August 2014 PMID 25009290

PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.

Glenn C Rowe, Srilatha Raghuram, Cholsoon Jang, Janice A Nagy, Ian S Patten, Amrita Goyal, Mun Chun Chan, Laura X Liu, Aihua Jiang, Katherine C Spokes, David Beeler, Harold Dvorak, William C Aird, Zolt Arany

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Mentions

Peak: 3 in Jul 2021

across 2 sources since Jul 2021

Extended reach

148,139

potential audience

Total likes

4,511

Video views

145,640

Mentions per month

Jul 2021 – Dec 2023

Where it's discussed

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What people are saying

The comments mainly reflect casual or humorous references to diet and fasting, like joking about protein shakes or suggesting simple weight loss foods, which indicates these discussions are disconnected from the scientific article's focus on angiogenesis and muscle biology, and therefore show low levels of agreement, engagement, and impact despite minimal interest.

AgreementLow agreement

Most posts dismiss the scientific study or are unrelated, showing little support or acknowledgment of the research.

InterestNeutral interest

The overall discussion level is neutral; the posts focus on food, fasting, and dieting topics rather than the research itself, indicating low interest.

EngagementLow engagement

Posts are brief, lacking depth or reference to scientific methods or implications, reflecting minimal engagement with the article's content.

ImpactNeutral impact

The posts do not seem to influence or alter perspectives on vascular biology; they are more casual comments on diet trends.

Abstract in brief

PGC1 promotes the activation of macrophages through the secretion of SPP1 to facilitate the formation of healthy, organized blood vessels in skeletal muscle, especially in aged and diabetic mice.
The process involves complex cell interactions, with PGC1-induced SPP1 recruiting macrophages that then stimulate endothelial cells and other vessel-supporting cells, leading to effective angiogenesis, unlike the disorganized vessels formed by just VEGF.
Delivering PGC1 directly into muscles can improve blood flow in models of ischemia, suggesting it might be a promising approach to treat vascular diseases related to diabetes and aging by promoting functional blood vessel growth.]

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blubber_bones

@blubber_bones · X

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blubber_bones

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David Thomas

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Cheo (Chāy Ō)

@CheoWalker · X

This Kind of “Fasting” is Great for Days When You Don’t Exercise https://t.co/FDgwvKvR1y #keto

Jul 19, 2021 · 1 like · 349 followers View post →