Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Findings highlight the need for broader education and vigilance in lidocaine use across specialties. https://t.co/GHMajHzZPu https://t.co/QOGDTLJVyi
Local anesthetic systemic toxicity.
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Jul 2018 – Nov 2025Where it's discussed
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X / Twitter97 posts
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Bluesky6 posts
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YouTube2 videos
AI synopsis
What people are saying
The overall discussions demonstrate a strong focus on recognition, protocol, and treatment of LAST, with posts like 'Recognize LAST early' and mentions of lipid emulsions and protocols. The tone is professional and educational, indicating active engagement and recognition of the importance of this complication in clinical practice.
Most discussions acknowledge the seriousness and importance of recognizing and managing LAST, indicating a general agreement on its clinical significance.
The posts show high interest, with many references to protocols, treatment strategies, and educational resources highlighting engagement from medical professionals.
Several comments involve detailed discussions of management protocols, treatment medications, case examples, and technological approaches, reflecting deep engagement.
The discussions emphasize the potential for improved patient outcomes and awareness, especially through education, protocols, and new research, signifying moderate impact.
Abstract in brief
- LAST (Local Anesthetic Systemic Toxicity) is a rare but serious complication that can happen when local anesthesia is used, potentially causing severe health issues.
- Early recognition and treatment of LAST are crucial for clinicians to prevent severe outcomes.
- The authors reviewed current research on how LAST occurs, how to treat it, and how to prevent it, aiming to provide practical guidelines for managing this complication.]
Top posts
Most liked on X and Bluesky(dla medyków) Leki stosowane do znieczulenia miejscowego, podane w zbyt dużej dawce, mogą prowadzić do działań niepożądanych, z których najpoważniejszym jest tzw. zespół LAST. Jak go rozpoznać i jak reagować? Kolejny odcinek anestezji regionalnej
Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report 全麻中の局所麻酔薬中毒の診断と治療における脳波モニタリングの役割 JA Clin Rep. 2024 Dec. 28 https://t.co/HlXpEjs51u
Local Anesthetic Systemic Toxicity (LAST). https://t.co/wDJ4kpaAYd LAST - Rare but serious complication of regional anesthesia. Early recognition and management are critical. Intravenous Lipid Emulsion has revolutionized treatment. https://t.co/cjrGJfscaA
Hey #ansky: consider giving @mfettiplace.bsky.social a follow! He is an expert on local anesthetic systemic toxicity and has multiple papers w/ his mentor Guy Weinberg. He is also an all around great guy!
All mentions
Understanding Local Anesthetic Toxicity and Management Strategies
Local anesthetic toxicity can occur from rapid or excessive administration, leading to neurological symptoms like numbness, tinnitus, blurred vision, nausea, seizures, and severe cardiac issues. Early recognition and…
Understanding Local Anesthetic Systemic Toxicity and Management Strategies
Local anesthetic systemic toxicity (LAST) is a rare but serious complication. Early recognition and treatment are essential to prevent severe health issues. This video reviews LAST causes, symptoms, and effective…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
RT @BJAJournals: Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Fin…
Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Findings highlight the need for broader education and vigilance in lidocaine use across specialties. https://t.co/GHMajHzZPu https://t.co/QOGDTLJVyi
Deaths from local anesthetic systemic toxicity have declined for long-acting agents, but remain steady for #lidocaine. Findings highlight the need for broader education and vigilance in lidocaine use across specialties. https://www.bjanaesthesia.org/article/S0007-0912(25)00460-X/fulltext
Recognize LAST (local anesthetic systemic toxicity) early—treat with 20% lipid emulsion and supportive care. Do you follow a protocol for LAST?
I did not need to see a Facebook reel about this today, eep! https://t.co/x2QREEwFqT
@garrywalia_ @fortis_hospital cardiac arrest was due to Local anesthetic systemic toxicity? Did you find any depression of vitals before the arrest? Did you discussed possible ADRs of drugs which you people gave him? What is the cause of death?
In the brand new, patient-oriented infographics from @rcoanews.bsky.social about risks from Epidurals in labor, the section about Local anesthetic systemic toxicity gave me a pause : 1/1000 case of possible seizure/cardiac arrest seems really high and scary. doi.org/10.1186/s128... cites 4/10 000..
RT @sureuwanttoknow: @CMerandi Yeah, Exparel didn't work at all for me - just like Fentanyl. I don't know what my BP was coming out of surg…
@CMerandi Yeah, Exparel didn't work at all for me - just like Fentanyl. I don't know what my BP was coming out of surgery. I should have asked. Wide awake and in agony. Fentanyl is a joke and so is Exparel. Exparel's lipid nanoparticles are toxic as well. https://t.co/ANhv66Zd1e
@drsthanus The management of Local Anesthetic Systemic Toxicity (LAST) is critical and involves immediate attention and specific interventions. It's important to familiarize oneself with the most recent protocols since guidelines can evolve. How do you see the integration of technology
You’re managing a patient with suspected LAST (local anesthetic systemic toxicity). What’s your immediate course of action and treatment plan?
