Trends Cell Biol August 2014 PMID 24786309

NAD+ and sirtuins in aging and disease.

Shin-ichiro Imai, Leonard Guarente

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AI synopsis

What people are saying

The discussions reflect an overall positive reception, highlighting key figures like Sinclair and Imai & Guarente, and emphasizing the significance of NAD+ levels and sirtuins in aging. Words such as 'trends,' 'strategies,' and references to authoritative sources demonstrate active engagement and acknowledgment of the research's importance, contributing to a perception of moderate but meaningful impact.

AgreementModerate agreement

Most discussions express support or recognition of the importance of NAD+ and sirtuins in aging, citing authoritative sources like Sinclair and Imai & Guarente, indicating general agreement with the article's relevance.

InterestHigh interest

The shared emphasis on aging, molecular mechanisms, and potential interventions shows high curiosity and engagement with the topic.

EngagementModerate engagement

Some discussions include specific references to influential researchers and recent reviews, suggesting active interest rather than superficial mentions.

ImpactModerate impact

The focus on aging and disease mechanisms indicates recognition of the research's potential to influence future studies and therapeutic strategies.

Abstract in brief

NAD is a vital coenzyme involved in redox reactions and the regulation of enzymes like sirtuins, PARPs, and CD38 that consume NAD.
During aging, NAD levels decrease, leading to defects in nuclear and mitochondrial functions, which contribute to age-related diseases.
Restoring NAD levels through supplementation of NAD intermediates and activating sirtuins offers promising strategies to combat aging and age-associated diseases.]

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