N Engl J Med October 2014 PMID 25317870

Chimeric antigen receptor T cells for sustained remissions in leukemia.

Shannon L Maude, Noelle Frey, Pamela A Shaw, Richard Aplenc, David M Barrett, Nancy J Bunin, Anne Chew, Vanessa E Gonzalez, Zhaohui Zheng, Simon F Lacey, Yolanda D Mahnke, Jan J Melenhorst, Susan R Rheingold, Angela Shen, David T Teachey

Mentions

27
Peak: 4 in Oct 2014
across 5 sources since Oct 2014

Extended reach

23,435
potential audience

Total likes

11

Video views

102

Mentions per month

Oct 2014 – Sep 2025

Where it's discussed

  • News13 articles
  • X / Twitter8 posts
  • Facebook3 posts
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

Many discussions highlight the promising results, with references to high remission rates (e.g., 90% in pediatric ALL trials), using words like 'published results' and 'potential connection' to convey excitement and curiosity. The tone ranges from clinical acknowledgment to speculative queries, underscoring both confidence in findings and interest in broader implications.

AgreementModerate agreement

Most posts acknowledge the effectiveness of the therapy, such as high remission rates and positive trial results, indicating general consensus on its promising nature.

InterestHigh interest

Discussions show strong interest, especially with mentions of trial outcomes, historical context, and potential connections to zoonotic pathogens, sparking curiosity.

EngagementModerate engagement

Some posts delve into specific studies and question potential broader implications, reflecting moderate engagement with technical details.

ImpactModerate impact

The emphasis on trial success, remission rates, and future connections suggests an awareness of the treatment's significant impact on cancer therapy.

Abstract in brief

  • Chimeric antigen receptor T cell therapy targeting CD19 shows high effectiveness in inducing remission in patients with relapsed or refractory acute lymphoblastic leukemia (ALL), including those who previously failed stem cell transplantation.
  • The study involved 30 patients, with 90% achieving complete remission, and a significant number maintaining remission at 6 months, with many T cells persisting in the body and effectively targeting cancer cells.
  • While most patients experienced cytokine-release syndrome, it was manageable with the drug tocilizumab, indicating that the treatment is promising but requires careful monitoring for side effects.]

Top posts

Most liked on X and Bluesky
Bruce Levine, Ph.D.
@BLLPHD · X

On reporting fewer than 5 #genetherapy patients: @ScienceTM 2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE @NEJM 2011 case report on one of the above pts, cited by 4,081 https://t.co/nrB8GLdnAT

Oct 26, 2021 · 5 likes · 2 shares · 9,569 followers View post →
PaulaCBlades17
@PaulaCBlades17 · X

Wondering if there is a Connection to these “Zoonotic Pathogens” & “Chimeric Antigen Receptor T Cells”? https://t.co/GW0e5cNvIO https://t.co/PSNc6ZTOeX Thoughts? @aime3verde https://t.co/jfvAwVWK8s https://t.co/Z0HpdxdbEd

Sep 12, 2021 · 3 likes · 3,832 followers View post →
Benjamin Solomon
@BenjaminSolomo2 · X

Q342 answer: Acute lymphoblastic leukemia https://t.co/iMu9IPrcpl https://t.co/2ghV9an9fl https://t.co/6SFnJpj3tq https://t.co/VNpNA7RdgI https://t.co/WpYRzF2fE0

May 14, 2021 · 1 like · 1,911 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/AnWS3VcfHh

Apr 15, 2021 · 1 like · 46 followers View post →
Christopher Heery MD
@ChrisHeery · X

RT @BLLPHD: On reporting fewer than 5 #genetherapy patients: @ScienceTM 2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE…

Oct 26, 2021 · 2 shares · 3,050 followers View post →
Adriana Bello
@adrianabello · X

RT @cells_nnm: CHOP/ Penn team published results of Ph1 trial for CART-19 cells in pediatric ALL - CR 90% http://t.co/hdSLUQ3XgV

Apr 18, 2020 · 6 shares · 1,981 followers View post →

All mentions

☆お麻☆@戦国ビジネスサテライト
@oasa56701780 · X

RT @StuckInStock: $NVS Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia — NEJM http://t.co/4bfTMfgQIS http://t.co/eKP…

Jan 4, 2023 · 1 share · 1,219 followers View post →
Inspecting Immunology
@InspectingI · X

RT @BLLPHD: On reporting fewer than 5 #genetherapy patients: @ScienceTM 2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE…

Oct 29, 2021 · 2 shares · 1,530 followers View post →
Christopher Heery MD
@ChrisHeery · X

RT @BLLPHD: On reporting fewer than 5 #genetherapy patients: @ScienceTM 2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE…

Oct 26, 2021 · 2 shares · 3,050 followers View post →
Bruce Levine, Ph.D.
@BLLPHD · X

On reporting fewer than 5 #genetherapy patients: @ScienceTM 2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE @NEJM 2011 case report on one of the above pts, cited by 4,081 https://t.co/nrB8GLdnAT

Oct 26, 2021 · 5 likes · 2 shares · 9,569 followers View post →
PaulaCBlades17
@PaulaCBlades17 · X

Wondering if there is a Connection to these “Zoonotic Pathogens” & “Chimeric Antigen Receptor T Cells”? https://t.co/GW0e5cNvIO https://t.co/PSNc6ZTOeX Thoughts? @aime3verde https://t.co/jfvAwVWK8s https://t.co/Z0HpdxdbEd

Sep 12, 2021 · 3 likes · 3,832 followers View post →
Benjamin Solomon
@BenjaminSolomo2 · X

Q342 answer: Acute lymphoblastic leukemia https://t.co/iMu9IPrcpl https://t.co/2ghV9an9fl https://t.co/6SFnJpj3tq https://t.co/VNpNA7RdgI https://t.co/WpYRzF2fE0

May 14, 2021 · 1 like · 1,911 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/AnWS3VcfHh

Apr 15, 2021 · 1 like · 46 followers View post →
Adriana Bello
@adrianabello · X

RT @cells_nnm: CHOP/ Penn team published results of Ph1 trial for CART-19 cells in pediatric ALL - CR 90% http://t.co/hdSLUQ3XgV

Apr 18, 2020 · 6 shares · 1,981 followers View post →
CAR T cell immunotherapy for human cancer | Science
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10.1056/NEJMoa1407222. Crossref · PubMed · Web of Science · Google Scholar. 35. D. M. Barrett, D. T. Teachey, S. A. Grupp, Toxicity management for patients ...

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org/doi/full/10.1056/nejmoa1407222#t=article https://www.nature.com/articles/nrc.2016.97 (Hình ảnh: từ Internet) · Nguyen Nguyen and 26 others.

Sep 17, 2025 View →
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Mar 30, 2025 View →
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Jul 16, 2020 View →
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