The effects of light at night on circadian clocks and metabolism.

TD

⚡️ The Blue Light Diet ⚡️

@BlueLightDiet · X

#Artificiallightatnight or #ALAN gives you bad #mitochondria and/or a bad body mass index. "The increase in exposure to light at night parallels the global increase in the prevalence of #obesity and metabolic disorders." https://t.co/SPyQ4TMuCm

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عبدالله

@AbdullaQandeel · X

@Mustafa32908795 https://t.co/rwxCzTcakZ

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Nigel Ten Fleming

@TenFleming · X

“Epidemiological evidence from shift workers suggests that prolonged exposure to light at night increases the risk of developing cancer, sleep disturbances, mood disorders, metabolic dysfunction, and cognitive impairments.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The SCN receives additional indirect input from intrinsically photosensitive melanopsin-containing retinal ganglion cells via the intergeniculate nucleus and input from rods and cones.” (SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Light is the most potent synchronizing factor for the SCN. Light information travels directly from intrinsically photosensitive melanopsin-containing retinal ganglion cells through the retinohypothalamic tract to the SCN.”(SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Exposure to dim light at night specifically attenuates the rhythm in Per1 and Per2 gene and protein expression in the SCN around the light/dark transition.” (SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Unidos Por Tecnología Responsable

@u_x_t_r · X

Estudio

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Denís Estévez - Dietista

@denis_dietista · X

La exposición a luz artificial por las noches se relaciona directamente con la obesidad y otros trastornos (cáncer, diabetes,…) mediante la disrupción del ritmo circadiano. Intenta reducir el uso de pantallas por la noche, tu salud lo agradecerá https://t.co/TrhHhMf43P https://t.co/OJfpSz1hBQ

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Eve Beavers Fain is espacetimeCO

@espacetimeCO · X

RT @bluelightdiet: #Artificiallightatnight or #ALAN gives you bad #mitochondria and/or a bad body mass index. "The increase in exposure t…

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Chipman

@Chipin8or · X

RT @bluelightdiet: #Artificiallightatnight or #ALAN gives you bad #mitochondria and/or a bad body mass index. "The increase in exposure t…

BB

Bucky.btc

@Bucky85 · X

RT @bluelightdiet: #Artificiallightatnight or #ALAN gives you bad #mitochondria and/or a bad body mass index. "The increase in exposure t…

TD

⚡️ The Blue Light Diet ⚡️

@BlueLightDiet · X

#Artificiallightatnight or #ALAN gives you bad #mitochondria and/or a bad body mass index. "The increase in exposure to light at night parallels the global increase in the prevalence of #obesity and metabolic disorders." https://t.co/SPyQ4TMuCm

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Nigel Ten Fleming

@TenFleming · X

“Unnatural exposure to light at night may have significant ecological implications.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Many plant and animal species are affected by nighttime light exposure, as lighting from infrastructure strays into the atmosphere creating a general nighttime glow termed light pollution.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“It is important to note that exposure to light at night is not just a human issue.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders.” https://t.co/lxbhApH0a4

NF

Nigel Ten Fleming

@TenFleming · X

“Epidemiological evidence from shift workers suggests that prolonged exposure to light at night increases the risk of developing cancer, sleep disturbances, mood disorders, metabolic dysfunction, and cognitive impairments.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Shift workers, who are exposed to high levels of light at night in the workplace, have served as society's canaries in the coal mine for maladaptive consequences of nighttime light exposure.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Exposure to continuous-light, non–24-hour light schedules, and dim light at night are all associated with metabolic changes in rodents.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Given the well-established role of light in modulating the circadian system, and the relationship between circadian and metabolic functions, it is not surprising that exposure to light at unnatural times affects metabolism.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Multiple genes involved in nutrient metabolism display rhythmic oscillations, and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Appropriate circadian regulation is important for many homeostatic functions including energy regulation.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Features of metabolic syndrome including weight gain, elevated adiposity, reductions in glucose processing, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“High-fat meals eaten at the end, as compared with the beginning, of the dark phase lead to features of metabolic syndrome.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The time of day at which dietary fat is eaten also influences multiple cardiometabolic parameters.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Obese individuals lack typical daily rhythms in glucose and insulin sensitivity. Moreover, obese women have significantly lower wrist temperature and a flattened temperature rhythm compared with normal-weight controls.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“In humans, metabolically related diseases such as obesity and anorexia nervosa are associated with altered hormone and body temperature rhythms.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The relationship between the circadian system and metabolism appears to be bidirectional. In addition to circadian system disruptions causing obesity, metabolic abnormalities alter circadian rhythms.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Loss of clock function in peripheral tissues similarly affects metabolism. For example, altering Clock gene expression in liver and skeletal muscle impairs glucose processing and alters insulin secretion.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“When rhythmicity is rescued in Bmal1−/− mice with Bmal2, insulin secretion and activity patterns are restored.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Mice deficient in Bmal1 alter glucose and insulin secretion. Bmal1−/− mice increase concentrations of circulating fatty acids resulting in formation of ectopic fat in the liver and skeletal muscle.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Clock mutant mice on a BALB/c and C57BL/6J background are susceptible to diet-induced obesity. Clock mutants display profound changes in circadian rhythmicity as well as disruptions in diurnal food intake and increased body mass.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Mice harboring mutations in various components of the circadian clock are susceptible to obesity and metabolic syndrome.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

