May 2014 PMID 24635773

A randomized trial of protocol-based care for early septic shock.

Mentions

69
Peak: 9 in Jan 2019
across 6 sources since Mar 2014

Extended reach

491,353
potential audience

Total likes

764

Video views

56,918

Mentions per month

Mar 2014 – Oct 2025

Where it's discussed

  • X / Twitter39 posts
  • Blogs11 articles
  • News9 articles
  • Facebook7 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect mixed but generally supportive reactions to the study, with references to past influential trials like ProCESS and the broad implications for sepsis management. Words such as 'changed how we looked at EGDT' and questions like 'Is this the end of early goal-directed therapy' demonstrate a tone of reevaluation and potential paradigm shifts, signifying moderate engagement and recognition of clinical impact.

AgreementModerate agreement

Most discussions acknowledge that the study challenges the effectiveness of EGDT, indicating moderate agreement on its findings.

InterestModerate interest

The topic appears to generate moderate curiosity, especially given the historical significance of earlier studies like ProCESS.

EngagementModerate engagement

Participants reference multiple studies, data points, and implications, showing a balanced engagement with the research.

ImpactModerate impact

The discussions imply that the trial could influence clinical practice and future research directions, signifying a notable but not definitive impact.

Abstract in brief

  • A study was conducted to see if early goal-directed therapy (EGDT), which involves specific steps to manage septic shock in emergency departments, actually reduces 60-day inhospital mortality compared to usual care.
  • The trial involved 1,341 patients across 31 U.S. emergency departments, comparing three treatment strategies: EGDT, standard protocol-based therapy without central venous catheter placement, and usual care, focusing on survival and need for organ support.
  • The results showed no significant difference in 60-day mortality between groups, indicating that the structured EGDT protocol did not improve survival over usual care, suggesting that all aspects of the protocol may not be necessary.]

Top posts

Most liked on X and Bluesky
Jacob de Wolff
@jfdwolff · X

Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinician judgement and the "shock index" (HR/SBP) rather than other measurements to determine circulatory management. https://t.co/YqkNZesRQj @NEJM

Nov 15, 2021 · 14 likes · 3 shares · 11,294 followers View post →
Tejas Desai, MD, MBA
@nephondemand · X

Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients No changes in mortality Specifically, worse kidney function in group that received high fluid volumes #meded #FOAmed https://t.co/Go7usLOYNE

Jan 13, 2019 · 12 likes · 6 shares · 11,979 followers View post →
CanadiEM
@WeAreCanadiEM · X

Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic available here: https://t.co/AvpxZAqo8q Original paper: https://t.co/DvrMiUxwlY https://t.co/MaRBpMfZiJ

Mar 11, 2019 · 10 likes · 8 shares · 12,160 followers View post →
Deep Ramachandran MD
@LungSleepDeep · X

The Process trial changed how we looked at EGDT in #sepsis. https://t.co/uDeukJcA3i #chestchat

Dec 19, 2019 · 6 likes · 2 shares · 1,873 followers View post →
Samaher Hashim
@SamaherHashim · X

Sepsis/septic shock: ( EGDT “Rivers”, ProCESS, ARISE, ProMISe, ADRENAL, VASST, ATHOS-3, ANDROMEDA-Shock, APROCCHSS, VITAMINS) https://t.co/TGShbtW2M2 https://t.co/lLoPnCCql5 https://t.co/GKZ0bwEeNJ https://t.co/kMdsFMAjcv https://t.co/RhXliqKHJt https://t.co/2qf8ROLRRQ

May 27, 2020 · 4 likes · 2 shares · 1,662 followers View post →
Crit Care Nephrology
@CCCNPitt · X

Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with over 2,000 citations has to say about "A randomized trial of protocol-based care for early septic shock" https://t.co/stkf98w3xn

Dec 30, 2020 · 2 likes · 1 share · 3,916 followers View post →

All mentions

Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

Mar 23, 2024 · 6,838 followers View post →
Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

Mar 20, 2024 · 6,838 followers View post →
James Wilson, DO, FACP, FAWM, CTropMed®
@JamesWilsonDO1 · X

