The discussions reflect mixed but generally supportive reactions to the study, with references to past influential trials like ProCESS and the broad implications for sepsis management. Words such as 'changed how we looked at EGDT' and questions like 'Is this the end of early goal-directed therapy' demonstrate a tone of reevaluation and potential paradigm shifts, signifying moderate engagement and recognition of clinical impact.
AgreementModerate agreement
Most discussions acknowledge that the study challenges the effectiveness of EGDT, indicating moderate agreement on its findings.
InterestModerate interest
The topic appears to generate moderate curiosity, especially given the historical significance of earlier studies like ProCESS.
EngagementModerate engagement
Participants reference multiple studies, data points, and implications, showing a balanced engagement with the research.
ImpactModerate impact
The discussions imply that the trial could influence clinical practice and future research directions, signifying a notable but not definitive impact.
Abstract in brief
A study was conducted to see if early goal-directed therapy (EGDT), which involves specific steps to manage septic shock in emergency departments, actually reduces 60-day inhospital mortality compared to usual care.
The trial involved 1,341 patients across 31 U.S. emergency departments, comparing three treatment strategies: EGDT, standard protocol-based therapy without central venous catheter placement, and usual care, focusing on survival and need for organ support.
The results showed no significant difference in 60-day mortality between groups, indicating that the structured EGDT protocol did not improve survival over usual care, suggesting that all aspects of the protocol may not be necessary.]
Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinician judgement and the "shock index" (HR/SBP) rather than other measurements to determine circulatory management. https://t.co/YqkNZesRQj @NEJM
Nov 15, 2021 · 14 likes · 3 shares · 11,294 followersView post →
TM
Tejas Desai, MD, MBA
@nephondemand · X
Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients
No changes in mortality
Specifically, worse kidney function in group that received high fluid volumes
#meded #FOAmed https://t.co/Go7usLOYNE
Jan 13, 2019 · 12 likes · 6 shares · 11,979 followersView post →
C
CanadiEM
@WeAreCanadiEM · X
Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989
Full infographic available here: https://t.co/AvpxZAqo8q
Original paper: https://t.co/DvrMiUxwlY https://t.co/MaRBpMfZiJ
Mar 11, 2019 · 10 likes · 8 shares · 12,160 followersView post →
DM
Deep Ramachandran MD
@LungSleepDeep · X
The Process trial changed how we looked at EGDT in #sepsis. https://t.co/uDeukJcA3i #chestchat
Dec 19, 2019 · 6 likes · 2 shares · 1,873 followersView post →
May 27, 2020 · 4 likes · 2 shares · 1,662 followersView post →
CN
Crit Care Nephrology
@CCCNPitt · X
Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with over 2,000 citations has to say about "A randomized trial of protocol-based care for early septic shock" https://t.co/stkf98w3xn
Dec 30, 2020 · 2 likes · 1 share · 3,916 followersView post →
This educational video reviews the current state of septic shock management, emphasizing recent clinical trials comparing early goal-directed therapy with standard care and its impact on patient survival and organ…
This episode discusses critical care advancements, focusing on early goal-directed therapy, fluid responsiveness, oxygen delivery, and integrating data points for patient management. Highlights include recent trials and…
RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…
Nov 16, 2021 · 3 shares · 118 followersView post →
SN
Syed Shahrul Naz
@drshahrul80 · X
RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…
Nov 16, 2021 · 3 shares · 6,931 followersView post →
LC
Lakshay Chanana
@EMDidactic · X
RT @jfdwolff: Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinic…
Nov 16, 2021 · 3 shares · 1,106 followersView post →
JW
Jacob de Wolff
@jfdwolff · X
Back in the previous decade I quite enjoyed the ProCESS study, which was one of three to overturn EGDT/Rivers. It used clinician judgement and the "shock index" (HR/SBP) rather than other measurements to determine circulatory management. https://t.co/YqkNZesRQj @NEJM
