. Sottile
@GPZO · X

3 Things you MUST do to Lose Fat without Losing Muscle [3 Studies] https://t.co/PvSRekx4UT via @YouTube

Mar 24, 2024 · 1,073 followers View post →
Karageorgos
@Karageorgos15 · X

https://t.co/qyeJ5Qqp2E

Mar 20, 2024 · 610 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/8cXuGJmMB4 https://t.co/GWEVB97z6p

Dec 22, 2023 · 7 likes · 52,115 followers View post →
Miiro
@MiiroV1 · X

@docnoir_ @bungee_gum0 @tyler02020202 @normalkay https://t.co/wNgHgWDonx Can cite a few others that also demonstrate this if you’d like, but in essence, as this randomised control trial shows, in the presence of adequate protein intake and resistance training, muscle synthesis still occurs

Jun 18, 2023 · 12 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/8cXuGJnkqC https://t.co/GWEVB986VX

Mar 11, 2023 · 18 likes · 52,115 followers View post →
Tsukiyuki/スポーツ栄養
@Tsukiyuki6 · X

A29: こちらの研究報告https://t.co/CtyKVy4tuw のFig. 3.を見ると、エネルギーが十分な場合の安静時に比べてエネルギー不足の安静時は筋肉合成率が下ってしまいますが、トレーニングによる刺激でエネルギーが十分な安静時程度まで回復し、さらにたんぱく質の摂取でより高くなっています。続

Jun 11, 2022 · 3 likes · 845 followers View post →
OJSN
@iamojsn · X

Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit - PubMed - https://t.co/Gl3MDdHlFx 面白…

Oct 7, 2021 · 1 like · 14,942 followers View post →
عرف
@areiffroslan_ · X

Source: https://t.co/ZmGVjfTFtK https://t.co/nZMZmZn4gJ https://t.co/YkwbpVx671 https://t.co/r69yKgSUxB https://t.co/TaaE0AgQbW https://t.co/wl2is3V7ao

Jul 14, 2021 · 2 likes · 349 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @DrMyohead: @NanciGuestRDPhD @ExphysPhD @mackinprof @mackinprof & others have touched on this W/ better indicators of anabolism than hor…

Dec 29, 2020 · 1 share · 1,362 followers View post →
Rentia Denissen
@RentiaDenissen · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 11, 2020 · 9 shares · 146 followers View post →
Angelo
@AngeloSabag · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 11, 2020 · 9 shares · 644 followers View post →
Paul Morgan
@_PaulMorgan · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 11, 2020 · 9 shares · 1,312 followers View post →
Konstantinos Prokopidis
@KostasProko · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 11, 2020 · 9 shares · 1,490 followers View post →
Ben Kirk, PhD
@DrBenKirk · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 10, 2020 · 9 shares · 2,226 followers View post →
Inaki bestetraining
@InakiSedano · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 10, 2020 · 9 shares · 201 followers View post →
Eric Rawson, Ph.D.
@EricRawsonPhD · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 10, 2020 · 9 shares · 7,532 followers View post →
Jeffery Nutrition
@JefferyNutr · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 10, 2020 · 9 shares · 280 followers View post →
Matthew Stratton PhD
@MTSstrength89 · X

RT @drcodyhaun: 5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance…

Oct 10, 2020 · 9 shares · 165 followers View post →
Cody Haun, Ph.D.
@drcodyhaun · X

5 days of calorie restriction (~30% below maintenance cals) ⬇️ resting muscle protein synthesis (MPS) by ~30%. Resistance exercise + 30g protein post-ex ⬆️ MPS by ~35% vs. resting MPS when subjects consumed maintenance cals for 5 days.

Oct 10, 2020 · 58 likes · 9 shares · 3,421 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@ExphysPhD @NanciGuestRDPhD Acute mechanism https://t.co/BgDW9YTQS7 Short-term trial https://t.co/J22Q17CQtm 'anabolic resistance' isn't what was measured in that paper IMO, look at the hormones in the Longland trial

Apr 4, 2020 · 3 likes · 56,047 followers View post →
Dr. Myohead
@DrMyohead · X

@NanciGuestRDPhD @ExphysPhD @mackinprof @mackinprof & others have touched on this W/ better indicators of anabolism than hormones alone. See: https://t.co/61wo8gnI5f https://t.co/CcWXGjlDvs https://t.co/mg0IaRC6fm

Apr 4, 2020 · 16 likes · 1 share · 2,649 followers View post →
Brad Schoenfeld, PhD
@BradSchoenfeld · X

@PeterFaberSP Food is anabolic; an energy defict is catabolic. This has been well-demonstrated in the literature. Energy deficits show reductions in MPS and intracellular signaling; even RT only increases the response to that at rest during energy balance https://t.co/oWfQur3IF0

Aug 4, 2019 · 2 likes · 95,693 followers View post →