PROCESS trial https://t.co/ROlq1Wjv4Z

Nov 25, 2023 · 1 like · 994 followers View post →
Denisse Garcia
@GarciaDenisse20 · X

A Randomized Trial of Protocol-Based Care for Early Septic Shock https://t.co/WywoToPfDt

Jan 15, 2023 · 25 followers View post →
Josh Davis
@MedFactChecks · X

@CynWilliams3 @BKetabchi @SuttonScience @DrJaimeFriedman https://t.co/ZNlsNfiw20

Dec 3, 2022 · 680 followers View post →
Stephen Lee
@stephenkleemd · X

RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…

Nov 16, 2021 · 3 shares · 118 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…

Nov 16, 2021 · 3 shares · 6,931 followers View post →
Lakshay Chanana
@EMDidactic · X

RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…

Nov 16, 2021 · 3 shares · 1,106 followers View post →
Jacob de Wolff
@jfdwolff · X

Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinician judgement and the "shock index" (HR/SBP) rather than other measurements to determine circulatory management. https://t.co/YqkNZesRQj @NEJM

Nov 15, 2021 · 14 likes · 3 shares · 11,294 followers View post →
Hirotsugu Kitayama
@HirotsuguKitay1 · X

RT @CCCNPitt: Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with…

Dec 31, 2020 · 1 share · 176 followers View post →
Crit Care Nephrology
@CCCNPitt · X

Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with over 2,000 citations has to say about "A randomized trial of protocol-based care for early septic shock" https://t.co/stkf98w3xn

Dec 30, 2020 · 2 likes · 1 share · 3,916 followers View post →
Dr. Anil Maske, MD
@maskeanil · X

RT @SamaherHashim: Sepsis/septic shock: ( EGDT “Rivers”, ProCESS, ARISE, ProMISe, ADRENAL, VASST, ATHOS-3, ANDROMEDA-Shock, APROCCHSS, VITA…

Aug 29, 2020 · 2 shares · 606 followers View post →
مركز الجهاز الهضمي المتكامل
@IGCCENTERSAUDI · X

RT @SamaherHashim: Sepsis/septic shock: ( EGDT “Rivers”, ProCESS, ARISE, ProMISe, ADRENAL, VASST, ATHOS-3, ANDROMEDA-Shock, APROCCHSS, VITA…

May 27, 2020 · 2 shares · 282,846 followers View post →
Samaher Hashim
@SamaherHashim · X

Sepsis/septic shock: ( EGDT “Rivers”, ProCESS, ARISE, ProMISe, ADRENAL, VASST, ATHOS-3, ANDROMEDA-Shock, APROCCHSS, VITAMINS) https://t.co/TGShbtW2M2 https://t.co/lLoPnCCql5 https://t.co/GKZ0bwEeNJ https://t.co/kMdsFMAjcv https://t.co/RhXliqKHJt https://t.co/2qf8ROLRRQ

May 27, 2020 · 4 likes · 2 shares · 1,662 followers View post →
Guillermo Pinzon Velasquez MD MSc
@guillepinv · X

RT @CCCNPitt: Is protocol-based resuscitation superior to usual care with sepsis? Find out in this multi-center trial comparing alternative…

Apr 8, 2020 · 3 shares · 30 followers View post →
Crit Care Nephrology
@CCCNPitt · X

Is protocol-based resuscitation superior to usual care with sepsis? Find out in this multi-center trial comparing alternative resuscitation strategies in a broad cohort of patients with septic shock #AKI https://t.co/504QIMPo3S

Apr 8, 2020 · 2 likes · 3 shares · 3,916 followers View post →
Dr. Johnny Stewart. MD , FRCSC / RMC, CAF
@DrJonnys · X

RT @drkt: and b/c i'll be tied up for the next little bit: let's take a look at the PROCESS trial on sepsis bundles. #CCMJC #COVID19 #surgi…

Apr 3, 2020 · 1 share · 10,768 followers View post →
Kate B Savoie, MD MS
@drkt · X

and b/c i'll be tied up for the next little bit: let's take a look at the PROCESS trial on sepsis bundles. #CCMJC #COVID19 #surgicalcriticalcare #SoMe4Surgery #SoMe4CriticalCare #critcaremed #CriticalCare #CriticalCareMedicine #surgicaleducation https://t.co/ohdimfK2Lj