Circadian hormones. “Circadian fluctuations in hunger and appetite have also been reported.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

Circadian hormones. “There is rhythmic expression of orexigenic signals including neuropeptide Y, galanin, and preopiomelanocortin within the hypothalamus, an area critical for coordinating metabolic signals.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

Circadian hormones. “Metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone oscillate in a circadian manner.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Ablation of any of the core clock genes, Clock or Bmal1, Per1 or Per2, or Cry1 or Cry2, disrupts circadian physiology.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Core clock components are defined as genes with protein products that are essential for the generation and regulation of circadian rhythms.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

The circadian clock feedback loop. “This process takes approximately 24 hours to complete a full cycle.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

The circadian clock feedback loop. “Upon reaching critical levels, PER and CRY form a complex that translocates back to the nucleus to associate with CLOCK and BMAL1 and repress their own transcription.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

The circadian clock feedback loop. “CLOCK and BMAL1 form a heterodimer that induces expression of Per and Cry through E-box enhancers. PER and CRY proteins accumulate in the cytoplasm throughout the circadian day. CK GENES.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The circadian clock is driven by an autoregulatory feedback loop.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Furthermore, exposure to light at night affects foraging and predation and migration in multiple species.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Diurnal Nile Grass rats (Arvicanthis niloticus) exposed to light at night have impaired learning and memory and increase depressive-like responses compared with rats maintained in dark nights.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Overall, these results indicate that exposure to levels of nighttime lighting commonly experienced in urban settings can affect the circadian system.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Exposure to dim light at night specifically attenuates the rhythm in Per1 and Per2 gene and protein expression in the SCN around the light/dark transition.” (SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“Exposure to chronic low levels of light at night alters circadian clock genes in both the SCN and peripheral tissue in mice.” (SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“In contrast to constant dark or dim light, exposure to continuous bright light produces locomotor activity arrhythmicity and flattens circadian rhythms in glucocorticoids and body temperature, two principle outputs of the circadian system.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The SCN receives additional indirect input from intrinsically photosensitive melanopsin-containing retinal ganglion cells via the intergeniculate nucleus and input from rods and cones.” (SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

NF

Nigel Ten Fleming

@TenFleming · X

“Light is the most potent synchronizing factor for the SCN. Light information travels directly from intrinsically photosensitive melanopsin-containing retinal ganglion cells through the retinohypothalamic tract to the SCN.”(SCN = Suprachiasmatic nucleus). https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

The circadian system. “For example, glucose transporters and the glucagon receptor, as well as multiple enzymes involved in the metabolism of sugars and the biosynthesis of cholesterols, are rhythmically expressed.” https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

The circadian system. “Among the rhythmic genes identified, many have a specific role in coordinating nutrient metabolism.“ https://t.co/lxbhApH0a4

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Nigel Ten Fleming

@TenFleming · X

“The circadian system is involved in maintaining energy homeostasis. Approximately 10% of the mammalian transcriptome display circadian oscillations.” https://t.co/lxbhApH0a4

ع

عبدالله

@AbdullaQandeel · X

@Mustafa32908795 https://t.co/rwxCzTcakZ