Many discussions highlight the promising results, with references to high remission rates (e.g., 90% in pediatric ALL trials), using words like 'published results' and 'potential connection' to convey excitement and curiosity. The tone ranges from clinical acknowledgment to speculative queries, underscoring both confidence in findings and interest in broader implications.
AgreementModerate agreement
Most posts acknowledge the effectiveness of the therapy, such as high remission rates and positive trial results, indicating general consensus on its promising nature.
InterestHigh interest
Discussions show strong interest, especially with mentions of trial outcomes, historical context, and potential connections to zoonotic pathogens, sparking curiosity.
EngagementModerate engagement
Some posts delve into specific studies and question potential broader implications, reflecting moderate engagement with technical details.
ImpactModerate impact
The emphasis on trial success, remission rates, and future connections suggests an awareness of the treatment's significant impact on cancer therapy.
Abstract in brief
Chimeric antigen receptor T cell therapy targeting CD19 shows high effectiveness in inducing remission in patients with relapsed or refractory acute lymphoblastic leukemia (ALL), including those who previously failed stem cell transplantation.
The study involved 30 patients, with 90% achieving complete remission, and a significant number maintaining remission at 6 months, with many T cells persisting in the body and effectively targeting cancer cells.
While most patients experienced cytokine-release syndrome, it was manageable with the drug tocilizumab, indicating that the treatment is promising but requires careful monitoring for side effects.]
On reporting fewer than 5 #genetherapy patients:
@ScienceTM
2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE
@NEJM 2011 case report on one of the above pts, cited by 4,081 https://t.co/nrB8GLdnAT
Oct 26, 2021 · 5 likes · 2 shares · 9,569 followersView post →
P
PaulaCBlades17
@PaulaCBlades17 · X
Wondering if there is a Connection to these “Zoonotic Pathogens” & “Chimeric Antigen Receptor T Cells”?
https://t.co/GW0e5cNvIO
https://t.co/PSNc6ZTOeX
Thoughts? @aime3verde https://t.co/jfvAwVWK8s https://t.co/Z0HpdxdbEd
Chimeric antigen receptor T cell therapy targeting CD19 demonstrates high effectiveness in inducing remission in relapsed or refractory acute lymphoblastic leukemia, with most patients achieving complete remission and…
Chimeric antigen receptor T cell therapy targeting CD19 shows high effectiveness in inducing remission in leukemia patients, including those who failed previous treatments. Most patients achieved complete remission…
RT @StuckInStock: $NVS Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia — NEJM http://t.co/4bfTMfgQIS http://t.co/eKP…
Jan 4, 2023 · 1 share · 1,219 followersView post →
II
Inspecting Immunology
@InspectingI · X
RT @BLLPHD: On reporting fewer than 5 #genetherapy patients:
@ScienceTM
2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE…
Oct 29, 2021 · 2 shares · 1,530 followersView post →
CM
Christopher Heery MD
@ChrisHeery · X
RT @BLLPHD: On reporting fewer than 5 #genetherapy patients:
@ScienceTM
2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE…
Oct 26, 2021 · 2 shares · 3,050 followersView post →
BD
Bruce Levine, Ph.D.
@BLLPHD · X
On reporting fewer than 5 #genetherapy patients:
@ScienceTM
2011 reported 3 CAR T pts, cited by 2,516 https://t.co/lFgvmTAfRE
@NEJM 2011 case report on one of the above pts, cited by 4,081 https://t.co/nrB8GLdnAT
Oct 26, 2021 · 5 likes · 2 shares · 9,569 followersView post →
P
PaulaCBlades17
@PaulaCBlades17 · X
Wondering if there is a Connection to these “Zoonotic Pathogens” & “Chimeric Antigen Receptor T Cells”?
https://t.co/GW0e5cNvIO
https://t.co/PSNc6ZTOeX
Thoughts? @aime3verde https://t.co/jfvAwVWK8s https://t.co/Z0HpdxdbEd
CAR T cell immunotherapy for human cancer | Science
News
10.1056/NEJMoa1407222. Crossref · PubMed · Web of Science · Google Scholar. 35. D. M. Barrett, D. T. Teachey, S. A. Grupp, Toxicity management for patients ...