The protocol for managing Local Anesthetic Systemic Toxicity (LAST). https://t.co/igoUUuCQes https://t.co/5gzvChcr2D
MD/DNB Anesthesia - Local Anesthetic Systemic Toxicity (LAST) by Prof. Ranjith Karthekeyan on the RAAONLINE App. Android: https://t.co/fSlaHVpc0T IOS:https://t.co/oJAMS4dSCa Watch Now: https://t.co/vIDRVshGFa Contact: +91-9994994266 #raaonline #freelecture #lectureupdate https://t.co/77UF30rNtg
Learn Free Exam Topic – Anesthesia - Local Anesthetic Systemic Toxicity by Prof. Ranjith Karthekeyan on the RAAONLINE App. Android: https://t.co/fSlaHVpc0T IOS: https://t.co/oJAMS4dSCa Contact: +91-9994994266 #freelecture #localanesthetic #systemic #toxicity #pharmacology https://t.co/h5hzNwZqEA
Did you know? Bupivacaine is cardiotoxic at high doses. What’s your strategy for preventing local anesthetic systemic toxicity (LAST)?
Welcome to AEMP's Pulse Dose! Weekly pharmacy pearls to upgrade your EM practice! This week's topic: Local anesthetic systemic toxicity, or "LAST". Don't be the LAST to know! #AEMP #SAEM #AEMPPulseDose #RxPearls #LAST https://t.co/NKJQo9fUy0
Welcome to AEMP's Pulse Dose! Weekly pharmacy pearls to upgrade your EM practice! This week's topic: Local anesthetic systemic toxicity, or "LAST". Don't be the LAST to know! #AEMP #SAEM #AEMPPulseDose #RxPearls #LAST
The impact of local anesthetic systemic toxicity advisories on reporting to the National Poison Data System (NPDS) https://t.co/TMdczKYBYt Lidocaine is not a particularly potent local anesthetic, yet able to produce toxicity.
Question of the day: --- Indicate whether the following statements regarding the management of local anesthetic systemic toxicity (LAST) are true or false: Choose True or False for each statement: . 1. The primary treatment for LAST is the administration of lipid emulsion
RT @jackcfchong: Local Anesthetic Systemic Toxicity (LAST). https://t.co/wDJ4kpaAYd LAST - Rare but serious complication of regional anes…
RT @jackcfchong: Local Anesthetic Systemic Toxicity (LAST). https://t.co/wDJ4kpaAYd LAST - Rare but serious complication of regional anes…
RT @jackcfchong: Local Anesthetic Systemic Toxicity (LAST). https://t.co/wDJ4kpaAYd LAST - Rare but serious complication of regional anes…
Local Anesthetic Systemic Toxicity (LAST). https://t.co/wDJ4kpaAYd LAST - Rare but serious complication of regional anesthesia. Early recognition and management are critical. Intravenous Lipid Emulsion has revolutionized treatment. https://t.co/cjrGJfscaA
Grand Rounds question of the week, Matthew Colontonio What treatment should be considered and initiated early for Local Anesthetic Systemic Toxicity (LAST)? https://t.co/zPQ1sJq1UJ
The Journal of Emergency Nursing is honored to recognize Dr. Nancy Denke as the recipient of the 2025 Clinical Article of the Year for her 2024 article, "Local Anesthetic Systemic Toxicity (LAST): More Common Than You Think." https://t.co/8Cnuk9hp5e
Quiz: What’s the first drug to administer in a case of suspected local anesthetic systemic toxicity (LAST)?
