Front Aging Neurosci August 2014 PMID 25157231

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle.

Marta Gonzalez-Freire, Rafael de Cabo, Stephanie A Studenski, Luigi Ferrucci

Mentions

158
Peak: 100 in Oct 2025
across 6 sources since Mar 2020

Extended reach

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Total likes

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Where it's discussed

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AI synopsis

What people are saying

Discussions about the publication highlight its focus on the neuromuscular junction's role in aging, with examples like mentions of mitochondrial dysfunction, oxidative stress, and inflammation, showing active engagement with the scientific content. The tone ranges from supportive and explanatory to personal reflections, indicating a genuine interest in understanding and applying the research findings.

AgreementModerate agreement

Most discussions recognize and support the importance of the article, with some emphasizing the potential for interventions like exercise and caloric restriction to improve neuromuscular health.

InterestHigh interest

The topic attracts high interest, with many people showing curiosity about how aging affects muscle and nerve functions, and referencing specific neural components like the NMJ.

EngagementModerate engagement

Posts largely demonstrate moderate engagement, including summarizations of the research, mentioning specific biological processes, or sharing related experiences and opinions.

ImpactModerate impact

Although the discussions don't seem to be groundbreaking on a societal scale, they reflect a meaningful awareness of research implications, especially regarding aging and health interventions.

Abstract in brief

  • Aging causes a decline in muscle mass, strength, and neurophysiological functions, with the neuromuscular junction (NMJ) playing a critical role in this process.
  • It is unclear whether changes in the NMJ happen before or after muscle deterioration, but factors like mitochondrial dysfunction, oxidative stress, and inflammation are believed to contribute to NMJ degeneration and muscle decline.
  • Interventions such as caloric restriction and exercise might improve NMJ health and help slow down age-related motor function loss.]

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Prof Omid Khaiyat M.D., PhD
@Omid_HopeUni · X

Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential

Nov 6, 2024 · 97 likes · 18 shares · 14,648 followers View post →
Prof Omid Khaiyat M.D., PhD
@Omid_HopeUni · X

Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in muscle fibre innervation ✅ altered properties of motor units #muscle #ageing #NMJ https://t.co/ZkwmowQpZX https://t.co/8HwUV4iPXB

Apr 9, 2025 · 46 likes · 11 shares · 14,648 followers View post →
Edgar V. Lerma
@edgarvlermamd · X

Neuromuscular junction #PathophysiologyPearls

Mar 20, 2022 · 35 likes · 5 shares · 33,758 followers View post →
Strength For Life
@Strength4_Life · X

The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5T6ZlfY

Jun 19, 2020 · 13 likes · 5 shares · 11,549 followers View post →
Strength For Life
@Strength4_Life · X

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5spsW9CF

Mar 22, 2020 · 9 likes · 6 shares · 11,549 followers View post →
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Maid of Orleans
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Oct 29, 2025 · 1 share View post →
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@euobserver.com · Bluesky

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The WolfmANDOS
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euobserver — EU news that matters
@euobserver.com · Bluesky

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Ruthjic
@Rutijc · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

Jun 20, 2025 · 11 shares · 101 followers View post →
RaM
@ramah000082 · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Antonio Juárez
@tonojuarezjaj · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Daniel Corchado
@med__gym · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Missael
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RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Madhan Ramanathan
@sportsphysiouk · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Abdillah Simba Mdou
@MdouSimba · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Ertania
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RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Koushik
@koushikphysio · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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mer.
@maarleyruiz · X

RT @Omid_HopeUni: Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in m…

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Prof Omid Khaiyat M.D., PhD
@Omid_HopeUni · X

Primary causes of NMJ dysfunction during ageing ✅mitochondrial dysfunction ✅oxidative stress ✅inflammation ✅changes in muscle fibre innervation ✅ altered properties of motor units #muscle #ageing #NMJ https://t.co/ZkwmowQpZX https://t.co/8HwUV4iPXB

