April 2014 PMID 24732920

Relations of change in plasma levels of LDL-C, non-HDL-C and apoB with risk reduction from statin therapy: a meta-analysis of randomized trials.

George Thanassoulis, Ken Williams, Keying Ye, Robert Brook, Patrick Couture, Patrick R Lawler, Jacqueline de Graaf, Curt D Furberg, Allan Sniderman

Mentions

37
Peak: 8 in Oct 2022
across 3 sources since Oct 2022

Extended reach

715,201
potential audience

Total likes

8,547

Video views

389,159

Mentions per month

Oct 2022 – Sep 2024

Where it's discussed

  • X / Twitter33 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

This collection of discussions exhibits high interest and engagement, with participants referencing detailed meta-analyses, clinical trial data, and related expert opinions, such as Ethan Weiss's insights on apoB and LDL-C, which contribute to a nuanced understanding of the research's significance. The tone emphasizes the importance of the findings for clinical practice and lifestyle considerations, supporting the view that apoB may become a more central marker in cardiovascular risk assessment.

AgreementModerate agreement

Most discussions support the article's conclusion that apoB is a superior marker for cardiovascular risk reduction, reflecting widespread agreement among posters.

InterestHigh interest

Posts demonstrate high interest by referencing multiple detailed analyses, personal opinions, and related research, indicating strong engagement with the topic.

EngagementHigh engagement

Many discussions delve into the specifics of lipid markers, referencing studies, alternative viewpoints, and practical implications, showing deep engagement.

ImpactModerate impact

While the posts highlight the significance of research findings, the overall influence on broader clinical practices appears moderate, mainly influencing specialist discussions.

Abstract in brief

  • The study analyzed data from 7 placebo-controlled statin trials to determine which lipid marker (LDL-C, non-HDL-C, or apoB) best predicts the reduction in coronary heart disease risk from statin therapy, finding that apoB is most closely related.
  • Both frequentist and Bayesian statistical methods showed that decreases in apoB levels are more strongly associated with the reduction in cardiovascular risk compared to LDL-C and non-HDL-C, with Bayesian analysis strongly favoring apoB as the best marker.
  • The findings suggest that monitoring apoB levels may provide a better assessment of lipid-lowering treatment effectiveness and overall risk reduction in coronary heart disease prevention than traditional lipid markers.

Top posts

Most liked on X and Bluesky
Gil Carvalho MD PhD
@NutritionMadeS3 · X

▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol harmless if HDL-C is high and triglycerides are low? ▶️is high cholesterol safe if my calcium score is zero? etc ft @ethanjweiss https://t.co/lKIlRy9LZU

Oct 31, 2022 · 49 likes · 11 shares · 27,945 followers View post →
Dr. Ozan Ünlü
@DrOzanUnlu · X

Referanslar: https://t.co/2MCIsciADI https://t.co/7y7XESNHz0

Mar 27, 2024 · 14 likes · 1 share · 36,647 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

Fair and balanced conversation between @NutritionMadeS3 and @ethanjweiss on Saturated Fat, Cholesterol, and ApoB.

Dec 1, 2022 · 9 likes · 15,985 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

summarized well here by @ethanjweiss https://t.co/lKIlRy9LZU

Sep 16, 2024 · 5 likes · 1 share · 27,945 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@DrNadolsky @BenjaminYeezus sure. this 1 with @ethanjweiss goes over some of the FAQs about sufficiency and other risk factors https://t.co/lKIlRy9LZU we have a lot of other content on this. @theproof has a 3 part pod with @Drlipid that is a banger intro to this field

Jun 26, 2023 · 5 likes · 27,945 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@Cary44495408 definitely not zero. don't think a healthy diet can be designed with 0. it's more about the whole diet pattern, here are some thoughts: https://t.co/vakqrBat3V also I agree with Ethan´s takes here: https://t.co/lKIlRy9LZU

Jun 26, 2023 · 5 likes · 1 share · 27,945 followers View post →

All mentions

Colleen Griffith
@Griffith17431 · X

RT @NutritionMadeS3: summarized well here by @ethanjweiss https://t.co/lKIlRy9LZU

Sep 16, 2024 · 1 share · 936 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

summarized well here by @ethanjweiss https://t.co/lKIlRy9LZU

Sep 16, 2024 · 5 likes · 1 share · 27,945 followers View post →
Thomas Dayspring
@Drlipid · X

@bjcohenmd @DavidLBrownMD ApoB data exists from almost all of the statin and the subsequent drug trials. Cholesterol metrics are not needed but TG are - to exclude the very high genetic TG lipidoses. Rx article for you https://t.co/PSVsUnl3Q4

Aug 23, 2024 · 2 likes · 42,320 followers View post →
fipco
@fipco · X

@A_Khan_QRS @VPrasadMDMPH LDL-C and apoB are interrelated. See https://t.co/6zF3Xh4bll In statin trials, apoB is a better marker of benefit than LDL-C. https://t.co/hnuSwvZIKY Analysis of non-statin trials concludes

Apr 10, 2024 · 4 likes · 234 followers View post →
Zeynep
@zeypi78 · X

RT @DrOzanUnlu: Referanslar: https://t.co/2MCIsciADI https://t.co/7y7XESNHz0

Mar 27, 2024 · 1 share · 783 followers View post →
Dr. Ozan Ünlü
@DrOzanUnlu · X

Referanslar: https://t.co/2MCIsciADI https://t.co/7y7XESNHz0

Mar 27, 2024 · 14 likes · 1 share · 36,647 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@drewlocke @theproof https://t.co/lKIlRy9LZU and https://t.co/HcC8FdaUiJ