Nov 15, 2021 · 14 likes · 3 shares · 11,294 followersView post →
HK
Hirotsugu Kitayama
@HirotsuguKitay1 · X
RT @CCCNPitt: Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with…
Dr. Kellum's number one most cited article of the decade deals with Sepsis! Remind yourself what this article from 2014 with over 2,000 citations has to say about "A randomized trial of protocol-based care for early septic shock" https://t.co/stkf98w3xn
Dec 30, 2020 · 2 likes · 1 share · 3,916 followersView post →
Is protocol-based resuscitation superior to usual care with sepsis? Find out in this multi-center trial comparing alternative resuscitation strategies in a broad cohort of patients with septic shock #AKI https://t.co/504QIMPo3S
and b/c i'll be tied up for the next little bit: let's take a look at the PROCESS trial on sepsis bundles. #CCMJC #COVID19 #surgicalcriticalcare #SoMe4Surgery #SoMe4CriticalCare #critcaremed #CriticalCare #CriticalCareMedicine #surgicaleducation https://t.co/ohdimfK2Lj
Apr 2, 2020 · 1 like · 1 share · 934 followersView post →
خا
خالد القرني
@DrKhaledAlqarni · X
A Randomized Trial of Protocol-Based Care for Early Septic Shock | NEJM https://t.co/OGQKhPqaQG
RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989
Full infographic…
Mar 11, 2019 · 8 shares · 14,628 followersView post →
NS
Narani Sivayoham
@NSivayoham · X
RT @WeAreCanadiEM: Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989
Full infographic…
Mar 11, 2019 · 8 shares · 464 followersView post →
C
CanadiEM
@WeAreCanadiEM · X
Check out the new #MVPInfographic detailing the 2014 ProCESS trial from @NEJM ! @AnsonDinh @AylC1989
Full infographic available here: https://t.co/AvpxZAqo8q
Original paper: https://t.co/DvrMiUxwlY https://t.co/MaRBpMfZiJ
Mar 11, 2019 · 10 likes · 8 shares · 12,160 followersView post →
SN
Syed Shahrul Naz
@drshahrul80 · X
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
Jan 14, 2019 · 6 shares · 6,931 followersView post →
AR
Anace Pastor ✨️ Renalis
@anace710 · X
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
Jan 14, 2019 · 6 shares · 1,898 followersView post →
PV
Pedro Villarreal
@PedrVillarreal · X
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
Jan 14, 2019 · 6 shares · 2,357 followersView post →
GM
Gonzalo Bautista Prieto. MD
@GonzalBautistaP · X
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
Jan 13, 2019 · 6 shares · 827 followersView post →
SB
Szymon Brzósko
@brzoskos · X
RT @nephondemand: Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients…
Jan 13, 2019 · 6 shares · 1,939 followersView post →
TM
Tejas Desai, MD, MBA
@nephondemand · X
Trials in AKI: Tweet Summaries
• ProCESS https://t.co/g7YQSkHOnn
Comparing 3 forms of fluid therapy for septic patients
No changes in mortality
Specifically, worse kidney function in group that received high fluid volumes
#meded #FOAmed https://t.co/Go7usLOYNE
Jan 13, 2019 · 12 likes · 6 shares · 11,979 followersView post →
VS
Vane Savinek
@VainSavin · X
RT @1stJohnnyMac: @dr_doddle @ketaminh It seems to be open access on the nejm site. https://t.co/risaaoc6yY
Diagnostic Insights That Can Improve Patient Care | Clinical Lab ...
News
The impact of serial use of PCT* was demonstrated in a health economic model that compared procalcitonin-aided antibiotic stewardship vs. usual care for ...
HealthPro Education and Certification | Lake Forest CA
Facebook
doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18. PMID: 24635773. Source: NIH HealthPro offers custom classes to meet your needs. Give us a call at 951-279-6110 ...
Neutrophil-to-lymphocyte ratio in patients with gram-negative sepsis ...
News
A randomized trial of protocol-based care for early septic shock. N. Engl J Med. 2014; 370(18): 1683–1693, doi: 10.1056/NEJMoa1401602, indexed in Pubmed: ...
COVID-19 and haemodynamic failure: a point of view on ...
News
A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370: 1683-1693. doi: 10.1056/nejmoa1401602. 59. ARISE Investigators; ANZICS ...
Shock settico. Con l'albumina si potrebbero salvare tra il il 6 e il 7 ...
News
... 10.1056/NEJMoa1401602) ha confrontato tra loro tre diversi modalità ... Sempre sul New England, viene pubblicato lo studio ALBIOS (Albumin Italian ...