Relations of change in plasma levels of LDL-C, non-HDL-C and apoB with risk reduction from statin therapy: a meta-analysis of randomized trials.

George Thanassoulis, Ken Williams, Keying Ye, Robert Brook, Patrick Couture, Patrick R Lawler, Jacqueline de Graaf, Curt D Furberg, Allan Sniderman

April 2014

Synopsis of Social media discussions

This collection of discussions exhibits high interest and engagement, with participants referencing detailed meta-analyses, clinical trial data, and related expert opinions, such as Ethan Weiss's insights on apoB and LDL-C, which contribute to a nuanced understanding of the research's significance. The tone emphasizes the importance of the findings for clinical practice and lifestyle considerations, supporting the view that apoB may become a more central marker in cardiovascular risk assessment.

A
Agreement
 Moderate agreement

Most discussions support the article's conclusion that apoB is a superior marker for cardiovascular risk reduction, reflecting widespread agreement among posters.

I
Interest
 High level of interest

Posts demonstrate high interest by referencing multiple detailed analyses, personal opinions, and related research, indicating strong engagement with the topic.

E
Engagement
 High engagement

Many discussions delve into the specifics of lipid markers, referencing studies, alternative viewpoints, and practical implications, showing deep engagement.

I
Impact
 Moderate level of impact

While the posts highlight the significance of research findings, the overall influence on broader clinical practices appears moderate, mainly influencing specialist discussions.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

33 Posts

Metrics

Video Views

389,159

Total Likes

8,547

Extended Reach

715,201

Social Features

37

Timeline: Posts about article

Top Social Media Posts

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  • Colleen Griffith
    @Griffith17431 (Twitter)

    RT @NutritionMadeS3: summarized well here by @ethanjweiss https://t.co/lKIlRy9LZU
    view full post

    September 16, 2024

    1

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    summarized well here by @ethanjweiss https://t.co/lKIlRy9LZU
    view full post

    September 16, 2024

    5

    1

  • Thomas Dayspring
    @Drlipid (Twitter)

    @bjcohenmd @DavidLBrownMD ApoB data exists from almost all of the statin and the subsequent drug trials. Cholesterol metrics are not needed but TG are - to exclude the very high genetic TG lipidoses. Rx article for you https://t.co/PSVsUnl3Q4
    view full post

    August 23, 2024

    2

  • fipco
    @fipco (Twitter)

    @A_Khan_QRS @VPrasadMDMPH LDL-C and apoB are interrelated. See https://t.co/6zF3Xh4bll In statin trials, apoB is a better marker of benefit than LDL-C. https://t.co/hnuSwvZIKY Analysis of non-statin trials concludes
    view full post

    April 10, 2024

    4

  • Zeynep
    @zeypi78 (Twitter)

    RT @DrOzanUnlu: Referanslar: https://t.co/2MCIsciADI https://t.co/7y7XESNHz0
    view full post

    March 27, 2024

    1

  • Dr. Ozan Ünlü
    @DrOzanUnlu (Twitter)

    Referanslar: https://t.co/2MCIsciADI https://t.co/7y7XESNHz0
    view full post

    March 27, 2024

    14

    1

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    @drewlocke @theproof https://t.co/lKIlRy9LZU and https://t.co/HcC8FdaUiJ
    view full post

    November 20, 2023

    3

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    @DrNadolsky @TarbuckSam @BioLayne Ethan Weiss touched on it here https://t.co/lKIlRy9LZU eyeryone with lipid training I´ve asked says they dont look at oxLDL. dont request it. dont use it
    view full post

    September 21, 2023

    5

  • The Aggregate
    @AggregateReads (Twitter)

    @artillain @lj202022 @AdamSinger If you won't take it from me, take it from a low-carb cardiologist. Roughly the 2-6 minute mark in particular: https://t.co/g6gDZgrMUv
    view full post

    September 1, 2023

  • The Aggregate
    @AggregateReads (Twitter)

    @harry15489997 @gammaoptimized @PaulSkallas Take it from a low-carb doctor himself if you don't want to take it from me. https://t.co/tgwzafcfU9
    view full post

    August 23, 2023

  • Health News
    @HealthNews2012 (Twitter)

    Gil's channel has @ethanjweiss and his view https://t.co/NroT3k65Kx
    view full post

    June 28, 2023

  • Katie Smith
    @KatieSm73640241 (Twitter)

    RT @NutritionMadeS3: @Cary44495408 definitely not zero. don't think a healthy diet can be designed with 0. it's more about the whole diet p…
    view full post