Nov 20, 2023 · 3 likes · 27,945 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@DrNadolsky @TarbuckSam @BioLayne Ethan Weiss touched on it here https://t.co/lKIlRy9LZU eyeryone with lipid training I´ve asked says they dont look at oxLDL. dont request it. dont use it

Sep 21, 2023 · 5 likes · 27,945 followers View post →
The Aggregate
@AggregateReads · X

@artillain @lj202022 @AdamSinger If you won't take it from me, take it from a low-carb cardiologist. Roughly the 2-6 minute mark in particular: https://t.co/g6gDZgrMUv

Sep 1, 2023 · 67 followers View post →
The Aggregate
@AggregateReads · X

@harry15489997 @gammaoptimized @PaulSkallas Take it from a low-carb doctor himself if you don't want to take it from me. https://t.co/tgwzafcfU9

Aug 23, 2023 · 67 followers View post →
Health News
@HealthNews2012 · X

Gil's channel has @ethanjweiss and his view https://t.co/NroT3k65Kx

Jun 28, 2023 · 7 followers View post →
Katie Smith
@KatieSm73640241 · X

RT @NutritionMadeS3: @Cary44495408 definitely not zero. don't think a healthy diet can be designed with 0. it's more about the whole diet p…

Jun 27, 2023 · 1 share · 126 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@Cary44495408 definitely not zero. don't think a healthy diet can be designed with 0. it's more about the whole diet pattern, here are some thoughts: https://t.co/vakqrBat3V also I agree with Ethan´s takes here: https://t.co/lKIlRy9LZU

Jun 26, 2023 · 5 likes · 1 share · 27,945 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@DrNadolsky @BenjaminYeezus sure. this 1 with @ethanjweiss goes over some of the FAQs about sufficiency and other risk factors https://t.co/lKIlRy9LZU we have a lot of other content on this. @theproof has a 3 part pod with @Drlipid that is a banger intro to this field

Jun 26, 2023 · 5 likes · 27,945 followers View post →
Clean Comments
@CommentsClean · X

@ethanjweiss @mattyglesias Ha ha, got you. Dr, I watched your interviews with Peter Attia , they were educational. Your points on LowCarb and Saturated fat points are spot on. This is the most articulate summary on how to navigate diet vis-a-vis artheroscelrosis - https://t.co/kwaXF3r2tr

Jun 21, 2023 · 1 like · 1 followers View post →
Will Brink
@WillBrink · X

Good balanced objective info via @NutritionMadeS3 , so it will be rejected by followers of various fad diets: https://t.co/oNK9KyN0aM

May 8, 2023 · 3,613 followers View post →
S B
@Conigman · X

@MohammedAlo LOL cardiologist Dr Ethan Weiss literally says to take olive oil https://t.co/TMlFMoucTZ

Apr 20, 2023 · 1,262 followers View post →
Honeybadger69
@honeybadger6769 · X

@DudzLightLime @theproof @realDaveFeldman This cardiologist gets it right. Get that apoB low. Sub olive oil for SF. https://t.co/8TJPANozO2

Mar 7, 2023 · 67 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

Fair and balanced conversation between @NutritionMadeS3 and @ethanjweiss on Saturated Fat, Cholesterol, and ApoB.

Dec 1, 2022 · 9 likes · 15,985 followers View post →
Carrie Diulus, M.D., FAAOS
@cadiulus · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Nov 3, 2022 · 11 shares · 11,089 followers View post →
Pablo
@pablomf1976 · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Nov 2, 2022 · 11 shares · 6 followers View post →
Tommy_Tentacles
@TentaclesTom · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Nov 2, 2022 · 11 shares · 5 followers View post →
fipco
@fipco · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Nov 1, 2022 · 11 shares · 232 followers View post →
fipco
@fipco · X

@lipo_fan @neeche41 This meta analysis of statin trials favored apoB over LDL-C and non-HDL-C in head to head comparisons looking at CHD risk reduction per standard deviation change. https://t.co/6zF3Xh4bll

Nov 1, 2022 · 2 likes · 234 followers View post →
M.DiPrimo
@MDiPrimo · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Nov 1, 2022 · 11 shares · 11 followers View post →
Smiles Health and Fitness / Fat Loss SOS
@MrJosephSmiles · X

Well this was a weird conversation... Low Carb Cardiologist on Saturated Fat, Cholesterol & ApoB | Dr. Ethan Weiss / Nutrition Made Simple! https://t.co/vPNgVWk0aD

Nov 1, 2022 · 75 followers View post →
Aaron Lepeska
@AaronLepeska · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 188 followers View post →
Katie Smith
@KatieSm73640241 · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 126 followers View post →
Cindy Kugler
@Exspec85 · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 233 followers View post →
Alan Aragon
@TheAlanAragon · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 42,092 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 1,368 followers View post →
NotYourAverageLayman
@ParadymRap · X

RT @NutritionMadeS3: ▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol…

Oct 31, 2022 · 11 shares · 323 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

▶️is high cholesterol ok on low carb? ▶️is high intake of saturated fat safe if I eat low carb? ▶️is high cholesterol harmless if HDL-C is high and triglycerides are low? ▶️is high cholesterol safe if my calcium score is zero? etc ft @ethanjweiss https://t.co/lKIlRy9LZU

Oct 31, 2022 · 49 likes · 11 shares · 27,945 followers View post →