The editor who contributed most to one of my papers is Miranda Robertson. After https://t.co/a7bsBCBNbp had been rejected numerous times, she got it reviewed and agreed to publish it IF David and I made it longer!! She wanted the argument to be fleshed out in full. She was right!
An inside-out origin for the eukaryotic cell.
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May 2019 – Aug 2025Where it's discussed
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AI synopsis
What people are saying
Discussions frequently express fascination with the inside-out origin theory, with posts mentioning supporting evidence, such as laments about what the Loki archaeal cells look like, and examples comparing different models like Baum and Baum's idea. The tone ranges from enthusiastic support to scientific curiosity, reflecting deep engagement with the research’s implications and potential impact on understanding eukaryotic cell origins.
Most discussions show enthusiasm and support for the inside-out theory, with many expressing interest or positive reactions, reflecting overall agreement or curiosity.
The majority of discussions are highly engaged, often referencing specific models, theories, and scientific debates, indicating strong interest.
Posts delve into detailed aspects of the theory, sharing related research, commentaries, and personal insights, showing active engagement.
The conversations center around alternative models of cell evolution, indicating some influence on current scientific discourse but not yet broadly revolutionary.
Abstract in brief
- The inside-out theory suggests that eukaryotic cells originated from an ancestral prokaryotic cell that extended membrane-bound blebs outward to interact with symbiotic mitochondria, leading to the formation of the cytoplasm and internal structures like the endoplasmic reticulum.
- This model proposes that the nucleus and endomembrane system evolved from these outward protrusions, challenging traditional ideas which assume they formed inside the cytoplasm of primitive prokaryotes.
- The theory helps explain features such as the nucleus’s independence in syncytia and the localization of protein glycosylation, offering new ideas about cell organization and predicting novel mechanisms like nuclear pore insertion during cell cycle phases.]
Top posts
Most liked on X and BlueskyMore evidence consistent with my favorite working theory of how the modern eukaryotic cell evolved (see Baum and Baum: https://t.co/cgAFKclMsU) https://t.co/oE9qWGPtwF
Le modèle "inside-out" pour expliquer l'origine de eukaryotes https://t.co/eZdDvCPXEh https://t.co/7MpomwG6T7
Amazing work: Asgard Lokiarcheon isolated and characterised. Is hydrogen-producing amino-acid fermenter. Makes membrane protrusions. Supports "reverse-flow" hypothesis https://t.co/o95TjuFphk and "inside-out" hypothesis https://t.co/H6i6zrCWkw. No evidence of phagocytosis, though https://t.co/M4rke7ctp4
So now I want to take a bit of a detour into what is apparently controversial in some circles, but I think is intellectually thrilling: A paper by @BaumBuzz and @baobabbaum titled "An inside-out origin for the eukaryotic cell." https://t.co/JNyUCrstzf
I love the image of Loki interacting with protobacteria. Reminds me of the Baum and Baum inside-out theory paper which is still my favorite model for how mitochondria became what they are (https://t.co/cgAFKc4JqU) https://t.co/goXOWx9Nl8 https://t.co/qjqH15WwMQ
All mentions
Unraveling the Evolution of the Cell Nucleus
This episode discusses the crucial role of the cell nucleus in multicellular life and explores the theories surrounding its evolution, including the intriguing idea of giant viruses. Join host Stefan Chin as we delve…
Origins of Eukaryotic Cells and the Endosymbiotic Theory Explored
This episode discusses the evolution of eukaryotic cells from prokaryotes, focusing on how the origin of these cells was a pivotal event in life's diversity. It explores endosymbiosis and the inside-out theory…
RT @LucreSnooker: @how_now00 @greegle_mudzone @odoreida @norvid_studies @Silicon_alien @manic_pixie_agi @jboysen0 @davmlaw @lu_sichu @virid…
@how_now00 @greegle_mudzone @odoreida @norvid_studies @Silicon_alien @manic_pixie_agi @jboysen0 @davmlaw @lu_sichu @viriditax not really, but the guy who struck me as barking up the right tree has the entertaining name Buzz Baum https://t.co/E2iSuxbzSx https://t.co/xz3E7ewpoh
I love the image of Loki interacting with protobacteria. Reminds me of the Baum and Baum inside-out theory paper which is still my favorite model for how mitochondria became what they are (https://t.co/cgAFKc4JqU) https://t.co/goXOWx9Nl8 https://t.co/qjqH15WwMQ
RT @BaumBuzz: The editor who contributed most to one of my papers is Miranda Robertson. After https://t.co/a7bsBCBNbp had been rejected num…
The editor who contributed most to one of my papers is Miranda Robertson. After https://t.co/a7bsBCBNbp had been rejected numerous times, she got it reviewed and agreed to publish it IF David and I made it longer!! She wanted the argument to be fleshed out in full. She was right!
