PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.

Glenn C Rowe, Srilatha Raghuram, Cholsoon Jang, Janice A Nagy, Ian S Patten, Amrita Goyal, Mun Chun Chan, Laura X Liu, Aihua Jiang, Katherine C Spokes, David Beeler, Harold Dvorak, William C Aird, Zolt Arany

August 2014

Synopsis of Social media discussions

The comments mainly reflect casual or humorous references to diet and fasting, like joking about protein shakes or suggesting simple weight loss foods, which indicates these discussions are disconnected from the scientific article's focus on angiogenesis and muscle biology, and therefore show low levels of agreement, engagement, and impact despite minimal interest.

A
Agreement
 Low agreement

Most posts dismiss the scientific study or are unrelated, showing little support or acknowledgment of the research.

I
Interest
 Neutral level of interest

The overall discussion level is neutral; the posts focus on food, fasting, and dieting topics rather than the research itself, indicating low interest.

E
Engagement
 Low engagement

Posts are brief, lacking depth or reference to scientific methods or implications, reflecting minimal engagement with the article's content.

I
Impact
 Neutral impact

The posts do not seem to influence or alter perspectives on vascular biology; they are more casual comments on diet trends.

Social Mentions

YouTube

2 Videos

Twitter

4 Posts

Metrics

Video Views

145,640

Total Likes

4,511

Extended Reach

148,139

Social Features

6

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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    1

Abstract Synopsis

  • PGC1 promotes the activation of macrophages through the secretion of SPP1 to facilitate the formation of healthy, organized blood vessels in skeletal muscle, especially in aged and diabetic mice.
  • The process involves complex cell interactions, with PGC1-induced SPP1 recruiting macrophages that then stimulate endothelial cells and other vessel-supporting cells, leading to effective angiogenesis, unlike the disorganized vessels formed by just VEGF.
  • Delivering PGC1 directly into muscles can improve blood flow in models of ischemia, suggesting it might be a promising approach to treat vascular diseases related to diabetes and aging by promoting functional blood vessel growth.]