PubHawk
December 2014 PMID 25173806

Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

Yadong Huang, Robert W Mahley

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Mentions

4
Peak: 1 in Dec 2020
across 2 sources since Dec 2020

Extended reach

25,338
potential audience

Total likes

99

Video views

3,038

Mentions per month

Dec 2020 – Jun 2025

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reveal a focus on ApoE’s role in lipid transport, such as its involvement in organ systems like the liver and muscle, and its interaction with cell surface receptors, which shows an appreciation for its biological function. The tone is scientific and factual, with phrases like 'ApoE is a component of circulating lipoproteins' and references to experimental findings, highlighting a strong foundational understanding but limited exploration of broader impacts or novel insights.

AgreementModerate agreement

Most posts align with the content, acknowledging ApoE’s role in lipid metabolism and its relevance to physiology, indicating a general agreement with the publication’s significance.

InterestHigh interest

Posts reflect high interest, with discussions on ApoE's functions, its presence in key organs, and its role in lipid clearance, demonstrating curiosity and engagement.

EngagementModerate engagement

Comments include specific references to molecular mechanisms and experimental findings, suggesting moderate but meaningful engagement.

ImpactModerate impact

While the discussion recognizes the biological importance of ApoE, the impact scores are modest, as the posts mainly reinforce known functions rather than proposing new applications or implications.

Abstract in brief

  • Apolipoprotein E (apoE) is a multifunctional protein crucial for lipid transport, neurobiology, and neurodegenerative diseases, with three main isoforms—apoE2, apoE3, and apoE4—that have different effects on cell and brain health.
  • ApoE primarily helps in the binding and internalization of lipoprotein particles via cell-surface receptors, aiding in lipid distribution across tissues, and also influences cellular processes like cytoskeletal stability, mitochondrial function, and neuron structure.
  • Understanding the structure and specific functional domains of apoE has advanced knowledge of its role in normal physiology and disease, especially in how it might contribute to neuronal repair, remodeling, and degeneration in disorders like Alzheimer’s disease.]
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Top posts

Most liked on X and Bluesky
Veera Rajagopal 
@doctorveera · X

Apo E is a component of the circulating lipoprotiens and is the ligand for them to bind to cell surface receptors such as LDL. Higher the binding, higher the clearance of lipids from the blood. https://t.co/Kf6c6iB0mA https://t.co/wSBFf3awst

Dec 17, 2020 · 19,255 followers View post →
53v3n0fn1n3
@53v3n0fn1n3 · X

@Sabisteb The ApoE uptake was described pre-licensing. ApoE is present in organs with fat metabolism/energy supply (liver, endothelials, heart, brain). The luciferase animal trial showed the liver containing 20% stays in the muscle? i.m. is depot systemic delivery! https://t.co/Wyiit2lhTG

Oct 10, 2023 · 1 share · 3,044 followers View post →

All mentions

53v3n0fn1n3
@53v3n0fn1n3 · X

@Sabisteb The ApoE uptake was described pre-licensing. ApoE is present in organs with fat metabolism/energy supply (liver, endothelials, heart, brain). The luciferase animal trial showed the liver containing 20% stays in the muscle? i.m. is depot systemic delivery! https://t.co/Wyiit2lhTG

Oct 10, 2023 · 1 share · 3,044 followers View post →
Veera Rajagopal 
@doctorveera · X

Apo E is a component of the circulating lipoprotiens and is the ligand for them to bind to cell surface receptors such as LDL. Higher the binding, higher the clearance of lipids from the blood. https://t.co/Kf6c6iB0mA https://t.co/wSBFf3awst

Dec 17, 2020 · 19,255 followers View post →