More evidence consistent with my favorite working theory of how the modern eukaryotic cell evolved (see Baum and Baum: https://t.co/cgAFKclMsU) https://t.co/oE9qWGPtwF
@baym @baobabbaum & @BaumBuzz's "An inside-out origin for the eukaryotic cell" https://t.co/ROCLxALYuf
@Poppi62 Buzz Baum @lab_baum and his brother had a model on an alternative route to mitochondrial endosymbiosis, argued here: https://t.co/sZu44mwixC Update here: https://t.co/j0cq9fh0VO (tho’ it would place a double-membrane endosymbiont in the ER lumen)
Happy #CellfieSaturday! The eukaryotic origin story is often told of one cell taking up residence after being ‘eaten.’ So me upon first reading the idea of two cells as ‘friends with benefits':
@phylogenomics @ucdavis Have you ever read the inside out theory by Baum and Baum? I highly recommend it. Of course I’m partial, because in that theory the nuclear envelope proteins I work on had to come before almost everything else! https://t.co/jBz06dXfME
RT @ThomasCabaret84: Le modèle "inside-out" pour expliquer l'origine de eukaryotes https://t.co/eZdDvCPXEh https://t.co/7MpomwG6T7
Le modèle "inside-out" pour expliquer l'origine de eukaryotes https://t.co/eZdDvCPXEh https://t.co/7MpomwG6T7
RT @efraimeph: @CMooreAnderson I like how the endomembrane system has direct openings to the outside environment. Reminded me of the inside…
@CMooreAnderson I like how the endomembrane system has direct openings to the outside environment. Reminded me of the inside-out theory for endosymbiosis. https://t.co/FsJwtLURme
@RickCorrington 1) https://t.co/NqMjBNlYbh 2) https://t.co/JPc6sj1D4m 3) https://t.co/uWi7ZCEGdp
And take a look at Buzz's original theoretical paper with his cousin: https://t.co/pGNthqFtiY As Buzz says, compare the drawings in this paper with what the Loki archaeal cell actually looks like: https://t.co/ImW1gl15nS
RT @apmweber: Amazing work: Asgard Lokiarcheon isolated and characterised. Is hydrogen-producing amino-acid fermenter. Makes membrane protr…
Amazing work: Asgard Lokiarcheon isolated and characterised. Is hydrogen-producing amino-acid fermenter. Makes membrane protrusions. Supports "reverse-flow" hypothesis https://t.co/o95TjuFphk and "inside-out" hypothesis https://t.co/H6i6zrCWkw. No evidence of phagocytosis, though https://t.co/M4rke7ctp4
@vivekmalhotra18 What do you think about this paper? https://t.co/cgAFKclMsU
So now I want to take a bit of a detour into what is apparently controversial in some circles, but I think is intellectually thrilling: A paper by @BaumBuzz and @baobabbaum titled "An inside-out origin for the eukaryotic cell." https://t.co/JNyUCrstzf