Apr 9, 2025 · 46 likes · 11 shares · 14,648 followers View post →
Grisel Brizuela
@DieteticaVya · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 8, 2024 · 18 shares · 41 followers View post →
Valerio Persichetti
@valepersico93 · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 7, 2024 · 18 shares · 427 followers View post →
Dan VC
@KineStomp · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 7, 2024 · 18 shares · 23 followers View post →
Adirek
@Adirek2056608 · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 7, 2024 · 18 shares · 22 followers View post →
Thomas
@gireviktmac619 · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 7, 2024 · 18 shares · 192 followers View post →
Antonio Juárez
@tonojuarezjaj · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 76 followers View post →
Stephen Ferguson
@SteveAFerguson · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 21 followers View post →
Budi Setiawan
@linyangyi · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 83 followers View post →
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@unstopped33 · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 9 followers View post →
Ryu
@Ryu231094 · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 74 followers View post →
Fred
@DrSharonO · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 779 followers View post →
Mikołaj Stańczak
@mstanczako · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 71 followers View post →
mer.
@maarleyruiz · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 129 followers View post →
Arlete Bernal fisio
@arlete_bernal · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 194 followers View post →
Koushik
@koushikphysio · X

RT @Omid_HopeUni: Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential…

Nov 6, 2024 · 18 shares · 523 followers View post →
Prof Omid Khaiyat M.D., PhD
@Omid_HopeUni · X

Neuromuscular Junction (NMJ) A,B) pre-synaptic, intrasynaptic, & post-synaptic components of the NMJ ⬇️ Action potential

Nov 6, 2024 · 97 likes · 18 shares · 14,648 followers View post →
Prof Alejandro Bimbo Diaz,MD
@hyperneuro · X

RT @edgarvlermamd: Neuromuscular junction #PathophysiologyPearls

Apr 20, 2022 · 5 shares · 286 followers View post →
Marvin Josué Bustamante Gutiérrez
@MarvinBustama20 · X

RT @edgarvlermamd: Neuromuscular junction #PathophysiologyPearls

Mar 21, 2022 · 5 shares · 753 followers View post →
El coyote de la pata mala
@giiohinojosa · X

RT @edgarvlermamd: Neuromuscular junction #PathophysiologyPearls

Mar 21, 2022 · 5 shares · 305 followers View post →
RIM
@Ricardoscientia · X

RT @edgarvlermamd: Neuromuscular junction #PathophysiologyPearls

Mar 20, 2022 · 5 shares · 921 followers View post →
Edgar V. Lerma
@edgarvlermamd · X

Neuromuscular junction #PathophysiologyPearls

Mar 20, 2022 · 35 likes · 5 shares · 33,758 followers View post →
Pablo J. Marcos PhD.
@pablojmarcos · X

RT @Strength4_Life: The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5…

Jun 20, 2020 · 5 shares · 1,783 followers View post →
Gonzalo Marquez
@gmarquez_11 · X

RT @Strength4_Life: The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5…

Jun 20, 2020 · 5 shares · 967 followers View post →
physiotwiss
@physiotwiss · X

RT @Strength4_Life: The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5…

Jun 20, 2020 · 5 shares · 106 followers View post →
EskeleThor
@EskeleThor · X

RT @Strength4_Life: The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5…

Jun 19, 2020 · 5 shares · 405 followers View post →
Strength For Life
@Strength4_Life · X

The neuromuscular junction: aging at the crossroad between nerves and muscle https://t.co/Q79bguLmN0 https://t.co/N3b5T6ZlfY

Jun 19, 2020 · 13 likes · 5 shares · 11,549 followers View post →
EskeleThor
@EskeleThor · X

RT @Strength4_Life: The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5s…

Mar 23, 2020 · 6 shares · 405 followers View post →
Bilen HOCAOĞLU
@bilenhocaoglu · X

RT @Strength4_Life: The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5s…

Mar 22, 2020 · 6 shares · 592 followers View post →
joe brtan
@jbrtan · X

RT @Strength4_Life: The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5s…

Mar 22, 2020 · 6 shares · 522 followers View post →
Ирина Баринова
@DAZy81 · X

RT @Strength4_Life: The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5s…

Mar 22, 2020 · 6 shares · 34 followers View post →
Strength For Life
@Strength4_Life · X

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle https://t.co/uiLIWgM2k7 https://t.co/0I5spsW9CF

Mar 22, 2020 · 9 likes · 6 shares · 11,549 followers View post →