Proc Natl Acad Sci U S A December 2014 PMID 25404319

Melanopsin mediates light-dependent relaxation in blood vessels.

Gautam Sikka, G Patrick Hussmann, Deepesh Pandey, Suyi Cao, Daijiro Hori, Jong Taek Park, Jochen Steppan, Jae Hyung Kim, Viachaslau Barodka, Allen C Myers, Lakshmi Santhanam, Daniel Nyhan, Marc K Halushka, Raymond C Koehler, Solomon H Snyder

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Peak: 2 in Jun 2019

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The discussions reflect a generally neutral stance, with references to prior mentions and interests in related topics such as blue light and electromagnetic fields. The tone is cautious, with some users suggesting potential applications, but few delve deeply into methodological details or broader implications, indicating moderate engagement and impact.

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Posts show neutral to cautious acknowledgment of the research, with some recalling previous mentions or expressing curiosity rather than outright agreement.

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Discussions demonstrate moderate interest, especially concerning potential practical applications like blue light and electromagnetic fields, but lack enthusiasm or detailed engagement.

EngagementModerate engagement

Some posts reference specific aspects or ask for further information, indicating basic curiosity and surface-level engagement rather than deep analysis.

ImpactNeutral impact

Overall impact seems limited, with signs of interest in future implications but no strong claims about major scientific or societal influence.

Abstract in brief

Melanopsin (Opn4) is a non-image-forming opsin that influences various light-related behaviors and has now been shown to play a role in regulating blood vessel function through photorelaxation.
PCR results confirm the presence of Opn4 in blood vessels, and studies reveal that Opn4(-/-) mice do not exhibit photorelaxation, suggesting its critical role in this process.
The vasorelaxation response is wavelength-specific, primarily occurring at blue light (430-460 nm), and operates through a unique signaling pathway not involving traditional vasorelaxation signals, indicating a potential therapeutic target for diseases linked to abnormal blood vessel function.

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drMAWZ

@TheDrMAWZ · X

Friday Journal Club! What are we reading today? "Melanopsin mediates light-dependent relaxation in blood vessels" https://t.co/pvciYpr1I5 (2014)

Feb 2, 2024 · 4 likes · 3,388 followers View post →

Thomas Hall

@Thomass27612448 · X

@DrJackKruse Hi Dr Jack. One of your tweets sent 21/2/22 had a sub heading 'Clue I was right 2014' and said "Melanopsin mediates light-dependent relaxation in blood vessels _ _ _". Please let me know the page number in your REpi-Paleo RV of the reference to such. Cheers TH Perth

Apr 24, 2022 · 831 followers View post →

ENDALA klinika zdraví

@endalaclinic · X

Melanopsin mediates light-dependent relaxation in blood vessels | PNAS. blue light and nnEMF is the game changer https://t.co/hIeW4ZtrUd

Feb 21, 2022 · 5 likes · 1 share · 254 followers View post →

Don Tidwell

@tidwell_don · X

RT @Mitominder: Melanopsin mediates light-dependent relaxation in blood vessels https://t.co/HUyGlrih3m 1/8

Jun 1, 2019 · 1 share · 2,807 followers View post →

Mitominder

@Mitominder · X

Melanopsin mediates light-dependent relaxation in blood vessels https://t.co/HUyGlrih3m 1/8

Jun 1, 2019 · 10 likes · 1 share · 2,259 followers View post →

Рецептор света, родственный родопсину сетчатки, регулирует ...

News

Published online before print November 17, 2014. Doi:10.1073/pnas.1420258111. Юлия Кондратенко ...

Dec 2, 2014 View →

Blood vessel receptor that responds to light may be new target for ...