Phytother Res December 2014 PMID 25044209

Turmeric toxicity in A431 epidermoid cancer cells associates with autophagy degradation of anti-apoptotic and anti-autophagic p53 mutant.

Visa Thongrakard, Rossella Titone, Carlo Follo, Federica Morani, Apichart Suksamrarn, Tewin Tencomnao, Ciro Isidoro

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19
Peak: 11 in Dec 2024
across 2 sources since Jun 2022

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AI synopsis

What people are saying

The discussions highlight key aspects of the research such as the role of turmeric and curcumin in inducing autophagy, with users engaging through detailed commentary on molecular pathways and potential therapies, reflecting a nuanced but not overwhelmingly enthusiastic perspective.

AgreementNeither agree nor disagree

The discussion doesn't strongly agree or disagree with the publication, indicating mixed or neutral opinions.

InterestModerate interest

While overall interest is moderate, some comments show curiosity about the mechanisms involved.

EngagementModerate engagement

Participants are actively discussing specific details like autophagy, p53 degradation, and potential therapeutic implications.

ImpactNeutral impact

The discussions suggest a moderate level of impact, with some users recognizing the significance but not widely emphasizing immediate real-world applications.

Abstract in brief

  • A431 Squamous Cell Carcinoma cells with the p53R273H mutant can resist cell death, but turmeric and its compound curcumin can trigger both apoptosis and autophagy, leading to p53 degradation.
  • Turmeric and curcumin also activate mTOR, which normally boosts cell growth and hinders autophagy; when mTOR is inhibited by rapamycin, it enhances the effects of turmeric and curcumin, resulting in more autophagosomes and increased cell damage.
  • Silencing autophagy proteins BECLIN 1 and ATG7 prevents autophagy and stabilizes p53, suggesting that autophagy plays a critical role in the degradation of the mutant p53, revealing a new

Top posts

Most liked on X and Bluesky
Zeljko Bilandzic
@zeljkobil · X

"Turmeric Toxicity in A431 Epidermoid Cancer Cells Associates with Autophagy Degradation of Anti-apoptotic and Anti-autophagic p53 Mutant" https://t.co/J1JfDxLOJZ

Jun 12, 2024 · 161 followers View post →

All mentions

Zeljko Bilandzic
@zeljkobil · X

"Turmeric Toxicity in A431 Epidermoid Cancer Cells Associates with Autophagy Degradation of Anti-apoptotic and Anti-autophagic p53 Mutant" https://t.co/J1JfDxLOJZ

Jun 12, 2024 · 161 followers View post →