Lecture Update in Anesthesia - Local Anesthetic Systemic Toxicity(Last) by Prof. Ranjith Karthekeyan on the RAAONLINE App. Android: https://t.co/fSlaHVoEbl IOS: https://t.co/oJAMS4dkMC Contact: +91-9994994266 #Raaonline #freelecture #lectureupdate #localanesthesic #medicine https://t.co/vXQ2b4yBWG
医科歯科連携の基礎知識⑫(局所麻酔中毒) リドカイン(キシロカイン)の極量 ・成人:3~4mg/kg (リドカイン単独)、7~8mg/kg (アドレナリン含有時) ・小児:4.4 mg/kg (2%リドカイン8万分の1アドレナリン含有時) https://t.co/X8kCgsy602
On May 9, the operating room team at Misericordia Community Hospital came together for their annual simulation training. This year’s training focused on local anesthetic systemic toxicity and included a full code team response, all within a simulated OR environment. https://t.co/94Wsj5Rv05
4860mgのリドカイン使っておいて、術中に起きた痙攣と高熱から悪性高熱を疑う能力がないなら手術しちゃだめだし、local anesthetic systemic toxicityの可能性もあるけど、どっちにしても手術を行う施設はダントロレンも20%脂質エマルジョンも、どっちもオペ室ごとに用意しておくべきだろ。 https://t.co/jHh06MQW5I
@DialedMedics 1/wide PR, QRS, QTi ,NA+ blockade diagnosis : Local anesthetic systemic toxicity (LAST) Management : Ventilation,supportive care ,intravenous infusion of a 20% lipid emulsion, which helps to reverse the effects of the local anesthetic by absorbing it from the blood and tissues
RT @ApoThera: Local Anesthetic Systemic Toxicity (LAST) https://t.co/EcCDQOiQY4 #MedEd #MedTwitter #TwitteRx #emergencymedicine #CriticalCa…
RT @wszczeklik: (dla medyków) Leki stosowane do znieczulenia miejscowego, podane w zbyt dużej dawce, mogą prowadzić do działań niepożądanyc…
RT @wszczeklik: (dla medyków) Leki stosowane do znieczulenia miejscowego, podane w zbyt dużej dawce, mogą prowadzić do działań niepożądanyc…
(dla medyków) Leki stosowane do znieczulenia miejscowego, podane w zbyt dużej dawce, mogą prowadzić do działań niepożądanych, z których najpoważniejszym jest tzw. zespół LAST. Jak go rozpoznać i jak reagować? Kolejny odcinek anestezji regionalnej
@study_around40 https://t.co/xH9qNItOcn ↑参考までに
@killoxium @pseudo_speedo Local Anesthetic Systemic Toxicity (LAST) is a rare, serious condition from excessive local anesthetic in the bloodstream, affecting the nervous and heart systems. It’s often caused by accidental injection into blood vessels, rapid absorption, or high doses. Symptoms include
【麻酔科専門医試験受験生へのお知らせ】 "読んで学ぶシリーズ"と"解いて学ぶシリーズ"に「局所麻酔薬中毒」を追加しました.サンプルのため全文公開しています. ・読: https://t.co/t9qZ5sPiNV ・解: https://t.co/WMrbDgCywx https://t.co/r0ccCEjFRX
RT @JSAnesth: Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during…
RT @JSAnesth: Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during…
RT @JSAnesth: Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during…
RT @JSAnesth: Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during…
Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report 全麻中の局所麻酔薬中毒の診断と治療における脳波モニタリングの役割 JA Clin Rep. 2024 Dec. 28 https://t.co/HlXpEjs51u
Did you know? Local Anesthetic Systemic Toxicity (LAST) can be a rare but serious risk in pediatric anesthesia! A recent case shows the importance of vigilance and quick action. Learn more: https://t.co/Sr6qm8p07a #PediatricAnesthesia #LAST #PatientSafety
RT @EMSaintJohn: https://t.co/N9yqIc7S91 #EMSJ #Dalhousie #DalhousieEM #DalEM #FOAMed #meded #emergencymedicine #medstudent #resident #cl…
https://t.co/N9yqIc7S91 #EMSJ #Dalhousie #DalhousieEM #DalEM #FOAMed #meded #emergencymedicine #medstudent #resident #clinicalpearl #anesthesia #localanesthetic #localanesthetictoxicity #lidocainetoxicity #toxicology
After injecting local anesthetic for a pt with a complex laceration you notice they are tremulous. They also feel “off”, have tinnitus, and their lips feel numb. Check out our latest clinical pearl “Local Anesthetic Systemic Toxicity” by Anesthesia resident Dr. Bridgette Chan
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https://t.co/pLjof8jBV5
RT @NeuroanestMx: #localanesthetictoxicity https://t.co/E7y8P40Z8T #neuroanesthesiology
#localanesthetictoxicity https://t.co/v1wvZd4qFU #neuroanesthesiology
Hey #ansky: consider giving @mfettiplace.bsky.social a follow! He is an expert on local anesthetic systemic toxicity and has multiple papers w/ his mentor Guy Weinberg. He is also an all around great guy!
Local Anesthetic Systemic Toxicity in Pregnancy: A Retrospective Cohort Analysis https://www.medrxiv.org/content/10.1101/2024.02.25.24303333v1
Local anesthetic systemic toxicity: current perspectives. Worth a read folks...is this THAT bad a problem?! #FOAMed #POCUS #FOAMcc @amit_pawa https://www.ncbi.nlm.nih.gov/pubmed/30122981/
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