    June 27, 2023

    1

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    @Cary44495408 definitely not zero. don't think a healthy diet can be designed with 0. it's more about the whole diet pattern, here are some thoughts: https://t.co/vakqrBat3V also I agree with Ethan´s takes here: https://t.co/lKIlRy9LZU
    view full post

    June 26, 2023

    5

    1

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    @DrNadolsky @BenjaminYeezus sure. this 1 with @ethanjweiss goes over some of the FAQs about sufficiency and other risk factors https://t.co/lKIlRy9LZU we have a lot of other content on this. @theproof has a 3 part pod with @Drlipid that is a banger intro to this field
    view full post

    June 26, 2023

    5

  • Clean Comments
    @CommentsClean (Twitter)

    @ethanjweiss @mattyglesias Ha ha, got you. Dr, I watched your interviews with Peter Attia , they were educational. Your points on LowCarb and Saturated fat points are spot on. This is the most articulate summary on how to navigate diet vis-a-vis artheroscelrosis - https://t.co/kwaXF3r2tr
    view full post

    June 21, 2023

    1

  • Will Brink
    @WillBrink (Twitter)

    Good balanced objective info via @NutritionMadeS3 , so it will be rejected by followers of various fad diets: https://t.co/oNK9KyN0aM
    view full post

    May 8, 2023

  • S B
    @Conigman (Twitter)

    @MohammedAlo LOL cardiologist Dr Ethan Weiss literally says to take olive oil https://t.co/TMlFMoucTZ
    view full post

    April 20, 2023

  • Honeybadger69
    @honeybadger6769 (Twitter)

    @DudzLightLime @theproof @realDaveFeldman This cardiologist gets it right. Get that apoB low. Sub olive oil for SF. https://t.co/8TJPANozO2
    view full post

    March 7, 2023

  • Michael Albert, MD
    @MichaelAlbertMD (Twitter)

    Fair and balanced conversation between @NutritionMadeS3 and @ethanjweiss on Saturated Fat, Cholesterol, and ApoB.
    view full post

    December 1, 2022

    9

  • Carrie Diulus, M.D., FAAOS
    @cadiulus (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    November 3, 2022

    11

  • Pablo
    @pablomf1976 (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    November 2, 2022

    11

  • Tommy_Tentacles
    @TentaclesTom (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    November 2, 2022

    11

  • fipco
    @fipco (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    November 1, 2022

    11

  • fipco
    @fipco (Twitter)

    @lipo_fan @neeche41 This meta analysis of statin trials favored apoB over LDL-C and non-HDL-C in head to head comparisons looking at CHD risk reduction per standard deviation change. https://t.co/6zF3Xh4bll
    view full post

    November 1, 2022

    2

  • M.DiPrimo
    @MDiPrimo (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    November 1, 2022

    11

  • Smiles Health and Fitness / Fat Loss SOS
    @MrJosephSmiles (Twitter)

    Well this was a weird conversation... Low Carb Cardiologist on Saturated Fat, Cholesterol & ApoB | Dr. Ethan Weiss / Nutrition Made Simple! https://t.co/vPNgVWk0aD
    view full post

    November 1, 2022

  • Aaron Lepeska
    @AaronLepeska (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • Katie Smith
    @KatieSm73640241 (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • Cindy Kugler
    @Exspec85 (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • Alan Aragon
    @TheAlanAragon (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • NotYourAverageLayman
    @ParadymRap (Twitter)

    RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…
    view full post

    October 31, 2022

    11

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol harmless if HDL-C is high and triglycerides are low? ▶️is high cholesterol safe if my calcium score is zero? etc ft @ethanjweiss https://t.co/lKIlRy9LZU
    view full post

    October 31, 2022

    49

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Abstract Synopsis

  • The study analyzed data from 7 placebo-controlled statin trials to determine which lipid marker (LDL-C, non-HDL-C, or apoB) best predicts the reduction in coronary heart disease risk from statin therapy, finding that apoB is most closely related.
  • Both frequentist and Bayesian statistical methods showed that decreases in apoB levels are more strongly associated with the reduction in cardiovascular risk compared to LDL-C and non-HDL-C, with Bayesian analysis strongly favoring apoB as the best marker.
  • The findings suggest that monitoring apoB levels may provide a better assessment of lipid-lowering treatment effectiveness and overall risk reduction in coronary heart disease prevention than traditional lipid markers.