Apr 2, 2020 · 1 like · 1 share · 934 followers View post →
خالد القرني
@DrKhaledAlqarni · X

A Randomized Trial of Protocol-Based Care for Early Septic Shock | NEJM https://t.co/OGQKhPqaQG

Jan 30, 2020 · 1,338 followers View post →
S Faiz
@sfaiz212 · X

RT @Caduceusblogger: The Process trial changed how we looked at EGDT in #sepsis. https://t.co/uDeukJcA3i #chestchat

Dec 19, 2019 · 2 shares · 4,302 followers View post →
Chris Carroll MD
@ChrisCarrollMD · X

RT @Caduceusblogger: The Process trial changed how we looked at EGDT in #sepsis. https://t.co/uDeukJcA3i #chestchat

Dec 19, 2019 · 2 shares · 20,158 followers View post →
Deep Ramachandran MD
@LungSleepDeep · X

The Process trial changed how we looked at EGDT in #sepsis. https://t.co/uDeukJcA3i #chestchat

Dec 19, 2019 · 6 likes · 2 shares · 1,873 followers View post →
Alvin Chin
@AylC1989 · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 13, 2019 · 8 shares · 361 followers View post →
McMaster Emerg Med
@MacEmerg · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 12, 2019 · 8 shares · 3,079 followers View post →
Anson Dinh
@AnsonDinh · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 11, 2019 · 8 shares · 73 followers View post →
Brent Thoma
@Brent_Thoma · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 11, 2019 · 8 shares · 9,110 followers View post →
ER 35
@MishalRafe · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 11, 2019 · 8 shares · 31 followers View post →
Teresa Chan | 陳敏怡
@TChanMD · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 11, 2019 · 8 shares · 14,628 followers View post →
Narani Sivayoham
@NSivayoham · X

RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic…

Mar 11, 2019 · 8 shares · 464 followers View post →
CanadiEM
@WeAreCanadiEM · X

Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989 Full infographic available here: https://t.co/AvpxZAqo8q Original paper: https://t.co/DvrMiUxwlY https://t.co/MaRBpMfZiJ

Mar 11, 2019 · 10 likes · 8 shares · 12,160 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 14, 2019 · 6 shares · 6,931 followers View post →
Anace Pastor ✨️ Renalis
@anace710 · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 14, 2019 · 6 shares · 1,898 followers View post →
Pedro Villarreal
@PedrVillarreal · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 14, 2019 · 6 shares · 59 followers View post →
maría marques vidas
@mmvidas · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 14, 2019 · 6 shares · 2,357 followers View post →
Gonzalo Bautista Prieto. MD
@GonzalBautistaP · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 13, 2019 · 6 shares · 827 followers View post →
Szymon Brzósko
@brzoskos · X

RT @nephondemand: Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients…

Jan 13, 2019 · 6 shares · 1,939 followers View post →
Tejas Desai, MD, MBA
@nephondemand · X

Trials in AKI: Tweet Summaries • ProCESS https://t.co/g7YQSkHOnn Comparing 3 forms of fluid therapy for septic patients No changes in mortality Specifically, worse kidney function in group that received high fluid volumes #meded #FOAmed https://t.co/Go7usLOYNE

Jan 13, 2019 · 12 likes · 6 shares · 11,979 followers View post →
Vane Savinek
@VainSavin · X

RT @1stJohnnyMac: @dr_doddle @ketaminh It seems to be open access on the nejm site. https://t.co/risaaoc6yY

Jan 6, 2019 · 1 share · 318 followers View post →
John McNamara
@1stJohnnyMac · X

@dr_doddle @ketaminh It seems to be open access on the nejm site. https://t.co/risaaoc6yY

Jan 6, 2019 · 1 like · 1 share · 319 followers View post →
Joel Topf
@kidneyboy.bsky.social · Bluesky

“@Skepticscalpel: NEJM: Is this the end of early goal-directed therapy for sepsis? http://www.nejm.org/doi/full/10.1056/NEJMoa1401602?query=OF” OMG!

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