Nat Rev Genet May 2014 PMID 24690881

A guide to genome engineering with programmable nucleases.

Hyongbum Kim, Jin-Soo Kim

Mentions

15
Peak: 6 in Feb 2020
across 4 sources since Feb 2020

Extended reach

162,270
potential audience

Total likes

1,726

Video views

157,871

Mentions per month

Feb 2020 – Jun 2024

Where it's discussed

  • X / Twitter8 posts
  • Blogs3 articles
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The overall tone reflects a positive reception, with several posts mentioning detailed presentations about TALENs and ZFNs hosted by academic institutions, indicating interest and recognition of their importance in genome editing. Words like 'nice presentation' and references to the architecture of these nucleases demonstrate an appreciation for technical depth, which influences the scores for interest and agreement.

AgreementModerate agreement

Most discussions acknowledge the importance and utility of genome editing tools like TALENs and ZFNs, indicating general agreement with the article’s emphasis on their mechanisms.

InterestHigh interest

Participants show high interest, with references to educational presentations and detailed explanations, demonstrating engagement with the technical content.

EngagementNeutral engagement

While some posts share links and summaries, there is limited personal critique or deeper debate, suggesting moderate engagement.

ImpactModerate impact

The discussions highlight the significance of these tools for research and biotech, recognizing their role in advancing gene editing, although they stop short of stressing immediate revolutionary impacts.

Abstract in brief

  • Programmable nucleases like ZFNs, TALENs, and CRISPR-based RGENs enable precise genetic modifications in cells, animals, and plants by cutting DNA at specific sites.
  • These enzymes are valuable in research, medicine, and biotech because they leverage the cell’s natural repair mechanisms to make accurate edits to the genome.
  • Different nucleases vary in their structure, target sites, specificity, and mutation outcomes, so understanding these differences helps researchers select the best tool for particular applications.]

Top posts

Most liked on X and Bluesky
Genomics Gurus
@GenomicsGurus · X

ZINC FINGER NUCLEASES Part 2 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of zinc finger nucleases, which are engineered proteins used for genome editing https://t.co/zo8PfHUvvr via @YouTube

Feb 18, 2020 · 3 likes · 1 share · 130 followers View post →
GeneSoc
@GeneSoc1983 · X

West, A. (2020).

Nov 17, 2021 · 2 likes · 937 followers View post →
Genomics Gurus
@GenomicsGurus · X

TALENs - TALE NUCLEASES Part 3 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of TALE nucleases, which are engineered proteins used for genome editing https://t.co/eSJsBbla37 via @YouTube

Feb 18, 2020 · 2 likes · 1 share · 130 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

TALENs - TALE NUCLEASES - GENE EDITING EXPLAINED @YouTube ! To watch a very nice presentation by Adam West from the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland, click on the following link: https://t.co/0wGSnR27nj via @YouTube https://t.co/qM9MDwOwGO

Jan 12, 2023 · 2,046 followers View post →
junko rh
@junkorh · X

メモ:TALENs https://t.co/0in62irFuE

Jun 29, 2020 · 530 followers View post →
☁️はる☁️
@Ltan_theta · X

@ChamoroJ https://t.co/Cz7iuY6CmH

Jun 26, 2024 · 245 followers View post →

All mentions

☁️はる☁️
@Ltan_theta · X

@ChamoroJ https://t.co/Cz7iuY6CmH

Jun 26, 2024 · 245 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

TALENs - TALE NUCLEASES - GENE EDITING EXPLAINED @YouTube ! To watch a very nice presentation by Adam West from the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland, click on the following link: https://t.co/0wGSnR27nj via @YouTube https://t.co/qM9MDwOwGO

Jan 12, 2023 · 2,046 followers View post →
GeneSoc
@GeneSoc1983 · X

West, A. (2020).

Nov 17, 2021 · 2 likes · 937 followers View post →
junko rh
@junkorh · X

メモ:TALENs https://t.co/0in62irFuE

Jun 29, 2020 · 530 followers View post →
Adam West
@chromatingroup · X

RT @GenomicsGurus: TALENs - TALE NUCLEASES Part 3 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of TAL…

Feb 18, 2020 · 1 share · 187 followers View post →
Adam West
@chromatingroup · X

RT @GenomicsGurus: ZINC FINGER NUCLEASES Part 2 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of zinc…

Feb 18, 2020 · 1 share · 187 followers View post →
Genomics Gurus
@GenomicsGurus · X

TALENs - TALE NUCLEASES Part 3 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of TALE nucleases, which are engineered proteins used for genome editing https://t.co/eSJsBbla37 via @YouTube

Feb 18, 2020 · 2 likes · 1 share · 130 followers View post →
Genomics Gurus
@GenomicsGurus · X

ZINC FINGER NUCLEASES Part 2 of the GENE EDITING EXPLAINED! series This presentation describes the architecture of zinc finger nucleases, which are engineered proteins used for genome editing https://t.co/zo8PfHUvvr via @YouTube

Feb 18, 2020 · 3 likes · 1 share · 130 followers View post →